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Year Number of Results
2003 3
2004 2
2005 4
2006 4
2007 4
2008 5
2009 15
2010 11
2011 9
2012 13
2013 19
2014 19
2015 18
2016 19
2017 32
2018 35
2019 39
2020 54
2021 55
2022 4
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335 results
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Idiopathic pulmonary fibrosis: Disease mechanisms and drug development.
Spagnolo P, Kropski JA, Jones MG, Lee JS, Rossi G, Karampitsakos T, Maher TM, Tzouvelekis A, Ryerson CJ. Spagnolo P, et al. Pharmacol Ther. 2021 Jun;222:107798. doi: 10.1016/j.pharmthera.2020.107798. Epub 2020 Dec 24. Pharmacol Ther. 2021. PMID: 33359599 Review.
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause characterized by relentless scarring of the lung parenchyma leading to reduced quality of life and earlier mortality. IPF is an age-related disorder, and with the population
Idiopathic pulmonary fibrosis (IPF) is a chronic progressive disease of unknown cause characterized by relentless scarr
Cellular and molecular mechanisms of fibrosis.
Wynn TA. Wynn TA. J Pathol. 2008 Jan;214(2):199-210. doi: 10.1002/path.2277. J Pathol. 2008. PMID: 18161745 Free PMC article. Review.
Although current treatments for fibrotic diseases such as idiopathic pulmonary fibrosis, liver cirrhosis, systemic sclerosis, progressive kidney disease, and cardiovascular fibrosis typically target the inflammatory response, there is accumulating evid …
Although current treatments for fibrotic diseases such as idiopathic pulmonary fibrosis, liver cirrhosis, systemic scle …
Progressive Pulmonary Fibrosis Is Caused by Elevated Mechanical Tension on Alveolar Stem Cells.
Wu H, Yu Y, Huang H, Hu Y, Fu S, Wang Z, Shi M, Zhao X, Yuan J, Li J, Yang X, Bin E, Wei D, Zhang H, Zhang J, Yang C, Cai T, Dai H, Chen J, Tang N. Wu H, et al. Cell. 2020 Jan 9;180(1):107-121.e17. doi: 10.1016/j.cell.2019.11.027. Epub 2019 Dec 19. Cell. 2020. PMID: 31866069 Free article.
Fibrosis can develop in most organs and causes organ failure. The most common type of lung fibrosis is known as idiopathic pulmonary fibrosis, in which fibrosis starts at the lung periphery and then progresses toward the lung center, even
Fibrosis can develop in most organs and causes organ failure. The most common type of lung fibrosis is known as idiopathic
Alveolar Epithelial Type II Cells as Drivers of Lung Fibrosis in Idiopathic Pulmonary Fibrosis.
Parimon T, Yao C, Stripp BR, Noble PW, Chen P. Parimon T, et al. Int J Mol Sci. 2020 Mar 25;21(7):2269. doi: 10.3390/ijms21072269. Int J Mol Sci. 2020. PMID: 32218238 Free PMC article. Review.
However, impairment to their normal functional capacity and development of a pro-fibrotic phenotype has been demonstrated to contribute to the development of idiopathic pulmonary fibrosis (IPF). A number of factors contribute to AT2 death and dysfunction. ... …
However, impairment to their normal functional capacity and development of a pro-fibrotic phenotype has been demonstrated to contribute to t …
Single-Cell Transcriptomic Analysis of Human Lung Provides Insights into the Pathobiology of Pulmonary Fibrosis.
Reyfman PA, Walter JM, Joshi N, Anekalla KR, McQuattie-Pimentel AC, Chiu S, Fernandez R, Akbarpour M, Chen CI, Ren Z, Verma R, Abdala-Valencia H, Nam K, Chi M, Han S, Gonzalez-Gonzalez FJ, Soberanes S, Watanabe S, Williams KJN, Flozak AS, Nicholson TT, Morgan VK, Winter DR, Hinchcliff M, Hrusch CL, Guzy RD, Bonham CA, Sperling AI, Bag R, Hamanaka RB, Mutlu GM, Yeldandi AV, Marshall SA, Shilatifard A, Amaral LAN, Perlman H, Sznajder JI, Argento AC, Gillespie CT, Dematte J, Jain M, Singer BD, Ridge KM, Lam AP, Bharat A, Bhorade SM, Gottardi CJ, Budinger GRS, Misharin AV. Reyfman PA, et al. Am J Respir Crit Care Med. 2019 Jun 15;199(12):1517-1536. doi: 10.1164/rccm.201712-2410OC. Am J Respir Crit Care Med. 2019. PMID: 30554520 Free PMC article.
