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Pharmacological Interventions in Autism Spectrum Disorder: A Comprehensive Review of Mechanisms and Efficacy.
Sclabassi E, Peret S, Qian C, Gao Y. Sclabassi E, et al. Biomedicines. 2025 Dec 10;13(12):3025. doi: 10.3390/biomedicines13123025. Biomedicines. 2025. PMID: 41463035 Free PMC article. Review.
Across all categories, pharmacological treatments are most effective when embedded in individualized, multimodal care plans that integrate behavioral, rehabilitative, and psychological interventions. Conclusions: This review maps pharmacologic strategies in ASD onto their …
Across all categories, pharmacological treatments are most effective when embedded in individualized, multimodal care plans that integrate b …
Intervention characteristics and speech therapy strategies in care for autistic children in health services: a scoping review.
Barros RCB, Ferreira EB, Silva PMVA, Khalil MM, Oliveira APM. Barros RCB, et al. Codas. 2025 Dec 8;37(6):e20250012. doi: 10.1590/2317-1782/e20250012pt. eCollection 2025. Codas. 2025. PMID: 41370523 Free PMC article.
CONCLUSION: although speech therapy has advanced in the personalization of care and adaptation of therapeutic strategies, there is still a predominance of interventions focused on diagnosis and rehabilitation, with a limited number of studies addressing health promotion an …
CONCLUSION: although speech therapy has advanced in the personalization of care and adaptation of therapeutic strategies, there is still a p …
Autism, bullying, and mental health: a comprehensive systematic review.
Daghustani WH, Abo Hamza EG, Hogg R, Moustafa A. Daghustani WH, et al. Front Psychiatry. 2025 Dec 5;16:1653663. doi: 10.3389/fpsyt.2025.1653663. eCollection 2025. Front Psychiatry. 2025. PMID: 41425822 Free PMC article.
The importance of education, creating inclusive environments, building resilience, collaborative efforts, policy and legislation, mental health support, and prevention and protection implications, are discussed. By implementing these strategies, we can work to reduce vulne …
The importance of education, creating inclusive environments, building resilience, collaborative efforts, policy and legislation, mental hea …
Comparative effectiveness of non-pharmacological interventions for anxiety, depression, and quality of life in individuals with autism spectrum disorder: A systematic review and network meta-analysis.
Ding X, Luo H, Zhang J, Yang H, Fan Y, Wu J, Wu S. Ding X, et al. Front Psychiatry. 2025 Dec 2;16:1660412. doi: 10.3389/fpsyt.2025.1660412. eCollection 2025. Front Psychiatry. 2025. PMID: 41409332 Free PMC article.
MBI, CBT, and PHYS demonstrate relative superiority for anxiety, depression, and QoL respectively, supporting their targeted application in clinical and rehabilitative settings. Future studies should prioritize long-term follow-up, refined intervention designs, and persona …
MBI, CBT, and PHYS demonstrate relative superiority for anxiety, depression, and QoL respectively, supporting their targeted application in …
Maternal and cord blood lipidomics as predictors of autism spectrum disorders: A systematic review.
Sarantaki A, Ghanchi A, Vermeulen J, Barbouni A, Charvalos E, Sousamli A, Anagnostopoulos DK. Sarantaki A, et al. Metabol Open. 2025 Oct 3;28:100403. doi: 10.1016/j.metop.2025.100403. eCollection 2025 Dec. Metabol Open. 2025. PMID: 41141245 Free PMC article. Review.
Standardized lipidomic protocols, longitudinal sampling, and replication in diverse cohorts are needed to establish clinical utility and inform prevention strategies....
Standardized lipidomic protocols, longitudinal sampling, and replication in diverse cohorts are needed to establish clinical utility and inf …
Gut Microbiota and Autism: Unlocking Connections.
Biagioli V, Matera M, Cavecchia I, Di Pierro F, Zerbinati N, Striano P. Biagioli V, et al. Nutrients. 2025 Nov 26;17(23):3706. doi: 10.3390/nu17233706. Nutrients. 2025. PMID: 41373997 Free PMC article. Review.
It is, therefore, necessary to transform current knowledge about the microbiota and neurodevelopment into clinical, social, and health actions that offer real solutions to people with ASD and their families. From this perspective, focusing on prevention, promoting healthy …
It is, therefore, necessary to transform current knowledge about the microbiota and neurodevelopment into clinical, social, and health actio …
Camouflaging Autism in Pursuit of Friendship and Intimate Relationships: A Systematic Review.
Ridgway K, Cooke K, Demmer DH, Hooley M, Westrupp E, Stokes MA. Ridgway K, et al. Autism Adulthood. 2025 Oct 24;7(5):543-557. doi: 10.1089/aut.2023.0160. eCollection 2025 Oct. Autism Adulthood. 2025. PMID: 41340673 Free article. Review.
However, many autistic individuals remained dissatisfied with the friendships and intimate relationships gained through its use. For many, camouflaging prevented genuine social interactions, and the friendships that resulted from its use were often lacking in closeness and …
However, many autistic individuals remained dissatisfied with the friendships and intimate relationships gained through its use. For many, c …
Genetic and Environmental Risk Factors for Autism Spectrum Disorder in Saudi Arabia: A Systematic Review.
Hamed NF, Alqahtani AM, Alshaibani F, Elsharif SM, Alamri SAS, Serhan A. Hamed NF, et al. Cureus. 2025 Oct 14;17(10):e94607. doi: 10.7759/cureus.94607. eCollection 2025 Oct. Cureus. 2025. PMID: 41246720 Free PMC article. Review.
Future investigations should employ larger, balanced cohorts and integrate epigenetic and prospective designs to facilitate the development of targeted preventive and therapeutic strategies....
Future investigations should employ larger, balanced cohorts and integrate epigenetic and prospective designs to facilitate the development …
The relationships between anxiety, psychotic-like experiences and autism: a systematic review.
