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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1929 1
1935 1
1937 1
1941 1
1944 11
1945 553
1946 2530
1947 4246
1948 4036
1949 3739
1950 8125
1951 6679
1952 6396
1953 7033
1954 6840
1955 6625
1956 6655
1957 7243
1958 6610
1959 3894
1960 2043
1961 1472
1962 2081
1963 2041
1964 2420
1965 8151
1966 10860
1967 10894
1968 11490
1969 10908
1970 11043
1971 11871
1972 12121
1973 12476
1974 12671
1975 18150
1976 20444
1977 20272
1978 20828
1979 23566
1980 23730
1981 24818
1982 26516
1983 29760
1984 32493
1985 33872
1986 34627
1987 37194
1988 38444
1989 45598
1990 47757
1991 49217
1992 49919
1993 51752
1994 54325
1995 57222
1996 60664
1997 61039
1998 65301
1999 67842
2000 69625
2001 72598
2002 75253
2003 80537
2004 86941
2005 94680
2006 99382
2007 104583
2008 111115
2009 115964
2010 127286
2011 132862
2012 140152
2013 147231
2014 151952
2015 159134
2016 154869
2017 156487
2018 152816
2019 92515
2020 4614
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3,286,832 results
Results by year
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Page 1
A pneumonia outbreak associated with a new coronavirus of probable bat origin.
Zhou P, Yang XL, Wang XG, Hu B, Zhang L, Zhang W, Si HR, Zhu Y, Li B, Huang CL, Chen HD, Chen J, Luo Y, Guo H, Jiang RD, Liu MQ, Chen Y, Shen XR, Wang X, Zheng XS, Zhao K, Chen QJ, Deng F, Liu LL, Yan B, Zhan FX, Wang YY, Xiao GF, Shi ZL. Zhou P, et al. Nature. 2020 Mar;579(7798):270-273. doi: 10.1038/s41586-020-2012-7. Epub 2020 Feb 3. Nature. 2020. PMID: 32015507 Free PMC article.
Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans(5-7). Here we report the identification and characterization of a new coronavirus (2019-nCoV), which caused an epidemic of acute respiratory syndrome in humans in Wuhan, China. ...Furthermore, we show that 2019-nCoV is 96% identical at the whole-genome level to a bat coronavirus. Pairwise protein sequence analysis of seven conserved non-structural proteins domains show that this virus belongs to the species of SARSr-CoV. ...
Previous studies have shown that some bat SARSr-CoVs have the potential to infect humans(5-7). Here we report the identificati …
Overlapping and discrete aspects of the pathology and pathogenesis of the emerging human pathogenic coronaviruses SARS-CoV, MERS-CoV, and 2019-nCoV.
Liu J, Zheng X, Tong Q, Li W, Wang B, Sutter K, Trilling M, Lu M, Dittmer U, Yang D. Liu J, et al. J Med Virol. 2020 May;92(5):491-494. doi: 10.1002/jmv.25709. Epub 2020 Feb 21. J Med Virol. 2020. PMID: 32056249 Review.
First reported from Wuhan, The People's Republic of China, on 31 December 2019, the ongoing outbreak of a novel coronavirus (2019-nCoV) causes great global concerns. ...Together with the other two highly pathogenic coronaviruses, the severe acute respiratory syndrome coronavirus (SARS-CoV) and Middle East respiratory syndrome coronavirus (MERS-CoV), 2019-nCov and other yet to be identified coronaviruses pose a global threat to public health. ...
First reported from Wuhan, The People's Republic of China, on 31 December 2019, the ongoing outbreak of a novel coronavirus (2 …
Coronaviruses - drug discovery and therapeutic options.
Zumla A, Chan JF, Azhar EI, Hui DS, Yuen KY. Zumla A, et al. Nat Rev Drug Discov. 2016 May;15(5):327-47. doi: 10.1038/nrd.2015.37. Epub 2016 Feb 12. Nat Rev Drug Discov. 2016. PMID: 26868298 Free PMC article. Review.
In humans, infections with the human coronavirus (HCoV) strains HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 usually result in mild, self-limiting upper respiratory tract infections, such as the common cold. ...
In humans, infections with the human coronavirus (HCoV) strains HCoV-229E, HCoV-OC43, HCoV-NL63 and HCoV-HKU1 usually result i …
A new coronavirus associated with human respiratory disease in China.
Wu F, Zhao S, Yu B, Chen YM, Wang W, Song ZG, Hu Y, Tao ZW, Tian JH, Pei YY, Yuan ML, Zhang YL, Dai FH, Liu Y, Wang QM, Zheng JJ, Xu L, Holmes EC, Zhang YZ. Wu F, et al. Nature. 2020 Mar;579(7798):265-269. doi: 10.1038/s41586-020-2008-3. Epub 2020 Feb 3. Nature. 2020. PMID: 32015508 Free PMC article.
Metagenomic RNA sequencing(4) of a sample of bronchoalveolar lavage fluid from the patient identified a new RNA virus strain from the family Coronaviridae, which is designated here 'WH-Human 1' coronavirus (and has also been referred to as '2019-nCoV'). ...This outbreak highlights the ongoing ability of viral spill-over from animals to cause severe disease in humans....
Metagenomic RNA sequencing(4) of a sample of bronchoalveolar lavage fluid from the patient identified a new RNA virus strain from the family …
The structure and functions of coronavirus genomic 3' and 5' ends.
