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Year Number of Results
2016 7
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70 results

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Page 1
Metabolic profiling stratifies colorectal cancer and reveals adenosylhomocysteinase as a therapeutic target.
Vande Voorde J, Steven RT, Najumudeen AK, Ford CA, Dexter A, Gonzalez-Fernandez A, Nikula CJ, Xiang Y, Ford L, Maneta Stavrakaki S, Gilroy K, Zeiger LB, Pennel K, Hatthakarnkul P, Elia EA, Nasif A, Murta T, Manoli E, Mason S, Gillespie M, Lannagan TRM, Vlahov N, Ridgway RA, Nixon C, Raven A, Mills M, Athineos D, Kanellos G, Nourse C, Gay DM, Hughes M, Burton A, Yan B, Sellers K, Wu V, De Ridder K, Shokry E, Huerta Uribe A, Clark W, Clark G, Kirschner K, Thienpont B, Li VSW, Maddocks ODK, Barry ST, Goodwin RJA, Kinross J, Edwards J, Yuneva MO, Sumpton D, Takats Z, Campbell AD, Bunch J, Sansom OJ. Vande Voorde J, et al. Nat Metab. 2023 Aug;5(8):1303-1318. doi: 10.1038/s42255-023-00857-0. Epub 2023 Aug 14. Nat Metab. 2023. PMID: 37580540 Free PMC article.
Loss of Apc in the mouse intestine was found to be sufficient to drive expression of one of its enzymes, adenosylhomocysteinase (AHCY), which was also found to be transcriptionally upregulated in human CRC. ...Finally, pharmacological inhibition of AHCY reduc …
Loss of Apc in the mouse intestine was found to be sufficient to drive expression of one of its enzymes, adenosylhomocysteinase (A …
Epigenetic Upregulation of H19 and AMPK Inhibition Concurrently Contribute to S-Adenosylhomocysteine Hydrolase Deficiency-Promoted Atherosclerotic Calcification.
Dai X, Liu S, Cheng L, Huang T, Guo H, Wang D, Xia M, Ling W, Xiao Y. Dai X, et al. Circ Res. 2022 May 13;130(10):1565-1582. doi: 10.1161/CIRCRESAHA.121.320251. Epub 2022 Apr 12. Circ Res. 2022. PMID: 35410483 Free article.
However, the effect and mechanism of SAHH in atherosclerotic calcification is still unclear. We aimed to explore the role and mechanism of SAHH in atherosclerotic calcification. ...Heterozygote knockout of SAHH promoted atherosclerotic calcification. Specific …
However, the effect and mechanism of SAHH in atherosclerotic calcification is still unclear. We aimed to explore the role and mechani …
Single-cell RNA-seq reveals novel immune-associated biomarkers for predicting prognosis in AML patients with RUNX1::RUNX1T1.
Li XP, Dai Y, Zhang WN, Pan MM, Mao J, Zhao B, Jiang L, Gao Y. Li XP, et al. Int Immunopharmacol. 2023 Dec;125(Pt B):111178. doi: 10.1016/j.intimp.2023.111178. Epub 2023 Nov 9. Int Immunopharmacol. 2023. PMID: 37951201 Free article.
Additionally, we discovered that AHCY was an effective biomarker to predict the overall survival as well as relapse-free survival of AML patients with RUNX1::RUNX1T1. The correlation of AHCY with infiltrated immune cells and immune checkpoints was also investigated. …
Additionally, we discovered that AHCY was an effective biomarker to predict the overall survival as well as relapse-free survival of …
Genome-wide DNA methylation regulated by AHCY through SAM / SAH axis promotes psoriasis pathogenesis.
Liu L, Chen L, Hu Y, Zhang Q, Chen K, Zhang J. Liu L, et al. J Dermatol Sci. 2024 Dec;116(3):100-110. doi: 10.1016/j.jdermsci.2024.10.004. Epub 2024 Oct 31. J Dermatol Sci. 2024. PMID: 39521647
Furthermore, alterations in DNA methylation patterns resulting from AHCY knockdown were analyzed. RESULTS: Our findings revealed that AHCY was upregulated in psoriatic lesions and exhibited a positive correlation with disease severity. ...Consequently, AHCY m …
Furthermore, alterations in DNA methylation patterns resulting from AHCY knockdown were analyzed. RESULTS: Our findings revealed that …
Inhibition of S-adenosylhomocysteine hydrolase induces endothelial senescence via hTERT downregulation.