Rowe M, Shergill S, Maitra R. Rowe M, et al. Front Psychol. 2025 Oct 13;16:1549886. doi: 10.3389/fpsyg.2025.1549886. eCollection 2025. Front Psychol. 2025. PMID: 41159185 Free PMC article.
Such insights have important implications for psychosis prevention, indicating that anxiety intervention in autistic populations may reduce PLE incidence. ...
Such insights have important implications for psychosis prevention, indicating that anxiety intervention in autistic populations may …
The Emerging Role of Phosphodiesterase Inhibitors in Fragile X Syndrome and Autism Spectrum Disorder.
Thomas SD, Mohammed HA, Hamad MIK, Oz M, Statsenko Y, Sadek B. Thomas SD, et al. Pharmaceuticals (Basel). 2025 Oct 8;18(10):1507. doi: 10.3390/ph18101507. Pharmaceuticals (Basel). 2025. PMID: 41155624 Free PMC article. Review.
Phosphodiesterase (PDE) inhibitors, which prevent the breakdown of cAMP and cGMP, have emerged as promising therapeutic candidates due to their ability to modulate neuronal signaling. ...
Phosphodiesterase (PDE) inhibitors, which prevent the breakdown of cAMP and cGMP, have emerged as promising therapeutic candidates du …
Neurodevelopmental Impact of Maternal Immune Activation and Autoimmune Disorders, Environmental Toxicants and Folate Metabolism on Autism Spectrum Disorder.
Ayoub G. Ayoub G. Curr Issues Mol Biol. 2025 Sep 4;47(9):721. doi: 10.3390/cimb47090721. Curr Issues Mol Biol. 2025. PMID: 41020843 Free PMC article. Review.
Further exploration of this framework will open paths for precision intervention and prevention....
Further exploration of this framework will open paths for precision intervention and prevention....
Efficacy of structured teaching program for rehabilitation of children with autism spectrum disorder: A systematic review and meta-analysis.
Zhu Y, Zhang M, Ma D, Wang P. Zhu Y, et al. Pak J Med Sci. 2025 Sep;41(9):2658-2666. doi: 10.12669/pjms.41.9.12634. Pak J Med Sci. 2025. PMID: 41070334 Free PMC article. Review.
BACKGROUND & OBJECTIVE: The Structured Teaching Program, based on the Treatment and Education of Autistic and Related Communication Handicapped Children (TEACCH) program approach, has been a cornerstone in the educational rehabilitation of children with autism spectrum …
BACKGROUND & OBJECTIVE: The Structured Teaching Program, based on the Treatment and Education of Autistic and Related Communication Hand …
Media Consumption by Preschool Children: The Risk of Autism and Developmental Disorders.
Kamp-Becker I, Poustka L. Kamp-Becker I, et al. Dtsch Arztebl Int. 2025 Aug 8;122(16):433-438. doi: 10.3238/arztebl.m2025.0087. Dtsch Arztebl Int. 2025. PMID: 40459056 Free PMC article. Review.
When risk factors are present, it is therefore essential to educate parents and implement preventive measures to promote the long-term healthy development of children....
When risk factors are present, it is therefore essential to educate parents and implement preventive measures to promote the long-ter …
Effect of maternal diet on gut bacteria and autism spectrum disorder in offspring.
Chen Z, Wang X, Hu Y, Zhang S, Han F. Chen Z, et al. Front Cell Neurosci. 2025 Aug 6;19:1623576. doi: 10.3389/fncel.2025.1623576. eCollection 2025. Front Cell Neurosci. 2025. PMID: 40842563 Free PMC article. Review.
Additionally, the article proposes potential strategies to prevent ASD by adjusting dietary structures and enhancing gut bacteria health....
Additionally, the article proposes potential strategies to prevent ASD by adjusting dietary structures and enhancing gut bacteria hea …
Emerging Epigenetic Therapeutics and Diagnostics for Autism Spectrum Disorder.
Kao C, Lim KK, Chen ES. Kao C, et al. Curr Issues Mol Biol. 2025 Jun 27;47(7):491. doi: 10.3390/cimb47070491. Curr Issues Mol Biol. 2025. PMID: 40728960 Free PMC article. Review.
We expound the implications of these findings to enable preventive measurements for mothers to reduce the impact of ASD at birth, non-invasive diagnostic tests for early detection, and personalized medicine management. ...
We expound the implications of these findings to enable preventive measurements for mothers to reduce the impact of ASD at birth, non …
Astroglial Kir4.1 and AQP4 Channels: Key Regulators of Potassium Homeostasis and Their Implications in Autism Spectrum Disorders.
Abbasian V, Davoudi S, Vahabzadeh A, Maftoon-Azad MJ, Janahmadi M. Abbasian V, et al. Cell Mol Neurobiol. 2025 Jun 11;45(1):56. doi: 10.1007/s10571-025-01574-w. Cell Mol Neurobiol. 2025. PMID: 40498219 Free PMC article. Review.
Kir4.1 channels promote the efficient uptake of K(+) ions from the extracellular space, particularly during periods of high neuronal activity, thereby preventing excessive neuronal excitability-a condition linked to several neurological disorders, including Autism Spectrum …
Kir4.1 channels promote the efficient uptake of K(+) ions from the extracellular space, particularly during periods of high neuronal activit …
Significance of Oral Care for Children with Autism Spectrum Disorder-A Narrative Literature Review.
Angelova S, Konstantinova D, Nenova-Nogalcheva A, Pancheva R. Angelova S, et al. Children (Basel). 2025 Jun 9;12(6):750. doi: 10.3390/children12060750. Children (Basel). 2025. PMID: 40564707 Free PMC article. Review.
These challenges contribute to a lack of effective dental prophylaxis and limited access to regular preventive care, ultimately resulting in poorer oral health outcomes and reduced oral health-related quality of life. ...
