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2000 1
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43 results
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Complement and microglia mediate early synapse loss in Alzheimer mouse models.
Hong S, Beja-Glasser VF, Nfonoyim BM, Frouin A, Li S, Ramakrishnan S, Merry KM, Shi Q, Rosenthal A, Barres BA, Lemere CA, Selkoe DJ, Stevens B. Hong S, et al. Among authors: stevens b. Science. 2016 May 6;352(6286):712-716. doi: 10.1126/science.aad8373. Epub 2016 Mar 31. Science. 2016. PMID: 27033548 Free PMC article.
Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. ...Together, these findings suggest that the complement-dependent pathway and microglia that prune excess synapses in development are inappropriately activated and mediate synapse loss in AD
Synapse loss in Alzheimer's disease (AD) correlates with cognitive decline. ...Together, these findings suggest that the complement-d
GABA-receptive microglia selectively sculpt developing inhibitory circuits.
Favuzzi E, Huang S, Saldi GA, Binan L, Ibrahim LA, Fernández-Otero M, Cao Y, Zeine A, Sefah A, Zheng K, Xu Q, Khlestova E, Farhi SL, Bonneau R, Datta SR, Stevens B, Fishell G. Favuzzi E, et al. Among authors: stevens b. Cell. 2021 Jul 22;184(15):4048-4063.e32. doi: 10.1016/j.cell.2021.06.018. Epub 2021 Jul 6. Cell. 2021. PMID: 34233165 Free PMC article.
Microglia, the resident immune cells of the brain, have emerged as crucial regulators of synaptic refinement and brain wiring. However, whether the remodeling of distinct synapse types during development is mediated by specialized microglia is unknown. Here, we show that G …
Microglia, the resident immune cells of the brain, have emerged as crucial regulators of synaptic refinement and brain wiring. However, whet …
Neuron-Glia Signaling in Synapse Elimination.
Wilton DK, Dissing-Olesen L, Stevens B. Wilton DK, et al. Among authors: stevens b. Annu Rev Neurosci. 2019 Jul 8;42:107-127. doi: 10.1146/annurev-neuro-070918-050306. Annu Rev Neurosci. 2019. PMID: 31283900 Review.
In addition to their role in synaptic refinement, glial cells have also been implicated in pathological synapse loss and dysfunction following injury or nervous system degeneration in adults. Although mechanisms regulating glia-mediated synaptic elimination are stil …
In addition to their role in synaptic refinement, glial cells have also been implicated in pathological synapse loss and dysfunction …
Single-Cell RNA Sequencing of Microglia throughout the Mouse Lifespan and in the Injured Brain Reveals Complex Cell-State Changes.
Hammond TR, Dufort C, Dissing-Olesen L, Giera S, Young A, Wysoker A, Walker AJ, Gergits F, Segel M, Nemesh J, Marsh SE, Saunders A, Macosko E, Ginhoux F, Chen J, Franklin RJM, Piao X, McCarroll SA, Stevens B. Hammond TR, et al. Among authors: stevens b. Immunity. 2019 Jan 15;50(1):253-271.e6. doi: 10.1016/j.immuni.2018.11.004. Epub 2018 Nov 21. Immunity. 2019. PMID: 30471926 Free PMC article.
The classical complement cascade mediates CNS synapse elimination.
Stevens B, Allen NJ, Vazquez LE, Howell GR, Christopherson KS, Nouri N, Micheva KD, Mehalow AK, Huberman AD, Stafford B, Sher A, Litke AM, Lambris JD, Smith SJ, John SW, Barres BA. Stevens B, et al. Cell. 2007 Dec 14;131(6):1164-78. doi: 10.1016/j.cell.2007.10.036. Cell. 2007. PMID: 18083105 Free article.
Mice deficient in complement protein C1q or the downstream complement protein C3 exhibit large sustained defects in CNS synapse elimination, as shown by the failure of anatomical refinement of retinogeniculate connections and the retention of excess retinal innervation by …
Mice deficient in complement protein C1q or the downstream complement protein C3 exhibit large sustained defects in CNS synapse elimi …
Microglia sculpt postnatal neural circuits in an activity and complement-dependent manner.
