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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1984 1
1985 1
1988 1
1991 1
1992 6
1993 9
1994 8
1995 11
1996 5
1997 5
1998 4
1999 2
2000 4
2001 5
2002 9
2003 5
2004 12
2005 8
2006 14
2007 15
2008 13
2009 11
2010 7
2011 12
2012 19
2013 19
2014 20
2015 37
2016 46
2017 38
2018 46
2019 45
2020 58
2021 56
2022 53
2023 40
2024 43
2025 62
2026 25

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698 results

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Page 1
Hallmarks of aging: An expanding universe.
López-Otín C, Blasco MA, Partridge L, Serrano M, Kroemer G. López-Otín C, et al. Cell. 2023 Jan 19;186(2):243-278. doi: 10.1016/j.cell.2022.11.001. Epub 2023 Jan 3. Cell. 2023. PMID: 36599349 Free article. Review.
We propose the following twelve hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, disabled macroautophagy, deregulated nutrient-sensing, mitochondrial dysfunction, cellular senescence, stem cell exhaustion, altered i …
We propose the following twelve hallmarks of aging: genomic instability, telomere attrition, epigenetic alterations, loss of proteostasis, d …
Long-term expanding human airway organoids for disease modeling.
Sachs N, Papaspyropoulos A, Zomer-van Ommen DD, Heo I, Böttinger L, Klay D, Weeber F, Huelsz-Prince G, Iakobachvili N, Amatngalim GD, de Ligt J, van Hoeck A, Proost N, Viveen MC, Lyubimova A, Teeven L, Derakhshan S, Korving J, Begthel H, Dekkers JF, Kumawat K, Ramos E, van Oosterhout MF, Offerhaus GJ, Wiener DJ, Olimpio EP, Dijkstra KK, Smit EF, van der Linden M, Jaksani S, van de Ven M, Jonkers J, Rios AC, Voest EE, van Moorsel CH, van der Ent CK, Cuppen E, van Oudenaarden A, Coenjaerts FE, Meyaard L, Bont LJ, Peters PJ, Tans SJ, van Zon JS, Boj SF, Vries RG, Beekman JM, Clevers H. Sachs N, et al. EMBO J. 2019 Feb 15;38(4):e100300. doi: 10.15252/embj.2018100300. Epub 2019 Jan 14. EMBO J. 2019. PMID: 30643021 Free PMC article.
Organoids are self-organizing 3D structures grown from stem cells that recapitulate essential aspects of organ structure and function. Here, we describe a method to establish long-term-expanding human airway organoids from broncho-alveolar resections or lavage mater …
Organoids are self-organizing 3D structures grown from stem cells that recapitulate essential aspects of organ structure and f …
Recent advances in lung organoid development and applications in disease modeling.
Vazquez-Armendariz AI, Tata PR. Vazquez-Armendariz AI, et al. J Clin Invest. 2023 Nov 15;133(22):e170500. doi: 10.1172/JCI170500. J Clin Invest. 2023. PMID: 37966116 Free PMC article. Review.
Advanced lung organoid platforms derived from various sources, including adult, fetal, and induced pluripotent stem cells, have now been generated, which more closely mimic the cellular architecture found within the airways and alveoli. ...Thus, these developments i …
Advanced lung organoid platforms derived from various sources, including adult, fetal, and induced pluripotent stem cells, hav …
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.
Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, Rogel N, Burgin G, Tsankov AM, Waghray A, Slyper M, Waldman J, Nguyen L, Dionne D, Rozenblatt-Rosen O, Tata PR, Mou H, Shivaraju M, Bihler H, Mense M, Tearney GJ, Rowe SM, Engelhardt JF, Regev A, Rajagopal J. Montoro DT, et al. Nature. 2018 Aug;560(7718):319-324. doi: 10.1038/s41586-018-0393-7. Epub 2018 Aug 1. Nature. 2018. PMID: 30069044 Free PMC article.
The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here we study the cellular composition and hierarchy of the mouse tracheal epithelium by single-cell RNA-sequencing (scRNA-seq) and in vivo lineage tracing. ...We developed 'puls …
The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here we study the cellular composition …
Lung organoids: current uses and future promise.
Barkauskas CE, Chung MI, Fioret B, Gao X, Katsura H, Hogan BL. Barkauskas CE, et al. Development. 2017 Mar 15;144(6):986-997. doi: 10.1242/dev.140103. Development. 2017. PMID: 28292845 Free PMC article. Review.
The proximal and distal regions of the lung contain epithelial cells specialized for different functions: basal, secretory and ciliated cells in the conducting airways and type II and type I cells lining the alveoli. ...We also discuss the potential and limit …
The proximal and distal regions of the lung contain epithelial cells specialized for different functions: basal, secretory and ciliat …
Prime editing functionally corrects cystic fibrosis-causing CFTR mutations in human organoids and airway epithelial cells.
