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Current therapeutic options for adult patients with urticarial vasculitis: A scoping review.
Groleau AS, Mereniuk A, Makhzoum JP. Groleau AS, et al. Among authors: makhzoum jp. J Am Acad Dermatol. 2025 Aug;93(2):423-428. doi: 10.1016/j.jaad.2025.03.056. Epub 2025 Mar 27. J Am Acad Dermatol. 2025. PMID: 40157507
BACKGROUND: Urticarial vasculitis (UV) is a rare form of small vessel vasculitis, and there are limited published data on its management. ...
BACKGROUND: Urticarial vasculitis (UV) is a rare form of small vessel vasculitis, and there are limited published data on its …
Updates in ANCA-associated vasculitis.
Ross C, Makhzoum JP, Pagnoux C. Ross C, et al. Among authors: makhzoum jp. Eur J Rheumatol. 2022 Jul;9(3):153-166. doi: 10.5152/eujrheum.2022.20248. Eur J Rheumatol. 2022. PMID: 35156630 Free PMC article.
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) are small-vessel vasculitides that include granulomatosis with polyangiitis (formerly Wegener's granulomatosis), microscopic polyangiitis, and eosinophilic granulomatosis with polyangiitis (Churg …
Antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) are small-vessel vasculitides that include granulomatos …
CanVasc consensus recommendations for the use of avacopan in antineutrophil cytoplasm antibody-associated vasculitis: 2022 addendum.
Turgeon D, Bakowsky V, Baldwin C, Cabral DA, Clements-Baker M, Clifford A, Cohen Tervaert JW, Dehghan N, Ennis D, Famorca L, Fifi-Mah A, Girard LP, Lefebvre F, Liang P, Makhzoum JP, Massicotte-Azarniouch D, Mendel A, Milman N, Reich HN, Robinson DB, Ross C, Rumsey DG, Soowamber M, Towheed TE, Trudeau J, Twilt M, Yacyshyn E, Yardimci GK, Khalidi N, Barra L, Pagnoux C. Turgeon D, et al. Among authors: makhzoum jp, ross c. Rheumatology (Oxford). 2023 Aug 1;62(8):2646-2651. doi: 10.1093/rheumatology/kead087. Rheumatology (Oxford). 2023. PMID: 36805625
OBJECTIVE: In 2020, the Canadian Vasculitis Research Network (CanVasc) published their updated recommendations for the management of ANCA-associated vasculitides (AAV). ...
OBJECTIVE: In 2020, the Canadian Vasculitis Research Network (CanVasc) published their updated recommendations for the management of …
CanVasc Consensus Recommendations for the Management of Antineutrophil Cytoplasm Antibody-associated Vasculitis: 2020 Update.
Mendel A, Ennis D, Go E, Bakowsky V, Baldwin C, Benseler SM, Cabral DA, Carette S, Clements-Baker M, Clifford AH, Cohen Tervaert JW, Cox G, Dehghan N, Dipchand C, Dhindsa N, Famorca L, Fifi-Mah A, Garner S, Girard LP, Lessard C, Liang P, Noone D, Makhzoum JP, Milman N, Pineau CA, Reich HN, Rhéaume M, Robinson DB, Rumsey DG, Towheed TE, Trudeau J, Twilt M, Yacyshyn E, Yeung RSM, Barra LB, Khalidi N, Pagnoux C. Mendel A, et al. Among authors: makhzoum jp, rheaume m. J Rheumatol. 2021 Apr;48(4):555-566. doi: 10.3899/jrheum.200721. Epub 2020 Sep 15. J Rheumatol. 2021. PMID: 32934123 Free article.
OBJECTIVE: In 2015, the Canadian Vasculitis Research Network (CanVasc) created recommendations for the management of antineutrophil cytoplasm antibody (ANCA)-associated vasculitides (AAV) in Canada. ...
OBJECTIVE: In 2015, the Canadian Vasculitis Research Network (CanVasc) created recommendations for the management of antineutrophil c …
Colour Doppler ultrasound and the giant cell arteritis probability score for the diagnosis of giant cell arteritis: a Canadian single-centre experience.
Zarka F, Rhéaume M, Belhocine M, Goulet M, Febrer G, Mansour AM, Troyanov Y, Starnino T, Meunier RS, Chagnon I, Routhier N, Bénard V, Ducharme-Bénard S, Ross C, Makhzoum JP. Zarka F, et al. Among authors: makhzoum jp, belhocine m, ducharme benard s, mansour am, rheaume m, ross c, goulet m. Rheumatol Adv Pract. 2021 Nov 10;5(3):rkab083. doi: 10.1093/rap/rkab083. eCollection 2021. Rheumatol Adv Pract. 2021. PMID: 34859177 Free PMC article.
