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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1970 1
1978 1
1989 1
1990 6
1991 2
1992 1
1993 2
1994 5
1995 3
1996 2
1997 3
1998 10
1999 5
2000 16
2001 12
2002 18
2003 17
2004 22
2005 24
2006 41
2007 46
2008 54
2009 78
2010 113
2011 126
2012 141
2013 170
2014 276
2015 312
2016 331
2017 339
2018 388
2019 393
2020 362
2021 427
2022 244
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3,550 results
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Page 1
Targeting the epigenetic regulation of antitumour immunity.
Hogg SJ, Beavis PA, Dawson MA, Johnstone RW. Hogg SJ, et al. Nat Rev Drug Discov. 2020 Nov;19(11):776-800. doi: 10.1038/s41573-020-0077-5. Epub 2020 Sep 14. Nat Rev Drug Discov. 2020. PMID: 32929243 Review.
Dysregulation of the epigenome drives aberrant transcriptional programmes that promote cancer onset and progression. ...We emphasize opportunities for small-molecule inhibitors of epigenetic regulators to enhance antitumour immune responses, and discuss the challeng …
Dysregulation of the epigenome drives aberrant transcriptional programmes that promote cancer onset and progression. ...We emphasize …
Longitudinal Multi-omics Reveals Subset-Specific Mechanisms Underlying Irritable Bowel Syndrome.
Mars RAT, Yang Y, Ward T, Houtti M, Priya S, Lekatz HR, Tang X, Sun Z, Kalari KR, Korem T, Bhattarai Y, Zheng T, Bar N, Frost G, Johnson AJ, van Treuren W, Han S, Ordog T, Grover M, Sonnenburg J, D'Amato M, Camilleri M, Elinav E, Segal E, Blekhman R, Farrugia G, Swann JR, Knights D, Kashyap PC. Mars RAT, et al. Cell. 2020 Sep 17;182(6):1460-1473.e17. doi: 10.1016/j.cell.2020.08.007. Epub 2020 Sep 10. Cell. 2020. PMID: 32916129 Free PMC article.
We integrated longitudinal multi-omics data from the gut microbiome, metabolome, host epigenome, and transcriptome in the context of irritable bowel syndrome (IBS) host physiology. ...
We integrated longitudinal multi-omics data from the gut microbiome, metabolome, host epigenome, and transcriptome in the context of …
The DNA methylation landscape in cancer.
Skvortsova K, Stirzaker C, Taberlay P. Skvortsova K, et al. Essays Biochem. 2019 Dec 20;63(6):797-811. doi: 10.1042/EBC20190037. Essays Biochem. 2019. PMID: 31845735 Free PMC article. Review.
As one of the most abundant and well-studied epigenetic modifications, DNA methylation plays an essential role in normal development and cellular biology. ...
As one of the most abundant and well-studied epigenetic modifications, DNA methylation plays an essential role in normal development …
Functions and mechanisms of epigenetic inheritance in animals.
Skvortsova K, Iovino N, Bogdanović O. Skvortsova K, et al. Nat Rev Mol Cell Biol. 2018 Dec;19(12):774-790. doi: 10.1038/s41580-018-0074-2. Nat Rev Mol Cell Biol. 2018. PMID: 30425324 Review.
Such meiotic epigenetic inheritance (MEI) is fairly common in yeast, plants and nematodes, but its extent in mammals has been much debated. ...It is important to note that MEI in mammals rarely constitutes transgenerational epigenetic inheritance (TEI), which spans …
Such meiotic epigenetic inheritance (MEI) is fairly common in yeast, plants and nematodes, but its extent in mammals has been much de …
Diabetes in pregnancy: a new decade of challenges ahead.
Schaefer-Graf U, Napoli A, Nolan CJ; Diabetic Pregnancy Study Group. Schaefer-Graf U, et al. Diabetologia. 2018 May;61(5):1012-1021. doi: 10.1007/s00125-018-4545-y. Epub 2018 Jan 22. Diabetologia. 2018. PMID: 29356835 Free PMC article. Review.
Genetic and epigenetic regulation of human aging and longevity.
Morris BJ, Willcox BJ, Donlon TA. Morris BJ, et al. Biochim Biophys Acta Mol Basis Dis. 2019 Jul 1;1865(7):1718-1744. doi: 10.1016/j.bbadis.2018.08.039. Epub 2018 Sep 1. Biochim Biophys Acta Mol Basis Dis. 2019. PMID: 31109447 Free PMC article. Review.
Here we summarize the latest data on genetic and epigenetic contributions to human aging and longevity. Whereas environmental and lifestyle factors are important at younger ages, the contribution of genetics appears more important in reaching extreme old age. Genome-wide s …
Here we summarize the latest data on genetic and epigenetic contributions to human aging and longevity. Whereas environmental and lif …
The DNA methylation landscape of advanced prostate cancer.
