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2024 4
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Personalized Circulating Tumor DNA Testing for Detection of Progression and Treatment Response Monitoring in Patients With Metastatic Invasive Lobular Carcinoma of the Breast.
Foldi J, Oesterreich S, Tin A, Rivero-Hinojosa S, Fielder J, Ferguson J, George GV, Kalashnikova E, Rodriguez AA, Liu MC, Lee AV. Foldi J, et al. JCO Precis Oncol. 2025 May;9:e2400577. doi: 10.1200/PO-24-00577. Epub 2025 May 5. JCO Precis Oncol. 2025. PMID: 40324116 Free PMC article.
PURPOSE: Despite varying treatment responses and vastly different clinicopathologic characteristics, invasive lobular carcinoma (ILC) is treated similar to other subtypes of breast cancer. Serial personalized and tumor-informed, circulating tumor DNA ( …
PURPOSE: Despite varying treatment responses and vastly different clinicopathologic characteristics, invasive lobular carci …
Immune infiltration correlates with transcriptomic subtypes in primary estrogen receptor positive invasive lobular breast cancer.
Chen F, Onkar S, Zou J, Li Y, Arbore H, Maley S, Tseng G, Lucas PC, Bruno TC, Vignali DAA, Foldi J, Balic M, Lee AV, Oesterreich S. Chen F, et al. Among authors: foldi j. NPJ Precis Oncol. 2024 Nov 9;8(1):257. doi: 10.1038/s41698-024-00746-z. NPJ Precis Oncol. 2024. PMID: 39521942 Free PMC article.
We found proliferative subtype associated with increased suppressive immune infiltration, and defined a signature associated with lower proliferative, pro-inflammatory TAM infiltration, and improved survival in ER+ breast cancer. Our work identified genes related to ILC im …
We found proliferative subtype associated with increased suppressive immune infiltration, and defined a signature associated with lower prol …
Immune Infiltration Correlates with Transcriptomic Subtypes in Primary ER+ Invasive Lobular Breast Cancer.
Chen F, Onkar S, Zou J, Li Y, Arbore H, Maley S, Tseng G, Lucas P, Bruno T, Vignali D, Foldi J, Balic M, Lee A, Oesterreich S. Chen F, et al. Among authors: foldi j. Res Sq [Preprint]. 2024 Aug 13:rs.3.rs-4579052. doi: 10.21203/rs.3.rs-4579052/v1. Res Sq. 2024. Update in: NPJ Precis Oncol. 2024 Nov 9;8(1):257. doi: 10.1038/s41698-024-00746-z. PMID: 39184073 Free PMC article. Updated. Preprint.
Here, we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 21 ER+/HER2- invasive lobular breast cancers. The proliferative subtype associated with increased immune infiltration especiall …
Here, we identified two transcriptomic subtypes and five immune infiltration patterns from RNA-seq and multiplex immunohistochemistry from 2 …
Long-term outcomes by lobular vs ductal histology in 4 National Surgical Adjuvant Breast and Bowel Project adjuvant breast cancer trials.
Foldi J, Carleton N, Anderson SJ, Rastogi P, Lee A, Balic M, Geyer CE Jr, Oesterreich S, Wolmark N. Foldi J, et al. J Natl Cancer Inst. 2025 Jan 1;117(1):163-168. doi: 10.1093/jnci/djae188. J Natl Cancer Inst. 2025. PMID: 39128018 Free PMC article. Clinical Trial.
Our cohort included 11 251 patients with no special type and 1231 with invasive lobular carcinoma. Patients with invasive lobular carcinoma were older, had larger and more frequently estrogen receptor-positive tumors, and more positive ly …
Our cohort included 11 251 patients with no special type and 1231 with invasive lobular carcinoma. Patients with inv …
Spatial molecular profiling of mixed invasive ductal and lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.
Shah OS, Nasrazadani A, Foldi J, Atkinson JM, Kleer CG, McAuliffe PF, Johnston TJ, Stallaert W, da Silva EM, Selenica P, Dopeso H, Pareja F, Mandelker D, Weigelt B, Reis-Filho JS, Bhargava R, Lucas PC, Lee AV, Oesterreich S. Shah OS, et al. Among authors: foldi j. Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2322068121. doi: 10.1073/pnas.2322068121. Epub 2024 Jul 23. Proc Natl Acad Sci U S A. 2024. PMID: 39042692 Free PMC article.
Mixed invasive ductal and lobular carcinoma (MDLC) is a rare histologic subtype of breast cancer displaying both E-cadherin positive ductal and E-cadherin negative lobular morphologies within the same tumor, posing challenges with regard to anticipated …
Mixed invasive ductal and lobular carcinoma (MDLC) is a rare histologic subtype of breast cancer displaying both E-cadh …
Spatial molecular profiling of mixed invasive ductal-lobular breast cancers reveals heterogeneity in intrinsic molecular subtypes, oncogenic signatures, and mutations.
Shah OS, Nasrazadani A, Foldi J, Atkinson JM, Kleer CG, McAuliffe PF, Johnston TJ, Stallaert W, da Silva EM, Selenica P, Dopeso H, Pareja F, Mandelker D, Weigelt B, Reis-Filho JS, Bhargava R, Lucas PC, Lee AV, Oesterreich S. Shah OS, et al. Among authors: foldi j. bioRxiv [Preprint]. 2024 Jun 16:2023.09.09.557013. doi: 10.1101/2023.09.09.557013. bioRxiv. 2024. Update in: Proc Natl Acad Sci U S A. 2024 Jul 30;121(31):e2322068121. doi: 10.1073/pnas.2322068121. PMID: 38915645 Free PMC article. Updated. Preprint.
Mixed invasive ductal and lobular carcinoma (MDLC) is a rare histologic subtype of breast cancer displaying both E-cadherin positive ductal and E-cadherin negative lobular morphologies within the same tumor, posing challenges with regard to anticipated …
Mixed invasive ductal and lobular carcinoma (MDLC) is a rare histologic subtype of breast cancer displaying both E-cadh …