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Regenerative Rehabilitation and Stem Cell Therapy Targeting Chronic Spinal Cord Injury: A Review of Preclinical Studies.
Tashiro S, Nakamura M, Okano H. Tashiro S, et al. Cells. 2022 Feb 16;11(4):685. doi: 10.3390/cells11040685. Cells. 2022. PMID: 35203335 Free PMC article. Review.
Rehabilitation upon SCI in preclinical studies has recently attracted more attention because it is safe, induces neuronal plasticity involving transplanted stem cells and sensorimotor circuits, and is routinely implemented in human clinics. ...Here, we summar
Rehabilitation upon SCI in preclinical studies has recently attracted more attention because it is safe, induces neuronal plas
Combined treatment with chondroitinase ABC and treadmill rehabilitation for chronic severe spinal cord injury in adult rats.
Shinozaki M, Iwanami A, Fujiyoshi K, Tashiro S, Kitamura K, Shibata S, Fujita H, Nakamura M, Okano H. Shinozaki M, et al. Among authors: tashiro s. Neurosci Res. 2016 Dec;113:37-47. doi: 10.1016/j.neures.2016.07.005. Epub 2016 Aug 4. Neurosci Res. 2016. PMID: 27497528
Next, we performed treadmill rehabilitation from weeks 6 to 14 after SCI, for a total period of eight weeks. ...We suggest that, when combined with intensive rehabilitation, C-ABC may play a beneficial role, even in severe and chronic SCI....
Next, we performed treadmill rehabilitation from weeks 6 to 14 after SCI, for a total period of eight weeks. ...We suggest that, when …
Treadmill Training for Common Marmoset to Strengthen Corticospinal Connections After Thoracic Contusion Spinal Cord Injury.
Kondo T, Saito R, Sato Y, Sato K, Uchida A, Yoshino-Saito K, Shinozaki M, Tashiro S, Nagoshi N, Nakamura M, Ushiba J, Okano H. Kondo T, et al. Among authors: tashiro s. Front Cell Neurosci. 2022 Apr 22;16:858562. doi: 10.3389/fncel.2022.858562. eCollection 2022. Front Cell Neurosci. 2022. PMID: 35530175 Free PMC article.
To explain this discrepancy between different species, a nonhuman primate rehabilitation model with a severe SCI would be useful. In this study, we developed a rehabilitation model of paraplegia caused by a severe traumatic SCI in a nonhuman primate, common marmoset …
To explain this discrepancy between different species, a nonhuman primate rehabilitation model with a severe SCI would be useful. In …
BDNF Induced by Treadmill Training Contributes to the Suppression of Spasticity and Allodynia After Spinal Cord Injury via Upregulation of KCC2.
Tashiro S, Shinozaki M, Mukaino M, Renault-Mihara F, Toyama Y, Liu M, Nakamura M, Okano H. Tashiro S, et al. Among authors: liu m. Neurorehabil Neural Repair. 2015 Aug;29(7):677-89. doi: 10.1177/1545968314562110. Epub 2014 Dec 19. Neurorehabil Neural Repair. 2015. PMID: 25527489
OBJECTIVE: To investigate the molecular mechanisms by which rehabilitation ameliorates spasticity and allodynia after SCI in rats. ...CONCLUSIONS: BDNF-mediated restoration of KCC2 expression underlies the suppression of spasticity and allodynia caused by rehabil
OBJECTIVE: To investigate the molecular mechanisms by which rehabilitation ameliorates spasticity and allodynia after SCI in rats
Treadmill training based on the overload principle promotes locomotor recovery in a mouse model of chronic spinal cord injury.
Shibata T, Tashiro S, Shinozaki M, Hashimoto S, Matsumoto M, Nakamura M, Okano H, Nagoshi N. Shibata T, et al. Among authors: tashiro s. Exp Neurol. 2021 Nov;345:113834. doi: 10.1016/j.expneurol.2021.113834. Epub 2021 Aug 8. Exp Neurol. 2021. PMID: 34370998
However, many unexplained problems persist regarding the appropriate rehabilitative method and the mechanism underlying the beneficial effects of rehabilitation. Moreover, only a few preclinical studies have been performed on rehabilitative interventions for chronic …
However, many unexplained problems persist regarding the appropriate rehabilitative method and the mechanism underlying the beneficial effec …
Concise Review: Laying the Groundwork for a First-In-Human Study of an Induced Pluripotent Stem Cell-Based Intervention for Spinal Cord Injury.
