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2015 1
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132 results

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Page 1
Microglia replacement halts the progression of microgliopathy in mice and humans.
Wu J, Wang Y, Li X, Ouyang P, Cai Y, He Y, Zhang M, Luan X, Jin Y, Wang J, Xiao Y, Liang Y, Xie F, Shu Y, Hu J, Chang C, Jiang J, Wu D, Zhao Y, Liu T, Li Y, Huang X, Li Y, Zhang J, Cao Y, Cheng X, Mao Y, Rao Y, Cao L, Peng B. Wu J, et al. Science. 2025 Jul 10;389(6756):eadr1015. doi: 10.1126/science.adr1015. Epub 2025 Jul 10. Science. 2025. PMID: 40638739
Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) and a fatal neurological disease without c …
Its monoallelic mutation causes CSF1R-associated microgliopathy (CAMP), a major form of adult-onset leukoencephalopathy …
Therapeutic potential of human microglia transplantation in a chimeric model of CSF1R-related leukoencephalopathy.
Chadarevian JP, Hasselmann J, Lahian A, Capocchi JK, Escobar A, Lim TE, Le L, Tu C, Nguyen J, Kiani Shabestari S, Carlen-Jones W, Gandhi S, Bu G, Hume DA, Pridans C, Wszolek ZK, Spitale RC, Davtyan H, Blurton-Jones M. Chadarevian JP, et al. Neuron. 2024 Aug 21;112(16):2686-2707.e8. doi: 10.1016/j.neuron.2024.05.023. Epub 2024 Jun 18. Neuron. 2024. PMID: 38897209 Free PMC article.
Microglia replacement strategies are increasingly being considered for the treatment of primary microgliopathies like adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). However, av …
Microglia replacement strategies are increasingly being considered for the treatment of primary microgliopathies like adult-onset …
An update on clinical, pathological, diagnostic, and therapeutic perspectives of childhood leukodystrophies.
Ashrafi MR, Amanat M, Garshasbi M, Kameli R, Nilipour Y, Heidari M, Rezaei Z, Tavasoli AR. Ashrafi MR, et al. Expert Rev Neurother. 2020 Jan;20(1):65-84. doi: 10.1080/14737175.2020.1699060. Epub 2019 Dec 12. Expert Rev Neurother. 2020. PMID: 31829048 Review.
New genetic methods and stem cell transplantation are also under investigation to further increase the quality and duration of life in affected population.Expert opinion: The improvements in molecular diagnostic tools allow us to identify the meticulous underlying etiology of leu …
New genetic methods and stem cell transplantation are also under investigation to further increase the quality and duration of life in affec …
Microglial Homeostasis Requires Balanced CSF-1/CSF-2 Receptor Signaling.
Chitu V, Biundo F, Shlager GGL, Park ES, Wang P, Gulinello ME, Gokhan Ş, Ketchum HC, Saha K, DeTure MA, Dickson DW, Wszolek ZK, Zheng D, Croxford AL, Becher B, Sun D, Mehler MF, Stanley ER. Chitu V, et al. Cell Rep. 2020 Mar 3;30(9):3004-3019.e5. doi: 10.1016/j.celrep.2020.02.028. Cell Rep. 2020. PMID: 32130903 Free PMC article.
CSF-1R haploinsufficiency causes adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP). Previous studies in the Csf1r(+/-) mouse model of ALSP hypothesized a central role of ele …
CSF-1R haploinsufficiency causes adult-onset leukoencephalopathy with axonal spheroids and …
Mutations in the human CSF1R gene impact microglia's maintenance of brain white matter integrity.
Du S, Zhou Y, Li D, Lier J, Cella M, Tada M, Hamasaki H, Wu J, Cai Z, Orthmann-Murphy JL, Kakita A, Kipnis J, Bergner CG, Colonna M. Du S, et al. Nat Immunol. 2025 Jul;26(7):1198-1211. doi: 10.1038/s41590-025-02195-7. Epub 2025 Jun 26. Nat Immunol. 2025. PMID: 40571738 Free PMC article.
Microglia, the brain's resident macrophages, depend on interleukin-34 and colony-stimulating factor 1 (CSF1) for their development and maintenance, engaging the CSF1 receptor (CSF1R). Adult-onset leukoencephalopathy with axonal spheroids …
Microglia, the brain's resident macrophages, depend on interleukin-34 and colony-stimulating factor 1 (CSF1) for their development and maint …
Analyzing bacterial extracellular vesicles in human body fluids by orthogonal biophysical separation and biochemical characterization.
Tulkens J, De Wever O, Hendrix A. Tulkens J, et al. Nat Protoc. 2020 Jan;15(1):40-67. doi: 10.1038/s41596-019-0236-5. Epub 2019 Nov 27. Nat Protoc. 2020. PMID: 31776460
Size separates BEVs from bacteria, flagella and cell debris in stool; and blood cells, high density lipoproteins (HDLs) and soluble proteins in blood. Density separates BEVs from fibers, protein aggregates and EEVs in stool; and low-density lipoproteins (LDLs), very-low-de …
Size separates BEVs from bacteria, flagella and cell debris in stool; and blood cells, high density lipoproteins (HDLs) and soluble p …
CSF1R-related leukoencephalopathy.
Shetty D, Desai A, Gupta V, Agarwal A. Shetty D, et al. J Clin Neurosci. 2023 Jul;113:60-61. doi: 10.1016/j.jocn.2023.05.008. Epub 2023 May 18. J Clin Neurosci. 2023. PMID: 37209513 No abstract available.
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia.
Wade C, Lynch DS. Wade C, et al. Handb Clin Neurol. 2024;204:263-271. doi: 10.1016/B978-0-323-99209-1.00005-3. Handb Clin Neurol. 2024. PMID: 39322383 Review.
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is an adult-onset, inherited white matter disorder encompassing two previously identified clinicopathologically similar entities: …
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia ( …
The Primary Microglial Leukodystrophies: A Review.
Ferrer I. Ferrer I. Int J Mol Sci. 2022 Jun 6;23(11):6341. doi: 10.3390/ijms23116341. Int J Mol Sci. 2022. PMID: 35683020 Free PMC article. Review.
Pigmented orthochromatic leukodystrophy, adult-onset orthochromatic leukodystrophy associated with pigmented macrophages, hereditary diffuse leukoencephalopathy with (axonal) spheroids, and adult-onset leukoencephalopathy with axonal spheroid …
Pigmented orthochromatic leukodystrophy, adult-onset orthochromatic leukodystrophy associated with pigmented macrophages, hereditary diffuse …
Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP): Estimation of pathological lesion stage from brain images.
Kinoshita M, Oyanagi K, Matsushima A, Kondo Y, Hirano S, Ishizawa K, Ishihara K, Terada S, Inoue T, Yazawa I, Washimi Y, Yamada M, Nakayama J, Mitsuyama Y, Ikeda SI, Sekijima Y. Kinoshita M, et al. J Neurol Sci. 2024 Jun 15;461:123027. doi: 10.1016/j.jns.2024.123027. Epub 2024 May 10. J Neurol Sci. 2024. PMID: 38805875
BACKGROUND: Adult-onset leukoencephalopathy with axonal spheroids and pigmented glia (ALSP) is a disease responsible for cognitive impairment in adult humans. ...METHODS: MRI images of eight patients with AL …
BACKGROUND: Adult-onset leukoencephalopathy with axonal spheroids and pigmented g …
132 results