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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
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1998 6
1999 7
2000 2
2001 8
2002 3
2003 6
2004 4
2005 5
2006 3
2007 4
2008 3
2009 5
2010 3
2011 4
2012 6
2013 6
2014 5
2015 6
2016 4
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2019 8
2020 7
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132 results

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Page 1
Proteases in Pemphigoid Diseases.
Hiroyasu S, Turner CT, Richardson KC, Granville DJ. Hiroyasu S, et al. Among authors: granville dj. Front Immunol. 2019 Jun 26;10:1454. doi: 10.3389/fimmu.2019.01454. eCollection 2019. Front Immunol. 2019. PMID: 31297118 Free PMC article. Review.
The insect caspases.
Cooper DM, Granville DJ, Lowenberger C. Cooper DM, et al. Among authors: granville dj. Apoptosis. 2009 Mar;14(3):247-56. doi: 10.1007/s10495-009-0322-1. Apoptosis. 2009. PMID: 19212814 Review.
Granzyme B in Autoimmune Skin Disease.
Gleave A, Granville DJ. Gleave A, et al. Among authors: granville dj. Biomolecules. 2023 Feb 18;13(2):388. doi: 10.3390/biom13020388. Biomolecules. 2023. PMID: 36830757 Free PMC article. Review.
Hence, there is an unmet need for novel therapies that block molecular drivers of disease in a local and/or targeted manner. Granzyme B (GzmB) is a serine protease with known cytotoxic activity and emerging extracellular functions, including the cleavage of cell-cell junct …
Hence, there is an unmet need for novel therapies that block molecular drivers of disease in a local and/or targeted manner. Granzyme
Exploring the role of granzyme B in subretinal fibrosis of age-related macular degeneration.
Gill K, Yoo HS, Chakravarthy H, Granville DJ, Matsubara JA. Gill K, et al. Among authors: granville dj. Front Immunol. 2024 Jul 18;15:1421175. doi: 10.3389/fimmu.2024.1421175. eCollection 2024. Front Immunol. 2024. PMID: 39091492 Free PMC article. Review.
Special attention is given to the potential role of mast cells in CNV and subretinal fibrosis, with a focus on putative mast cell mediators, tryptase and granzyme B. We summarize our findings on the role of GzmB in CNV and speculate how GzmB may be involved in the patholog …
Special attention is given to the potential role of mast cells in CNV and subretinal fibrosis, with a focus on putative mast cell mediators, …
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization.
Obasanmi G, Uppal M, Cui JZ, Xi J, Ju MJ, Song J, To E, Li S, Khan W, Cheng D, Zhu J, Irani L, Samad I, Zhu J, Yoo HS, Aubert A, Stoddard J, Neuringer M, Granville DJ, Matsubara JA. Obasanmi G, et al. Among authors: granville dj. Angiogenesis. 2024 Aug;27(3):351-373. doi: 10.1007/s10456-024-09909-9. Epub 2024 Mar 18. Angiogenesis. 2024. PMID: 38498232 Free PMC article.
Here we investigate a novel target for AMD. Granzyme B (GzmB) is a serine protease that promotes aging, chronic inflammation and vascular permeability through the degradation of the extracellular matrix (ECM) and tight junctions. ...
Here we investigate a novel target for AMD. Granzyme B (GzmB) is a serine protease that promotes aging, chronic inflammation and vasc …
Granzyme K contributes to endothelial microvascular damage and leakage during skin inflammation.
Turner CT, Zeglinski MR, Boivin W, Zhao H, Pawluk MA, Richardson KC, Chandrabalan A, Bird P, Ramachandran R, Sehmi R, Lima H, Gauvreau G, Granville DJ. Turner CT, et al. Among authors: granville dj. Br J Dermatol. 2023 Aug 24;189(3):279-291. doi: 10.1093/bjd/ljac017. Br J Dermatol. 2023. PMID: 36652225
BACKGROUND: Granzyme K (GzmK) is a serine protease with minimal presence in healthy tissues while abundant in inflamed tissues. ...
BACKGROUND: Granzyme K (GzmK) is a serine protease with minimal presence in healthy tissues while abundant in inflamed tissues. ...
Granzymes in cardiovascular injury and disease.
Zeglinski MR, Granville DJ. Zeglinski MR, et al. Among authors: granville dj. Cell Signal. 2020 Dec;76:109804. doi: 10.1016/j.cellsig.2020.109804. Epub 2020 Oct 7. Cell Signal. 2020. PMID: 33035645 Review.
Moreover, the aberrant secretion of proteases plays a critical role in pathological tissue remodeling in chronic inflammatory conditions. Human Granzymes (Granule secreted enzymes - Gzms) comprise a family of five (GzmA, B, H, K, M) cell-secreted serine proteases. ...
Moreover, the aberrant secretion of proteases plays a critical role in pathological tissue remodeling in chronic inflammatory conditions. Hu …
Granzyme serine proteases in inflammation and rheumatic diseases.
Aubert A, Jung K, Hiroyasu S, Pardo J, Granville DJ. Aubert A, et al. Among authors: granville dj. Nat Rev Rheumatol. 2024 Jun;20(6):361-376. doi: 10.1038/s41584-024-01109-5. Epub 2024 Apr 30. Nat Rev Rheumatol. 2024. PMID: 38689140 Review.
After internalization, granzymes can initiate cell death through the cleavage of intracellular substrates. However, evidence now also demonstrates the existence of non-cytotoxic, pro-inflammatory, intracellular and extracellular functions that are granzyme specific. …
After internalization, granzymes can initiate cell death through the cleavage of intracellular substrates. However, evidence now also …
Granzyme B in epithelial barrier dysfunction and related skin diseases.
Jung K, Pawluk MA, Lane M, Nabai L, Granville DJ. Jung K, et al. Among authors: granville dj. Am J Physiol Cell Physiol. 2022 Jul 1;323(1):C170-C189. doi: 10.1152/ajpcell.00052.2022. Epub 2022 Apr 20. Am J Physiol Cell Physiol. 2022. PMID: 35442832 Free article. Review.
Increasing evidence has emerged in recent years supporting a role for granzyme B in promoting barrier dysfunction in the epidermis by direct cleavage of barrier proteins and eliciting immunoreactivity. Likewise, granzyme B contributes to impaired epithelial function …
Increasing evidence has emerged in recent years supporting a role for granzyme B in promoting barrier dysfunction in the epidermis by …
Pathogenic mechanisms and the potential of drug therapies for aortic aneurysm.
Liu B, Granville DJ, Golledge J, Kassiri Z. Liu B, et al. Among authors: granville dj. Am J Physiol Heart Circ Physiol. 2020 Mar 1;318(3):H652-H670. doi: 10.1152/ajpheart.00621.2019. Epub 2020 Feb 21. Am J Physiol Heart Circ Physiol. 2020. PMID: 32083977 Free PMC article. Review.
The present review provides an overview of cellular and noncellular factors as well as enzymes that process extracellular matrix and regulate cellular functions (e.g., matrix metalloproteinases, granzymes, and cathepsins) in the context of aneurysm pathogenesis. An update …
The present review provides an overview of cellular and noncellular factors as well as enzymes that process extracellular matrix and regulat …
132 results