You Y, Sun X, Xiao J, Chen Y, Chen X, Pang J, Mi J, Tang Y, Liu Q, Ling W. You Y, et al. Atherosclerosis. 2022 Jul;353:1-10. doi: 10.1016/j.atherosclerosis.2022.06.002. Epub 2022 Jun 6. Atherosclerosis. 2022. PMID: 35753115
Elevated S-adenosylhomocysteine (SAH) level induced by inhibition of S-adenosylhomocysteine hydrolase (SAHH) is one of the risk factors of atherosclerosis; however, the interplay between endothelial senescence and inhibition of SAHH is largely u …
Elevated S-adenosylhomocysteine (SAH) level induced by inhibition of S-adenosylhomocysteine hydrolase (SAHH) is …
Epigenetic regulation of TXNIP-mediated oxidative stress and NLRP3 inflammasome activation contributes to SAHH inhibition-aggravated diabetic nephropathy.
Dai X, Liao R, Liu C, Liu S, Huang H, Liu J, Jin T, Guo H, Zheng Z, Xia M, Ling W, Xiao Y. Dai X, et al. Redox Biol. 2021 Sep;45:102033. doi: 10.1016/j.redox.2021.102033. Epub 2021 Jun 5. Redox Biol. 2021. PMID: 34119876 Free PMC article.
Moreover, EGR1 is activated and enriched at promoters of TXNIP by SAHH inhibition and is essential for SAHH inhibition-induced TXNIP expression. Inhibition of EGR1 protected against SAHH inhibition-induced NLRP3 inflammasome activation and oxidative stress an …
Moreover, EGR1 is activated and enriched at promoters of TXNIP by SAHH inhibition and is essential for SAHH inhibition-induced …
3-deazaadenosine (3DA) alleviates senescence to promote cellular fitness and cell therapy efficiency in mice.
Guerrero A, Innes AJ, Roux PF, Buisman SC, Jung J, Ortet L, Moiseeva V, Wagner V, Robinson L, Ausema A, Potapova A, Perdiguero E, Weersing E, Aarts M, Martin N, Wuestefeld T, Muñoz-Cánoves P, de Haan G, Bischof O, Gil J. Guerrero A, et al. Nat Aging. 2022 Sep;2:851-866. doi: 10.1038/s43587-022-00279-9. Epub 2022 Sep 13. Nat Aging. 2022. PMID: 36438588 Free PMC article.
Here, we show that 3-deazaadenosine (3DA), an S-adenosyl homocysteinase (AHCY) inhibitor, alleviates replicative and oncogene-induced senescence. 3DA-treated senescent cells showed reduced global Histone H3 Lysine 36 trimethylation (H3K36me3), an epigenetic modification th …
Here, we show that 3-deazaadenosine (3DA), an S-adenosyl homocysteinase (AHCY) inhibitor, alleviates replicative and oncogene-induced …
The role of S-adenosylhomocysteine hydrolase-like 1 in cancer.
Budnik N, Leroux AE, Cooke M, Kazanietz MG, Vigliano C, Kobayashi K, Perez-Castro C. Budnik N, et al. Biochim Biophys Acta Mol Cell Res. 2024 Oct;1871(7):119819. doi: 10.1016/j.bbamcr.2024.119819. Epub 2024 Aug 17. Biochim Biophys Acta Mol Cell Res. 2024. PMID: 39154900 Free article. Review.
S-adenosylhomocysteine Hydrolase Participates in DNA Methylation Inheritance.
Ponnaluri VKC, Estève PO, Ruse CI, Pradhan S. Ponnaluri VKC, et al. J Mol Biol. 2018 Jul 6;430(14):2051-2065. doi: 10.1016/j.jmb.2018.05.014. Epub 2018 May 28. J Mol Biol. 2018. PMID: 29758262 Free article.
The DNA methylation process generates S-adenosyl-l-homocysteine, a strong inhibitor of DNMT1. Here we report that S-adenosylhomocysteine hydrolase (SAHH/AHCY), the only mammalian enzyme capable of hydrolyzing S-adenosyl-l-homocysteine binds to D …
The DNA methylation process generates S-adenosyl-l-homocysteine, a strong inhibitor of DNMT1. Here we report that S-adenosylhomocy …
Abnormal Hypermethylation at Imprinting Control Regions in Patients with S-Adenosylhomocysteine Hydrolase (AHCY) Deficiency.
Motzek A, Knežević J, Switzeny OJ, Cooper A, Barić I, Beluzić R, Strauss KA, Puffenberger EG, Mudd SH, Vugrek O, Zechner U. Motzek A, et al. PLoS One. 2016 Mar 14;11(3):e0151261. doi: 10.1371/journal.pone.0151261. eCollection 2016. PLoS One. 2016. PMID: 26974671 Free PMC article. Clinical Trial.
S-adenosylhomocysteine hydrolase (AHCY) deficiency is a rare autosomal recessive disorder in methionine metabolism caused by mutations in the AHCY gene. ...We conclude that DNA hypermethylation seems to be a frequent but not a constant feature a …
S-adenosylhomocysteine hydrolase (AHCY) deficiency is a rare autosomal recessive disorder in methionine metaboli …
70 results