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Year Number of Results
2014 3
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2017 3
2018 1
2019 7
2020 9
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Page 1
The Human Glyoxalase Gene Family in Health and Disease.
Farrera DO, Galligan JJ. Farrera DO, et al. Chem Res Toxicol. 2022 Oct 17;35(10):1766-1776. doi: 10.1021/acs.chemrestox.2c00182. Epub 2022 Sep 1. Chem Res Toxicol. 2022. PMID: 36048613 Free PMC article. Review.
These family members have been implicated in a variety of physiological processes, including amino-acid metabolism (4-hydroxyphenylpyruvate dioxygenase; HPD), primary metabolism (methylmalonyl-CoA epimerase; MCEE), and aldehyde detoxication (glyoxalase …
These family members have been implicated in a variety of physiological processes, including amino-acid metabolism (4-hydroxypheny
From Weed Killer to Wonder Drug.
Lock EA. Lock EA. Adv Exp Med Biol. 2017;959:175-185. doi: 10.1007/978-3-319-55780-9_16. Adv Exp Med Biol. 2017. PMID: 28755195 Review.
Research discovered that NTBC caused tyrosinaemia which was due to inhibition of the enzyme 4-hydroxyphenylpyruvate dioxygenase in both mammals and plants thereby finding a novel target for killing plants. ...
Research discovered that NTBC caused tyrosinaemia which was due to inhibition of the enzyme 4-hydroxyphenylpyruvate dioxyge
The mutation spectrum and ethnic distribution of non-hepatorenal tyrosinemia (types II, III).
Beyzaei Z, Nabavizadeh S, Karimzadeh S, Geramizadeh B. Beyzaei Z, et al. Orphanet J Rare Dis. 2022 Dec 5;17(1):424. doi: 10.1186/s13023-022-02579-0. Orphanet J Rare Dis. 2022. PMID: 36471409 Free PMC article. Review.
BACKGROUND: Different types of non-hepatorenal tyrosinemia are among the rare forms of tyrosinemia. Tyrosinemia type II and III are autosomal recessive disorders caused by pathogenic variants in the tyrosine aminotransferase (TAT), and 4-hydroxyphenyl-pyruvat …
BACKGROUND: Different types of non-hepatorenal tyrosinemia are among the rare forms of tyrosinemia. Tyrosinemia type II …
4-Hydroxyphenylpyruvate Dioxygenase and Its Inhibition in Plants and Animals: Small Molecules as Herbicides and Agents for the Treatment of Human Inherited Diseases.
Santucci A, Bernardini G, Braconi D, Petricci E, Manetti F. Santucci A, et al. J Med Chem. 2017 May 25;60(10):4101-4125. doi: 10.1021/acs.jmedchem.6b01395. Epub 2017 Feb 14. J Med Chem. 2017. PMID: 28128559 Review.
This review mainly focuses on the physiological function of 4-hydroxyphenylpyruvate dioxygenase (HPPD), as well as on the development and application of HPPD inhibitors of several structural classes. ...Informed reasoning on nitisinone (NTBC, 14), a triketone …
This review mainly focuses on the physiological function of 4-hydroxyphenylpyruvate dioxygenase (HPPD), as well as on t …
Biallelic variants in HPDL, encoding 4-hydroxyphenylpyruvate dioxygenase-like protein, lead to an infantile neurodegenerative condition.
Ghosh SG, Lee S, Fabunan R, Chai G, Zaki MS, Abdel-Salam G, Sultan T, Ben-Omran T, Alvi JR, McEvoy-Venneri J, Stanley V, Patel A, Ross D, Ding J, Jain M, Pan D, Lübbert P, Kammerer B, Wiedemann N, Verhoeven-Duif NM, Jans JJ, Murphy D, Toosi MB, Ashrafzadeh F, Imannezhad S, Karimiani EG, Ibrahim K, Waters ER, Maroofian R, Gleeson JG. Ghosh SG, et al. Genet Med. 2021 Mar;23(3):524-533. doi: 10.1038/s41436-020-01010-y. Epub 2020 Nov 14. Genet Med. 2021. PMID: 33188300 Free article.