METHODS: Descriptive statistics were performed on a retrospective cohort of patients referred to our vasculitis referral centre between 1 July 2017 and 1 October 2020 for suspected GCA. CDUS, TAB, centre-specific TAB (vasculitis centre vs referring hospitals) and GC …
METHODS: Descriptive statistics were performed on a retrospective cohort of patients referred to our vasculitis referral centre betwe …
A phase 2, randomised, placebo-controlled study of guselkumab in adults with new-onset or relapsing giant cell arteritis.
Makhzoum JP, Cid MC, Samson M, Henes J, Schönau V, Espigol-Frigole G, Ross C, Ahlman MA, Hsu MC, Li S, Verdijk P, Okonkwo L, Grayson PC, Blockmans D. Makhzoum JP, et al. Among authors: ross c. Ann Rheum Dis. 2026 Feb 12:S0003-4967(26)00013-0. doi: 10.1016/j.ard.2026.01.009. Online ahead of print. Ann Rheum Dis. 2026. PMID: 41688258 Free article.
Update in the Management of ANCA-Associated Vasculitis: Recent Developments and Future Perspectives.
Samman KN, Ross C, Pagnoux C, Makhzoum JP. Samman KN, et al. Among authors: makhzoum jp, ross c. Int J Rheumatol. 2021 Apr 8;2021:5534851. doi: 10.1155/2021/5534851. eCollection 2021. Int J Rheumatol. 2021. PMID: 33927768 Free PMC article. Review.
Significant progress has been made in the treatment of ANCA-associated vasculitides (AAV), notably in granulomatosis with polyangiitis and microscopic polyangiitis. ...
Significant progress has been made in the treatment of ANCA-associated vasculitides (AAV), notably in granulomatosis with polyangiiti …
Characterization of visual manifestations and identification of risk factors for permanent vision loss in patients with giant cell arteritis.
Baalbaki H, Jalaledin D, Lachance C, Febrer G, Rhéaume M, Makhzoum JP. Baalbaki H, et al. Among authors: makhzoum jp, rheaume m. Clin Rheumatol. 2021 Aug;40(8):3207-3217. doi: 10.1007/s10067-021-05643-5. Epub 2021 Feb 12. Clin Rheumatol. 2021. PMID: 33580374
METHODS: A retrospective database from a single vasculitis referral center was used. Descriptive statistics comparing patients with and without ocular involvement were performed. ...
METHODS: A retrospective database from a single vasculitis referral center was used. Descriptive statistics comparing patients with a …
Association of Vasculitis and Familial Mediterranean Fever.
Abbara S, Grateau G, Ducharme-Bénard S, Saadoun D, Georgin-Lavialle S. Abbara S, et al. Among authors: ducharme benard s. Front Immunol. 2019 Apr 12;10:763. doi: 10.3389/fimmu.2019.00763. eCollection 2019. Front Immunol. 2019. PMID: 31031761 Free PMC article.
Clinical case reports were available for 167 patients (IgA vasculitis n = 46, PAN n = 61, BD n = 46, other vasculitis n = 14), and unavailable for 45 patients (IgA vasculitis n = 38, PAN n = 7). IgA vasculitis was the most common vasculitis in F …
Clinical case reports were available for 167 patients (IgA vasculitis n = 46, PAN n = 61, BD n = 46, other vasculitis n = 14), …
DADA2 diagnosed in adulthood versus childhood: A comparative study on 306 patients including a systematic literature review and 12 French cases.
Fayand A, Chasset F, Boutboul D, Queyrel V, Tieulié N, Guichard I, Dupin N, Franck N, Cohen P, Bessis D, Guenno GL, Koné-Paut I, Belot A, Bonhomme A, Ducharme-Bénard S, Grateau G, Sarrabay G, Touitou I, Boursier G, Georgin-Lavialle S. Fayand A, et al. Among authors: ducharme benard s. Semin Arthritis Rheum. 2021 Dec;51(6):1170-1179. doi: 10.1016/j.semarthrit.2021.09.001. Epub 2021 Sep 16. Semin Arthritis Rheum. 2021. PMID: 34571400
Pulmonary involvement in primary systemic vasculitides.
Makhzoum JP, Grayson PC, Ponte C, Robson J, Suppiah R, Watts RA, Luqmani R, Merkel PA, Pagnoux C; DCVAS Collaborators. Makhzoum JP, et al. Rheumatology (Oxford). 2021 Dec 24;61(1):319-330. doi: 10.1093/rheumatology/keab325. Rheumatology (Oxford). 2021. PMID: 33788906 Free PMC article.
