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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2003 1
2004 1
2006 1
2007 1
2009 6
2010 3
2011 3
2012 3
2013 1
2014 8
2015 12
2016 12
2017 17
2018 20
2019 20
2020 45
2021 59
2022 36
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229 results
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Live attenuated influenza A virus vaccines with modified NS1 proteins for veterinary use.
Nogales A, DeDiego ML, Martínez-Sobrido L. Nogales A, et al. Front Cell Infect Microbiol. 2022 Jul 22;12:954811. doi: 10.3389/fcimb.2022.954811. eCollection 2022. Front Cell Infect Microbiol. 2022. PMID: 35937688 Free PMC article. Review.
Moreover, this strategy allows the development of novel assays to distinguish between vaccinated and/or infected animals, also known as Differentiating Infected from Vaccinated Animals (DIVA) strategy. In this review, we briefly discuss the potential of NS1 deficien …
Moreover, this strategy allows the development of novel assays to distinguish between vaccinated and/or infected animals, also known …
A highly efficacious live attenuated mumps virus-based SARS-CoV-2 vaccine candidate expressing a six-proline stabilized prefusion spike.
Zhang Y, Lu M, Mahesh KC, Kim E, Shamseldin MM, Ye C, Dravid P, Chamblee M, Park JG, Hall JM, Trivedi S, Chaiwatpongsakorn S, Kenny AD, Murthy SS, Sharma H, Liang X, Yount JS, Kapoor A, Martinez-Sobrido L, Dubey P, Boyaka PN, Peeples ME, Li J. Zhang Y, et al. Proc Natl Acad Sci U S A. 2022 Aug 16;119(33):e2201616119. doi: 10.1073/pnas.2201616119. Epub 2022 Jul 27. Proc Natl Acad Sci U S A. 2022. PMID: 35895717 Free article.
With the rapid increase in SARS-CoV-2 cases in children, a safe and effective vaccine for this population is urgently needed. The MMR (measles/mumps/rubella) vaccine has been one of the safest and most effective human vaccines used in infants and children sin …
With the rapid increase in SARS-CoV-2 cases in children, a safe and effective vaccine for this population is urgently needed. The MMR …
GMP Manufacturing and IND-Enabling Studies of a Recombinant Hyperimmune Globulin Targeting SARS-CoV-2.
Mizrahi RA, Lin WY, Gras A, Niedecken AR, Wagner EK, Keating SM, Ikon N, Manickam VA, Asensio MA, Leong J, Medina-Cucurella AV, Benzie E, Carter KP, Chiang Y, Edgar RC, Leong R, Lim YW, Simons JF, Spindler MJ, Stadtmiller K, Wayham N, Büscher D, Terencio JV, Germanio CD, Chamow SM, Olson C, Pino PA, Park JG, Hicks A, Ye C, Garcia-Vilanova A, Martinez-Sobrido L, Torrelles JB, Johnson DS, Adler AS. Mizrahi RA, et al. Pathogens. 2022 Jul 19;11(7):806. doi: 10.3390/pathogens11070806. Pathogens. 2022. PMID: 35890050 Free PMC article.
Conventionally, hyperimmune globulin drugs manufactured from pooled immunoglobulins from vaccinated or convalescent donors have been used in treating infections where no treatment is available. ...
Conventionally, hyperimmune globulin drugs manufactured from pooled immunoglobulins from vaccinated or convalescent donors have been …
Potent universal beta-coronavirus therapeutic activity mediated by direct respiratory administration of a Spike S2 domain-specific human neutralizing monoclonal antibody.
Piepenbrink MS, Park JG, Deshpande A, Loos A, Ye C, Basu M, Sarkar S, Khalil AM, Chauvin D, Woo J, Lovalenti P, Erdmann NB, Goepfert PA, Truong VL, Bowen RA, Walter MR, Martinez-Sobrido L, Kobie JJ. Piepenbrink MS, et al. PLoS Pathog. 2022 Jul 21;18(7):e1010691. doi: 10.1371/journal.ppat.1010691. eCollection 2022 Jul. PLoS Pathog. 2022. PMID: 35862475 Free PMC article.
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) marks the third novel beta-coronavirus to cause significant human mortality in the last two decades. Although vaccines are available, too few have been administered worldwide to keep the virus in check and to pre …
Severe Acute Respiratory Syndrome Coronavirus-2 (SARS-CoV-2) marks the third novel beta-coronavirus to cause significant human mortality in …
Isoniazid and rifapentine treatment effectively reduces persistent M. tuberculosis infection in macaque lungs.
Sharan R, Ganatra SR, Singh DK, Cole J, Foreman TW, Thippeshappa R, Peloquin CA, Shivanna V, Gonzalez O, Day CL, Gandhi NR, Dick EJ Jr, Hall-Ursone S, Mehra S, Schlesinger LS, Rengarajan J, Kaushal D. Sharan R, et al. J Clin Invest. 2022 Jul 21:e161564. doi: 10.1172/JCI161564. Online ahead of print. J Clin Invest. 2022. PMID: 35862216 Free article.
