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Page 1
Ketogenic diet reshapes cancer metabolism through lysine β-hydroxybutyrylation.
Qin J, Huang X, Gou S, Zhang S, Gou Y, Zhang Q, Chen H, Sun L, Chen M, Liu D, Han C, Tang M, Feng Z, Niu S, Zhao L, Tu Y, Liu Z, Xuan W, Dai L, Jia D, Xue Y. Qin J, et al. Nat Metab. 2024 Aug;6(8):1505-1528. doi: 10.1038/s42255-024-01093-w. Epub 2024 Aug 12. Nat Metab. 2024. PMID: 39134903
Using a small training dataset with known functions, we developed a bioinformatics method for the prediction of functionally important lysine modification sites (pFunK), which revealed functionally relevant Kbhb sites on various proteins, including aldolase B (AL …
Using a small training dataset with known functions, we developed a bioinformatics method for the prediction of functionally important lysin …
CBX4 suppresses CD8+ T cell antitumor immunity by reprogramming glycolytic metabolism.
Wang J, Jia W, Zhou X, Ma Z, Liu J, Lan P. Wang J, et al. Theranostics. 2024 Jun 17;14(10):3793-3809. doi: 10.7150/thno.95748. eCollection 2024. Theranostics. 2024. PMID: 38994031 Free PMC article.
Mechanistically, CBX4 increases the expression of the metabolism-associated molecule aldolase B (Aldob) through sumoylation of trans-acting transcription factor 1 (SP1) and Kruppel-like factor 3 (KLF3). In addition, Aldob inhibits glycolysis and ATP sy …
Mechanistically, CBX4 increases the expression of the metabolism-associated molecule aldolase B (Aldob) through sumoyla …
ALDOB/KAT2A interactions epigenetically modulate TGF-beta expression and T cell functions in hepatocellular carcinogenesis.
Yin C, Zhang C, Wang Y, Liu G, Wang N, Liang N, Zhang L, Tu Q, Lv J, Jiang H, Ma H, Du C, Li M, He X, Chen S, Guo J, Li S, Qin J, Li N, Tao Y, Yin H. Yin C, et al. Hepatology. 2025 Jan 1;81(1):77-93. doi: 10.1097/HEP.0000000000000704. Epub 2023 Dec 5. Hepatology. 2025. PMID: 38051951
Previous studies have identified that downregulation of the glycolytic enzyme fructose-1,6-bisphosphate aldolase B (ALDOB) in tumor cells orchestrated metabolic programming to favor HCC. However, it remains elusive whether and how ALDOB expression in t …
Previous studies have identified that downregulation of the glycolytic enzyme fructose-1,6-bisphosphate aldolase B (ALDOB …
Associations between ALDOB polymorphisms and intrahepatic cholestasis of pregnancy susceptibility in the Chinese Han population.
Liu X, Xin S, Zheng J, Liu H, Zeng Y, Wu X, Zhang F, Zeng X, Zou Y, Lai H. Liu X, et al. Ginekol Pol. 2024;95(2):132-142. doi: 10.5603/gpl.92931. Epub 2023 Sep 25. Ginekol Pol. 2024. PMID: 37743645
OBJECTIVES: To research the associations between fructose-bisphosphate aldolase B (ALDOB) gene polymorphisms and intrahepatic cholestasis of pregnancy (ICP) risk. ...Protein structure comparisons between the reference and ALDOB-modified samples were pe …
OBJECTIVES: To research the associations between fructose-bisphosphate aldolase B (ALDOB) gene polymorphisms and intrah …
Estimation of hereditary fructose intolerance prevalence in the Chinese population.
Tang M, Chen X, Ni Q, Lu Y, Wu B, Wang H, Yin Z, Zhou W, Dong X. Tang M, et al. Orphanet J Rare Dis. 2022 Aug 26;17(1):326. doi: 10.1186/s13023-022-02487-3. Orphanet J Rare Dis. 2022. PMID: 36028839 Free PMC article. Review.
