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Ki-67 distribution, alpha-methylacyl-CoA racemase (AMACR) expression and mucin phenotypes are associated with non-polypoid growth in ulcerative colitis-associated neoplasia.
Okano S, Fukata M, Murakami T, Nojiri S, Kodama M, Abe K, Yamana T, Saito T, Yao T. Okano S, et al. Histopathology. 2024 Oct;85(4):671-685. doi: 10.1111/his.15243. Epub 2024 Jun 21. Histopathology. 2024. PMID: 39031700
UC lesions were divided into the conventional UCAN group, defined as p53 mutant pattern and normal expression of beta-catenin, and the non-conventional UCAN group, defined as the rest. Ki-67 distribution, alpha-methylacyl-CoA racemase (AMACR) ex …
UC lesions were divided into the conventional UCAN group, defined as p53 mutant pattern and normal expression of beta-catenin, and the non-c …
Redefining the phenotype of alpha-methylacyl-CoA racemase (AMACR) deficiency.
Klouwer FCC, Roosendaal SD, Hollak CEM, Langeveld M, Poll-The BT, Sorge AJV, Wolf NI, Knaap MSV, Engelen M. Klouwer FCC, et al. Orphanet J Rare Dis. 2024 Sep 23;19(1):350. doi: 10.1186/s13023-024-03358-9. Orphanet J Rare Dis. 2024. PMID: 39313810 Free PMC article.
BACKGROUND: Alpha-methylacyl-CoA racemase (AMACR) deficiency is a rare peroxisomal enzyme deficiency caused by biallelic variants in the AMACR gene. ...CONCLUSION: AMACR deficiency can be considered as an adult slowly progressive d …
BACKGROUND: Alpha-methylacyl-CoA racemase (AMACR) deficiency is a rare peroxisomal enzyme deficiency caus …
HMGCS2 and AMACR as potential targets linking mitochondrial dysfunction and ulcerative colitis.
Zhu R, Bai X, Li Z, Liang H, Song H, Chen L, Miao Y, Zhang F, Niu J. Zhu R, et al. Sci Rep. 2024 Dec 30;14(1):31783. doi: 10.1038/s41598-024-82900-y. Sci Rep. 2024. PMID: 39738583 Free PMC article.
In the inflammatory environment, knockout of both HMGCS2 and AMACR showed disruption of mitochondrial structure and function. Among them, the AMACR knockdown group had an increased number of damaged mitochondria and a significant reduction in the length, area and ci …
In the inflammatory environment, knockout of both HMGCS2 and AMACR showed disruption of mitochondrial structure and function. Among t …
Oncogenic Activity of Solute Carrier Family 45 Member 2 and Alpha-Methylacyl-Coenzyme A Racemase Gene Fusion Is Mediated by Mitogen-Activated Protein Kinase.
Zuo ZH, Yu YP, Ren BG, Liu S, Nelson J, Wang Z, Tao J, Pradhan-Sundd T, Bhargava R, Michalopoulos G, Chen Q, Zhang J, Ma D, Pennathur A, Luketich J, Satdarshan Monga P, Nalesnik M, Luo JH. Zuo ZH, et al. Hepatol Commun. 2022 Jan;6(1):209-222. doi: 10.1002/hep4.1724. Epub 2021 Sep 10. Hepatol Commun. 2022. PMID: 34505419 Free PMC article.
In this report, we show that gene fusion between solute carrier family 45 member 2 (SLC45A2) and alpha-methylacyl-coenzyme A racemase (AMACR) occurs in eight different types of human malignancies, with frequencies ranging from 45% to 97%. ...Conclusion: The gene fusion bet …
In this report, we show that gene fusion between solute carrier family 45 member 2 (SLC45A2) and alpha-methylacyl-coenzyme A racemase (AM …
Screening of differentially expressed genes and identification of AMACR as a prognostic marker in prostate cancer.
Fu P, Bu C, Cui B, Li N, Wu J. Fu P, et al. Andrologia. 2021 Jul;53(6):e14067. doi: 10.1111/and.14067. Epub 2021 Apr 16. Andrologia. 2021. PMID: 33861880
Further DEGs validation in TCGA and Human Protein Atlas Database identified AMACR as the core gene. We then analysed the role of AMACR in prostate cancer cell lines and found that AMACR-knockdown resulted in the decreased cell proliferation and increased apop …
Further DEGs validation in TCGA and Human Protein Atlas Database identified AMACR as the core gene. We then analysed the role of A …
Skin Phototype and Disease: A Comprehensive Genetic Approach to Pigmentary Traits Pleiotropy Using PRS in the GCAT Cohort.
