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Page 1
Vascular Effects of Early versus Late Postmenopausal Treatment with Estradiol.
Hodis HN, Mack WJ, Henderson VW, Shoupe D, Budoff MJ, Hwang-Levine J, Li Y, Feng M, Dustin L, Kono N, Stanczyk FZ, Selzer RH, Azen SP; ELITE Research Group. Hodis HN, et al. N Engl J Med. 2016 Mar 31;374(13):1221-31. doi: 10.1056/NEJMoa1505241. N Engl J Med. 2016. PMID: 27028912 Free PMC article. Clinical Trial.
However, the hypothesis that the cardiovascular effects of postmenopausal hormone therapy vary with the timing of therapy initiation (the hormone-timing hypothesis) has not been tested. ...
However, the hypothesis that the cardiovascular effects of postmenopausal hormone therapy vary with the timing of therapy initiation …
Perimenopausal use of hormone therapy is associated with enhanced memory and hippocampal function later in life.
Maki PM, Dennerstein L, Clark M, Guthrie J, LaMontagne P, Fornelli D, Little D, Henderson VW, Resnick SM. Maki PM, et al. Brain Res. 2011 Mar 16;1379:232-43. doi: 10.1016/j.brainres.2010.11.030. Epub 2010 Nov 13. Brain Res. 2011. PMID: 21078303 Free PMC article. Clinical Trial.
Evidence suggests that initiation of some forms of hormone therapy (HT) early in the perimenopausal or postmenopausal stage might confer benefit to verbal memory and the neural systems underlying memory, whereas late-life initiation confers no benefit or harm. This "critical …
Evidence suggests that initiation of some forms of hormone therapy (HT) early in the perimenopausal or postmenopausal stage might confer ben …
Methods and baseline cardiovascular data from the Early versus Late Intervention Trial with Estradiol testing the menopausal hormone timing hypothesis.
Hodis HN, Mack WJ, Shoupe D, Azen SP, Stanczyk FZ, Hwang-Levine J, Budoff MJ, Henderson VW. Hodis HN, et al. Menopause. 2015 Apr;22(4):391-401. doi: 10.1097/GME.0000000000000343. Menopause. 2015. PMID: 25380275 Free PMC article. Clinical Trial.
OBJECTIVE: This study aims to present methods and baseline data from the Early versus Late Intervention Trial with Estradiol (ELITE), the only clinical trial designed to specifically test the timing hypothesis of postmenopausal hormone therapy (HT). The timing hypot …
OBJECTIVE: This study aims to present methods and baseline data from the Early versus Late Intervention Trial with Estradiol (ELITE), the on …
Oral estradiol administration modulates continuous intravenous growth hormone (GH)-releasing peptide-2-driven GH secretion in postmenopausal women.
Shah N, Evans WS, Bowers CY, Veldhuis JD. Shah N, et al. J Clin Endocrinol Metab. 2000 Aug;85(8):2649-59. doi: 10.1210/jcem.85.8.6729. J Clin Endocrinol Metab. 2000. PMID: 10946861 Clinical Trial.
In summary, short-term oral E2 replacement in post-menopausal women strongly modulates the actions of a synthetic hexapeptide GH secretagogue on three quantifiable modes of GH secretion [i.e. 1) basal (nonpulsatile) GH release; 2) feedback-dependent ApEn; and 3) the mesor, amplit …
In summary, short-term oral E2 replacement in post-menopausal women strongly modulates the actions of a synthetic hexapeptide GH secretagogu …
Effects of Estradiol Dose and Serum Estradiol Levels on Metabolic Measures in Early and Late Postmenopausal Women in the REPLENISH Trial.
Sriprasert I, Hodis HN, Bernick B, Mirkin S, Mack WJ. Sriprasert I, et al. J Womens Health (Larchmt). 2020 Aug;29(8):1052-1058. doi: 10.1089/jwh.2019.8238. Epub 2020 Jul 9. J Womens Health (Larchmt). 2020. PMID: 32644875 Free PMC article. Clinical Trial.
As the metabolic parameters studied are risk factors for cardiovascular events, these results support the timing hypothesis of E2 therapy and its cardiovascular benefits....
As the metabolic parameters studied are risk factors for cardiovascular events, these results support the timing hypothesis of E2 the …