OBJECTIVES: This study describes the spectrum and initial impact of pulmonary manifestations in the primary systemic vasculitides. METHODS: Description and comparison of pulmonary manifestations in adults with Takayasu's arteritis (TAK), GCA, granulomatosis with polyangiit …
OBJECTIVES: This study describes the spectrum and initial impact of pulmonary manifestations in the primary systemic vasculitides. ME …
A Case of Severe and Refractory Membranous Nephropathy Associated to Mucous Membrane Pemphigoid.
Mereniuk E, Sabbah L, Makhzoum JP. Mereniuk E, et al. Among authors: makhzoum jp. Case Rep Nephrol. 2021 May 11;2021:9940293. doi: 10.1155/2021/9940293. eCollection 2021. Case Rep Nephrol. 2021. PMID: 34055432 Free PMC article.
Primary membranous nephropathy (MN) and mucous membrane pemphigoid (MMP) are two autoimmune conditions with well-defined diagnostic and treatment guidelines. MN has been linked to bullous pemphigoid (BP) in certain case reports, though little is known regarding the associa …
Primary membranous nephropathy (MN) and mucous membrane pemphigoid (MMP) are two autoimmune conditions with well-defined diagnostic a …
American College of Rheumatology Guidance Statement for Diagnosis and Management of VEXAS Developed by the International VEXAS Working Group Expert Panel.
Mekinian A, Georgin-Lavialle S, Ferrada MA, Savic S, Koster MJ, Kosmider O, Comont T, Heiblig M, Arostegui JI, Bosco A, Bourguiba R, Calvo KR, Cargo C, Cattaneo C, Chasset F, Coelho H, Campochiaro C, Crisafulli F, Ducharme-Benard S, Faria R, Franceschini F, Frassi M, Groarke EM, Gurnari C, Hakobyan Y, Jamilloux Y, Jurcut C, Kirino Y, Kulasekararaj A, Kunimoto H, Madigan LM, Mann HF, Marvisi C, Milchert M, Morais S, Sockel K, Muratore F, Nakajima H, Patnaik MM, Regadas L, Robin M, Rutgers A, Salvarani C, Sammel AM, Seebach J, Sujobert P, Tomelleri A, Urbanski G, Vandergheynst F, Vieira R, Viswanatha DS, Więsik-Szewczyk E, Diral E, Terrier B, Patel BA, Fenaux P, Grayson PC, Beck DB; International VEXAS working group, and with endorsement of EuroBloodNet, the European Reference Network in Rare Hematological Diseases. Mekinian A, et al. Among authors: ducharme benard s. Arthritis Rheumatol. 2026 Mar;78(3):509-522. doi: 10.1002/art.43287. Epub 2025 Aug 11. Arthritis Rheumatol. 2026. PMID: 40787890 Free PMC article.
Systemic autoinflammatory diseases: Clinical state of the art.
Georgin-Lavialle S, Ducharme-Benard S, Sarrabay G, Savey L, Grateau G, Hentgen V. Georgin-Lavialle S, et al. Among authors: ducharme benard s. Best Pract Res Clin Rheumatol. 2020 Aug;34(4):101529. doi: 10.1016/j.berh.2020.101529. Epub 2020 Jun 13. Best Pract Res Clin Rheumatol. 2020. PMID: 32546426 Free article. Review.
They were initially defined in opposition to autoimmune diseases due to the lack of involvement of the adaptive immune system and circulating autoantibodies. ...
They were initially defined in opposition to autoimmune diseases due to the lack of involvement of the adaptive immune system and cir …
Management of antineutrophil cytoplasmic antibody vasculitis-associated orbital inflammatory disease: A systematic literature review.
Neary E, Healey K, Clements-Baker M, Makhzoum JP, Mendel A. Neary E, et al. Among authors: makhzoum jp. Semin Arthritis Rheum. 2026 Feb;76:152900. doi: 10.1016/j.semarthrit.2025.152900. Epub 2025 Dec 23. Semin Arthritis Rheum. 2026. PMID: 41456508 Free article.
OBJECTIVE: Ocular manifestations frequently occur in ANCA-associated vasculitides (AAV). Orbital inflammatory disease (OID) is a subset with limited management guidelines. ...
OBJECTIVE: Ocular manifestations frequently occur in ANCA-associated vasculitides (AAV). Orbital inflammatory disease (OID) is a subs …
Reply.
