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Page 1
Glucagon-like peptide-1 receptor agonists but not dipeptidyl peptidase-4 inhibitors reduce alcohol intake.
Farokhnia M, Tazare J, Pince CL, Bruns Vi N, Gray JC, Lo Re Iii V, Fiellin DA, Kranzler HR, Koob GF, Justice AC, Vendruscolo LF, Rentsch CT, Leggio L. Farokhnia M, et al. Among authors: leggio l. J Clin Invest. 2025 Mar 6:e188314. doi: 10.1172/JCI188314. Online ahead of print. J Clin Invest. 2025. PMID: 40048376 Free article.
BACKGROUND: Despite growing preclinical evidence that glucagon-like peptide-1 receptor agonists (GLP-1RAs) could be repurposed to treat alcohol use disorder (AUD), clinical evidence is scarce. ...We further tested the effects of two DPP-4Is, lin …
BACKGROUND: Despite growing preclinical evidence that glucagon-like peptide-1 receptor agonists (GLP-1RAs) could …
The combination of a glucagon-like peptide-1 and amylin receptor agonists reduces alcohol consumption in both male and female rats.
Aranäs C, Edvardsson CE, Zentveld L, Vallöf D, Witley S, Tufvesson-Alm M, Shevchouk OT, Vestlund J, Jerlhag E. Aranäs C, et al. Among authors: jerlhag e. Acta Neuropsychiatr. 2024 Dec 6;37:e42. doi: 10.1017/neu.2024.58. Acta Neuropsychiatr. 2024. PMID: 39639536
While the combination of amylin receptor (AMYR) and glucagon-like peptide-1 receptor (GLP-1R) agonists have been found to decrease feeding and body weight in obese male rats synergistically, their combined impact on alcohol intake is unkn …
While the combination of amylin receptor (AMYR) and glucagon-like peptide-1 receptor (GLP-1R) agonists have been …
Synergistic-like decreases in alcohol intake following combined pharmacotherapy with GLP-1 and amylin in male rats.
Aranäs C, Caffrey A, Edvardsson CE, Vestlund J, Schmidt HD, Jerlhag E. Aranäs C, et al. Among authors: schmidt hd, jerlhag e. Br J Pharmacol. 2025 Mar;182(6):1292-1305. doi: 10.1111/bph.17406. Epub 2024 Dec 2. Br J Pharmacol. 2025. PMID: 39622492
BACKGROUND AND PURPOSE: The limited effectiveness of current pharmacological treatments for alcohol use disorder (AUD) highlights the need for novel therapies. These may involve the glucagon-like peptide-1 receptor or the amylin receptor, as tre …
BACKGROUND AND PURPOSE: The limited effectiveness of current pharmacological treatments for alcohol use disorder (AUD) highlights the …
Antismoking agents do not contribute synergistically to semaglutide's ability to reduce alcohol intake in rats.
Aranäs C, Blid Sköldheden S, Jerlhag E. Aranäs C, et al. Among authors: jerlhag e. Front Pharmacol. 2023 Aug 31;14:1180512. doi: 10.3389/fphar.2023.1180512. eCollection 2023. Front Pharmacol. 2023. PMID: 37719854 Free PMC article.
Preclinical studies have identified glucagon-like peptide-1 receptor (GLP-1R) agonists, and the antismoking agents varenicline and bupropion as tentative agents for treatment of alcohol use disorder (AUD). ...Successfully, this approach has been …
Preclinical studies have identified glucagon-like peptide-1 receptor (GLP-1R) agonists, and the antismoking agen …
The glucagon-like peptide-1 (GLP-1) analogue semaglutide reduces alcohol drinking and modulates central GABA neurotransmission.
Chuong V, Farokhnia M, Khom S, Pince CL, Elvig SK, Vlkolinsky R, Marchette RC, Koob GF, Roberto M, Vendruscolo LF, Leggio L. Chuong V, et al. Among authors: leggio l. JCI Insight. 2023 Jun 22;8(12):e170671. doi: 10.1172/jci.insight.170671. JCI Insight. 2023. PMID: 37192005 Free PMC article.