Tsuji O, Sugai K, Yamaguchi R, Tashiro S, Nagoshi N, Kohyama J, Iida T, Ohkubo T, Itakura G, Isoda M, Shinozaki M, Fujiyoshi K, Kanemura Y, Yamanaka S, Nakamura M, Okano H. Tsuji O, et al. Among authors: tashiro s. Stem Cells. 2019 Jan;37(1):6-13. doi: 10.1002/stem.2926. Epub 2018 Nov 12. Stem Cells. 2019. PMID: 30371964 Free PMC article. Review.
This trial was conducted as class I regenerative medicine protocol as provided for under Japan's Act on the Safety of Regenerative Medicine, using neural stem/progenitor cells derived from a clinical-grade, integration-free human "iPSC stock" generated by the Kyoto Univers …
This trial was conducted as class I regenerative medicine protocol as provided for under Japan's Act on the Safety of Regenerative Medicine, …
Hyperglycemia Promotes Schwann Cell De-differentiation and De-myelination via Sorbitol Accumulation and Igf1 Protein Down-regulation.
Hao W, Tashiro S, Hasegawa T, Sato Y, Kobayashi T, Tando T, Katsuyama E, Fujie A, Watanabe R, Morita M, Miyamoto K, Morioka H, Nakamura M, Matsumoto M, Amizuka N, Toyama Y, Miyamoto T. Hao W, et al. Among authors: tashiro s. J Biol Chem. 2015 Jul 10;290(28):17106-15. doi: 10.1074/jbc.M114.631291. Epub 2015 May 21. J Biol Chem. 2015. PMID: 25998127 Free PMC article.
Here, we report that Schwann cells de-differentiate into immature cells under hyperglycemic conditions as a result of sorbitol accumulation and decreased Igf1 expression in those cells. We found that de-differentiated Schwann cells could be re-differen …
Here, we report that Schwann cells de-differentiate into immature cells under hyperglycemic conditions as a result of sorbitol …
The Amelioration of Pain-Related Behavior in Mice with Chronic Spinal Cord Injury Treated with Neural Stem/Progenitor Cell Transplantation Combined with Treadmill Training.
Tashiro S, Nishimura S, Shinozaki M, Takano M, Konomi T, Tsuji O, Nagoshi N, Toyama Y, Liu M, Okano H, Nakamura M. Tashiro S, et al. Among authors: liu m. J Neurotrauma. 2018 Nov 1;35(21):2561-2571. doi: 10.1089/neu.2017.5537. Epub 2018 Jul 23. J Neurotrauma. 2018. PMID: 29790403
Progress in regenerative medicine is realizing the possibility of neural regeneration and functional recovery in spinal cord injury (SCI). Recently, rehabilitation has attracted much attention with respect to the synergistic promotion of functional recovery in combination …
Progress in regenerative medicine is realizing the possibility of neural regeneration and functional recovery in spinal cord injury (SCI). R …
Anti-IL-6-receptor antibody promotes repair of spinal cord injury by inducing microglia-dominant inflammation.
Mukaino M, Nakamura M, Yamada O, Okada S, Morikawa S, Renault-Mihara F, Iwanami A, Ikegami T, Ohsugi Y, Tsuji O, Katoh H, Matsuzaki Y, Toyama Y, Liu M, Okano H. Mukaino M, et al. Among authors: liu m. Exp Neurol. 2010 Aug;224(2):403-14. doi: 10.1016/j.expneurol.2010.04.020. Epub 2010 May 16. Exp Neurol. 2010. PMID: 20478301
We previously reported the beneficial effect of administering an anti-mouse IL-6 receptor antibody (MR16-1) immediately after spinal cord injury (SCI). The purpose of our present study was to clarify the mechanism underlying how MR16-1 improves motor function after SCI. Qu …
We previously reported the beneficial effect of administering an anti-mouse IL-6 receptor antibody (MR16-1) immediately after spinal …
The prospects of regenerative medicine combined with rehabilitative approaches for chronic spinal cord injury animal models.
Tashiro S, Nakamura M, Okano H. Tashiro S, et al. Neural Regen Res. 2017 Jan;12(1):43-46. doi: 10.4103/1673-5374.198972. Neural Regen Res. 2017. PMID: 28250738 Free PMC article. Review.
In this review article, we summarize the present progress and consider the prospect of the cell-based regenerative medicine particularly combined with rehabilitative approaches for chronic SCI animal models....
In this review article, we summarize the present progress and consider the prospect of the cell-based regenerative medicine particularly com …
16 results