These challenges contribute to a lack of effective dental prophylaxis and limited access to regular preventive care, ultimately resul …
Children and Adolescents with Co-Occurring Attention-Deficit/Hyperactivity Disorder and Autism Spectrum Disorder: A Systematic Review of Multimodal Interventions.
De Domenico C, Alito A, Leonardi G, Pironti E, Di Cara M, Piccolo A, Settimo C, Quartarone A, Gagliano A, Cucinotta F. De Domenico C, et al. J Clin Med. 2025 Jun 5;14(11):4000. doi: 10.3390/jcm14114000. J Clin Med. 2025. PMID: 40507763 Free PMC article. Review.
Four studies (12.5%) examined non-pharmacological interventions, including treatment with virtual reality tools, digital platforms, educational animations, and biomedical protocols; improvements in emotion recognition, behavioral regulation, attention, and social functioning were …
Four studies (12.5%) examined non-pharmacological interventions, including treatment with virtual reality tools, digital platforms, educatio …
Autism-like features and FOXP1 syndrome: A scoping review.
Stewart J, Cho GHY. Stewart J, et al. Brain Dev. 2025 Jun;47(3):104346. doi: 10.1016/j.braindev.2025.104346. Epub 2025 Mar 17. Brain Dev. 2025. PMID: 40101508 Free article.
However, significant heterogeneity in study methodologies and diagnostic criteria prevented direct comparisons and may have led to an underestimation of certain symptoms. ...
However, significant heterogeneity in study methodologies and diagnostic criteria prevented direct comparisons and may have led to an …
The Effects of Fecal Microbial Transplantation on the Symptoms in Autism Spectrum Disorder, Gut Microbiota and Metabolites: A Scoping Review.
Maniscalco I, Bartochowski P, Priori V, Iancau SP, De Francesco M, Innamorati M, Jagodzinska N, Giupponi G, Masucci L, Conca A, Mroczek M. Maniscalco I, et al. Microorganisms. 2025 May 31;13(6):1290. doi: 10.3390/microorganisms13061290. Microorganisms. 2025. PMID: 40572178 Free PMC article. Review.
The microbiome-gut-brain axis could provide new targets for preventing and treating psychiatric disorders. However, a recent large randomized clinical trial has shed light on the previously collected data and suggested a possible contribution of the placebo effect. ...
The microbiome-gut-brain axis could provide new targets for preventing and treating psychiatric disorders. However, a recent large ra …
Developing the allied health professionals workforce within mental health, learning disability and autism inpatient services: rapid review of learning from quality and safety incidents.
Wilson C, Wakefield R, Prothero L, Janes G, Nolan F, Fowler-Davis S. Wilson C, et al. BMJ Qual Saf. 2025 May 19;34(6):389-403. doi: 10.1136/bmjqs-2024-017746. BMJ Qual Saf. 2025. PMID: 39740987 Free PMC article. Review.
METHODS: A rapid literature review was conducted on material published from February 2014 to February 2024, reporting safety incidents within adult inpatient mental health, learning disability and autism services in England, with identifiable learning for AHPs. 115 reports/public …
METHODS: A rapid literature review was conducted on material published from February 2014 to February 2024, reporting safety incidents withi …
Building and testing of a robotic intervention framework to enhancing the social engagement of children with autism spectrum disorder.
Chung EY, Sin KK, Chow DH. Chung EY, et al. Disabil Rehabil Assist Technol. 2025 May;20(4):878-888. doi: 10.1080/17483107.2024.2412076. Epub 2024 Oct 8. Disabil Rehabil Assist Technol. 2025. PMID: 39378054 Free article. Review.
Contribute to the development of knowledge of and theoretical base for using robotic interventions for children with ASD.This study developed a testable program framework and inform researchers about scientific evidence regarding effective use of robotic intervention in the field …
Contribute to the development of knowledge of and theoretical base for using robotic interventions for children with ASD.This study develope …
A scoping review on parental/caregiver challenges in maintaining oral hygiene among children with autism spectrum disorder.
Mahabala KY, Dutt A, Shenoy R, Lee Y, Thimmaiah C, Bhat S, Nayak A, Rao A. Mahabala KY, et al. Int J Paediatr Dent. 2025 May;35(3):566-576. doi: 10.1111/ipd.13268. Epub 2024 Sep 23. Int J Paediatr Dent. 2025. PMID: 39311389 Free PMC article.
CONCLUSION: Challenges experienced by parents/caregivers of children with ASD were numerous, which resulted in deviations from routine oral hygiene practices from recommended guidelines for the prevention of dental caries....
CONCLUSION: Challenges experienced by parents/caregivers of children with ASD were numerous, which resulted in deviations from routine oral …
The Increasing Prevalence of Autism Spectrum Disorder in the U.S. and Its Implications for Pediatric Micronutrient Status: A Narrative Review of Case Reports and Series.
Daniel KS, Jiang Q, Wood MS. Daniel KS, et al. Nutrients. 2025 Mar 12;17(6):990. doi: 10.3390/nu17060990. Nutrients. 2025. PMID: 40290005 Free PMC article. Review.
Further research is needed to develop a standardized nutrition assessment, but combining anthropometric, biochemical, and dietary assessments can aid in early intervention and prevent complications....
Further research is needed to develop a standardized nutrition assessment, but combining anthropometric, biochemical, and dietary assessment …
Intervention and research progress of gut microbiota-immune-nervous system in autism spectrum disorders among students.
Zhou M, Niu B, Ma J, Ge Y, Han Y, Wu W, Yue C. Zhou M, et al. Front Microbiol. 2025 Mar 12;16:1535455. doi: 10.3389/fmicb.2025.1535455. eCollection 2025. Front Microbiol. 2025. PMID: 40143866 Free PMC article. Review.
This paper reviews the mechanisms and interrelationships among gut microbiota, immune system, and nervous system in ASD and discusses the challenges and future directions of existing research, aiming to provide new insights for the prevention and treatment of ASD....
