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Year Number of Results
1988 1
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1999 5
2000 5
2001 9
2002 1
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2004 13
2005 13
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2007 11
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396 results

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Page 1
Foam cells in atherosclerosis.
Yu XH, Fu YC, Zhang DW, Yin K, Tang CK. Yu XH, et al. Clin Chim Acta. 2013 Sep 23;424:245-52. doi: 10.1016/j.cca.2013.06.006. Epub 2013 Jun 16. Clin Chim Acta. 2013. PMID: 23782937 Free article. Review.
Acyl coenzyme A:cholesterol acyltransferase-1 (ACAT1) and neutral cholesteryl ester hydrolase (nCEH) regulate cholesterol esterification. ...
Acyl coenzyme A:cholesterol acyltransferase-1 (ACAT1) and neutral cholesteryl ester hydrolase (nCEH) regulate cholesterol esterificat …
Acetylation in the regulation of autophagy.
Xu Y, Wan W. Xu Y, et al. Autophagy. 2023 Feb;19(2):379-387. doi: 10.1080/15548627.2022.2062112. Epub 2022 Apr 18. Autophagy. 2023. PMID: 35435793 Free PMC article. Review.
Here, we review the current knowledge on acetylation of autophagy proteins and their regulations and functions in the autophagy pathway with focus on recent findings.Abbreviations : ACAT1: acetyl-CoA acetyltransferase 1; ACSS2: acyl-CoA synthetase short chain family member …
Here, we review the current knowledge on acetylation of autophagy proteins and their regulations and functions in the autophagy pathway with …
Mechanisms of foam cell formation in atherosclerosis.
Chistiakov DA, Melnichenko AA, Myasoedova VA, Grechko AV, Orekhov AN. Chistiakov DA, et al. J Mol Med (Berl). 2017 Nov;95(11):1153-1165. doi: 10.1007/s00109-017-1575-8. Epub 2017 Aug 7. J Mol Med (Berl). 2017. PMID: 28785870 Review.
Free cholesterol in turn is processed by acetyl-CoA acetyltransferase (ACAT1), an enzyme that transforms cholesterol to cholesteryl esters. The endoplasmic reticulum serves as a depot for maintaining newly synthesized cholesteryl esters that can be processed by neutral cho …
Free cholesterol in turn is processed by acetyl-CoA acetyltransferase (ACAT1), an enzyme that transforms cholesterol to cholesteryl e …
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Nugent AA, Lin K, van Lengerich B, Lianoglou S, Przybyla L, Davis SS, Llapashtica C, Wang J, Kim DJ, Xia D, Lucas A, Baskaran S, Haddick PCG, Lenser M, Earr TK, Shi J, Dugas JC, Andreone BJ, Logan T, Solanoy HO, Chen H, Srivastava A, Poda SB, Sanchez PE, Watts RJ, Sandmann T, Astarita G, Lewcock JW, Monroe KM, Di Paolo G. Nugent AA, et al. Neuron. 2020 Mar 4;105(5):837-854.e9. doi: 10.1016/j.neuron.2019.12.007. Epub 2020 Jan 2. Neuron. 2020. PMID: 31902528 Free article.
This finding replicates in myelin-treated TREM2-deficient murine macrophages and human iPSC-derived microglia, where it is rescued by an ACAT1 inhibitor and LXR agonist. Our studies identify TREM2 as a key transcriptional regulator of cholesterol transport and metabolism u …
This finding replicates in myelin-treated TREM2-deficient murine macrophages and human iPSC-derived microglia, where it is rescued by an …
PARPs in lipid metabolism and related diseases.
Szántó M, Gupte R, Kraus WL, Pacher P, Bai P. Szántó M, et al. Prog Lipid Res. 2021 Nov;84:101117. doi: 10.1016/j.plipres.2021.101117. Epub 2021 Aug 25. Prog Lipid Res. 2021. PMID: 34450194 Free article. Review.
Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis.