Methods: We performed single-cell RNA sequencing on lung tissue obtained from eight transplant donors and eight recipients with pulmonary fibrosis and on one bronchoscopic cryobiospy sample from a patient with idiopathic pulmonary fibrosis. ...W …
Methods: We performed single-cell RNA sequencing on lung tissue obtained from eight transplant donors and eight recipients with pulmonary
Inhalation of lung spheroid cell secretome and exosomes promotes lung repair in pulmonary fibrosis.
Dinh PC, Paudel D, Brochu H, Popowski KD, Gracieux MC, Cores J, Huang K, Hensley MT, Harrell E, Vandergriff AC, George AK, Barrio RT, Hu S, Allen TA, Blackburn K, Caranasos TG, Peng X, Schnabel LV, Adler KB, Lobo LJ, Goshe MB, Cheng K. Dinh PC, et al. Nat Commun. 2020 Feb 28;11(1):1064. doi: 10.1038/s41467-020-14344-7. Nat Commun. 2020. PMID: 32111836 Free PMC article.
Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which persistent injury results in scar tissue formation. ...Additionally, LSC-Sec and LSC-Exo exhibit superior therapeutic benefits than their counterparts deri
Idiopathic pulmonary fibrosis (IPF) is a fatal and incurable form of interstitial lung disease in which persistent inju
Alveolar cells under mechanical stressed niche: critical contributors to pulmonary fibrosis.
Yang J, Pan X, Wang L, Yu G. Yang J, et al. Mol Med. 2020 Oct 14;26(1):95. doi: 10.1186/s10020-020-00223-w. Mol Med. 2020. PMID: 33054759 Free PMC article. Review.
Therefore, mechanical stress has a significant role in the whole development process of pulmonary fibrosis. The alveoli are covered by abundant capillaries and function as the main gas exchange unit. Constantly subject to variety of damages, the alveolar epithelium …
Therefore, mechanical stress has a significant role in the whole development process of pulmonary fibrosis. The alveoli are co …
Single-Cell Reconstruction of Human Basal Cell Diversity in Normal and Idiopathic Pulmonary Fibrosis Lungs.
Carraro G, Mulay A, Yao C, Mizuno T, Konda B, Petrov M, Lafkas D, Arron JR, Hogaboam CM, Chen P, Jiang D, Noble PW, Randell SH, McQualter JL, Stripp BR. Carraro G, et al. Am J Respir Crit Care Med. 2020 Dec 1;202(11):1540-1550. doi: 10.1164/rccm.201904-0792OC. Am J Respir Crit Care Med. 2020. PMID: 32692579 Free PMC article.
There is a need to better understand the contribution of basal cell hyperplasia and associated mucosecretory dysfunction to the development of idiopathic pulmonary fibrosis (IPF).Objectives: We sought to decipher the transcriptome of freshly isolated epitheli …
There is a need to better understand the contribution of basal cell hyperplasia and associated mucosecretory dysfunction to the development …
The potential of mesenchymal stem cell therapy for chronic lung disease.
Cruz FF, Rocco PRM. Cruz FF, et al. Expert Rev Respir Med. 2020 Jan;14(1):31-39. doi: 10.1080/17476348.2020.1679628. Epub 2019 Oct 15. Expert Rev Respir Med. 2020. PMID: 31608724 Review.
Introduction: Mesenchymal stem/stromal cells (MSCs) have been shown to improve lung function and survival in chronic inflammatory lung diseases, including asthma, chronic obstructive pulmonary disease (COPD), idiopathic pulmonary fibrosis
Introduction: Mesenchymal stem/stromal cells (MSCs) have been shown to improve lung function and survival in chronic inflammat …
FBW7 Mediates Senescence and Pulmonary Fibrosis through Telomere Uncapping.
Wang L, Chen R, Li G, Wang Z, Liu J, Liang Y, Liu JP. Wang L, et al. Cell Metab. 2020 Nov 3;32(5):860-877.e9. doi: 10.1016/j.cmet.2020.10.004. Epub 2020 Oct 20. Cell Metab. 2020. PMID: 33086033 Free article.
Tissue stem cells undergo premature senescence under stress, promoting age-related diseases; however, the associated mechanisms remain unclear. ...Our findings elucidate a pivotal mechanism underlying stress-induced pulmonary epithelial stem cell senes …
Tissue stem cells undergo premature senescence under stress, promoting age-related diseases; however, the associated mechanism …
335 results