This paper reviews the mechanisms and interrelationships among gut microbiota, immune system, and nervous system in ASD and discusses the ch …
Breastfeeding duration and neurodevelopment: insights into autism spectrum disorders and weaning practices.
Saigh BH. Saigh BH. J Health Popul Nutr. 2025 Mar 4;44(1):62. doi: 10.1186/s41043-025-00784-8. J Health Popul Nutr. 2025. PMID: 40033428 Free PMC article. Review.
Key findings suggest that breastfeeding may play a preventive role in mitigating ASD symptoms and enhancing neurodevelopment through mechanisms such as immune regulation, microbiome diversity, and hormonal pathways. ...
Key findings suggest that breastfeeding may play a preventive role in mitigating ASD symptoms and enhancing neurodevelopment through …
The Role of Nutrition, Oxidative Stress, and Trace Elements in the Pathophysiology of Autism Spectrum Disorders.
Długosz A, Wróblewski M, Błaszak B, Szulc J. Długosz A, et al. Int J Mol Sci. 2025 Jan 18;26(2):808. doi: 10.3390/ijms26020808. Int J Mol Sci. 2025. PMID: 39859522 Free PMC article. Review.
The growing prevalence of ASD has driven substantial advancements in research aimed at understanding its etiology, preventing its onset, and mitigating its impact. This ongoing effort necessitates continuous updates to the body of knowledge and the identification of previo …
The growing prevalence of ASD has driven substantial advancements in research aimed at understanding its etiology, preventing its ons …
Collaborative arts therapies as a supportive intervention for autism spectrum disorders: Bibliometric analysis, insights, and directions.
Zhang A, Luo X, Ying F, Wang J, Huang G. Zhang A, et al. Heliyon. 2024 Dec 19;11(1):e41333. doi: 10.1016/j.heliyon.2024.e41333. eCollection 2025 Jan 15. Heliyon. 2024. PMID: 39958733 Free PMC article. Review.
CONCLUSIONS: Research on CATs as an adjunctive therapy for the treatment of ASD is evolving. Providing comprehensive rehabilitation and support intervention for patients with ASD is a key research direction. ...
CONCLUSIONS: Research on CATs as an adjunctive therapy for the treatment of ASD is evolving. Providing comprehensive rehabilitation a …
Vocational rehabilitation of adolescents and young adults with autism spectrum disorder: a review.
Syriopoulou-Delli CK, Sarri K. Syriopoulou-Delli CK, et al. Int J Dev Disabil. 2023 May 11;71(1):41-60. doi: 10.1080/20473869.2023.2208898. eCollection 2025. Int J Dev Disabil. 2023. PMID: 39882416 Free PMC article. Review.
People with autism spectrum disorder (ASD), face several difficulties entering the workforce; yet when provided with appropriate support programs, can be expected to benefit from vocational rehabilitation and become independent. In this systematic literature review, suppor …
People with autism spectrum disorder (ASD), face several difficulties entering the workforce; yet when provided with appropriate support pro …
Understanding early maladaptive schemas in autistic and ADHD individuals: exploring the impact, changing the narrative, and schema therapy considerations.
Spicer L, DeCicco E, Clarke A, Ambrosius R, Yalcin O. Spicer L, et al. Front Psychol. 2024 Dec 4;15:1436053. doi: 10.3389/fpsyg.2024.1436053. eCollection 2024. Front Psychol. 2024. PMID: 39726631 Free PMC article. Review.
This will include an overview of the current literature in this area, reconsideration of understandings of Autism and ADHD, particular therapeutic considerations and adjustments and importantly discussion around the wider societal changes that need to occur to prevent sche …
This will include an overview of the current literature in this area, reconsideration of understandings of Autism and ADHD, particular thera …
Predictive coding for the actions and emotions of others and its deficits in autism spectrum disorders.
Keysers C, Silani G, Gazzola V. Keysers C, et al. Neurosci Biobehav Rev. 2024 Dec;167:105877. doi: 10.1016/j.neubiorev.2024.105877. Epub 2024 Sep 10. Neurosci Biobehav Rev. 2024. PMID: 39260714 Free article. Review.
Traditionally, the neural basis of social perception has been studied by showing participants brief examples of the actions or emotions of others presented in randomized order to prevent participants from anticipating what others do and feel. This approach is optimal to is …
Traditionally, the neural basis of social perception has been studied by showing participants brief examples of the actions or emotions of o …
Increased Risk of Dentoalveolar Trauma in Patients with Autism Spectrum Disorder: A Systematic Review with Meta-Analysis.
da Costa I, Junqueira RB, Faé DS, de Souza LAP, Lemos CAA. da Costa I, et al. Int J Environ Res Public Health. 2024 Nov 26;21(12):1563. doi: 10.3390/ijerph21121563. Int J Environ Res Public Health. 2024. PMID: 39767406 Free PMC article.
Despite the limitations of this study, the findings suggest that patients with ASD are at a higher risk of developing TDI than the risk observed in neurotypical patients. Therefore, preventive educational initiatives are recommended to reduce the risk of TDI in this popula …
Despite the limitations of this study, the findings suggest that patients with ASD are at a higher risk of developing TDI than the risk obse …
Suicidal Thoughts and Behaviors in People on the Autism Spectrum.
Reid M, Delgado D, Heinly J, Kiernan B, Shapiro S, Morgan L, Maddox B, Jager-Hyman S. Reid M, et al. Curr Psychiatry Rep. 2024 Nov;26(11):563-572. doi: 10.1007/s11920-024-01533-0. Epub 2024 Sep 30. Curr Psychiatry Rep. 2024. PMID: 39348035 Free PMC article. Review.
We recommend community-partnered, multi-faceted, and strength-based approaches to inform tailored prevention and intervention efforts....