Rhéaume M, Pagnoux C, Khalidi NA. Rhéaume M, et al. Arthritis Rheumatol. 2017 Feb;69(2):477-478. doi: 10.1002/art.39936. Arthritis Rheumatol. 2017. PMID: 27696761 No abstract available.
Treatment Patterns and Clinical Outcomes for Patients Living with Active Giant Cell Arteritis in Canada.
Makhzoum JP, Avadisian M, Liazoghli D. Makhzoum JP, et al. Rheumatol Ther. 2026 Feb;13(1):243-263. doi: 10.1007/s40744-025-00817-y. Epub 2025 Dec 24. Rheumatol Ther. 2026. PMID: 41444463 Free PMC article.
INTRODUCTION: Giant cell arteritis (GCA) is a chronic inflammatory vasculitis in large and medium-sized arteries. Glucocorticoids (GCs) remain the cornerstone of treatment but carry significant long-term adverse effects. ...
INTRODUCTION: Giant cell arteritis (GCA) is a chronic inflammatory vasculitis in large and medium-sized arteries. Glucocorticoids (GC …
Revisiting the link between oropharyngeal dysphagia and cancer in autoimmune myositis: a descriptive study.
Shen HC, Landon-Cardinal O, Bourré-Tessier J, Hoa S, Zarka F, Nehme J, Mansour AM, Makhzoum JP, Mereniuk A, Meunier RS, Bouchard-Marmen M, Poirier-Blanchette L, Landry M, Lévesque M, Massie R, Blanchard O, Lefebvre F, Goulet JR, Rich E, Raynauld JP, Pérez G, Koenig M, Allard-Chamard H, Drouin J, Chartrand S, Aaron M, Ivensky V, Infantino M, Giannini M, Betteridge Z, Leclair V, Hudson M, Karamchandani J, Hervier B, O'Ferrall E, Ellezam B, Targoff IN, Satoh M, Fritzler MJ, Senécal JL, Meyer A, Troyanov Y. Shen HC, et al. Among authors: makhzoum jp, mansour am. Arthritis Res Ther. 2025 Nov 13;27(1):210. doi: 10.1186/s13075-025-03662-0. Arthritis Res Ther. 2025. PMID: 41233913 Free PMC article.
OBJECTIVES: To explore the link between moderate to severe oropharyngeal dysphagia and cancer in autoimmune myositis (AIM) other than inclusion body myositis (IBM). METHODS: The medical records of patients with AIM seen in rheumatology in two university hospitals from Janu …
OBJECTIVES: To explore the link between moderate to severe oropharyngeal dysphagia and cancer in autoimmune myositis (AIM) other than …
CanVasc Recommendations for the Management of Antineutrophil Cytoplasm Antibody-associated Vasculitides.
McGeoch L, Twilt M, Famorca L, Bakowsky V, Barra L, Benseler SM, Cabral DA, Carette S, Cox GP, Dhindsa N, Dipchand CS, Fifi-Mah A, Goulet M, Khalidi N, Khraishi MM, Liang P, Milman N, Pineau CA, Reich HN, Samadi N, Shojania K, Taylor-Gjevre R, Towheed TE, Trudeau J, Walsh M, Yacyshyn E, Pagnoux C; Canadian Vasculitis Research Network. McGeoch L, et al. Among authors: goulet m. J Rheumatol. 2016 Jan;43(1):97-120. doi: 10.3899/jrheum.150376. Epub 2015 Nov 1. J Rheumatol. 2016. PMID: 26523024
OBJECTIVE: The Canadian Vasculitis research network (CanVasc) is composed of physicians from different medical specialties and researchers with expertise in vasculitis. ...A systematic review of existing non-Canadian recommendations and guidelines for the diagnosis …
OBJECTIVE: The Canadian Vasculitis research network (CanVasc) is composed of physicians from different medical specialties and resear …
Pregnancy Outcomes in Systemic Vasculitides.
Ross C, D'Souza R, Pagnoux C. Ross C, et al. Curr Rheumatol Rep. 2020 Aug 26;22(10):63. doi: 10.1007/s11926-020-00940-5. Curr Rheumatol Rep. 2020. PMID: 32845412 Free PMC article. Review.
Therefore, pregnancy in women with vasculitis has become a more frequent consideration or event. Literature on pregnancy outcomes in this population has grown and allowed us, in this article, to review the effects of pregnancy on disease activity, as well as maternal and f …
Therefore, pregnancy in women with vasculitis has become a more frequent consideration or event. Literature on pregnancy outcomes in …
Somatic Mutation in UBA1 and ANCA-associated Vasculitis.
