Alox8 knockout exacerbates imiquimod-induced psoriasis-like inflammation.
Palmer MA, Kirchhoff R, Hahnefeld L, Thomas D, Elewa MAF, You X, Aliraj B, Benatzy Y, Weigert A, Schebb NH, Brüne B.
Palmer MA, et al. Among authors: brune b.
Cell Death Dis. 2026 Apr 10;17(1):390. doi: 10.1038/s41419-026-08727-9.
Cell Death Dis. 2026.
PMID: 41963292
Free article.
Lipoxygenases peroxidise polyunsaturated fatty acids, resulting in oxylipins, which may act pro- or anti-inflammatory. Arachidonate 15-lipoxygenase type B was shown to play a role in the resolution of keratinocyte inflammation and is upregulated in psoriasis. ...
Lipoxygenases peroxidise polyunsaturated fatty acids, resulting in oxylipins, which may act pro- or anti-inflammatory. Arachidonate 15-lipox …