We recommend community-partnered, multi-faceted, and strength-based approaches to inform tailored prevention and intervention efforts …
The global burden of suicide mortality among people on the autism spectrum: A systematic review, meta-analysis, and extension of estimates from the Global Burden of Disease Study 2021.
Santomauro DF, Hedley D, Sahin E, Brugha TS, Naghavi M, Vos T, Whiteford HA, Ferrari AJ, Stokes MA. Santomauro DF, et al. Psychiatry Res. 2024 Nov;341:116150. doi: 10.1016/j.psychres.2024.116150. Epub 2024 Aug 20. Psychiatry Res. 2024. PMID: 39197224 Free article.
Studies were limited in number and geographical coverage. Effective suicide prevention strategies for autistic persons may substantially reduce the fatal burden of suicides globally and reduce the health burden experienced within this population....
Studies were limited in number and geographical coverage. Effective suicide prevention strategies for autistic persons may substantia …
A Rapid Evidence Assessment on The Effectiveness of Interventions for Autistic Adolescents with Harmful Sexual Behaviors.
Trew S, Russell DH. Trew S, et al. Trauma Violence Abuse. 2024 Oct;25(4):3149-3163. doi: 10.1177/15248380241241024. Epub 2024 Mar 29. Trauma Violence Abuse. 2024. PMID: 38551117 Free PMC article. Review.
Inclusion criteria required articles to be published in a peer-reviewed journal, be related to HSB prevention and intervention in adolescents aged 12 to 18 with autism spectrum disorder, be written in English, and include original data. ...
Inclusion criteria required articles to be published in a peer-reviewed journal, be related to HSB prevention and intervention in ado …
The benefit of rhythm-based interventions for individuals with autism spectrum disorder: a systematic review and meta-analysis with random controlled trials.
Ding X, Wu J, Li D, Liu Z. Ding X, et al. Front Psychiatry. 2024 Sep 27;15:1436170. doi: 10.3389/fpsyt.2024.1436170. eCollection 2024. Front Psychiatry. 2024. PMID: 39398954 Free PMC article.
CONCLUSION: This result indicates the importance of rhythm in the clinical rehabilitation of individuals with ASD. We suggest adding appropriate rhythmic elements to clinical interventions, particularly for individuals with ASD who are less socially competent....
CONCLUSION: This result indicates the importance of rhythm in the clinical rehabilitation of individuals with ASD. We suggest adding …
Prenatal environmental risk factors for autism spectrum disorder and their potential mechanisms.
Love C, Sominsky L, O'Hely M, Berk M, Vuillermin P, Dawson SL. Love C, et al. BMC Med. 2024 Sep 16;22(1):393. doi: 10.1186/s12916-024-03617-3. BMC Med. 2024. PMID: 39278907 Free PMC article. Review.
This narrative review assesses the evidence of contributing prenatal environmental factors for ASD and associated mechanisms as potential targets for novel prevention strategies....
This narrative review assesses the evidence of contributing prenatal environmental factors for ASD and associated mechanisms as potential ta …
Exploring the landscape of adult autism research in psychology: a bibliometric and network analysis.
Mota FB, Braga LAM, Cabral BP. Mota FB, et al. Front Psychol. 2024 Sep 12;15:1427090. doi: 10.3389/fpsyg.2024.1427090. eCollection 2024. Front Psychol. 2024. PMID: 39328813 Free PMC article.
Key keywords include Emotion, Anxiety, and Depression, with Anxiety, Depression, and Mental Health as central nodes in the network. Rehabilitation, Behavioral Sciences, and Psychiatry frequently co-occur, and Psychology, Psychiatry, and 'Neurosciences and Neurology' are ce …
Key keywords include Emotion, Anxiety, and Depression, with Anxiety, Depression, and Mental Health as central nodes in the network. Rehab
Environmental pollutants as risk factors for autism spectrum disorders: a systematic review and meta-analysis of cohort studies.
Duque-Cartagena T, Dalla MDB, Mundstock E, Neto FK, Espinoza SAR, de Moura SK, Zanirati G, Padoin AV, Jimenez JGP, Stein AT, Cañon-Montañez W, Mattiello R. Duque-Cartagena T, et al. BMC Public Health. 2024 Sep 3;24(1):2388. doi: 10.1186/s12889-024-19742-w. BMC Public Health. 2024. PMID: 39223561 Free PMC article.
Therefore, it is important to identify these risk factors in children and adolescents to contribute to ASD and identify prevention strategies effectively....
Therefore, it is important to identify these risk factors in children and adolescents to contribute to ASD and identify prevention st …
Disrupted Prenatal Metabolism May Explain the Etiology of Suboptimal Neurodevelopment: A Focus on Phthalates and Micronutrients and their Relationship to Autism Spectrum Disorder.
Parenti M, Slupsky CM. Parenti M, et al. Adv Nutr. 2024 Sep;15(9):100279. doi: 10.1016/j.advnut.2024.100279. Epub 2024 Jul 24. Adv Nutr. 2024. PMID: 39059765 Free PMC article. Review.
By identifying the mechanisms through which phthalates and other ubiquitous endocrine disrupting chemicals influence development, and how nutritional interventions can impact those mechanisms, we can identify promising ways to prevent suboptimal neurodevelopment....
By identifying the mechanisms through which phthalates and other ubiquitous endocrine disrupting chemicals influence development, and how nu …
The Application of Extended Reality in Treating Children with Autism Spectrum Disorder.
Zhao W, Xu S, Zhang Y, Li D, Zhu C, Wang K. Zhao W, et al. Neurosci Bull. 2024 Aug;40(8):1189-1204. doi: 10.1007/s12264-024-01190-6. Epub 2024 Mar 18. Neurosci Bull. 2024. PMID: 38498091 Free PMC article. Review.
