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15,927 results

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Page 1
Developments in stem cell-derived islet replacement therapy for treating type 1 diabetes.
Hogrebe NJ, Ishahak M, Millman JR. Hogrebe NJ, et al. Cell Stem Cell. 2023 May 4;30(5):530-548. doi: 10.1016/j.stem.2023.04.002. Cell Stem Cell. 2023. PMID: 37146579 Free PMC article. Review.
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs) has the potential to provide an unlimited source of insulin-producing beta cells for the treatment of diabetes. In order for this cell therapy to become wi …
The generation of islet-like endocrine clusters from human pluripotent stem cells (hPSCs) has the potential to provide an unli …
Adipose-derived Mesenchymal Stem Cells Therapy as a new Treatment Option for Diabetes Mellitus.
Mikłosz A, Chabowski A. Mikłosz A, et al. J Clin Endocrinol Metab. 2023 Jul 14;108(8):1889-1897. doi: 10.1210/clinem/dgad142. J Clin Endocrinol Metab. 2023. PMID: 36916961 Free PMC article. Review.
Among different treatment options for diabetes, adipose-derived mesenchymal stem cells (ADMSCs) therapy attract the most attention. ...Nevertheless, transplantation of mesenchymal stem cells is associated with certain risks; therefore recently m …
Among different treatment options for diabetes, adipose-derived mesenchymal stem cells (ADMSCs) therapy attract the mos …
Stem Cell Therapy for Diabetes: Beta Cells versus Pancreatic Progenitors.
Memon B, Abdelalim EM. Memon B, et al. Cells. 2020 Jan 23;9(2):283. doi: 10.3390/cells9020283. Cells. 2020. PMID: 31979403 Free PMC article. Review.
Diabetes mellitus (DM) is one of the most prevalent metabolic disorders. In order to replace the function of the destroyed pancreatic beta cells in diabetes, islet transplantation is the most widely practiced treatment. ...As an alternative approach, h …
Diabetes mellitus (DM) is one of the most prevalent metabolic disorders. In order to replace the function of the destroyed pan …
Mesenchymal stem cells to treat type 1 diabetes.
Pixley JS. Pixley JS. Biochim Biophys Acta Mol Basis Dis. 2020 Apr 1;1866(4):165315. doi: 10.1016/j.bbadis.2018.10.033. Epub 2018 Nov 30. Biochim Biophys Acta Mol Basis Dis. 2020. PMID: 30508575 Free article. Review.
This review is an effort to meld our preclinical observations with others for the reader and to outline potential avenues to improve the present outlook for patients with diabetes. This effort exams the history or background of stem cell research in the labor …
This review is an effort to meld our preclinical observations with others for the reader and to outline potential avenues to improve the pre …
Identifying the Therapeutic Significance of Mesenchymal Stem Cells.
Mishra VK, Shih HH, Parveen F, Lenzen D, Ito E, Chan TF, Ke LY. Mishra VK, et al. Cells. 2020 May 6;9(5):1145. doi: 10.3390/cells9051145. Cells. 2020. PMID: 32384763 Free PMC article. Review.
The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due to their immense potential for immunosuppression and their therapeutic role in immune disorders. ...Also, we sum up the results of the enhancement, utilization, and therapeutic …
The pleiotropic behavior of mesenchymal stem cells (MSCs) has gained global attention due to their immense potential for immun …
The promise of CRISPR/Cas9 technology in diabetes mellitus therapy: How gene editing is revolutionizing diabetes research and treatment.
Cheng Y, Wang H, Li M. Cheng Y, et al. J Diabetes Complications. 2023 Aug;37(8):108524. doi: 10.1016/j.jdiacomp.2023.108524. Epub 2023 Jun 2. J Diabetes Complications. 2023. PMID: 37295292 Review.
Diabetes mellitus is a metabolic disease, characterized by chronic hyperglycemia caused by an abnormality in insulin secretion or action. ...In this review, we summarize what we know today about CRISPR/Cas9 technology's therapeutic potential for treating diabetes …
Diabetes mellitus is a metabolic disease, characterized by chronic hyperglycemia caused by an abnormality in insulin secretion …
Towards a better understanding of diabetes mellitus using organoid models.
Beydag-Tasöz BS, Yennek S, Grapin-Botton A. Beydag-Tasöz BS, et al. Nat Rev Endocrinol. 2023 Apr;19(4):232-248. doi: 10.1038/s41574-022-00797-x. Epub 2023 Jan 20. Nat Rev Endocrinol. 2023. PMID: 36670309 Free PMC article. Review.
Our understanding of diabetes mellitus has benefited from a combination of clinical investigations and work in model organisms and cell lines. ...Organoids can be derived from human tissue cells or pluripotent stem cells and enable the pr …
Our understanding of diabetes mellitus has benefited from a combination of clinical investigations and work in model organisms …
Generation of stem cell-derived beta-cells from patients with type 1 diabetes.
Millman JR, Xie C, Van Dervort A, Gürtler M, Pagliuca FW, Melton DA. Millman JR, et al. Nat Commun. 2016 May 10;7:11463. doi: 10.1038/ncomms11463. Nat Commun. 2016. PMID: 27163171 Free PMC article.
We recently reported the scalable in vitro production of functional stem cell-derived beta-cells (SC-beta cells). Here we extend this approach to generate the first SC-beta cells from type 1 diabetic patients (T1D). beta-cells are destroy …
We recently reported the scalable in vitro production of functional stem cell-derived beta-cells (SC-beta cells) …
Meta-analysis shows that mesenchymal stem cell therapy can be a possible treatment for diabetes.
Habiba UE, Khan N, Greene DL, Ahmad K, Shamim S, Umer A. Habiba UE, et al. Front Endocrinol (Lausanne). 2024 May 10;15:1380443. doi: 10.3389/fendo.2024.1380443. eCollection 2024. Front Endocrinol (Lausanne). 2024. PMID: 38800472 Free PMC article.
OBJECTIVE: This meta-analysis includes the systematic literature review and meta-analysis involving clinical trials to assess the efficacy and safety of mesenchymal stem cell (MSC) transplantation for treating T1DM and T2DM. METHODS: We searched PubMed, ScienceDirec …
OBJECTIVE: This meta-analysis includes the systematic literature review and meta-analysis involving clinical trials to assess the efficacy a …
Mesenchymal Stem Cell-Based Therapy for Diabetes Mellitus: Enhancement Strategies and Future Perspectives.
Li H, Zhu H, Ge T, Wang Z, Zhang C. Li H, et al. Stem Cell Rev Rep. 2021 Oct;17(5):1552-1569. doi: 10.1007/s12015-021-10139-5. Epub 2021 Mar 5. Stem Cell Rev Rep. 2021. PMID: 33675006 Review.
Diabetes mellitus (DM), a chronic disorder of carbohydrate metabolism, is characterized by the unbridled hyperglycemia resulted from the impaired ability of the body to either produce or respond to insulin. As a cell-based regenerative therapy, mesenchymal …
Diabetes mellitus (DM), a chronic disorder of carbohydrate metabolism, is characterized by the unbridled hyperglycemia resulte …
15,927 results
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