Ross C, Elfassy HL, Makhzoum JP. Ross C, et al. Among authors: makhzoum jp. J Rheumatol. 2021 Oct;48(10):1626-1627. doi: 10.3899/jrheum.210149. Epub 2021 Jun 1. J Rheumatol. 2021. PMID: 34074684 No abstract available.
Recognising the spectrum of scleromyositis: HEp-2 ANA patterns allow identification of a novel clinical subset with anti-SMN autoantibodies.
Landon-Cardinal O, Baril-Dionne A, Hoa S, Meyer A, Leclair V, Bourré-Tessier J, Mansour AM, Zarka F, Makhzoum JP, Nehme J, Rich E, Goulet JR, Grodzicky T, Koenig M, Joyal F, Richard I, Hudson M, Targoff I, Satoh M, Fritzler MJ, Troyanov Y, Senécal JL. Landon-Cardinal O, et al. Among authors: makhzoum jp, mansour am. RMD Open. 2020 Sep;6(2):e001357. doi: 10.1136/rmdopen-2020-001357. RMD Open. 2020. PMID: 32892170 Free PMC article.
Rare Ischemic Complications of Giant Cell Arteritis: Case Series and Literature Review.
Jalaledin DS, Ross C, Makhzoum JP. Jalaledin DS, et al. Among authors: makhzoum jp, ross c. Am J Case Rep. 2022 Oct 14;23:e937565. doi: 10.12659/AJCR.937565. Am J Case Rep. 2022. PMID: 36240129 Free PMC article. Review.
CONCLUSIONS Ischemic complications due to GCA can be part of the initial presentation of the vasculitis, making confirmation of the diagnosis more difficult. Physicians should be aware of these rare complications since rapid diagnosis and initiation of glucocorticoids may …
CONCLUSIONS Ischemic complications due to GCA can be part of the initial presentation of the vasculitis, making confirmation of the d …
A Review of Primary Vasculitis Mimickers Based on the Chapel Hill Consensus Classification.
Zarka F, Veillette C, Makhzoum JP. Zarka F, et al. Among authors: makhzoum jp. Int J Rheumatol. 2020 Feb 18;2020:8392542. doi: 10.1155/2020/8392542. eCollection 2020. Int J Rheumatol. 2020. PMID: 32148510 Free PMC article. Review.
Primary systemic vasculitides are rare diseases that may manifest similarly to more commonly encountered conditions. Depending on the size of the vessel affected (large vessel, medium vessel, or small vessel), different vasculitis mimics must be considered. Establis …
Primary systemic vasculitides are rare diseases that may manifest similarly to more commonly encountered conditions. Depending on the …
Estimating the Change in Renal Function During the First Year of Therapy in ANCA-Associated Vasculitis.
Lepeytre F, Royal V, Lavoie PL, Bollée G, Gougeon F, Beauchemin S, Rhéaume M, Brachemi S, Laurin LP, Troyanov S. Lepeytre F, et al. Among authors: rheaume m. Kidney Int Rep. 2019 Feb 13;4(4):594-602. doi: 10.1016/j.ekir.2019.02.005. eCollection 2019 Apr. Kidney Int Rep. 2019. PMID: 30993234 Free PMC article.
INTRODUCTION: Studies in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) consistently show that the months following diagnosis have the greatest impact on the long-term renal function. ...
INTRODUCTION: Studies in antineutrophil cytoplasmic autoantibody (ANCA)-associated vasculitis (AAV) consistently show that the months …
Statin-induced anti-HMGCR myopathy: successful therapeutic strategies for corticosteroid-free remission in 55 patients.
Meyer A, Troyanov Y, Drouin J, Oligny-Longpré G, Landon-Cardinal O, Hoa S, Hervier B, Bourré-Tessier J, Mansour AM, Hussein S, Morin V, Rich E, Goulet JR, Chartrand S, Hudson M, Nehme J, Makhzoum JP, Zarka F, Villeneuve E, Raynauld JP, Landry M, O'Ferrall EK, Ferreira J, Ellezam B, Karamchandani J, Larue S, Massie R, Isabelle C, Deschênes I, Leclair V, Couture H, Targoff IN, Fritzler MJ, Senécal JL. Meyer A, et al. Among authors: makhzoum jp, mansour am. Arthritis Res Ther. 2020 Jan 8;22(1):5. doi: 10.1186/s13075-019-2093-6. Arthritis Res Ther. 2020. PMID: 31915059 Free PMC article.
Antiplatelet therapy to prevent ischemic events in giant cell arteritis: protocol for a systematic review and meta-analysis.