Farré X, Blay N, Cortés B, Carreras A, Iraola-Guzmán S, de Cid R. Farré X, et al. Genes (Basel). 2023 Jan 5;14(1):149. doi: 10.3390/genes14010149. Genes (Basel). 2023. PMID: 36672889 Free PMC article.
Some of them have been widely reported, such as MC1R, HERC2, OCA2, TYR, TYRP1, SLC45A2, and some novel candidate genes C1QTNF3, LINC02876, and C1QTNF3-AMACR have not been reported in the GWAS Catalog, with regulatory potential. These results highlight the importance of the …
Some of them have been widely reported, such as MC1R, HERC2, OCA2, TYR, TYRP1, SLC45A2, and some novel candidate genes C1QTNF3, LINC02876, a …
Characterization and evaluation of gene fusions as a measure of genetic instability and disease prognosis in prostate cancer.
Schimmelpfennig C, Rade M, Füssel S, Löffler D, Blumert C, Bertram C, Borkowetz A, Otto DJ, Puppel SH, Hönscheid P, Sommer U, Baretton GB, Köhl U, Wirth M, Thomas C, Horn F, Kreuz M, Reiche K. Schimmelpfennig C, et al. BMC Cancer. 2023 Jun 22;23(1):575. doi: 10.1186/s12885-023-11019-6. BMC Cancer. 2023. PMID: 37349736 Free PMC article.
RESULTS: Our analyses identified two potential novel gene fusions, MBTTPS2,L0XNC01::SMS and AMACR::AMACR. These fusions were detected in all four studied cohorts, providing compelling evidence for the validity of these fusions and their relevance in PCa. ...
RESULTS: Our analyses identified two potential novel gene fusions, MBTTPS2,L0XNC01::SMS and AMACR::AMACR. These fusions were d …
LIN28B induces a differentiation program through CDX2 in colon cancer.
Suzuki K, Masuike Y, Mizuno R, Sachdeva UM, Chatterji P, Andres SF, Sun W, Klein-Szanto AJ, Besharati S, Remotti HE, Verzi MP, Rustgi AK. Suzuki K, et al. JCI Insight. 2021 May 10;6(9):e140382. doi: 10.1172/jci.insight.140382. JCI Insight. 2021. PMID: 33755595 Free PMC article.
Furthermore, LIN28B overexpression resulted in enhanced CDX2 expression to promote differentiation in subcutaneous xenograft tumors generated from CRC cells and metastatic tumor colonization through mesenchymal-epithelial transition in CRC liver metastasis mouse models. A ChIP se …
Furthermore, LIN28B overexpression resulted in enhanced CDX2 expression to promote differentiation in subcutaneous xenograft tumors generate …
Tracing TET1 expression in prostate cancer: discovery of malignant cells with a distinct oncogenic signature.
Schagdarsurengin U, Luo C, Slanina H, Sheridan D, Füssel S, Böğürcü-Seidel N, Gattenloehner S, Baretton GB, Hofbauer LC, Wagenlehner F, Dansranjav T. Schagdarsurengin U, et al. Clin Epigenetics. 2021 Nov 29;13(1):211. doi: 10.1186/s13148-021-01201-7. Clin Epigenetics. 2021. PMID: 34844636 Free PMC article.
In PCa, TET1 was frequently detected in alpha-methylacyl-CoA racemase (AMACR)-positive tumor cell clusters and was detectable at all tumor stages and Gleason scores. ...
In PCa, TET1 was frequently detected in alpha-methylacyl-CoA racemase (AMACR)-positive tumor cell cluster …
The role of FDX1 in granulosa cell of Polycystic ovary syndrome (PCOS).
Wang Z, Dong H, Yang L, Yi P, Wang Q, Huang D. Wang Z, et al. BMC Endocr Disord. 2021 Jun 15;21(1):119. doi: 10.1186/s12902-021-00775-w. BMC Endocr Disord. 2021. PMID: 34130686 Free PMC article.
Finally, five different genes including CYP11A1CYB5R1STARFDX1 and AMACR were obtained. RT-PCR was implemented to furtherly verify the downregulating mRNA of FDX1 in PCOS, which showed the consistent outcome with the transcriptomics. ...
Finally, five different genes including CYP11A1CYB5R1STARFDX1 and AMACR were obtained. RT-PCR was implemented to furtherly verify the …
33 results