Yang D, Leibowitz JL. Yang D, et al. Virus Res. 2015 Aug 3;206:120-33. doi: 10.1016/j.virusres.2015.02.025. Epub 2015 Feb 28. Virus Res. 2015. PMID: 25736566 Free PMC article. Review.
Coronaviruses (CoVs) are an important cause of illness in humans and animals. Most human coronaviruses commonly cause relatively mild respiratory illnesses; however two zoonotic coronaviruses, SARS-CoV and MERS-CoV, can cause severe illness and death. Investigations over the past 35 years have illuminated many aspects of coronavirus replication. The focus of this review is the functional analysis of conserved RNA secondary structures in the 5' and 3' of the betacoronavirus genomes. ...
Coronaviruses (CoVs) are an important cause of illness in humans and animals. Most human coronaviruses commonly cause relatively mild …
Porcine Deltacoronavirus nsp5 Antagonizes Type I Interferon Signaling by Cleaving STAT2.
Zhu X, Wang D, Zhou J, Pan T, Chen J, Yang Y, Lv M, Ye X, Peng G, Fang L, Xiao S. Zhu X, et al. J Virol. 2017 Apr 28;91(10):e00003-17. doi: 10.1128/JVI.00003-17. Print 2017 May 15. J Virol. 2017. PMID: 28250121 Free PMC article.
Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus. The first outbreak of PDCoV was announced from the United States in 2014, followed by reports in Asia. The nonstructural protein nsp5 is a 3C-like protease of coronavirus, and our previous study showed that PDCoV nsp5 inhibits type I interferon (IFN) production. ...
Porcine deltacoronavirus (PDCoV) is an emerging swine enteropathogenic coronavirus. The first outbreak of PDCoV was announced from th …
Molecular mechanisms of coronavirus RNA capping and methylation.
Chen Y, Guo D. Chen Y, et al. Virol Sin. 2016 Feb;31(1):3-11. doi: 10.1007/s12250-016-3726-4. Epub 2016 Feb 2. Virol Sin. 2016. PMID: 26847650 Free PMC article. Review.
The 5'-cap structures of eukaryotic mRNAs are important for RNA stability, pre-mRNA splicing, mRNA export, and protein translation. ...The RNA genomes of coronavirus were identified to have 5'-caps in the early 1980s. However, for decades the RNA capping mechanisms of coronaviruses remained unknown. ...
The 5'-cap structures of eukaryotic mRNAs are important for RNA stability, pre-mRNA splicing, mRNA export, and protein translation. . …
Protease inhibitors targeting coronavirus and filovirus entry.
Zhou Y, Vedantham P, Lu K, Agudelo J, Carrion R Jr, Nunneley JW, Barnard D, Pöhlmann S, McKerrow JH, Renslo AR, Simmons G. Zhou Y, et al. Antiviral Res. 2015 Apr;116:76-84. doi: 10.1016/j.antiviral.2015.01.011. Epub 2015 Feb 7. Antiviral Res. 2015. PMID: 25666761 Free PMC article.
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, depend on activation of their envelope glycoproteins by host cell proteases. ...We report here that the cysteine protease inhibitor K11777, ((2S)-N-[(1E,3S)-1-(benzenesulfonyl)-5-phenylpent-1-en-3-yl]-2-{[(E)-4-methylpiperazine-1-carbonyl]amino}-3-phenylpropanamide) and closely-related vinylsulfones act as broad-spectrum antivirals by targeting cathepsin-mediated cell entry. ...
In order to gain entry into cells, diverse viruses, including Ebola virus, SARS-coronavirus and the emerging MERS-coronavirus, …
Viral and Cellular mRNA Translation in Coronavirus-Infected Cells.
Nakagawa K, Lokugamage KG, Makino S. Nakagawa K, et al. Adv Virus Res. 2016;96:165-192. doi: 10.1016/bs.aivir.2016.08.001. Epub 2016 Sep 10. Adv Virus Res. 2016. PMID: 27712623 Free PMC article. Review.
Coronaviruses have large positive-strand RNA genomes that are 5' capped and 3' polyadenylated. The 5'-terminal two-thirds of the genome contain two open reading frames (ORFs), 1a and 1b, that together make up the viral replicase gene and encode two large polyproteins that are processed by viral proteases into 15-16 nonstructural proteins, most of them being involved in viral RNA synthesis. ...This chapter describes our current understanding of the mechanisms involved in coronavirus mRNA translation and changes in host mRNA translation observed in coronavirus-infected cells....
Coronaviruses have large positive-strand RNA genomes that are 5' capped and 3' polyadenylated. The 5'-terminal two-thirds of t …
Genomic characterization and pathogenicity of porcine deltacoronavirus strain CHN-HG-2017 from China.
Zhang MJ, Liu DJ, Liu XL, Ge XY, Jongkaewwattana A, He QG, Luo R. Zhang MJ, et al. Arch Virol. 2019 Feb;164(2):413-425. doi: 10.1007/s00705-018-4081-6. Epub 2018 Oct 30. Arch Virol. 2019. PMID: 30377826 Free PMC article.
Furthermore, the pathogenicity of this recombinant PDCoV strain was investigated in 5-day-old piglets by oral inoculation. The challenged piglets developed typical symptoms, such as vomiting, anorexia, diarrhea and lethargy, from 1 to 7 days post-inoculation (DPI). ...
Furthermore, the pathogenicity of this recombinant PDCoV strain was investigated in 5-day-old piglets by oral inoculation. The challe …
3,286,832 results
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