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Table representation of search results timeline featuring number of search results per year.

Year Number of Results
1988 1
1990 1
1992 3
1993 2
1994 2
1995 4
1996 3
1997 2
1998 6
1999 5
2000 5
2001 9
2002 1
2003 9
2004 13
2005 13
2006 12
2007 11
2008 10
2009 18
2010 16
2011 8
2012 16
2013 20
2014 21
2015 18
2016 19
2017 13
2018 21
2019 18
2020 27
2021 23
2022 21
2023 19
2024 14

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367 results

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Page 1
Foam cells in atherosclerosis.
Yu XH, Fu YC, Zhang DW, Yin K, Tang CK. Yu XH, et al. Clin Chim Acta. 2013 Sep 23;424:245-52. doi: 10.1016/j.cca.2013.06.006. Epub 2013 Jun 16. Clin Chim Acta. 2013. PMID: 23782937 Free article. Review.
Acyl coenzyme A:cholesterol acyltransferase-1 (ACAT1) and neutral cholesteryl ester hydrolase (nCEH) regulate cholesterol esterification. ...
Acyl coenzyme A:cholesterol acyltransferase-1 (ACAT1) and neutral cholesteryl ester hydrolase (nCEH) regulate cholesterol esterificat …
Acetylation in the regulation of autophagy.
Xu Y, Wan W. Xu Y, et al. Autophagy. 2023 Feb;19(2):379-387. doi: 10.1080/15548627.2022.2062112. Epub 2022 Apr 18. Autophagy. 2023. PMID: 35435793 Free PMC article. Review.
Here, we review the current knowledge on acetylation of autophagy proteins and their regulations and functions in the autophagy pathway with focus on recent findings.Abbreviations : ACAT1: acetyl-CoA acetyltransferase 1; ACSS2: acyl-CoA synthetase short chain family member …
Here, we review the current knowledge on acetylation of autophagy proteins and their regulations and functions in the autophagy pathway with …
Mechanisms of foam cell formation in atherosclerosis.
Chistiakov DA, Melnichenko AA, Myasoedova VA, Grechko AV, Orekhov AN. Chistiakov DA, et al. J Mol Med (Berl). 2017 Nov;95(11):1153-1165. doi: 10.1007/s00109-017-1575-8. Epub 2017 Aug 7. J Mol Med (Berl). 2017. PMID: 28785870 Review.
Free cholesterol in turn is processed by acetyl-CoA acetyltransferase (ACAT1), an enzyme that transforms cholesterol to cholesteryl esters. The endoplasmic reticulum serves as a depot for maintaining newly synthesized cholesteryl esters that can be processed by neutral cho …
Free cholesterol in turn is processed by acetyl-CoA acetyltransferase (ACAT1), an enzyme that transforms cholesterol to cholesteryl e …
TREM2 Regulates Microglial Cholesterol Metabolism upon Chronic Phagocytic Challenge.
Nugent AA, Lin K, van Lengerich B, Lianoglou S, Przybyla L, Davis SS, Llapashtica C, Wang J, Kim DJ, Xia D, Lucas A, Baskaran S, Haddick PCG, Lenser M, Earr TK, Shi J, Dugas JC, Andreone BJ, Logan T, Solanoy HO, Chen H, Srivastava A, Poda SB, Sanchez PE, Watts RJ, Sandmann T, Astarita G, Lewcock JW, Monroe KM, Di Paolo G. Nugent AA, et al. Neuron. 2020 Mar 4;105(5):837-854.e9. doi: 10.1016/j.neuron.2019.12.007. Epub 2020 Jan 2. Neuron. 2020. PMID: 31902528 Free article.
This finding replicates in myelin-treated TREM2-deficient murine macrophages and human iPSC-derived microglia, where it is rescued by an ACAT1 inhibitor and LXR agonist. Our studies identify TREM2 as a key transcriptional regulator of cholesterol transport and metabolism u …
This finding replicates in myelin-treated TREM2-deficient murine macrophages and human iPSC-derived microglia, where it is rescued by an …
PARPs in lipid metabolism and related diseases.
Szántó M, Gupte R, Kraus WL, Pacher P, Bai P. Szántó M, et al. Prog Lipid Res. 2021 Nov;84:101117. doi: 10.1016/j.plipres.2021.101117. Epub 2021 Aug 25. Prog Lipid Res. 2021. PMID: 34450194 Free article. Review.