Makhzoum JP, Baati Y, Tanase O, Mendel A, Pagnoux C, Ross C. Makhzoum JP, et al. Among authors: ross c. Syst Rev. 2024 Jul 8;13(1):173. doi: 10.1186/s13643-024-02599-w. Syst Rev. 2024. PMID: 38978122 Free PMC article.
BACKGROUND: Giant cell arteritis (GCA) is the most common systemic vasculitis in adults. Presenting features include new-onset headaches, constitutional symptoms, jaw claudication, polymyalgia rheumatica, and visual symptoms. ...
BACKGROUND: Giant cell arteritis (GCA) is the most common systemic vasculitis in adults. Presenting features include new-onset headac …
Comparison of Interstitial Lung Disease Between Antineutrophil Cytoplasmic Antibodies Positive and Negative Patients: A Retrospective Cohort Study.
Shen HC, Bui KA, Richard R, Toban N, Lévesque M, Meunier RS, Ross C, Makhzoum JP. Shen HC, et al. Among authors: makhzoum jp, ross c. ACR Open Rheumatol. 2024 Aug;6(8):463-469. doi: 10.1002/acr2.11679. Epub 2024 May 11. ACR Open Rheumatol. 2024. PMID: 38733262 Free PMC article.
OBJECTIVE: Positive antineutrophil cytoplasmic antibodies (ANCAs) may occur in the setting of interstitial lung disease (ILD), with or without ANCA-associated vasculitis (AAV). We aim to compare the characteristics and clinical course of patients with ILD and positive ANCA …
OBJECTIVE: Positive antineutrophil cytoplasmic antibodies (ANCAs) may occur in the setting of interstitial lung disease (ILD), with or witho …
Comparison of Two Rituximab Induction Regimens for Antineutrophil Cytoplasm Antibody-Associated Vasculitis: Systematic Review and Meta-Analysis.
Bénard V, Farhat C, Zarandi-Nowroozi M, Durand M, Charles P, Puéchal X, Guillevin L, Pagnoux C, Makhzoum JP. Bénard V, et al. Among authors: makhzoum jp. ACR Open Rheumatol. 2021 Jul;3(7):484-494. doi: 10.1002/acr2.11274. Epub 2021 Jun 11. ACR Open Rheumatol. 2021. PMID: 34114739 Free PMC article.
OBJECTIVE: The objective of this study was to compare the efficacy and safety of two rituximab (RTX) regimens for the induction of remission in severe antineutrophil cytoplasm antibody-associated vasculitis (AAV): the four-dose (375 mg/m(2) intravenously weekly) versus the …
OBJECTIVE: The objective of this study was to compare the efficacy and safety of two rituximab (RTX) regimens for the induction of remission …
Metabolite monitoring to guide thiopurine therapy in systemic autoimmune diseases.
Chapdelaine A, Mansour AM, Troyanov Y, Williamson DR, Doré M. Chapdelaine A, et al. Among authors: mansour am. Clin Rheumatol. 2017 Jun;36(6):1341-1348. doi: 10.1007/s10067-017-3554-4. Epub 2017 Jan 27. Clin Rheumatol. 2017. PMID: 28130685
This study sought to describe metabolite monitoring in patients receiving weight-based thiopurine for systemic autoimmune diseases. Patients were enrolled using a laboratory database, and data were retrospectively collected. ...Thiopurine metabolite monitoring shows wide v …
This study sought to describe metabolite monitoring in patients receiving weight-based thiopurine for systemic autoimmune diseases. P …
Optimizing Thiopurine Therapy with a Xanthine Oxidase Inhibitor in Patients with Systemic Autoimmune Diseases: A Single-Centre Experience.
Belhocine M, Mourad A, Chapdelaine A, Mansour AM, Troyanov Y, Doré M. Belhocine M, et al. Among authors: mansour am. Can J Hosp Pharm. 2021 Fall;74(4):361-369. doi: 10.4212/cjhp.v74i4.3199. Can J Hosp Pharm. 2021. PMID: 34602624 Free PMC article.
BACKGROUND: Thiopurines are a mainstay of therapy for autoimmune diseases. However, up to 20% to 30% of patients experience overproduction of the methylated metabolites, known as 6-MMP, to the detriment of the active metabolite, 6-thioguanine nucleotide (6-TGN). ...CONCLUS …
BACKGROUND: Thiopurines are a mainstay of therapy for autoimmune diseases. However, up to 20% to 30% of patients experience overprodu …
Aneurysmal Disease in Patients With Takayasu Arteritis.