The study reveals that XR intervention therapy is mainly based on cognitive rehabilitation, teaching, and social-emotional learning theories. It utilizes algorithms, models, artificial intelligence (AI), eye-tracking, and other technologies for interaction, achieving diver …
The study reveals that XR intervention therapy is mainly based on cognitive rehabilitation, teaching, and social-emotional learning t …
The Unmasking of Autism in South Africa and Nigeria.
Adams SN. Adams SN. Neuropsychiatr Dis Treat. 2024 May 8;20:947-955. doi: 10.2147/NDT.S461650. eCollection 2024. Neuropsychiatr Dis Treat. 2024. PMID: 38737770 Free PMC article. Review.
Rising prevalence highlights the need to increase access to services, rehabilitation, and provide support to families of children with autism. Furthermore, research has emphasized the inequitable support and access available to families living in low-and high-income househ …
Rising prevalence highlights the need to increase access to services, rehabilitation, and provide support to families of children wit …
Central Causation of Autism/ASDs via Excessive [Ca(2+)]i Impacting Six Mechanisms Controlling Synaptogenesis during the Perinatal Period: The Role of Electromagnetic Fields and Chemicals and the NO/ONOO(-) Cycle, as Well as Specific Mutations.
Pall ML. Pall ML. Brain Sci. 2024 Apr 30;14(5):454. doi: 10.3390/brainsci14050454. Brain Sci. 2024. PMID: 38790433 Free PMC article. Review.
The literature examining each of these steps is systematically examined and found to be consistent with predictions. Approaches that may be sed for ASD prevention or treatment are discussed in connection with this special issue: The current situation and prospects for chil …
The literature examining each of these steps is systematically examined and found to be consistent with predictions. Approaches that may be …
Roles of Epigenetics and Glial Cells in Drug-Induced Autism Spectrum Disorder.
Csoka AB, El Kouhen N, Bennani S, Getachew B, Aschner M, Tizabi Y. Csoka AB, et al. Biomolecules. 2024 Apr 3;14(4):437. doi: 10.3390/biom14040437. Biomolecules. 2024. PMID: 38672454 Free PMC article. Review.
Recently, epigenetic influences on ASD have come to the forefront of investigations on the etiology, prevention, and treatment of this disorder. Epigenetics refers to DNA modifications that alter gene expression without making any changes to the DNA sequence. ...
Recently, epigenetic influences on ASD have come to the forefront of investigations on the etiology, prevention, and treatment of thi …
Functional contribution of the intestinal microbiome in autism spectrum disorder, attention deficit hyperactivity disorder, and Rett syndrome: a systematic review of pediatric and adult studies.
Caputi V, Hill L, Figueiredo M, Popov J, Hartung E, Margolis KG, Baskaran K, Joharapurkar P, Moshkovich M, Pai N. Caputi V, et al. Front Neurosci. 2024 Mar 7;18:1341656. doi: 10.3389/fnins.2024.1341656. eCollection 2024. Front Neurosci. 2024. PMID: 38516317 Free PMC article.
Perinatal administration of Lactobacillus sp. prevented the onset of Asperger and ADHD symptoms in adolescence. Micronutrient supplementation improved disease symptomatology in ADHD without causing significant changes in microbiota communities' composition. ...
Perinatal administration of Lactobacillus sp. prevented the onset of Asperger and ADHD symptoms in adolescence. Micronutrient supplem …
Harnessing the Power of Mobile Phone Technology: Screening and Identifying Autism Spectrum Disorder With Smartphone Apps.
Reddy K, Taksande A, Kurian B. Reddy K, et al. Cureus. 2024 Feb 26;16(2):e55004. doi: 10.7759/cureus.55004. eCollection 2024 Feb. Cureus. 2024. PMID: 38550425 Free PMC article. Review.
This disparity in access must be considered when developing and implementing app-based screening solutions to prevent exacerbating existing healthcare inequalities. Nevertheless, the future of ASD screening apps holds significant promise. ...
This disparity in access must be considered when developing and implementing app-based screening solutions to prevent exacerbating ex …
Assisted Robots in Therapies for Children with Autism in Early Childhood.
Gómez-Espinosa A, Moreno JC, Pérez-de la Cruz S. Gómez-Espinosa A, et al. Sensors (Basel). 2024 Feb 26;24(5):1503. doi: 10.3390/s24051503. Sensors (Basel). 2024. PMID: 38475039 Free PMC article.
There are different types of treatment (pharmacological, educational, psychological, and rehabilitative). Currently, one way to address this problem is by using robotic systems to address the abilities that are altered in these children. ...
There are different types of treatment (pharmacological, educational, psychological, and rehabilitative). Currently, one way to addre …
The Autism Spectrum Disorder and Its Possible Origins in Pregnancy.
Botelho RM, Silva ALM, Borbely AU. Botelho RM, et al. Int J Environ Res Public Health. 2024 Feb 20;21(3):244. doi: 10.3390/ijerph21030244. Int J Environ Res Public Health. 2024. PMID: 38541246 Free PMC article. Review.
With this firmly in mind, this review aims to compile the most recent data on the gestational causes that may be associated with the development of ASD to help health professionals identify risk factors and act for the prevention and management of ASD....
With this firmly in mind, this review aims to compile the most recent data on the gestational causes that may be associated with the develop …
Supporting the health and wellbeing of trans autistic school-aged youth: a systematic literature review.
Manley J, Brownlow C, Brömdal A. Manley J, et al. Int J Transgend Health. 2024 Feb 18;25(3):439-455. doi: 10.1080/26895269.2024.2317392. eCollection 2024. Int J Transgend Health. 2024. PMID: 39055630 Free PMC article. Review.
Schools should work toward having well-articulated and embedded policies supporting gender affirmation and preventing bullying and ostracization to ensure trans autistic youth develop positive health and wellbeing, and overall good quality of life. ...
Schools should work toward having well-articulated and embedded policies supporting gender affirmation and preventing bullying and os …
Pharmacogenomics and non-genetic factors affecting drug response in autism spectrum disorder in Thai and other populations: current evidence and future implications.