Stabilization of FASN by ACAT1-mediated GNPAT acetylation promotes lipid metabolism and hepatocarcinogenesis.
Gu L, Zhu Y, Lin X, Tan X, Lu B, Li Y. Gu L, et al. Oncogene. 2020 Mar;39(11):2437-2449. doi: 10.1038/s41388-020-1156-0. Epub 2020 Jan 23. Oncogene. 2020. PMID: 31974474
However, the precise posttranslational regulation of GNPAT is still undiscovered. Here we show that ACAT1 is upregulated in response to extra palmitic acid (PA). ACAT1 acetylates GNPAT at K128, which represses TRIM21-mediated GNPAT ubiquitination and degradation. .. …
However, the precise posttranslational regulation of GNPAT is still undiscovered. Here we show that ACAT1 is upregulated in response …
Dynamic Regulation of ME1 Phosphorylation and Acetylation Affects Lipid Metabolism and Colorectal Tumorigenesis.
Zhu Y, Gu L, Lin X, Liu C, Lu B, Cui K, Zhou F, Zhao Q, Prochownik EV, Fan C, Li Y. Zhu Y, et al. Mol Cell. 2020 Jan 2;77(1):138-149.e5. doi: 10.1016/j.molcel.2019.10.015. Epub 2019 Nov 14. Mol Cell. 2020. PMID: 31735643 Free article.
SIRT6 deacetylase antagonizes ACAT1 function in a manner that involves mutually exclusive ME1 S336 phosphorylation and K337 acetylation. ...Thus, the balance between PGAM5-mediated dephosphorylation of ME1 S336 and ACAT1-mediated acetylation of K337 strongly influen …
SIRT6 deacetylase antagonizes ACAT1 function in a manner that involves mutually exclusive ME1 S336 phosphorylation and K337 acetylati …
ACAT1 as a Therapeutic Target and its Genetic Relationship with Alzheimer's Disease.
Alavez-Rubio JS, Juarez-Cedillo T. Alavez-Rubio JS, et al. Curr Alzheimer Res. 2019;16(8):699-709. doi: 10.2174/1567205016666190823125245. Curr Alzheimer Res. 2019. PMID: 31441726 Review.
There are evidences which indicate disturbances in cholesterol homeostasis can be related with AD pathology, especially the compartmentation of intracellular cholesterol and cytoplasmic cholesterol esters formed by acyl-CoA: cholesterol acyltransferase 1 (ACAT1) can be imp …
There are evidences which indicate disturbances in cholesterol homeostasis can be related with AD pathology, especially the compartmentation …
Mutation update on ACAT1 variants associated with mitochondrial acetoacetyl-CoA thiolase (T2) deficiency.
Abdelkreem E, Harijan RK, Yamaguchi S, Wierenga RK, Fukao T. Abdelkreem E, et al. Hum Mutat. 2019 Oct;40(10):1641-1663. doi: 10.1002/humu.23831. Epub 2019 Jul 3. Hum Mutat. 2019. PMID: 31268215 Free PMC article. Review.
Mitochondrial acetoacetyl-CoA thiolase (T2, encoded by the ACAT1 gene) deficiency is an inherited disorder of ketone body and isoleucine metabolism. ...The presence of isoleucine-derived metabolites is the key marker for biochemical diagnosis. To date, 105 ACAT1 var …
Mitochondrial acetoacetyl-CoA thiolase (T2, encoded by the ACAT1 gene) deficiency is an inherited disorder of ketone body and isoleuc …
Persistent organic pollutants promote aggressiveness in prostate cancer.
Buñay J, Kossai M, Damon-Soubeyrant C, De Haze A, Saru JP, Trousson A, de Joussineau C, Bouchareb E, Kocer A, Vialat M, Dallel S, Degoul F, Bost F, Clavel S, Penault-Llorca F, Valli MP, Guy L, Matthews J, Renaud Y, Ittmann M, Jones J, Morel L, Lobaccaro JM, Baron S. Buñay J, et al. Oncogene. 2023 Sep;42(38):2854-2867. doi: 10.1038/s41388-023-02788-2. Epub 2023 Aug 17. Oncogene. 2023. PMID: 37587334
We identified up-regulation of Acetyl-CoA Acetyltransferase-1 (ACAT1) involved in ketone bodies pathway as a potential target. Mechanistically, genetic inhibition confirmed that ACAT1 mediated dioxin effect on cell migration. ...We found that ACAT1 histoscore …
We identified up-regulation of Acetyl-CoA Acetyltransferase-1 (ACAT1) involved in ketone bodies pathway as a potential target. Mechan …
367 results