Single-Cell RNA Sequencing Identifies MMP11(+) Cancer-Associated Fibroblasts as Drivers of Angiogenesis and Bladder Cancer Progression.
Xu W, Liang T, Fang H, Fu L, Deng D, Tan X, Liu L, Tang D, Zheng H, Ding Q, Hou X, Feng D, Tao T, Wu S.
Xu W, et al.
Adv Sci (Weinh). 2025 Aug;12(32):e02774. doi: 10.1002/advs.202502774. Epub 2025 Jun 24.
Adv Sci (Weinh). 2025.
PMID: 40552583
Free PMC article.
This cell population regulates the migration of tip endothelial cell clusters (ESM1(+)tEC) via the WNT5A-MCAM signaling axis, and modulates the expression of key transcription factors, SOX18, NFIC, and HOXB9. ...Mouse experiments confirmed that inhibiting BMP2 can suppress …
This cell population regulates the migration of tip endothelial cell clusters (ESM1(+)tEC) via the WNT5A-MCAM signaling axis, and mod …