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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1982 1
1984 1
1985 1
1988 1
1991 1
1992 6
1993 9
1994 8
1995 11
1996 5
1997 5
1998 4
1999 2
2000 4
2001 5
2002 9
2003 5
2004 12
2005 8
2006 14
2007 15
2008 13
2009 11
2010 7
2011 12
2012 19
2013 19
2014 20
2015 37
2016 46
2017 38
2018 46
2019 45
2020 58
2021 56
2022 24
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511 results
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Page 1
Long-term expanding human airway organoids for disease modeling.
Sachs N, Papaspyropoulos A, Zomer-van Ommen DD, Heo I, Böttinger L, Klay D, Weeber F, Huelsz-Prince G, Iakobachvili N, Amatngalim GD, de Ligt J, van Hoeck A, Proost N, Viveen MC, Lyubimova A, Teeven L, Derakhshan S, Korving J, Begthel H, Dekkers JF, Kumawat K, Ramos E, van Oosterhout MF, Offerhaus GJ, Wiener DJ, Olimpio EP, Dijkstra KK, Smit EF, van der Linden M, Jaksani S, van de Ven M, Jonkers J, Rios AC, Voest EE, van Moorsel CH, van der Ent CK, Cuppen E, van Oudenaarden A, Coenjaerts FE, Meyaard L, Bont LJ, Peters PJ, Tans SJ, van Zon JS, Boj SF, Vries RG, Beekman JM, Clevers H. Sachs N, et al. EMBO J. 2019 Feb 15;38(4):e100300. doi: 10.15252/embj.2018100300. Epub 2019 Jan 14. EMBO J. 2019. PMID: 30643021 Free PMC article.
Organoids are self-organizing 3D structures grown from stem cells that recapitulate essential aspects of organ structure and function. ...Airway organoids derived from cystic fibrosis (CF) patients allow assessment of CFTR function in an organoid swell …
Organoids are self-organizing 3D structures grown from stem cells that recapitulate essential aspects of organ structure and f …
Lung organoids: current uses and future promise.
Barkauskas CE, Chung MI, Fioret B, Gao X, Katsura H, Hogan BL. Barkauskas CE, et al. Development. 2017 Mar 15;144(6):986-997. doi: 10.1242/dev.140103. Development. 2017. PMID: 28292845 Free PMC article. Review.
The proximal and distal regions of the lung contain epithelial cells specialized for different functions: basal, secretory and ciliated cells in the conducting airways and type II and type I cells lining the alveoli. ...We also discuss the potential and limit …
The proximal and distal regions of the lung contain epithelial cells specialized for different functions: basal, secretory and ciliat …
Functional repair of CFTR by CRISPR/Cas9 in intestinal stem cell organoids of cystic fibrosis patients.
Schwank G, Koo BK, Sasselli V, Dekkers JF, Heo I, Demircan T, Sasaki N, Boymans S, Cuppen E, van der Ent CK, Nieuwenhuis EE, Beekman JM, Clevers H. Schwank G, et al. Cell Stem Cell. 2013 Dec 5;13(6):653-8. doi: 10.1016/j.stem.2013.11.002. Cell Stem Cell. 2013. PMID: 24315439 Free article.
Single murine and human intestinal stem cells can be expanded in culture over long time periods as genetically and phenotypically stable epithelial organoids. Increased cAMP levels induce rapid swelling of such organoids by opening the cystic fibrosis
Single murine and human intestinal stem cells can be expanded in culture over long time periods as genetically and phenotypica …
Derivation of Airway Basal Stem Cells from Human Pluripotent Stem Cells.
Hawkins FJ, Suzuki S, Beermann ML, Barillà C, Wang R, Villacorta-Martin C, Berical A, Jean JC, Le Suer J, Matte T, Simone-Roach C, Tang Y, Schlaeger TM, Crane AM, Matthias N, Huang SXL, Randell SH, Wu J, Spence JR, Carraro G, Stripp BR, Rab A, Sorsher EJ, Horani A, Brody SL, Davis BR, Kotton DN. Hawkins FJ, et al. Cell Stem Cell. 2021 Jan 7;28(1):79-95.e8. doi: 10.1016/j.stem.2020.09.017. Epub 2020 Oct 23. Cell Stem Cell. 2021. PMID: 33098807 Free PMC article.
The derivation of tissue-specific stem cells from human induced pluripotent stem cells (iPSCs) would have broad reaching implications for regenerative medicine. Here, we report the directed differentiation of human iPSCs into airway basal cells
The derivation of tissue-specific stem cells from human induced pluripotent stem cells (iPSCs) would have broad …
A revised airway epithelial hierarchy includes CFTR-expressing ionocytes.
