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Page 1
Characterization of upregulated adhesion GPCRs in acute myeloid leukemia.
Yang J, Wu S, Alachkar H. Yang J, et al. Transl Res. 2019 Oct;212:26-35. doi: 10.1016/j.trsl.2019.05.004. Epub 2019 May 17. Transl Res. 2019. PMID: 31153896 Free PMC article.
The role of adhesion G protein-coupled receptors (aGPCRs) in cancer has become increasingly evident in recent years. ...Upregulation in one or more of eight aGPCR genes (ADGRB1, ADGRC2, ADGRD1, ADGRE1, ADGRE2, ADGRE5, ADGRG1, and/or ADGRG3) was significantly associa …
The role of adhesion G protein-coupled receptors (aGPCRs) in cancer has become increasingly evident in recent years. ...Upregulation …
Membrane-association of EMR2/ADGRE2-NTF is regulated by site-specific N-glycosylation.
Huang YS, Chiang NY, Chang GW, Lin HH. Huang YS, et al. Sci Rep. 2018 Mar 14;8(1):4532. doi: 10.1038/s41598-018-22849-x. Sci Rep. 2018. PMID: 29540735 Free PMC article.
The evolutionarily conserved adhesion G protein-coupled receptors (aGPCRs) play critical roles in biological processes as diverse as brain development, cell polarity and innate immune functions. ...The two NTF subtypes are expected to regulate aGPCR signaling via distinct …
The evolutionarily conserved adhesion G protein-coupled receptors (aGPCRs) play critical roles in biological processes as diverse as …
Vibratory Urticaria and ADGRE2.
Boyden SE, Metcalfe DD, Komarow HD. Boyden SE, et al. N Engl J Med. 2016 Jul 7;375(1):95. doi: 10.1056/NEJMc1604757. N Engl J Med. 2016. PMID: 27406365 No abstract available.
Vibratory Urticaria and ADGRE2.
Kaplan AP, Greenberger PA, Geller M. Kaplan AP, et al. N Engl J Med. 2016 Jul 7;375(1):94-5. doi: 10.1056/NEJMc1604757. N Engl J Med. 2016. PMID: 27406366 No abstract available.
Affinity Binding of EMR2 Expressing Cells by Surface-Grafted Chondroitin Sulfate B.
Burzava ALS, Jasieniak M, Cockshell MP, Bonder CS, Harding FJ, Griesser HJ, Voelcker NH. Burzava ALS, et al. Biomacromolecules. 2017 Jun 12;18(6):1697-1704. doi: 10.1021/acs.biomac.6b01687. Epub 2017 May 3. Biomacromolecules. 2017. PMID: 28437084
Chondroitin sulfate (CS)-B is of particular interest, since it interacts with the receptor (EGF)-like module-containing mucin-like hormone receptor-like 2 precursor (EMR2) displayed on the surface of leu …
Chondroitin sulfate (CS)-B is of particular interest, since it interacts with the receptor (EGF)-like module-contain …
Critical Signaling Events in the Mechanoactivation of Human Mast Cells through p.C492Y-ADGRE2.
Naranjo AN, Bandara G, Bai Y, Smelkinson MG, Tobío A, Komarow HD, Boyden SE, Kastner DL, Metcalfe DD, Olivera A. Naranjo AN, et al. J Invest Dermatol. 2020 Nov;140(11):2210-2220.e5. doi: 10.1016/j.jid.2020.03.936. Epub 2020 Mar 25. J Invest Dermatol. 2020. PMID: 32222457 Free PMC article.
A role for the adhesion G-protein coupled receptor ADGRE2 or EMR2 in mechanosensing was revealed by the finding of a missense substitution (p.C492Y) associated with familial vibratory urticaria. In these patients, friction of the skin induces mast cell hyper- …
A role for the adhesion G-protein coupled receptor ADGRE2 or EMR2 in mechanosensing was revealed by the finding of a mi …
Tethered agonist exposure in intact adhesion/class B2 GPCRs through intrinsic structural flexibility of the GAIN domain.
Beliu G, Altrichter S, Guixà-González R, Hemberger M, Brauer I, Dahse AK, Scholz N, Wieduwild R, Kuhlemann A, Batebi H, Seufert F, Pérez-Hernández G, Hildebrand PW, Sauer M, Langenhan T. Beliu G, et al. Mol Cell. 2021 Mar 4;81(5):905-921.e5. doi: 10.1016/j.molcel.2020.12.042. Epub 2021 Jan 25. Mol Cell. 2021. PMID: 33497605 Free article.
Adhesion G protein-coupled receptors (aGPCRs)/family B2 GPCRs execute critical tasks during development and the operation of organs, and their genetic lesions are associated with human disorders, including cancers. ...We investigated this matter in five mammalian aGPCR hom …
Adhesion G protein-coupled receptors (aGPCRs)/family B2 GPCRs execute critical tasks during development and the operation of organs, …
Transcriptome analysis of G protein-coupled receptors in distinct genetic subgroups of acute myeloid leukemia: identification of potential disease-specific targets.
Maiga A, Lemieux S, Pabst C, Lavallée VP, Bouvier M, Sauvageau G, Hébert J. Maiga A, et al. Blood Cancer J. 2016 Jun 3;6(6):e431. doi: 10.1038/bcj.2016.36. Blood Cancer J. 2016. PMID: 27258612 Free PMC article.
Acute myeloid leukemia (AML) is associated with poor clinical outcome and the development of more effective therapies is urgently needed. G protein-coupled receptors (GPCRs) represent attractive therapeutic targets, accounting for approximately 30% of all targets of market …
Acute myeloid leukemia (AML) is associated with poor clinical outcome and the development of more effective therapies is urgently needed. G …
Vibratory Urticaria Associated with a Missense Variant in ADGRE2.
Boyden SE, Desai A, Cruse G, Young ML, Bolan HC, Scott LM, Eisch AR, Long RD, Lee CC, Satorius CL, Pakstis AJ, Olivera A, Mullikin JC, Chouery E, Mégarbané A, Medlej-Hashim M, Kidd KK, Kastner DL, Metcalfe DD, Komarow HD. Boyden SE, et al. N Engl J Med. 2016 Feb 18;374(7):656-63. doi: 10.1056/NEJMoa1500611. Epub 2016 Feb 3. N Engl J Med. 2016. PMID: 26841242 Free PMC article.
We identified a previously unknown missense substitution in ADGRE2 (also known as EMR2), which was predicted to result in the replacement of cysteine with tyrosine at amino acid position 492 (p.C492Y), as the only nonsynonymous variant cosegregating with vibratory u …
We identified a previously unknown missense substitution in ADGRE2 (also known as EMR2), which was predicted to result in the …
miR-99a reveals two novel oncogenic proteins E2F2 and EMR2 and represses stemness in lung cancer.
Feliciano A, Garcia-Mayea Y, Jubierre L, Mir C, Hummel M, Castellvi J, Hernández-Losa J, Paciucci R, Sansano I, Sun Y, Ramón Y Cajal S, Kondon H, Soriano A, Segura M, Lyakhovich A, LLeonart ME. Feliciano A, et al. Cell Death Dis. 2017 Oct 26;8(10):e3141. doi: 10.1038/cddis.2017.544. Cell Death Dis. 2017. PMID: 29072692 Free PMC article.
We identified two novel proteins, E2F2 (E2F transcription factor 2) and EMR2 (EGF-like module-containing, mucin-like, hormone receptor-like 2), downregulated by miR-99a by its direct binding to their 3'- …
We identified two novel proteins, E2F2 (E2F transcription factor 2) and EMR2 (EGF-like module-containing, …
18 results