Biswas M, Vanwong N, Sukasem C. Biswas M, et al. Front Pharmacol. 2024 Feb 5;14:1285967. doi: 10.3389/fphar.2023.1285967. eCollection 2023. Front Pharmacol. 2024. PMID: 38375208 Free PMC article. Review.
Reimbursement, knowledge, and education of healthcare professionals are the key obstacles preventing the successful implementation of ASD pharmacogenomics into routine clinical practice. ...
Reimbursement, knowledge, and education of healthcare professionals are the key obstacles preventing the successful implementation of …
Autistic spectrum disorder children and adolescents' oral health characteristics - scoping review.
Barbosa MA, Lotito MCF, Masterson D, Pastura G, de Souza IP, Tavares-Silva CM, Castro GFBA. Barbosa MA, et al. Int J Dev Disabil. 2022 Jul 5;70(3):329-342. doi: 10.1080/20473869.2022.2092936. eCollection 2024. Int J Dev Disabil. 2022. PMID: 38699508 Free PMC article.
This study aimed to conduct a scoping review to know children and adolescents' main oral health concerns with Autism Spectrum Disorder (ASD) and thus identify any oral characteristic that stands out, aiming at preventive and interceptive clinical conduct. A search was perf …
This study aimed to conduct a scoping review to know children and adolescents' main oral health concerns with Autism Spectrum Disorder (ASD) …
Attention-deficit Hyperactivity Disorder and Autism Spectrum Disorder: Towards Better Diagnosis and Management.
Al Ghamdi K, AlMusailhi J. Al Ghamdi K, et al. Med Arch. 2024;78(2):159-163. doi: 10.5455/medarh.2024.78.159-163. Med Arch. 2024. PMID: 38566879 Free PMC article. Review.
CONCLUSION: More studies are needed to understand the mechanisms underlying these comorbidities, and to prevent the misdiagnosis and mismanagement of these disorders. Also, to develop up to date personalized therapeutic plans for such children....
CONCLUSION: More studies are needed to understand the mechanisms underlying these comorbidities, and to prevent the misdiagnosis and …
UBE3A: The Role in Autism Spectrum Disorders (ASDs) and a Potential Candidate for Biomarker Studies and Designing Therapeutic Strategies.
Roy B, Amemasor E, Hussain S, Castro K. Roy B, et al. Diseases. 2023 Dec 27;12(1):7. doi: 10.3390/diseases12010007. Diseases. 2023. PMID: 38248358 Free PMC article. Review.
Additionally, this review also attempts to lay optimistic feedback on the possible steps for the diagnosis, prevention, and therapy of these UBE3A-mediated ASDs in the upcoming years....
Additionally, this review also attempts to lay optimistic feedback on the possible steps for the diagnosis, prevention, and therapy o …
Oral Health Statuses of Children and Young Adults with Autism Spectrum Disorder: An Umbrella Review.
Sami W, Ahmad MS, Shaik RA, Miraj M, Ahmad S, Molla MH. Sami W, et al. J Clin Med. 2023 Dec 22;13(1):59. doi: 10.3390/jcm13010059. J Clin Med. 2023. PMID: 38202066 Free PMC article. Review.
Heterogeneous dental caries and periodontal disease prevalence rates were identified, highlighting the need for collaboration and preventive care. Several studies also reported higher prevalence rates of dental trauma and self-inflicted oral injuries among individuals with …
Heterogeneous dental caries and periodontal disease prevalence rates were identified, highlighting the need for collaboration and prevent
Unrealized Cross-System Opportunities to Improve Employment and Employment-Related Services Among Autistic Individuals.
Roux AM, Miller KK, Tao S, Rast JE, Ventimiglia J, Shattuck PT, Shea LL. Roux AM, et al. Milbank Q. 2023 Dec;101(4):1223-1279. doi: 10.1111/1468-0009.12666. Epub 2023 Aug 1. Milbank Q. 2023. PMID: 37526044 Free PMC article. Review.
Evaluation and monitoring of publicly funded employment services is paramount given the dramatic increases in adults with autism who need job supports. Vocational Rehabilitation agencies appeared to be absorbing short-term employment needs of autistic people, but Medicaid …
Evaluation and monitoring of publicly funded employment services is paramount given the dramatic increases in adults with autism who need jo …
Nurturing the Positive Mental Health of Autistic Children, Adolescents and Adults alongside That of Their Family Care-Givers: A Review of Reviews.
McConkey R. McConkey R. Brain Sci. 2023 Nov 27;13(12):1645. doi: 10.3390/brainsci13121645. Brain Sci. 2023. PMID: 38137093 Free PMC article. Review.
These low-cost interventions are especially pertinent in low-resourced settings, but they can be used internationally to prevent mental illness and assist in the treatment of anxiety and depression in autistic persons and their family carers. ...
These low-cost interventions are especially pertinent in low-resourced settings, but they can be used internationally to prevent ment …
The Physiology of Cognition in Autism Spectrum Disorder: Current and Future Challenges.
Al-Mazidi SH. Al-Mazidi SH. Cureus. 2023 Oct 6;15(10):e46581. doi: 10.7759/cureus.46581. eCollection 2023 Oct. Cureus. 2023. PMID: 37808604 Free PMC article. Review.
Developing clear treatment criteria for cognitive impairment for ASD would improve the quality of life of ASD people and their caregivers and would delay or prevent dementia-related disorders in ASD people....
Developing clear treatment criteria for cognitive impairment for ASD would improve the quality of life of ASD people and their caregivers an …
Autism, Discrimination and Masking: Disrupting a Recipe for Trauma.
Cleary M, West S, Kornhaber R, Hungerford C. Cleary M, et al. Issues Ment Health Nurs. 2023 Sep;44(9):799-808. doi: 10.1080/01612840.2023.2239916. Epub 2023 Aug 24. Issues Ment Health Nurs. 2023. PMID: 37616302 Free article. Review.
