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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1996 1
1997 1
1998 6
1999 7
2000 2
2001 8
2002 3
2003 6
2004 4
2005 5
2006 3
2007 4
2008 3
2009 5
2010 3
2011 4
2012 6
2013 6
2014 5
2015 6
2016 4
2017 3
2018 5
2019 8
2020 7
2021 7
2022 7
2023 5
2024 11
2025 6
2026 4

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138 results

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Page 1
The insect caspases.
Cooper DM, Granville DJ, Lowenberger C. Cooper DM, et al. Among authors: granville dj. Apoptosis. 2009 Mar;14(3):247-56. doi: 10.1007/s10495-009-0322-1. Apoptosis. 2009. PMID: 19212814 Review.
Proteases in Pemphigoid Diseases.
Hiroyasu S, Turner CT, Richardson KC, Granville DJ. Hiroyasu S, et al. Among authors: granville dj. Front Immunol. 2019 Jun 26;10:1454. doi: 10.3389/fimmu.2019.01454. eCollection 2019. Front Immunol. 2019. PMID: 31297118 Free PMC article. Review.
Granzyme B degrades extracellular matrix and promotes inflammation and choroidal neovascularization.
Obasanmi G, Uppal M, Cui JZ, Xi J, Ju MJ, Song J, To E, Li S, Khan W, Cheng D, Zhu J, Irani L, Samad I, Zhu J, Yoo HS, Aubert A, Stoddard J, Neuringer M, Granville DJ, Matsubara JA. Obasanmi G, et al. Among authors: granville dj. Angiogenesis. 2024 Aug;27(3):351-373. doi: 10.1007/s10456-024-09909-9. Epub 2024 Mar 18. Angiogenesis. 2024. PMID: 38498232 Free PMC article.
Here we investigate a novel target for AMD. Granzyme B (GzmB) is a serine protease that promotes aging, chronic inflammation and vascular permeability through the degradation of the extracellular matrix (ECM) and tight junctions. ...
Here we investigate a novel target for AMD. Granzyme B (GzmB) is a serine protease that promotes aging, chronic inflammation and vasc …
Exploring the role of granzyme B in subretinal fibrosis of age-related macular degeneration.
Gill K, Yoo HS, Chakravarthy H, Granville DJ, Matsubara JA. Gill K, et al. Among authors: granville dj. Front Immunol. 2024 Jul 18;15:1421175. doi: 10.3389/fimmu.2024.1421175. eCollection 2024. Front Immunol. 2024. PMID: 39091492 Free PMC article. Review.
Special attention is given to the potential role of mast cells in CNV and subretinal fibrosis, with a focus on putative mast cell mediators, tryptase and granzyme B. We summarize our findings on the role of GzmB in CNV and speculate how GzmB may be involved in the patholog …
Special attention is given to the potential role of mast cells in CNV and subretinal fibrosis, with a focus on putative mast cell mediators, …
Granzyme serine proteases in inflammation and rheumatic diseases.
Aubert A, Jung K, Hiroyasu S, Pardo J, Granville DJ. Aubert A, et al. Among authors: granville dj. Nat Rev Rheumatol. 2024 Jun;20(6):361-376. doi: 10.1038/s41584-024-01109-5. Epub 2024 Apr 30. Nat Rev Rheumatol. 2024. PMID: 38689140 Review.
After internalization, granzymes can initiate cell death through the cleavage of intracellular substrates. However, evidence now also demonstrates the existence of non-cytotoxic, pro-inflammatory, intracellular and extracellular functions that are granzyme specific. …
After internalization, granzymes can initiate cell death through the cleavage of intracellular substrates. However, evidence now also …
Granzyme K mediates IL-23-dependent inflammation and keratinocyte proliferation in psoriasis.
Richardson KC, Aubert A, Turner CT, Nabai L, Hiroyasu S, Pawluk MA, Cederberg RA, Zhao H, Jung K, Burleigh A, Crawford RI, Granville DJ. Richardson KC, et al. Among authors: granville dj. Front Immunol. 2024 Jun 5;15:1398120. doi: 10.3389/fimmu.2024.1398120. eCollection 2024. Front Immunol. 2024. PMID: 38903528 Free PMC article.
Activation of the IL-23/IL-17 pro-inflammatory signaling pathway is a hallmark of psoriasis and its inhibition is key to clinical management. Granzyme K (GzmK) is an immune cell-secreted serine protease elevated in inflammatory and proliferative skin conditions. ...
Activation of the IL-23/IL-17 pro-inflammatory signaling pathway is a hallmark of psoriasis and its inhibition is key to clinical management …
Granzyme B in Autoimmune Skin Disease.
Gleave A, Granville DJ. Gleave A, et al. Among authors: granville dj. Biomolecules. 2023 Feb 18;13(2):388. doi: 10.3390/biom13020388. Biomolecules. 2023. PMID: 36830757 Free PMC article. Review.
Hence, there is an unmet need for novel therapies that block molecular drivers of disease in a local and/or targeted manner. Granzyme B (GzmB) is a serine protease with known cytotoxic activity and emerging extracellular functions, including the cleavage of cell-cell junct …
Hence, there is an unmet need for novel therapies that block molecular drivers of disease in a local and/or targeted manner. Granzyme
Inflammation in myocardial diseases.
Marchant DJ, Boyd JH, Lin DC, Granville DJ, Garmaroudi FS, McManus BM. Marchant DJ, et al. Among authors: mcmanus bm, granville dj. Circ Res. 2012 Jan 6;110(1):126-44. doi: 10.1161/CIRCRESAHA.111.243170. Circ Res. 2012. PMID: 22223210 Free article. Review.
Granzymes in cardiovascular injury and disease.
Zeglinski MR, Granville DJ. Zeglinski MR, et al. Among authors: granville dj. Cell Signal. 2020 Dec;76:109804. doi: 10.1016/j.cellsig.2020.109804. Epub 2020 Oct 7. Cell Signal. 2020. PMID: 33035645 Review.
Moreover, the aberrant secretion of proteases plays a critical role in pathological tissue remodeling in chronic inflammatory conditions. Human Granzymes (Granule secreted enzymes - Gzms) comprise a family of five (GzmA, B, H, K, M) cell-secreted serine proteases. ...
Moreover, the aberrant secretion of proteases plays a critical role in pathological tissue remodeling in chronic inflammatory conditions. Hu …
Granzyme B in skin inflammation and disease.
Turner CT, Lim D, Granville DJ. Turner CT, et al. Among authors: granville dj. Matrix Biol. 2019 Jan;75-76:126-140. doi: 10.1016/j.matbio.2017.12.005. Epub 2017 Dec 14. Matrix Biol. 2019. PMID: 29247692 Review.
Granzyme B (GzmB) is a serine protease emerging as an important mediator of skin injury, inflammation and repair. ...
Granzyme B (GzmB) is a serine protease emerging as an important mediator of skin injury, inflammation and repair. ...
138 results