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2014 3
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2023 4
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Identification of prognostic lipid droplet-associated genes in pancreatic cancer patients via bioinformatics analysis.
Bai R, Rebelo A, Kleeff J, Sunami Y. Bai R, et al. Lipids Health Dis. 2021 Jun 2;20(1):58. doi: 10.1186/s12944-021-01476-y. Lipids Health Dis. 2021. PMID: 34078402 Free PMC article.
Bioinformatics analysis of 179 pancreatic cancer samples and 171 normal pancreatic tissue samples on the GEPIA platform identified 39 deferentially expressed genes in pancreatic cancer with 36 up-regulated genes (ACSL3, ACSL4, AGPAT2, BSCL2, CAV1, CAV2, CAVIN1, CES1, CIDEC …
Bioinformatics analysis of 179 pancreatic cancer samples and 171 normal pancreatic tissue samples on the GEPIA platform identified 39 defere …
AGPAT2 interaction with CDP-diacylglycerol synthases promotes the flux of fatty acids through the CDP-diacylglycerol pathway.
Mak HY, Ouyang Q, Tumanov S, Xu J, Rong P, Dong F, Lam SM, Wang X, Lukmantara I, Du X, Gao M, Brown AJ, Gong X, Shui G, Stocker R, Huang X, Chen S, Yang H. Mak HY, et al. Nat Commun. 2021 Nov 25;12(1):6877. doi: 10.1038/s41467-021-27279-4. Nat Commun. 2021. PMID: 34824276 Free PMC article.
Paradoxically, AGPAT2 deficiency is known to dramatically increase the level of its product, PA. Here, we find that AGPAT2 deficiency impairs the biogenesis and growth of lipid droplets. ...
Paradoxically, AGPAT2 deficiency is known to dramatically increase the level of its product, PA. Here, we find that AGPAT2 def …
Lipodystrophic gene Agpat2 deficiency aggravates hyperlipidemia and atherosclerosis in Ldlr(-/-) mice.
Peng K, Chen X, Pei K, Wang X, Ma X, Liang C, Dong Q, Liu Z, Han M, Liu G, Yang H, Zheng M, Liu G, Gao M. Peng K, et al. Biochim Biophys Acta Mol Basis Dis. 2024 Jan;1870(1):166850. doi: 10.1016/j.bbadis.2023.166850. Epub 2023 Aug 15. Biochim Biophys Acta Mol Basis Dis. 2024. PMID: 37591406
Agpat2(-/-) mice were then crossed with hypercholesterolemic and atherosclerotic prone LDL receptor knockout (Ldlr(-/-)) mice to obtain double knockout mouse model (Agpat2(-/-)Ldlr(-/-)). ...The liver weight of Agpat2(-/-)Ldlr(-/-) mice was about 4 times high …
Agpat2(-/-) mice were then crossed with hypercholesterolemic and atherosclerotic prone LDL receptor knockout (Ldlr(-/-)) mice to obta …
The worldwide mutational landscape of Berardinelli-Seip congenital lipodystrophy.
Craveiro Sarmento AS, Ferreira LC, Lima JG, de Azevedo Medeiros LB, Barbosa Cunha PT, Agnez-Lima LF, Galvão Ururahy MA, de Melo Campos JTA. Craveiro Sarmento AS, et al. Mutat Res Rev Mutat Res. 2019 Jul-Sep;781:30-52. doi: 10.1016/j.mrrev.2019.03.005. Epub 2019 Mar 23. Mutat Res Rev Mutat Res. 2019. PMID: 31416577 Review.
BSCL etiology involves genetic variations in four different genes: AGPAT2, BSCL2, CAV1, and CAVIN1. The four different biochemical subtypes of the disease are distinguished depending on which gene is mutated. ...The c.517dupA in the BSCL2 gene was the most frequent (13.3%) …
BSCL etiology involves genetic variations in four different genes: AGPAT2, BSCL2, CAV1, and CAVIN1. The four different biochemical su …
The Vitamin D Receptor Regulates Glycerolipid and Phospholipid Metabolism in Human Hepatocytes.
Martínez-Sena T, Soluyanova P, Guzmán C, Valdivielso JM, Castell JV, Jover R. Martínez-Sena T, et al. Biomolecules. 2020 Mar 24;10(3):493. doi: 10.3390/biom10030493. Biomolecules. 2020. PMID: 32213983 Free PMC article.
Twenty percent of the VDR responsive genes were related to lipid metabolism, including MOGAT1, LPGAT1, AGPAT2, and DGAT1 (glycerolipid metabolism); CDS1, PCTP, and MAT1A (phospholipid metabolism); and FATP2, SLC6A12, and AQP3 (uptake of fatty acids, betaine, and glycerol, …
Twenty percent of the VDR responsive genes were related to lipid metabolism, including MOGAT1, LPGAT1, AGPAT2, and DGAT1 (glycerolipi …
Inborn errors of cytoplasmic triglyceride metabolism.
