Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization.
Obasanmi G, Uppal M, Cui JZ, Xi J, Ju MJ, Song J, To E, Li S, Khan W, Cheng D, Zhu J, Irani L, Samad I, Zhu J, Yoo HS, Aubert A, Stoddard J, Neuringer M, Granville DJ, Matsubara JA.
Obasanmi G, et al. Among authors: granville dj.
Angiogenesis. 2024 Aug;27(3):351-373. doi: 10.1007/s10456-024-09909-9. Epub 2024 Mar 18.
Angiogenesis. 2024.
PMID: 38498232
Free PMC article.
Here we investigate a novel target for AMD. Granzyme B (GzmB) is a serine protease that promotes aging, chronic inflammation and vascular permeability through the degradation of the extracellular matrix (ECM) and tight junctions. ...
Here we investigate a novel target for AMD. Granzyme B (GzmB) is a serine protease that promotes aging, chronic inflammation and vasc …