Gu L, Zhu Y, Lin X, Tan X, Lu B, Li Y. Gu L, et al. Oncogene. 2020 Mar;39(11):2437-2449. doi: 10.1038/s41388-020-1156-0. Epub 2020 Jan 23. Oncogene. 2020. PMID: 31974474
However, the precise posttranslational regulation of GNPAT is still undiscovered. Here we show that ACAT1 is upregulated in response to extra palmitic acid (PA). ACAT1 acetylates GNPAT at K128, which represses TRIM21-mediated GNPAT ubiquitination and degradation. .. …
However, the precise posttranslational regulation of GNPAT is still undiscovered. Here we show that ACAT1 is upregulated in response …
Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis.
Zhu Y, Gu L, Lin X, Liu C, Lu B, Cui K, Zhou F, Zhao Q, Prochownik EV, Fan C, Li Y. Zhu Y, et al. Mol Cell. 2020 Jan 2;77(1):138-149.e5. doi: 10.1016/j.molcel.2019.10.015. Epub 2019 Nov 14. Mol Cell. 2020. PMID: 31735643 Free article.
SIRT6 deacetylase antagonizes ACAT1 function in a manner that involves mutually exclusive ME1 S336 phosphorylation and K337 acetylation. ...Thus, the balance between PGAM5-mediated dephosphorylation of ME1 S336 and ACAT1-mediated acetylation of K337 strongly influen …
SIRT6 deacetylase antagonizes ACAT1 function in a manner that involves mutually exclusive ME1 S336 phosphorylation and K337 acetylati …
Association of intestinal anti-inflammatory drug target genes with psychiatric Disorders: A Mendelian randomization study.
Zhao G, Lu Z, Liao Y, Sun Y, Zhang Y, Kang Z, Feng X, Sun J, Yue W. Zhao G, et al. J Adv Res. 2025 Apr;70:545-553. doi: 10.1016/j.jare.2024.05.002. Epub 2024 May 11. J Adv Res. 2025. PMID: 38735387 Free PMC article.
Interestingly, this causal effect was influenced by a decrease in the gut microbiota abundance of the genus Roseburia (effect proportion = 10.05 %). Moreover, elevated ACAT1 expression was associated with higher obsessive-compulsive disorder risk (OR = 1.62; P = 3.64 10(-4 …
Interestingly, this causal effect was influenced by a decrease in the gut microbiota abundance of the genus Roseburia (effect proportion = 1 …
ACAT1 as a Therapeutic Target and its Genetic Relationship with Alzheimer's Disease.
Alavez-Rubio JS, Juarez-Cedillo T. Alavez-Rubio JS, et al. Curr Alzheimer Res. 2019;16(8):699-709. doi: 10.2174/1567205016666190823125245. Curr Alzheimer Res. 2019. PMID: 31441726 Review.
There are evidences which indicate disturbances in cholesterol homeostasis can be related with AD pathology, especially the compartmentation of intracellular cholesterol and cytoplasmic cholesterol esters formed by acyl-CoA: cholesterol acyltransferase 1 (ACAT1) can be imp …
There are evidences which indicate disturbances in cholesterol homeostasis can be related with AD pathology, especially the compartmentation …
Nuclear mitochondrial acetyl-CoA acetyltransferase 1 orchestrates natural killer cell-dependent antitumor immunity in colorectal cancer.
Wei C, Liao K, Chen HJ, Xiao ZX, Meng Q, Liu ZK, Lu YX, Sheng H, Mo HY, Wu QN, Han Y, Zeng ZL, Guan XY, Luo HY, Ju HQ, Xu RH. Wei C, et al. Signal Transduct Target Ther. 2025 Apr 28;10(1):138. doi: 10.1038/s41392-025-02221-y. Signal Transduct Target Ther. 2025. PMID: 40289129 Free PMC article.
Furthermore, significant associations are found among low nuclear ACAT1 levels, decreased S60 phosphorylation, and reduced NK cell infiltration, as well as poor prognosis in CRC. Our findings reveal an unexpected function of ACAT1 as a nuclear acetyltransferase and …
Furthermore, significant associations are found among low nuclear ACAT1 levels, decreased S60 phosphorylation, and reduced NK cell in …
396 results