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in the neurobiology of addictive behaviors, and GLP-1 analogues may be used for the treatment of alcohol use disorder (AUD). ...Semaglutide also reduced binge …
Growing evidence indicates that the glucagon-like peptide-1 (GLP-1) system is involved in the neurobiology of ad …
Long-Acting Glucagon-Like Peptide-1 Receptor Agonists Suppress Voluntary Alcohol Intake in Male Wistar Rats.
Marty VN, Farokhnia M, Munier JJ, Mulpuri Y, Leggio L, Spigelman I. Marty VN, et al. Among authors: leggio l. Front Neurosci. 2020 Dec 23;14:599646. doi: 10.3389/fnins.2020.599646. eCollection 2020. Front Neurosci. 2020. PMID: 33424537 Free PMC article.
Despite high prevalence and societal burden, available approved medications to treat AUD are limited in number and efficacy, highlighting a critical need for more and novel pharmacotherapies. Glucagon-like peptide-1 (GLP-1) is a gut hormone and neurope …
Despite high prevalence and societal burden, available approved medications to treat AUD are limited in number and efficacy, highlighting a …
Activation of glucagon-like peptide-1 receptors and skilled reach foraging.
Vestlund J, Bergquist F, Licheri V, Adermark L, Jerlhag E. Vestlund J, et al. Among authors: jerlhag e. Addict Biol. 2021 May;26(3):e12953. doi: 10.1111/adb.12953. Epub 2020 Aug 8. Addict Biol. 2021. PMID: 32770792 Free PMC article.
Glucagon-like peptide-1 receptor (GLP-1R) agonists, such as exendin-4 (Ex4), liraglutide and dulaglutide, regulate glucose homeostasis and are thus used to treat diabetes type II. ...In rats without prior Montoya experience, dulaglutide but not …
Glucagon-like peptide-1 receptor (GLP-1R) agonists, such as exendin-4 (Ex4), liraglutide and dulaglutide, regula …
Long-term treatment with a glucagon-like peptide-1 receptor agonist reduces ethanol intake in male and female rats.
Vallöf D, Kalafateli AL, Jerlhag E. Vallöf D, et al. Among authors: jerlhag e. Transl Psychiatry. 2020 Jul 16;10(1):238. doi: 10.1038/s41398-020-00923-1. Transl Psychiatry. 2020. PMID: 32678077 Free PMC article.
Given the limited efficacy of available pharmacotherapies for treatment of alcohol use disorder (AUD), the need for new medications is substantial. Preclinical studies have shown that acute administration of glucagon-like peptide-1 receptor (GLP …
Given the limited efficacy of available pharmacotherapies for treatment of alcohol use disorder (AUD), the need for new medications i …
Glucagon-like peptide-1 receptors and sexual behaviors in male mice.
Vestlund J, Jerlhag E. Vestlund J, et al. Among authors: jerlhag e. Psychoneuroendocrinology. 2020 Jul;117:104687. doi: 10.1016/j.psyneuen.2020.104687. Epub 2020 Apr 24. Psychoneuroendocrinology. 2020. PMID: 32388229 Free article.
The gut-brain peptide glucagon-like peptide-1 (GLP-1) reduces reward from palatable food and drugs of abuse. Recent rodent studies show that activation of GLP-1 receptors (GLP-1R) within the nucleus of the solitary tract (NTS) not only suppresses the m …
The gut-brain peptide glucagon-like peptide-1 (GLP-1) reduces reward from palatable food and drugs of abuse. Rec …
Alcohol-mediated behaviours and the gut-brain axis; with focus on glucagon-like peptide-1.
Jerlhag E. Jerlhag E. Brain Res. 2020 Jan 15;1727:146562. doi: 10.1016/j.brainres.2019.146562. Epub 2019 Nov 21. Brain Res. 2020. PMID: 31759971 Free article. Review.
Gut-brain peptides, such as glucagon-like peptide-1 (GLP-1), are well known for their ability to regulate food intake and appetite. ...These pharmacotherapies, including exenatide/exendin-4(Ex4) and liraglutide, have also been tested in various animal …
Gut-brain peptides, such as glucagon-like peptide-1 (GLP-1), are well known for their ability to regulate food i …
15 results