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Thrombosis, cancer, and COVID-19.
Brito-Dellan N, Tsoukalas N, Font C. Brito-Dellan N, et al. Support Care Cancer. 2022 Oct;30(10):8491-8500. doi: 10.1007/s00520-022-07098-z. Epub 2022 May 14. Support Care Cancer. 2022. PMID: 35567609 Free PMC article. Review.
Cancer and coronavirus disease 2019 (COVID-19) have unusual similarities: they both result in a markedly elevated risk of thrombosis, exceptionally high D-dimer levels, and the failure of anticoagulation therapy in some cases. Cancer patients are more vulnerable to …
Cancer and coronavirus disease 2019 (COVID-19) have unusual similarities: they both result in a markedly elevated risk of thrombosis, except …
Anti-PF4 disorders: Pathogenesis, diagnosis and treatment.
Preece MV, Pathak DV, Laffan M, Arachchillage DJ. Preece MV, et al. Br J Haematol. 2025 Sep;207(3):709-722. doi: 10.1111/bjh.20216. Epub 2025 Jul 1. Br J Haematol. 2025. PMID: 40589323 Free PMC article. Review.
Clinical evaluation of HIT and VITT/VITT-like disorders is based on thrombotic events, platelet counts and D-dimer levels. Laboratory assays such as heparin/PF4-induced platelet activation assays can be used to distinguish between HIT and VITT. ...
Clinical evaluation of HIT and VITT/VITT-like disorders is based on thrombotic events, platelet counts and D-dimer levels. Lab …
Thrombosis with thrombocytopenia syndrome associated with COVID-19 vaccines.
Long B, Bridwell R, Gottlieb M. Long B, et al. Am J Emerg Med. 2021 Nov;49:58-61. doi: 10.1016/j.ajem.2021.05.054. Epub 2021 May 25. Am J Emerg Med. 2021. PMID: 34062319 Free PMC article. Review.
Evaluation should include complete blood count, peripheral smear, D-dimer, fibrinogen, coagulation panel, renal and liver function, and electrolytes, as well as PF4-heparin ELISA if available. ...
Evaluation should include complete blood count, peripheral smear, D-dimer, fibrinogen, coagulation panel, renal and liver func …
How to recognize and manage COVID-19-associated coagulopathy.
Gerber GF, Chaturvedi S. Gerber GF, et al. Hematology Am Soc Hematol Educ Program. 2021 Dec 10;2021(1):614-620. doi: 10.1182/hematology.2021000297. Hematology Am Soc Hematol Educ Program. 2021. PMID: 34889412 Free PMC article. Review.
COVID-19 is frequently associated with abnormalities on coagulation testing and a coagulopathy driven by inflammation, intravascular coagulation activation, and microvascular thrombosis. Elevated D-dimer is the most common finding and is a predictor of adverse outco …
COVID-19 is frequently associated with abnormalities on coagulation testing and a coagulopathy driven by inflammation, intravascular coagula …
COVID-19 vaccine-induced immune thrombotic thrombocytopenia: pathophysiology and diagnosis.
Dorgalaleh A, Shabannezhad A, Hassani S. Dorgalaleh A, et al. Ann Hematol. 2025 Jan;104(1):47-55. doi: 10.1007/s00277-023-05563-1. Epub 2023 Nov 30. Ann Hematol. 2025. PMID: 38030893 Review.
In addition to thrombocytopenia, thrombosis, and the presence of anti-PF4 Abs, the day of symptoms onset and the elevation of D-dimer are also required for definitive diagnosis of VITT. The absence of one or more criteria can result in the exclusion of definitive VI …
In addition to thrombocytopenia, thrombosis, and the presence of anti-PF4 Abs, the day of symptoms onset and the elevation of D-di …
Laboratory testing for suspected COVID-19 vaccine-induced (immune) thrombotic thrombocytopenia.