Bulcaen M, Kortleven P, Liu RB, Maule G, Dreano E, Kelly M, Ensinck MM, Thierie S, Smits M, Ciciani M, Hatton A, Chevalier B, Ramalho AS, Casadevall I Solvas X, Debyser Z, Vermeulen F, Gijsbers R, Sermet-Gaudelus I, Cereseto A, Carlon MS. Bulcaen M, et al. Cell Rep Med. 2024 May 21;5(5):101544. doi: 10.1016/j.xcrm.2024.101544. Epub 2024 May 1. Cell Rep Med. 2024. PMID: 38697102 Free PMC article.
Here, we present prime editing approaches to correct L227R- and N1303K-CFTR, two mutations that cause cystic fibrosis and are not eligible for current market-approved modulator therapies. We show that, upon DNA correction of the CFTR gene, the complex glycosylation, …
Here, we present prime editing approaches to correct L227R- and N1303K-CFTR, two mutations that cause cystic fibrosis and are …
In vivo editing of lung stem cells for durable gene correction in mice.
Sun Y, Chatterjee S, Lian X, Traylor Z, Sattiraju SR, Xiao Y, Dilliard SA, Sung YC, Kim M, Lee SM, Moore S, Wang X, Zhang D, Wu S, Basak P, Wang J, Liu J, Mann RJ, LePage DF, Jiang W, Abid S, Hennig M, Martinez A, Wustman BA, Lockhart DJ, Jain R, Conlon RA, Drumm ML, Hodges CA, Siegwart DJ. Sun Y, et al. Science. 2024 Jun 14;384(6701):1196-1202. doi: 10.1126/science.adk9428. Epub 2024 Jun 13. Science. 2024. PMID: 38870301 Free PMC article.
In vivo genome correction holds promise for generating durable disease cures; yet, effective stem cell editing remains challenging. In this work, we demonstrate that optimized lung-targeting lipid nanoparticles (LNPs) enable high levels of genome editing in stem …
In vivo genome correction holds promise for generating durable disease cures; yet, effective stem cell editing remains challenging. I …
Bone-marrow-homing lipid nanoparticles for genome editing in diseased and malignant haematopoietic stem cells.
Lian X, Chatterjee S, Sun Y, Dilliard SA, Moore S, Xiao Y, Bian X, Yamada K, Sung YC, Levine RM, Mayberry K, John S, Liu X, Smith C, Johnson LT, Wang X, Zhang CC, Liu DR, Newby GA, Weiss MJ, Yen JS, Siegwart DJ. Lian X, et al. Nat Nanotechnol. 2024 Sep;19(9):1409-1417. doi: 10.1038/s41565-024-01680-8. Epub 2024 May 23. Nat Nanotechnol. 2024. PMID: 38783058 Free PMC article.
Therapeutic genome editing of haematopoietic stem cells (HSCs) would provide long-lasting treatments for multiple diseases. However, the in vivo delivery of genetic medicines to HSCs remains challenging, especially in diseased and malignant settings. ...Bone-marrow- …
Therapeutic genome editing of haematopoietic stem cells (HSCs) would provide long-lasting treatments for multiple diseases. Ho …
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.
Schwank G, Koo BK, Sasselli V, Dekkers JF, Heo I, Demircan T, Sasaki N, Boymans S, Cuppen E, van der Ent CK, Nieuwenhuis EE, Beekman JM, Clevers H. Schwank G, et al. Cell Stem Cell. 2013 Dec 5;13(6):653-8. doi: 10.1016/j.stem.2013.11.002. Cell Stem Cell. 2013. PMID: 24315439 Free article.
Single murine and human intestinal stem cells can be expanded in culture over long time periods as genetically and phenotypically stable epithelial organoids. Increased cAMP levels induce rapid swelling of such organoids by opening the cystic fibrosis …
Single murine and human intestinal stem cells can be expanded in culture over long time periods as genetically and phenotypica …
Human distal airways contain a multipotent secretory cell that can regenerate alveoli.
Basil MC, Cardenas-Diaz FL, Kathiriya JJ, Morley MP, Carl J, Brumwell AN, Katzen J, Slovik KJ, Babu A, Zhou S, Kremp MM, McCauley KB, Li S, Planer JD, Hussain SS, Liu X, Windmueller R, Ying Y, Stewart KM, Oyster M, Christie JD, Diamond JM, Engelhardt JF, Cantu E, Rowe SM, Kotton DN, Chapman HA, Morrisey EE. Basil MC, et al. Nature. 2022 Apr;604(7904):120-126. doi: 10.1038/s41586-022-04552-0. Epub 2022 Mar 30. Nature. 2022. PMID: 35355013 Free PMC article.
Here we show that human respiratory bronchioles contain a unique secretory cell population that is distinct from cells in larger proximal airways. Organoid modelling reveals that these respiratory airway secretory (RAS) cells act as unidirectional progenitors for al …
Here we show that human respiratory bronchioles contain a unique secretory cell population that is distinct from cells in larger prox …
698 results