Schafer DP, Lehrman EK, Kautzman AG, Koyama R, Mardinly AR, Yamasaki R, Ransohoff RM, Greenberg ME, Barres BA, Stevens B. Schafer DP, et al. Among authors: stevens b. Neuron. 2012 May 24;74(4):691-705. doi: 10.1016/j.neuron.2012.03.026. Neuron. 2012. PMID: 22632727 Free PMC article.
Despite these intriguing observations, the precise function of microglia at remodeling synapses and the mechanisms that underlie microglia-synapse interactions remain elusive. In the current study, we demonstrate a role for microglia in activity-dependent synaptic pruning …
Despite these intriguing observations, the precise function of microglia at remodeling synapses and the mechanisms that underlie microglia- …
Overexpression of schizophrenia susceptibility factor human complement C4A promotes excessive synaptic loss and behavioral changes in mice.
Yilmaz M, Yalcin E, Presumey J, Aw E, Ma M, Whelan CW, Stevens B, McCarroll SA, Carroll MC. Yilmaz M, et al. Among authors: stevens b. Nat Neurosci. 2021 Feb;24(2):214-224. doi: 10.1038/s41593-020-00763-8. Epub 2020 Dec 22. Nat Neurosci. 2021. PMID: 33353966 Free PMC article.
Intriguingly, mice without C4 had normal numbers of cortical synapses, which suggests that complement is not required for normal developmental synaptic pruning. However, overexpressing C4A in mice reduced cortical synapse density, increased microglial engulfment of synapse …
Intriguingly, mice without C4 had normal numbers of cortical synapses, which suggests that complement is not required for normal development …
Local externalization of phosphatidylserine mediates developmental synaptic pruning by microglia.
Scott-Hewitt N, Perrucci F, Morini R, Erreni M, Mahoney M, Witkowska A, Carey A, Faggiani E, Schuetz LT, Mason S, Tamborini M, Bizzotto M, Passoni L, Filipello F, Jahn R, Stevens B, Matteoli M. Scott-Hewitt N, et al. Among authors: stevens b. EMBO J. 2020 Aug 17;39(16):e105380. doi: 10.15252/embj.2020105380. Epub 2020 Jul 13. EMBO J. 2020. PMID: 32657463 Free PMC article.
Neuronal circuit assembly requires the fine balance between synapse formation and elimination. Microglia, through the elimination of supernumerary synapses, have an established role in this process. ...These data provide mechanistic insight into microglial-mediated syna
Neuronal circuit assembly requires the fine balance between synapse formation and elimination. Microglia, through the elimination of …
CD47 Protects Synapses from Excess Microglia-Mediated Pruning during Development.
Lehrman EK, Wilton DK, Litvina EY, Welsh CA, Chang ST, Frouin A, Walker AJ, Heller MD, Umemori H, Chen C, Stevens B. Lehrman EK, et al. Among authors: stevens b. Neuron. 2018 Oct 10;100(1):120-134.e6. doi: 10.1016/j.neuron.2018.09.017. Neuron. 2018. PMID: 30308165 Free PMC article.
The expression patterns of CD47 and its receptor, SIRPalpha, correlated with peak pruning in the developing retinogeniculate system, and mice lacking these proteins exhibited increased microglial engulfment of retinogeniculate inputs and reduced synapse numbers in the dors …
The expression patterns of CD47 and its receptor, SIRPalpha, correlated with peak pruning in the developing retinogeniculate system, and mic …
New insights on the role of microglia in synaptic pruning in health and disease.
Hong S, Dissing-Olesen L, Stevens B. Hong S, et al. Among authors: stevens b. Curr Opin Neurobiol. 2016 Feb;36:128-34. doi: 10.1016/j.conb.2015.12.004. Epub 2015 Dec 30. Curr Opin Neurobiol. 2016. PMID: 26745839 Free PMC article. Review.
Recent genome-wide association studies implicate microglia in Alzheimer's disease (AD) pathogenesis; however, their biological significance remains poorly understood. Synapse loss is a significant correlate of cognitive decline that serves as a critical hallmark of AD and …
Recent genome-wide association studies implicate microglia in Alzheimer's disease (AD) pathogenesis; however, their biological significance …
43 results