Lefebvre F, Ross C, Soowamber M, Pagnoux C; Canadian Network for Research on Vasculitis (CanVasc). Lefebvre F, et al. Among authors: ross c. J Rheumatol. 2024 Mar 1;51(3):277-284. doi: 10.3899/jrheum.2023-0629. J Rheumatol. 2024. PMID: 38101913
METHODS: This monocentric retrospective study included patients with TA followed at the Mount Sinai Hospital Vasculitis Clinic in Toronto. Diagnosis of TA was based on clinical findings and/or satisfied the 1990 American College of Rheumatology classification criteria. ...
METHODS: This monocentric retrospective study included patients with TA followed at the Mount Sinai Hospital Vasculitis Clinic in Tor …
Hip involvement in familial Mediterranean fever.
Rodrigues F, Sellam J, Quartier P, Ducharme-Bénard S, Georgin-Lavialle S. Rodrigues F, et al. Among authors: ducharme benard s. Eur J Intern Med. 2023 Apr;110:110-112. doi: 10.1016/j.ejim.2022.11.008. Epub 2022 Nov 24. Eur J Intern Med. 2023. PMID: 36435696 No abstract available.
Atorvastatin-induced necrotizing autoimmune myositis: An emerging dominant entity in patients with autoimmune myositis presenting with a pure polymyositis phenotype.
Troyanov Y, Landon-Cardinal O, Fritzler MJ, Ferreira J, Targoff IN, Rich E, Goulet M, Goulet JR, Bourré-Tessier J, Robitaille Y, Drouin J, Albert A, Senécal JL. Troyanov Y, et al. Among authors: goulet m. Medicine (Baltimore). 2017 Jan;96(3):e5694. doi: 10.1097/MD.0000000000005694. Medicine (Baltimore). 2017. PMID: 28099331 Free PMC article.
Specific objectives were to characterize clinical features, autoantibodies (aAbs), and membrane attack complex (MAC) in muscle biopsies of patients with treatment-responsive, statin-exposed necrotizing autoimmune myositis (NAM). Patients from the Centre hospitalier de l'Un …
Specific objectives were to characterize clinical features, autoantibodies (aAbs), and membrane attack complex (MAC) in muscle biopsies of p …
Myositis with prominent B cell aggregates may meet classification criteria for sporadic inclusion body myositis.
Meyer A, Troyanov Y, Korathanakhun P, Landon-Cardinal O, Leclair V, Allard-Chamard H, Bourré-Tessier J, Makhzoum JP, Isabelle C, Larue S, Grand'Maison F, Massie R, Page ML, Mansour AM, Routhier N, Zarka F, Roy F, Sonnen J, Satoh M, Fritzler M, Hudson M, Senécal JL, Karamchandani J, Ellezam B, O'Ferrall E. Meyer A, et al. Among authors: makhzoum jp, mansour am. Neuromuscul Disord. 2023 Feb;33(2):169-182. doi: 10.1016/j.nmd.2022.12.001. Epub 2022 Dec 5. Neuromuscul Disord. 2023. PMID: 36649672
The objective of this study was to report the clinical, serological and pathological features of patients with autoimmune myositis other than dermatomyositis, who displayed both muscle weakness on physical examination and prominent B cell aggregates on muscle pathology, de …
The objective of this study was to report the clinical, serological and pathological features of patients with autoimmune myositis ot …
Assessment and comparison of probability scores to predict giant cell arteritis.
Sargi C, Ducharme-Benard S, Benard V, Meunier RS, Ross C, Makhzoum JP. Sargi C, et al. Among authors: makhzoum jp, ducharme benard s, ross c. Clin Rheumatol. 2024 Jan;43(1):357-365. doi: 10.1007/s10067-023-06721-6. Epub 2023 Aug 1. Clin Rheumatol. 2024. PMID: 37525060 Free PMC article.
Final diagnosis of GCA was confirmed clinically 6 months after the initial visit, by two blinded vasculitis specialists. Diagnostic accuracy and receiver operator characteristic (ROC) curves for each clinical and CDUS prediction scores were assessed. ...
Final diagnosis of GCA was confirmed clinically 6 months after the initial visit, by two blinded vasculitis specialists. Diagnostic a …
Non-amyloid liver involvement in familial Mediterranean fever: A systematic literature review.
Fraisse T, Savey L, Hentgen V, Rossi-Semerano L, Koné-Paut I, Grateau G, Georgin-Lavialle S, Ducharme-Bénard S. Fraisse T, et al. Among authors: ducharme benard s. Liver Int. 2020 Jun;40(6):1269-1277. doi: 10.1111/liv.14445. Epub 2020 Apr 15. Liver Int. 2020. PMID: 32196885
The evidence was insufficient to establish an association with BCS, hyperbilirubinaemia or autoimmune hepatitis....