Wu JW, Yang H, Wang SP, Soni KG, Brunel-Guitton C, Mitchell GA. Wu JW, et al. J Inherit Metab Dis. 2015 Jan;38(1):85-98. doi: 10.1007/s10545-014-9767-7. Epub 2014 Oct 10. J Inherit Metab Dis. 2015. PMID: 25300978 Review.
We discuss known inborn errors of CTGM, including deficiencies of: AGPAT2 (a form of generalized lipodystrophy), LPIN1 (childhood rhabdomyolysis), LPIN2 (an inflammatory condition, Majeed syndrome, described elsewhere in this issue), DGAT1 (protein loosing enteropathy), pe …
We discuss known inborn errors of CTGM, including deficiencies of: AGPAT2 (a form of generalized lipodystrophy), LPIN1 (childhood rha …
Human placental lipid content and lipid metabolic enzyme abundance in obesity and across gestation.
Bidne KL, Uhlson C, Palmer C, Zemski-Berry K, Powell TL. Bidne KL, et al. Clin Sci (Lond). 2022 Oct 14;136(19):1389-1404. doi: 10.1042/CS20220479. Clin Sci (Lond). 2022. PMID: 36103262 Free PMC article.
Placental protein abundance of glycerol-2-phosphate (GPAT3) and 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 (AGPAT2), involved in de novo synthesis of PC and TAG, were higher (P<0.05) in the first trimester (66 and 74%, respectively). ...
Placental protein abundance of glycerol-2-phosphate (GPAT3) and 1-acyl-sn-glycerol-3-phosphate acyltransferase 2 (AGPAT2), involved i …
Congenital generalized lipodystrophies--new insights into metabolic dysfunction.
Patni N, Garg A. Patni N, et al. Nat Rev Endocrinol. 2015 Sep;11(9):522-34. doi: 10.1038/nrendo.2015.123. Epub 2015 Aug 4. Nat Rev Endocrinol. 2015. PMID: 26239609 Free PMC article. Review.
Four distinct subtypes of CGL exist: type 1 is associated with AGPAT2 mutations; type 2 is associated with BSCL2 mutations; type 3 is associated with CAV1 mutations; and type 4 is associated with PTRF mutations. ...
Four distinct subtypes of CGL exist: type 1 is associated with AGPAT2 mutations; type 2 is associated with BSCL2 mutations; type 3 is …
Expression of AGPAT2, an enzyme involved in the glycerophospholipid/triacylglycerol biosynthesis pathway, is directly regulated by HIF-1 and promotes survival and etoposide resistance of cancer cells under hypoxia.
Triantafyllou EA, Georgatsou E, Mylonis I, Simos G, Paraskeva E. Triantafyllou EA, et al. Biochim Biophys Acta Mol Cell Biol Lipids. 2018 Sep;1863(9):1142-1152. doi: 10.1016/j.bbalip.2018.06.015. Epub 2018 Jun 15. Biochim Biophys Acta Mol Cell Biol Lipids. 2018. PMID: 29908837
Moreover, a sequence of the AGPAT2 gene promoter region, containing 6 putative Hypoxia Response Elements (HREs), activated transcription of a reporter gene under hypoxic conditions or in normoxic cells over-expressing HIF-1alpha. Chromatin immunoprecipitation experiments c …
Moreover, a sequence of the AGPAT2 gene promoter region, containing 6 putative Hypoxia Response Elements (HREs), activated transcript …
Different origin of adipogenic stem cells influences the response to antiretroviral drugs.
Gibellini L, De Biasi S, Nasi M, Carnevale G, Pisciotta A, Bianchini E, Bartolomeo R, Polo M, De Pol A, Pinti M, Cossarizza A. Gibellini L, et al. Exp Cell Res. 2015 Oct 1;337(2):160-9. doi: 10.1016/j.yexcr.2015.07.031. Epub 2015 Jul 31. Exp Cell Res. 2015. PMID: 26238601 Review.
CCAAT/enhancer-binding protein alpha (CEBPalpha) and peroxisome proliferator-activated receptor gamma (PPARgamma), and in adipocyte functions, i.e. fatty acid synthase (FASN), fatty acid binding protein-4 (FABP4), perilipin-1 (PLIN1) and 1-acylglycerol-3-p …
CCAAT/enhancer-binding protein alpha (CEBPalpha) and peroxisome proliferator-activated receptor gamma (PPARgamma), and in adipocyte function …
47 results