PURPOSE: Dioxygenases are oxidoreductase enzymes with roles in metabolic pathways necessary for aerobic life. 4-hydroxyphenylpyruvate dioxygenase-like protein (HPDL), encoded by HPDL, is an orphan paralogue of 4-hydroxyphenylpyruvate dioxygen
PURPOSE: Dioxygenases are oxidoreductase enzymes with roles in metabolic pathways necessary for aerobic life. 4-hydroxyphenylpyruv
HPD degradation regulated by the TTC36-STK33-PELI1 signaling axis induces tyrosinemia and neurological damage.
Xie Y, Lv X, Ni D, Liu J, Hu Y, Liu Y, Liu Y, Liu R, Zhao H, Lu Z, Zhou Q. Xie Y, et al. Nat Commun. 2019 Sep 19;10(1):4266. doi: 10.1038/s41467-019-12011-0. Nat Commun. 2019. PMID: 31537781 Free PMC article.
Decreased expression of 4-hydroxyphenylpyruvic acid dioxygenase (HPD), a key enzyme for tyrosine metabolism, is a cause of human tyrosinemia. ...These findings reveal a previously unknown regulation of HPD expression and highlight the physiological significan …
Decreased expression of 4-hydroxyphenylpyruvic acid dioxygenase (HPD), a key enzyme for tyrosine metabolism, is a cause of human t
4-Hydroxyphenylpyruvate Dioxygenase-Like predicts the prognosis and the immunotherapy response of cancers: a pan-cancer analysis.
Li H, Liu J, Wang S, Xu Y, Tang Q, Ying G. Li H, et al. Aging (Albany NY). 2024 Mar 6;16(5):4327-4347. doi: 10.18632/aging.205591. Epub 2024 Mar 6. Aging (Albany NY). 2024. PMID: 38451188 Free PMC article.
The 4-Hydroxyphenylpyruvate Dioxygenase-Like (HPDL) protein plays a crucial role in safeguarding cells from oxidative stress by orchestrating metabolic reprogramming. ...
The 4-Hydroxyphenylpyruvate Dioxygenase-Like (HPDL) protein plays a crucial role in safeguarding cells from oxidative s …
The role of nitisinone in tyrosine pathway disorders.
Lock E, Ranganath LR, Timmis O. Lock E, et al. Curr Rheumatol Rep. 2014 Nov;16(11):457. doi: 10.1007/s11926-014-0457-0. Curr Rheumatol Rep. 2014. PMID: 25266991 Review.
Its mode of action interrupts tyrosine metabolism through inhibition of 4-hydroxyphenylpyruvate dioxygenase (HPPD). Nitisinone is a remarkable safe drug to use with few side effects reported. ...
Its mode of action interrupts tyrosine metabolism through inhibition of 4-hydroxyphenylpyruvate dioxygenase (HPPD). Nit …
Underrepresented Impurities in 4-Hydroxyphenylpyruvate Affect the Catalytic Activity of Multiple Enzymes.
Parkins A, Sandin SI, Knittel J, Franz AH, Ren J, de Alba E, Pantouris G. Parkins A, et al. Anal Chem. 2023 Mar 21;95(11):4957-4965. doi: 10.1021/acs.analchem.2c04969. Epub 2023 Mar 6. Anal Chem. 2023. PMID: 36877482
Our MIF-based conclusions were independently evaluated and confirmed by 4-hydroxyphenylpyruvate dioxygenase (HPPD) and D-dopachrome tautomerase (D-DT); two additional enzymes that utilize 4-HPP as a substrate. ...
Our MIF-based conclusions were independently evaluated and confirmed by 4-hydroxyphenylpyruvate dioxygenase (HPPD) and …
51 results