Montoro DT, Haber AL, Biton M, Vinarsky V, Lin B, Birket SE, Yuan F, Chen S, Leung HM, Villoria J, Rogel N, Burgin G, Tsankov AM, Waghray A, Slyper M, Waldman J, Nguyen L, Dionne D, Rozenblatt-Rosen O, Tata PR, Mou H, Shivaraju M, Bihler H, Mense M, Tearney GJ, Rowe SM, Engelhardt JF, Regev A, Rajagopal J. Montoro DT, et al. Nature. 2018 Aug;560(7718):319-324. doi: 10.1038/s41586-018-0393-7. Epub 2018 Aug 1. Nature. 2018. PMID: 30069044 Free PMC article.
The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here we study the cellular composition and hierarchy of the mouse tracheal epithelium by single-cell RNA-sequencing (scRNA-seq) and in vivo lineage tracing. ...Ionocytes are the …
The airways of the lung are the primary sites of disease in asthma and cystic fibrosis. Here we study the cellular composition …
How autophagy controls the intestinal epithelial barrier.
Foerster EG, Mukherjee T, Cabral-Fernandes L, Rocha JDB, Girardin SE, Philpott DJ. Foerster EG, et al. Autophagy. 2022 Jan;18(1):86-103. doi: 10.1080/15548627.2021.1909406. Epub 2021 Apr 27. Autophagy. 2022. PMID: 33906557 Free PMC article. Review.
Furthermore, a clear role has emerged for autophagy not only in secretory cells but also in intestinal stem cells, where it affects their metabolism, as well as their proliferative and regenerative capacity. Here, we review the physiological role of autophagy …
Furthermore, a clear role has emerged for autophagy not only in secretory cells but also in intestinal stem cells, wher …
Role of the CXCL8-CXCR1/2 Axis in Cancer and Inflammatory Diseases.
Ha H, Debnath B, Neamati N. Ha H, et al. Theranostics. 2017 Apr 7;7(6):1543-1588. doi: 10.7150/thno.15625. eCollection 2017. Theranostics. 2017. PMID: 28529637 Free PMC article. Review.
The CXCL8-CXCR1/2 signaling axis is involved in the pathogenesis of several diseases including chronic obstructive pulmonary diseases (COPD), asthma, cystic fibrosis and cancer. Interaction between CXCL8 secreted by select cancer cells and CXCR1/2 in the tumo …
The CXCL8-CXCR1/2 signaling axis is involved in the pathogenesis of several diseases including chronic obstructive pulmonary diseases (COPD) …
Conditional reprogramming: next generation cell culture.
Wu X, Wang S, Li M, Li J, Shen J, Zhao Y, Pang J, Wen Q, Chen M, Wei B, Kaboli PJ, Du F, Zhao Q, Cho CH, Wang Y, Xiao Z, Wu X. Wu X, et al. Acta Pharm Sin B. 2020 Aug;10(8):1360-1381. doi: 10.1016/j.apsb.2020.01.011. Epub 2020 Jan 26. Acta Pharm Sin B. 2020. PMID: 32963937 Free PMC article. Review.
Recently, conditional reprogramming (CR) emerges as a novel next generation tool for long-term culture of primary epithelium cells derived from almost all origins without alteration of genetic background of primary cells. CR co-cultures primary cells with ina …
Recently, conditional reprogramming (CR) emerges as a novel next generation tool for long-term culture of primary epithelium cells de …
Organoids to model liver disease.
Nuciforo S, Heim MH. Nuciforo S, et al. JHEP Rep. 2020 Oct 22;3(1):100198. doi: 10.1016/j.jhepr.2020.100198. eCollection 2021 Feb. JHEP Rep. 2020. PMID: 33241206 Free PMC article. Review.
Transcriptional analysis of cystic fibrosis airways at single-cell resolution reveals altered epithelial cell states and composition.
Carraro G, Langerman J, Sabri S, Lorenzana Z, Purkayastha A, Zhang G, Konda B, Aros CJ, Calvert BA, Szymaniak A, Wilson E, Mulligan M, Bhatt P, Lu J, Vijayaraj P, Yao C, Shia DW, Lund AJ, Israely E, Rickabaugh TM, Ernst J, Mense M, Randell SH, Vladar EK, Ryan AL, Plath K, Mahoney JE, Stripp BR, Gomperts BN. Carraro G, et al. Nat Med. 2021 May;27(5):806-814. doi: 10.1038/s41591-021-01332-7. Epub 2021 May 6. Nat Med. 2021. PMID: 33958799 Free PMC article.
Cystic fibrosis (CF) is a lethal autosomal recessive disorder that afflicts more than 70,000 people. People with CF experience multi-organ dysfunction resulting from aberrant electrolyte transport across polarized epithelia due to mutations in the cystic f
Cystic fibrosis (CF) is a lethal autosomal recessive disorder that afflicts more than 70,000 people. People with CF experience
511 results