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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 3
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535 results

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Page 1
Idiopathic pulmonary fibrosis: Disease mechanisms and drug development.
Spagnolo P, Kropski JA, Jones MG, Lee JS, Rossi G, Karampitsakos T, Maher TM, Tzouvelekis A, Ryerson CJ. Spagnolo P, et al. Pharmacol Ther. 2021 Jun;222:107798. doi: 10.1016/j.pharmthera.2020.107798. Epub 2020 Dec 24. Pharmacol Ther. 2021. PMID: 33359599 Free PMC article. Review.
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause characterized by relentless scarring of the lung parenchyma leading to reduced quality of life and earlier mortality. IPF is an age-related disorder, and with the population …
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause characterized by relentless scarr …
Cellular and molecular mechanisms of fibrosis.
Wynn TA. Wynn TA. J Pathol. 2008 Jan;214(2):199-210. doi: 10.1002/path.2277. J Pathol. 2008. PMID: 18161745 Free PMC article. Review.
Although current treatments for fibrotic diseases such as idiopathic pulmonary fibrosis, liver cirrhosis, systemic sclerosis, progressive kidney disease, and cardiovascular fibrosis typically target the inflammatory response, there is accumulating evid …
Although current treatments for fibrotic diseases such as idiopathic pulmonary fibrosis, liver cirrhosis, systemic scle …
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV. Reyfman PA, et al. Am J Respir Crit Care Med. 2019 Jun 15;199(12):1517-1536. doi: 10.1164/rccm.201712-2410OC. Am J Respir Crit Care Med. 2019. PMID: 30554520 Free PMC article.
Methods: We performed single-cell RNA sequencing on lung tissue obtained from eight transplant donors and eight recipients with pulmonary fibrosis and on one bronchoscopic cryobiospy sample from a patient with idiopathic pulmonary fibrosis. ...W …
Methods: We performed single-cell RNA sequencing on lung tissue obtained from eight transplant donors and eight recipients with pulmonary …
Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells.
Wu H, Yu Y, Huang H, Hu Y, Fu S, Wang Z, Shi M, Zhao X, Yuan J, Li J, Yang X, Bin E, Wei D, Zhang H, Zhang J, Yang C, Cai T, Dai H, Chen J, Tang N. Wu H, et al. Cell. 2020 Jan 9;180(1):107-121.e17. doi: 10.1016/j.cell.2019.11.027. Epub 2019 Dec 19. Cell. 2020. PMID: 31866069 Free article.
Fibrosis can develop in most organs and causes organ failure. The most common type of lung fibrosis is known as idiopathic pulmonary fibrosis, in which fibrosis starts at the lung periphery and then progresses toward the lung center, even …
Fibrosis can develop in most organs and causes organ failure. The most common type of lung fibrosis is known as idiopathic …
Lung cell transplantation for pulmonary fibrosis.
Milman Krentsis I, Zheng Y, Rosen C, Shin SY, Blagdon C, Shoshan E, Qi Y, Wang J, Yadav SK, Bachar Lustig E, Shetzen E, Dickey BF, Karmouty-Quintana H, Reisner Y. Milman Krentsis I, et al. Sci Adv. 2024 Aug 23;10(34):eadk2524. doi: 10.1126/sciadv.adk2524. Epub 2024 Aug 23. Sci Adv. 2024. PMID: 39178253 Free PMC article.
Idiopathic pulmonary fibrosis is a major cause of death with few treatment options. Here, we demonstrate the therapeutic efficacy for lung fibrosis of adult lung cell transplantation using a single-cell suspension of the entire lung in two distinct mou …
Idiopathic pulmonary fibrosis is a major cause of death with few treatment options. Here, we demonstrate the therapeuti …
Lung endothelial cells regulate pulmonary fibrosis through FOXF1/R-Ras signaling.
Bian F, Lan YW, Zhao S, Deng Z, Shukla S, Acharya A, Donovan J, Le T, Milewski D, Bacchetta M, Hozain AE, Tipograf Y, Chen YW, Xu Y, Shi D, Kalinichenko VV, Kalin TV. Bian F, et al. Nat Commun. 2023 May 4;14(1):2560. doi: 10.1038/s41467-023-38177-2. Nat Commun. 2023. PMID: 37137915 Free PMC article.
Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types. ...Focusing on FOXF1, we found that FOXF1 is decreased in EC within human idiopathic pulmonary fibrosis (IPF) and mouse bleomycin-injured lungs. Endotheli …
Pulmonary fibrosis results from dysregulated lung repair and involves multiple cell types. ...Focusing on FOXF1, we found that …
Telomere-mediated lung disease.
Alder JK, Armanios M. Alder JK, et al. Physiol Rev. 2022 Oct 1;102(4):1703-1720. doi: 10.1152/physrev.00046.2021. Epub 2022 May 9. Physiol Rev. 2022. PMID: 35532056 Free PMC article. Review.
Telomeres and telomerase have historically been linked to cellular processes related to aging and cancer, but surprisingly, in the recent decade genetic discoveries have linked the most apparent manifestations of telomere and telomerase dysfunction in humans to the etiology of lu …
Telomeres and telomerase have historically been linked to cellular processes related to aging and cancer, but surprisingly, in the recent de …
Alveolar Organoids in Lung Disease Modeling.
Purev E, Bahmed K, Kosmider B. Purev E, et al. Biomolecules. 2024 Jan 16;14(1):115. doi: 10.3390/biom14010115. Biomolecules. 2024. PMID: 38254715 Free PMC article. Review.
Alveolar type 2 (AT2) cells have a stem cell potential in the adult lung. They produce and secrete pulmonary surfactant and proliferate to restore the epithelium after damage. ...Recently, they have been utilized to define mechanisms of disease development, s …
Alveolar type 2 (AT2) cells have a stem cell potential in the adult lung. They produce and secrete pulmonary surfactant …
Epithelial stem cells from human small bronchi offer a potential for therapy of idiopathic pulmonary fibrosis.
Liu Z, Zheng Q, Li Z, Huang M, Zhong C, Yu R, Jiang R, Dai H, Zhang J, Gu X, Xu Y, Li C, Shan S, Xu F, Hong Y, Ren T. Liu Z, et al. EBioMedicine. 2025 Feb;112:105538. doi: 10.1016/j.ebiom.2024.105538. Epub 2025 Jan 2. EBioMedicine. 2025. PMID: 39753035 Free PMC article.
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial pneumonia with restrictive ventilation. ...Autologous BCs transplantation in three advanced IPF patients with small airway dysfunction yielded significant clinical improvements in …
BACKGROUND: Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial pneumonia with restrictive ventilation. ... …
535 results