BACKGROUND: Hereditary fructose intolerance (HFI) caused by aldolase B reduction or deficiency that results in fructose metabolism disorder. The disease prevalence in the Chinese population is unknown, which impedes the formulation of HFI screening and diagnosis str …
BACKGROUND: Hereditary fructose intolerance (HFI) caused by aldolase B reduction or deficiency that results in fructose metabo …
Aldolase B attenuates clear cell renal cell carcinoma progression by inhibiting CtBP2.
Tan M, Pan Q, Wu Q, Li J, Wang J. Tan M, et al. Front Med. 2023 Jun;17(3):503-517. doi: 10.1007/s11684-022-0947-9. Epub 2023 Feb 15. Front Med. 2023. PMID: 36790589
Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCC) tissues. ...Furthermore, ALDOB overexpression decreased the proliferation and migration of ccRCC cells in an ALDOB-CtBP2 interaction-depend …
Aldolase B (ALDOB), a glycolytic enzyme, is uniformly depleted in clear cell renal cell carcinoma (ccRCC) tissues. ...F …
Fructose-1, 6-Bisphosphate Aldolase B Suppresses Glycolysis and Tumor Progression of Gastric Cancer.
Wu L, Dong J, Fei D, Le T, Xiao L, Liu J, Yu Z. Wu L, et al. Dig Dis Sci. 2024 Sep;69(9):3290-3304. doi: 10.1007/s10620-024-08568-6. Epub 2024 Jul 27. Dig Dis Sci. 2024. PMID: 39068380
In addition, cell viability assay confirmed that ALDOB acted as a tumor suppressor. Finally, drug sensitivity analysis revealed that ALDOB increased the sensitivity of gastric cancer cells to most antitumor drugs, especially talazoparib, XAV939, and FTI-277. Our res …
In addition, cell viability assay confirmed that ALDOB acted as a tumor suppressor. Finally, drug sensitivity analysis revealed that …
Aldolase B impairs DNA mismatch repair and induces apoptosis in colon adenocarcinoma.
Lian J, Xia L, Chen Y, Zheng J, Ma K, Luo L, Ye F. Lian J, et al. Pathol Res Pract. 2019 Nov;215(11):152597. doi: 10.1016/j.prp.2019.152597. Epub 2019 Aug 16. Pathol Res Pract. 2019. PMID: 31564566
Evidence suggests that DNA repair capacity manifested by intact functional base excision repair and mismatch repair (MMR) pathways is related to the prognosis of multiple cancer types. Aldolase B (ALDOB) is well known for its role in metabolism and glycolysis …
Evidence suggests that DNA repair capacity manifested by intact functional base excision repair and mismatch repair (MMR) pathways is relate …
Down-regulation of ALDOB during metabolic reprogramming mediates malignant behavior in hepatocellular carcinoma and insensitivity to postoperative adjuvant transarterial chemoembolization.
Xu JX, Qin SL, Wei HW, Chen YY, Peng YC, Qi LN. Xu JX, et al. Clin Sci (Lond). 2023 Feb 27;137(4):303-316. doi: 10.1042/CS20220661. Clin Sci (Lond). 2023. PMID: 36749124
Hypoxia and ALDOB down-regulation acted additively, which was closely related to PA-TACE insensitivity. The use of ALDOB and Ki67 as a combined marker has the potential to identify the 'PA-TACE beneficiary population'....
Hypoxia and ALDOB down-regulation acted additively, which was closely related to PA-TACE insensitivity. The use of ALDOB and K …
RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice.
Hou Y, Park JH, Dan X, Chu X, Yang B, Hussain M, Croteau DL, Bohr VA. Hou Y, et al. Neurobiol Dis. 2023 May;180:106092. doi: 10.1016/j.nbd.2023.106092. Epub 2023 Mar 21. Neurobiol Dis. 2023. PMID: 36948261 Free PMC article.
Notably, two genes, Aldolase Fructose-Bisphosphate B (Aldob) and NADPH Oxidase 4 (Nox4), were differentially expressed in RecQ-deficient mice. ...
Notably, two genes, Aldolase Fructose-Bisphosphate B (Aldob) and NADPH Oxidase 4 (Nox4), were differentially expressed in RecQ-defici …
52 results