Favaloro EJ. Favaloro EJ. Int J Lab Hematol. 2021 Aug;43(4):559-570. doi: 10.1111/ijlh.13629. Epub 2021 Jun 17. Int J Lab Hematol. 2021. PMID: 34138513 Free PMC article. Review.
In summary, testing typically comprises platelet counts, D-dimer, fibrinogen, and various immunological and functional assays for platelet factor 4 (PF4) antibodies. In suspected VITT, there is a generally highly elevated level of D-dimer, thrombocytop …
In summary, testing typically comprises platelet counts, D-dimer, fibrinogen, and various immunological and functional assays …
COVID-19 Vaccine-Associated Thrombosis With Thrombocytopenia Syndrome (TTS): A Systematic Review and Post Hoc Analysis.
Hafeez MU, Ikram M, Shafiq Z, Sarfraz A, Sarfraz Z, Jaiswal V, Sarfraz M, Chérrez-Ojeda I. Hafeez MU, et al. Clin Appl Thromb Hemost. 2021 Jan-Dec;27:10760296211048815. doi: 10.1177/10760296211048815. Clin Appl Thromb Hemost. 2021. PMID: 34698582 Free PMC article.
Data analysis was conducted using SPSS V25 for factors associated with mortality, including age, gender, anti-PF4/heparin antibodies, platelet nadir, D-dimer peak, time to event diagnosis, arterial or venous thrombi. RESULTS: Of the 175 studies identified, a total o …
Data analysis was conducted using SPSS V25 for factors associated with mortality, including age, gender, anti-PF4/heparin antibodies, platel …
Vaccine-induced immune thrombotic thrombocytopenia and patients with cancer.
Connors JM, Iba T. Connors JM, et al. Thromb Res. 2022 May;213 Suppl 1:S77-S83. doi: 10.1016/j.thromres.2022.02.009. Epub 2022 May 26. Thromb Res. 2022. PMID: 36210565 Free PMC article. Review.
Vaccination programs were started, but shortly thereafter a small number of patients with a constellation of findings including thrombosis in unusual locations, thrombocytopenia, elevated D-dimer and often low fibrinogen led another intense and concentrated scientif …
Vaccination programs were started, but shortly thereafter a small number of patients with a constellation of findings including thrombosis i …
Assessment of cardiac adverse events following COVID-19 vaccination by speckle tracking echocardiography.
Chaichuum S, Tseng CL, Chang SC, Chan CL, Hsu CY, Chiang E, Daimon M, Chiang SJ, Chen HH. Chaichuum S, et al. Sci Rep. 2024 May 13;14(1):10849. doi: 10.1038/s41598-024-61641-y. Sci Rep. 2024. PMID: 38740940 Free PMC article.
All had normal serum levels of creatine phosphokinase, creatine kinase myocardial band, troponin, N-terminal pro b-type natriuretic peptide, platelets, and D-dimer. Left ventricular ejection fraction in the symptomatic group (71.41% 7.12%) and the control group (7 …
All had normal serum levels of creatine phosphokinase, creatine kinase myocardial band, troponin, N-terminal pro b-type natriuretic peptide, …
Increment of D-dimer Associated with Immune Thrombotic Thrombocytopenia in ChAdOx1 nCoV-19 Vaccinated Individuals.
Ornelas-Aguirre JM, Gómez-Alcalá AV, Ramírez-Leyva DH. Ornelas-Aguirre JM, et al. Arch Med Res. 2022 Jun;53(4):341-351. doi: 10.1016/j.arcmed.2022.03.008. Epub 2022 May 6. Arch Med Res. 2022. PMID: 35534335
Our objective was to summarize case reports on VITT with/without D-dimer increments in AstraZeneca-Oxford vaccinated individuals. DATA SOURCES: MEDLINE, PubMed, and Scopus databases were searched. ...Clinicians should prepare for early identification of patients wit …
Our objective was to summarize case reports on VITT with/without D-dimer increments in AstraZeneca-Oxford vaccinated individua …
59 results