Zhao SG, Chen WS, Li H, Foye A, Zhang M, Sjöström M, Aggarwal R, Playdle D, Liao A, Alumkal JJ, Das R, Chou J, Hua JT, Barnard TJ, Bailey AM, Chow ED, Perry MD, Dang HX, Yang R, Moussavi-Baygi R, Zhang L, Alshalalfa M, Laura Chang S, Houlahan KE, Shiah YJ, Beer TM, Thomas G, Chi KN, Gleave M, Zoubeidi A, Reiter RE, Rettig MB, Witte O, Yvonne Kim M, Fong L, Spratt DE, Morgan TM, Bose R, Huang FW, Li H, Chesner L, Shenoy T, Goodarzi H, Asangani IA, Sandhu S, Lang JM, Mahajan NP, Lara PN, Evans CP, Febbo P, Batzoglou S, Knudsen KE, He HH, Huang J, Zwart W, Costello JF, Luo J, Tomlins SA, Wyatt AW, Dehm SM, Ashworth A, Gilbert LA, Boutros PC, Farh K, Chinnaiyan AM, Maher CA, Small EJ, Quigley DA, Feng FY. Zhao SG, et al. Nat Genet. 2020 Aug;52(8):778-789. doi: 10.1038/s41588-020-0648-8. Epub 2020 Jul 13. Nat Genet. 2020. PMID: 32661416 Free PMC article.
Notably, we observed that 22% of tumors exhibited a novel epigenomic subtype associated with hypermethylation and somatic mutations in TET2, DNMT3B, IDH1 and BRAF. ...
Notably, we observed that 22% of tumors exhibited a novel epigenomic subtype associated with hypermethylation and somatic mutations i …
Whole-genome landscape of pancreatic neuroendocrine tumours.
Scarpa A, Chang DK, Nones K, Corbo V, Patch AM, Bailey P, Lawlor RT, Johns AL, Miller DK, Mafficini A, Rusev B, Scardoni M, Antonello D, Barbi S, Sikora KO, Cingarlini S, Vicentini C, McKay S, Quinn MC, Bruxner TJ, Christ AN, Harliwong I, Idrisoglu S, McLean S, Nourse C, Nourbakhsh E, Wilson PJ, Anderson MJ, Fink JL, Newell F, Waddell N, Holmes O, Kazakoff SH, Leonard C, Wood S, Xu Q, Nagaraj SH, Amato E, Dalai I, Bersani S, Cataldo I, Dei Tos AP, Capelli P, Davì MV, Landoni L, Malpaga A, Miotto M, Whitehall VL, Leggett BA, Harris JL, Harris J, Jones MD, Humphris J, Chantrill LA, Chin V, Nagrial AM, Pajic M, Scarlett CJ, Pinho A, Rooman I, Toon C, Wu J, Pinese M, Cowley M, Barbour A, Mawson A, Humphrey ES, Colvin EK, Chou A, Lovell JA, Jamieson NB, Duthie F, Gingras MC, Fisher WE, Dagg RA, Lau LM, Lee M, Pickett HA, Reddel RR, Samra JS, Kench JG, Merrett ND, Epari K, Nguyen NQ, Zeps N, Falconi M, Simbolo M, Butturini G, Van Buren G, Partelli S, Fassan M; Australian Pancreatic Cancer Genome Initiative, Khanna KK, Gill AJ, Wheeler DA, Gibbs RA, Musgrove EA, Bassi C, Tortora G, Pederzoli P, Pearson JV, Waddell N, Biankin AV, Grimmond SM. Scarpa A, et al. Nature. 2017 Mar 2;543(7643):65-71. doi: 10.1038/nature21063. Epub 2017 Feb 15. Nature. 2017. PMID: 28199314 Free article.
Latest techniques to study DNA methylation.
Gouil Q, Keniry A. Gouil Q, et al. Essays Biochem. 2019 Dec 20;63(6):639-648. doi: 10.1042/EBC20190027. Essays Biochem. 2019. PMID: 31755932 Free PMC article. Review.
Bisulfite sequencing is a powerful technique to detect 5-methylcytosine in DNA that has immensely contributed to our understanding of epigenetic regulation in plants and animals. Meanwhile, research on other base modifications, including 6-methyladenine and 4-methylcytosin …
Bisulfite sequencing is a powerful technique to detect 5-methylcytosine in DNA that has immensely contributed to our understanding of epi
Establishment of mouse expanded potential stem cells.
Yang J, Ryan DJ, Wang W, Tsang JC, Lan G, Masaki H, Gao X, Antunes L, Yu Y, Zhu Z, Wang J, Kolodziejczyk AA, Campos LS, Wang C, Yang F, Zhong Z, Fu B, Eckersley-Maslin MA, Woods M, Tanaka Y, Chen X, Wilkinson AC, Bussell J, White J, Ramirez-Solis R, Reik W, Göttgens B, Teichmann SA, Tam PPL, Nakauchi H, Zou X, Lu L, Liu P. Yang J, et al. Nature. 2017 Oct 19;550(7676):393-397. doi: 10.1038/nature24052. Epub 2017 Oct 11. Nature. 2017. PMID: 29019987 Free PMC article.
Bona fide trophoblast stem cell lines and extra-embryonic endoderm stem cells can be directly derived from expanded potential stem cells in vitro. Molecular analyses of the epigenome and single-cell transcriptome reveal enrichment for blastomere-specific signature and a dy …
Bona fide trophoblast stem cell lines and extra-embryonic endoderm stem cells can be directly derived from expanded potential stem cells in …
3,550 results