Genetic variation that determines TAPBP expression levels associates with the course of malaria in an HLA allotype-dependent manner.
Walker-Sperling V, Digitale JC, Viard M, Martin MP, Bashirova A, Yuki Y, Ramsuran V, Kulkarni S, Naranbhai V, Li H, Anderson SK, Yum L, Clifford R, Kibuuka H, Ake J, Thomas R, Rowland-Jones S, Rek J, Arinaitwe E, Kamya M, Rodriguez-Barraquer I, Feeney ME, Carrington M. Walker-Sperling V, et al. Proc Natl Acad Sci U S A. 2022 Jul 19;119(29):e2205498119. doi: 10.1073/pnas.2205498119. Epub 2022 Jul 13. Proc Natl Acad Sci U S A. 2022. PMID: 35858344 Free PMC article.
Thus, an attenuated course of malaria may occur through enhanced breadth and/or magnitude of antigen presentation, an important consideration when evaluating vaccine efficacy....
Thus, an attenuated course of malaria may occur through enhanced breadth and/or magnitude of antigen presentation, an important consideratio …
Metformin Attenuates Inflammatory Responses and Enhances Antibody Production in an Acute Pneumonia Model of Streptococcus pneumoniae.
Lee GC, Moreira AG, Hinojosa C, Benavides R, Winter C, Anderson AC, Chen CJ, Borsa N, Hastings G, Black CA, Bandy SM, Shaffer A, Restrepo MI, Ahuja SK. Lee GC, et al. Front Aging. 2022 Apr 29;3:736835. doi: 10.3389/fragi.2022.736835. eCollection 2022. Front Aging. 2022. PMID: 35821804 Free PMC article.
We examined whether metformin promotes the preservation of immunological resilience in an acute S. pneumoniae (SPN) infection challenge in young adult mice. Mice were fed metformin (MET-alone) or standard chow (controls-alone) for 10 weeks prior to receiving intratracheal …
We examined whether metformin promotes the preservation of immunological resilience in an acute S. pneumoniae (SPN) infection challen …
Characterization of SARS-CoV-2 Spike mutations important for infection of mice and escape from human immune sera.
Rathnasinghe R, Jangra S, Ye C, Cupic A, Singh G, Martínez-Romero C, Mulder LCF, Kehrer T, Yildiz S, Choi A, Yeung ST, Mena I, Gillespie V, De Vrieze J, Aslam S, Stadlbauer D, Meekins DA, McDowell CD, Balaraman V, Corley MJ, Richt JA, De Geest BG, Miorin L; PVI study group, Krammer F, Martinez-Sobrido L, Simon V, García-Sastre A, Schotsaert M. Rathnasinghe R, et al. Nat Commun. 2022 Jul 7;13(1):3921. doi: 10.1038/s41467-022-30763-0. Nat Commun. 2022. PMID: 35798721 Free PMC article.
Here we show that serial passaging of USA-WA1/2020 strain in mouse lungs results in "mouse-adapted" SARS-CoV-2 (MA-SARS-CoV-2) with mutations in S, M, and N genes, and a twelve-nucleotide insertion in the S gene. ...N501Y in the receptor binding domain of viruses of …
Here we show that serial passaging of USA-WA1/2020 strain in mouse lungs results in "mouse-adapted" SARS-CoV-2 (MA-SARS-CoV-2) with mutation …
Selective delipidation of Mycobacterium bovis BCG retains antitumor efficacy against non-muscle invasive bladder cancer.
Ji N, Long M, Garcia-Vilanova A, Ault R, Moliva JI, Yusoof KA, Mukherjee N, Curiel TJ, Dixon H, Torrelles JB, Svatek RS. Ji N, et al. Cancer Immunol Immunother. 2022 Jun 24. doi: 10.1007/s00262-022-03236-y. Online ahead of print. Cancer Immunol Immunother. 2022. PMID: 35748904
To address the lack of treatment options for NMIBC with BCG-intolerance, we examined if selective delipidation would compromise BCG's antitumor efficacy and at the same time increase tolerability to the treatment. ...
To address the lack of treatment options for NMIBC with BCG-intolerance, we examined if selective delipidation would compromise BCG's …
Animal Models of COVID-19: Transgenic Mouse Model.
Park JG, Pino PA, Akhter A, Alvarez X, Torrelles JB, Martinez-Sobrido L. Park JG, et al. Methods Mol Biol. 2022;2452:259-289. doi: 10.1007/978-1-0716-2111-0_16. Methods Mol Biol. 2022. PMID: 35554912
This small rodent animal model based on the use of K18 hACE2 transgenic mice represents an excellent option to understand the pathogenicity of natural SARS-CoV-2 strains and its recently described Variants of Concern (VoC), and will be applicable to the identification and charact …
This small rodent animal model based on the use of K18 hACE2 transgenic mice represents an excellent option to understand the pathogenicity …
229 results