The evidence was insufficient to establish an association with BCS, hyperbilirubinaemia or autoimmune hepatitis....
Classification of primary antiphospholipid syndrome as systemic lupus erythematosus: Analysis of a cohort of 214 patients.
Paule R, Morel N, Le Guern V, Fredi M, Coutte L, Belhocine M, Mouthon L, le Jeunne C, Chauvin A, Piette JC, Costedoat-Chalumeau N. Paule R, et al. Among authors: belhocine m. Autoimmun Rev. 2018 Sep;17(9):866-872. doi: 10.1016/j.autrev.2018.03.011. Epub 2018 Jul 10. Autoimmun Rev. 2018. PMID: 30005859 Review.
We successively excluded patients with (1) at least one "SLE-specific" manifestation (biopsy-proven SLE nephropathy, arthritis, cutaneous, or neurologic SLE manifestations, pericarditis, autoimmune haemolytic anaemia, oral and nasal ulcers, non-scarring alopecia, anti-dsDN …
We successively excluded patients with (1) at least one "SLE-specific" manifestation (biopsy-proven SLE nephropathy, arthritis, cutaneous, o …
Cessation of immunosuppressive therapies in patients with Takayasu arteritis with sustained inactive disease.
Ross C, Lefebvre F, Pagnoux C. Ross C, et al. Semin Arthritis Rheum. 2022 Feb;52:151934. doi: 10.1016/j.semarthrit.2021.12.005. Epub 2021 Dec 31. Semin Arthritis Rheum. 2022. PMID: 35000787
OBJECTIVE: Takayasu arteritis (TA) is a chronic and relapsing vasculitis. The objectives of this study were to describe the characteristics and identify predictive factors associated with successful treatment discontinuation in a cohort of patients with TA. METHODS: We con …
OBJECTIVE: Takayasu arteritis (TA) is a chronic and relapsing vasculitis. The objectives of this study were to describe the character …
Variations in Takayasu arteritis characteristics in a cohort of patients with different racial backgrounds.
Jiang Z, Lefebvre F, Ross C, Dehghan N, Fifi-Mah A, Khalidi N, Pagnoux C, Barra L; Canadian Vasculitis Network (CanVasc). Jiang Z, et al. Among authors: ross c. Semin Arthritis Rheum. 2022 Apr;53:151971. doi: 10.1016/j.semarthrit.2022.151971. Epub 2022 Jan 22. Semin Arthritis Rheum. 2022. PMID: 35104688
METHODS: This was a retrospective cohort study consisting of TA patients seen at specialty vasculitis clinics from five academic hospitals across Canada. Disease features, treatments and outcomes were compared between White and non-White patients. ...
METHODS: This was a retrospective cohort study consisting of TA patients seen at specialty vasculitis clinics from five academic hosp …
Development of Canadian Recommendations for the Management of ANCA-Associated Vasculitides: Results of the National Needs Assessment Questionnaire.
Famorca L, Twilt M, Barra L, Bakowsky V, Benseler S, Cabral D, Carette S, Dhindsa N, Fifi-Mah A, Goulet M, Khalidi N, Khraishi M, McGeoch L, Milman N, Pineau C, Shojania K, Taylor-Gjevre R, Towheed T, Trudeau J, Yacyshyn E, Liang P, Pagnoux C; Canadian Vasculitis network (CanVasc). Famorca L, et al. Among authors: goulet m. Open Rheumatol J. 2015 Apr 14;9:16-20. doi: 10.2174/18743129014090100016. eCollection 2015. Open Rheumatol J. 2015. PMID: 25893028 Free PMC article.
OBJECTIVES: To study variations in Canadian clinical practice patterns for the management of ANCA-associated vasculitis (AAV) and identify points to consider for the development of national recommendations. ...RESULTS: Among 132 physicians who followed at least 1 vascul …
OBJECTIVES: To study variations in Canadian clinical practice patterns for the management of ANCA-associated vasculitis (AAV) and ide …
Do we need the PFAPA syndrome in adults with non-monogenic periodic fevers?
Fayand A, Hentgen V, Ducharme-Bénard S, Quartier P, Bader-Meunier B, Koné-Paut I, Grateau G, Georgin-Lavialle S. Fayand A, et al. Among authors: ducharme benard s. Ann Rheum Dis. 2022 Jan;81(1):e15. doi: 10.1136/annrheumdis-2019-216827. Epub 2019 Dec 31. Ann Rheum Dis. 2022. PMID: 31892530 Free article. No abstract available.
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