Further research can aid in minimizing and preventing discrimination against people with autism....
Further research can aid in minimizing and preventing discrimination against people with autism....
Early Screen-Time Exposure and Its Association With Risk of Developing Autism Spectrum Disorder: A Systematic Review.
Sarfraz S, Shlaghya G, Narayana SH, Mushtaq U, Shaman Ameen B, Nie C, Nechi D, Mazhar IJ, Yasir M, Arcia Franchini AP. Sarfraz S, et al. Cureus. 2023 Jul 22;15(7):e42292. doi: 10.7759/cureus.42292. eCollection 2023 Jul. Cureus. 2023. PMID: 37614255 Free PMC article. Review.
Autism spectrum disorder (ASD) is a neurological deficit in brain functions that prevents a child from having a normal social life like his peers. It results in the inability to interact and communicate with others. ...
Autism spectrum disorder (ASD) is a neurological deficit in brain functions that prevents a child from having a normal social life li …
Viruses and autism: A Bi-mutual cause and effect.
Al-Beltagi M, Saeed NK, Elbeltagi R, Bediwy AS, Aftab SAS, Alhawamdeh R. Al-Beltagi M, et al. World J Virol. 2023 Jun 25;12(3):172-192. doi: 10.5501/wjv.v12.i3.172. World J Virol. 2023. PMID: 37396705 Free PMC article. Review.
In addition, children with autism are at increased risk of infection, including viruses. Every effort should be made to prevent maternal and early-life infections and reduce the risk of autism. Immune modulation of children with autism should be considered to reduce the ri …
In addition, children with autism are at increased risk of infection, including viruses. Every effort should be made to prevent mater …
The Healthcare Experience of Autistic Patients in Orthopaedic Surgery and Closely Related Fields: A Scoping Review.
Criss SD, Kakulamarri S, Xu RF, Fajardo M, Keeney T, Tolchin DW, May CJ. Criss SD, et al. Children (Basel). 2023 May 22;10(5):906. doi: 10.3390/children10050906. Children (Basel). 2023. PMID: 37238454 Free PMC article.
Three major concepts were built into the search terms: (1) patients on the autism spectrum; (2) patient experience; and (3) movement sciences, including orthopaedics, physical medicine and rehabilitation (PM&R), occupational therapy (OT), and physical therapy (PT). Our …
Three major concepts were built into the search terms: (1) patients on the autism spectrum; (2) patient experience; and (3) movement science …
Epigenomic signatures reveal mechanistic clues and predictive markers for autism spectrum disorder.
LaSalle JM. LaSalle JM. Mol Psychiatry. 2023 May;28(5):1890-1901. doi: 10.1038/s41380-022-01917-9. Epub 2023 Jan 17. Mol Psychiatry. 2023. PMID: 36650278 Free PMC article. Review.
Together, these epigenomic signatures hold promising clues towards improved early prediction and prevention of ASD as well genes and gene pathways to target for pharmacological interventions. ...
Together, these epigenomic signatures hold promising clues towards improved early prediction and prevention of ASD as well genes and …
Molecular mechanisms of exercise intervention in alleviating the symptoms of autism spectrum disorder: Targeting the structural alterations of synapse.
Zong W, Lu X, Dong G, Zhang L, Li K. Zong W, et al. Front Psychiatry. 2023 Mar 31;14:1096503. doi: 10.3389/fpsyt.2023.1096503. eCollection 2023. Front Psychiatry. 2023. PMID: 37065903 Free PMC article. Review.
Finally, we explore the possible molecular mechanisms of improving ASD symptoms through exercise intervention from the perspective of regulating synaptic structural plasticity, which contributes to further optimizing the related strategies of exercise intervention promoting ASD …
Finally, we explore the possible molecular mechanisms of improving ASD symptoms through exercise intervention from the perspective of regula …
A systematic review and meta-analysis of suicidality in autistic and possibly autistic people without co-occurring intellectual disability.
Newell V, Phillips L, Jones C, Townsend E, Richards C, Cassidy S. Newell V, et al. Mol Autism. 2023 Mar 15;14(1):12. doi: 10.1186/s13229-023-00544-7. Mol Autism. 2023. PMID: 36922899 Free PMC article.
Possibly autistic individuals require more attention in clinical and research considerations going forward to further understand and prevent suicide in both groups....
Possibly autistic individuals require more attention in clinical and research considerations going forward to further understand and prev
Systematic Review on EEG Analysis to Diagnose and Treat Autism by Evaluating Functional Connectivity and Spectral Power.
Bogéa Ribeiro L, da Silva Filho M. Bogéa Ribeiro L, et al. Neuropsychiatr Dis Treat. 2023 Feb 22;19:415-424. doi: 10.2147/NDT.S394363. eCollection 2023. Neuropsychiatr Dis Treat. 2023. PMID: 36861010 Free PMC article. Review.
For ASD subtype delineation, the lack of research prevented the evaluation of these techniques as diagnostic tools. These findings confirm the presence of abnormalities in the EEG in ASD, but they are insufficient to diagnose. ...
For ASD subtype delineation, the lack of research prevented the evaluation of these techniques as diagnostic tools. These findings co …
mTOR Signaling Disruption and Its Association with the Development of Autism Spectrum Disorder.
Thomas SD, Jha NK, Ojha S, Sadek B. Thomas SD, et al. Molecules. 2023 Feb 16;28(4):1889. doi: 10.3390/molecules28041889. Molecules. 2023. PMID: 36838876 Free PMC article. Review.
We further discuss the various naturally occurring phytoconstituents that have been identified to be bioactive and modulate the pathway to prevent its disruption and contribute to beneficial therapeutic effects in ASD....
We further discuss the various naturally occurring phytoconstituents that have been identified to be bioactive and modulate the pathway to …