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Epigenetic/circadian clocks and PCOS.
Vatier C, Christin-Maitre S. Vatier C, et al. Hum Reprod. 2024 Jun 3;39(6):1167-1175. doi: 10.1093/humrep/deae066. Hum Reprod. 2024. PMID: 38600622 Review.
Furthermore, several animal models have illustrated a link between prenatal exposure to androgens or anti-Mullerian hormone and PCOS-like phenotypes in subsequent generations, illustrating an epigenetic programming in PCOS. ...
Furthermore, several animal models have illustrated a link between prenatal exposure to androgens or anti-Mullerian hormone …
The Effects of Myo-Inositol and D-Chiro-Inositol in a Ratio 40:1 on Hormonal and Metabolic Profile in Women with Polycystic Ovary Syndrome Classified as Phenotype A by the Rotterdam Criteria and EMS-Type 1 by the EGOI Criteria.
Pustotina O, Myers SH, Unfer V, Rasulova I. Pustotina O, et al. Gynecol Obstet Invest. 2024;89(2):131-139. doi: 10.1159/000536163. Epub 2024 Jan 31. Gynecol Obstet Invest. 2024. PMID: 38295772 Free PMC article.
METHODS: The following were measured before and after treatment: serum levels of follicular stimulating hormone, luteinizing hormone (LH), estradiol, total and free testosterone, sex hormone-binding globulin (SHBG), free androgen index (FAI), anti-Mullerian hormo …
METHODS: The following were measured before and after treatment: serum levels of follicular stimulating hormone, luteinizing hormone (LH), e …
Transgenerational inheritance of diminished ovarian reserve triggered by prenatal propylparaben exposure in mice.
Li M, Wu Y, Wei S, Zhang T, Yan W, Gao Y, Chen Y, Hu D, Wu T, Li M, Wang W, Li Y, Zhou S, He X, Wang S, Zhang J. Li M, et al. Nat Commun. 2025 Sep 16;16(1):8289. doi: 10.1038/s41467-025-63440-z. Nat Commun. 2025. PMID: 40957879 Free PMC article.
Here, we further reveal that the DOR phenotypes can be transgenerationally inherited in F1-F3 mice, manifested through increased follicular atresia and decreased anti-Mullerian hormone levels. Excessive apoptosis of granulosa cells is found to underlie these …
Here, we further reveal that the DOR phenotypes can be transgenerationally inherited in F1-F3 mice, manifested through increased follicular …
Polycystic ovary syndrome (PCOS): progress towards a better understanding and treatment of the syndrome.
Mimouni NEH, Giacobini P. Mimouni NEH, et al. C R Biol. 2024 Apr 19;347:19-25. doi: 10.5802/crbiol.147. C R Biol. 2024. PMID: 38639155 Free article. Review.
However, the underlying mechanisms of its transmission remain unknown, thus limiting the development of effective therapeutic strategies.This article highlights how an altered fetal environment (prenatal exposure to high levels of anti-Mullerian hormone) can …
However, the underlying mechanisms of its transmission remain unknown, thus limiting the development of effective therapeutic strategies.Thi …
Multi-ancestry genome-wide association analyses of polycystic ovary syndrome.
Zhao H, Xu Y, Xue B, Zhao S, Zhang M, Wu XK, Wang T, Wen Y, Li S, Zhang Q, Yang Z, Sun H, Pan T, Lian Y, Gao X, Gao C, Wang Z, Wu C, Zhang C, Jian X, Peng L, Zhang X, Wang B, Wei L, He Y, Xia D, Wu Z, Yang Q, Sun Y, Ding Y, Du S, Xia G, Jing Y, Xu H, Shi W, Liu J, He L, Chen ZJ, Cao Y, Li Z, Shi Y. Zhao H, et al. Nat Genet. 2025 Nov;57(11):2669-2681. doi: 10.1038/s41588-025-02393-x. Epub 2025 Nov 4. Nat Genet. 2025. PMID: 41188533
Integrative functional analyses prioritized regulatory variants controlling gene activity in specific tissues, disease-causing genes including anti-Mullerian hormone (AMH), and biological pathways involving ligand-binding domain interactions and peroxi …
Integrative functional analyses prioritized regulatory variants controlling gene activity in specific tissues, disease-causing genes includi …
Anti-Mullerian hormone in PCOS: Molecular regulation and emerging therapeutic strategies.
Ke Y, Tang D, Yang Q, Zhao H, Zheng J, Zhu C. Ke Y, et al. Biomol Biomed. 2025 Apr 15;26(2):173-185. doi: 10.17305/bb.2025.12070. Biomol Biomed. 2025. PMID: 40257231 Free PMC article. Review.
Anti-Mullerian hormone (AMH), a glycoprotein belonging to the transforming growth factor-beta (TGF-beta) superfamily, is a key regulator of ovarian folliculogenesis. ...Particular attention is given to the downstream SMAD-dependent signaling cascade, w …
Anti-Mullerian hormone (AMH), a glycoprotein belonging to the transforming growth factor-beta (TGF-beta) superfa …
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Genetics of polycystic ovary syndrome (PCOS).
Louwers YV, Visser JA, Dunaif A, Laven JSE. Louwers YV, et al. Reproduction. 2025 Sep 26;170(5):e250126. doi: 10.1530/REP-25-0126. Print 2025 Nov 1. Reproduction. 2025. PMID: 40889231 Free PMC article. Review.
Next-generation sequencing has found rare variants in AMH, AMHR2, and DENND1A, supporting these genes' central role in developing PCOS. Epigenetic mechanisms, such as DNA methylation and non-coding RNAs, influence gene regulation and may contribute to phenotypic heterogene …
Next-generation sequencing has found rare variants in AMH, AMHR2, and DENND1A, supporting these genes' central role in developing PCO …
POLYCYSTIC OVARY SYNDROME: ORIGINS AND IMPLICATIONS: Gestational anti-Mullerian hormone and testosterone excess combined with maternal adiposity program for polycystic ovary syndrome.
Abbott DH, Levine JE, Dumesic PA, Padmanabhan V, Dumesic DA. Abbott DH, et al. Reproduction. 2025 Jul 22;170(2):e250120. doi: 10.1530/REP-25-0120. Print 2025 Aug 1. Reproduction. 2025. PMID: 40701177 Review.
IN BRIEF: A 'two hit' developmental origin involving testosterone and anti-Mullerian hormone is proposed to initiate PCOS pathogenesis during gestation. Epigenetic mechanisms amplify genetically heritable traits, while accompanying metabolic perturbations, in …
IN BRIEF: A 'two hit' developmental origin involving testosterone and anti-Mullerian hormone is proposed to initiate PC …
Clustering Identifies Subtypes With Different Phenotypic Characteristics in Women With Polycystic Ovary Syndrome.
van der Ham K, Moolhuijsen LME, Brewer K, Sisk R, Dunaif A, Laven JSE, Louwers YV, Visser JA. van der Ham K, et al. J Clin Endocrinol Metab. 2024 Nov 18;109(12):3096-3107. doi: 10.1210/clinem/dgae298. J Clin Endocrinol Metab. 2024. PMID: 38753423 Free PMC article.
Subtype characterization was performed by analyzing the variables estradiol, androstenedione, dehydroepiandrosterone, cortisol, anti-Mullerian hormone (AMH), total follicle count (TFC), lipid profile, and blood pressure. ...In addition to high LH and S …
Subtype characterization was performed by analyzing the variables estradiol, androstenedione, dehydroepiandrosterone, cortisol, anti- …
128 results