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2021 12
2022 23
2023 17
2024 4

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49 results

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Page 1
Malignant clonal evolution drives multiple myeloma cellular ecological diversity and microenvironment reprogramming.
Liang Y, He H, Wang W, Wang H, Mo S, Fu R, Liu X, Song Q, Xia Z, Wang L. Liang Y, et al. Mol Cancer. 2022 Sep 22;21(1):182. doi: 10.1186/s12943-022-01648-z. Mol Cancer. 2022. PMID: 36131282 Free PMC article.
RESULTS: The malignant mutation event was localized to the tumor cell clusters with shared mutation of ANK1 and IFITM2 in all malignant subpopulations of all MM patients. ...
RESULTS: The malignant mutation event was localized to the tumor cell clusters with shared mutation of ANK1 and IFITM2 in all maligna …
Literature review on genotype-phenotype correlation in patients with hereditary spherocytosis.
Yang L, Shu H, Zhou M, Gong Y. Yang L, et al. Clin Genet. 2022 Dec;102(6):474-482. doi: 10.1111/cge.14223. Epub 2022 Sep 26. Clin Genet. 2022. PMID: 36071563 Review.
Recently, next-generation sequencing (NGS) techniques have shown tremendous potential in the diagnosis of HS. HS commonly originates from variants in ANK1, SPTB, SLC4A1, SPTA1, and EPB42. This review is focused on 13 previous clinical studies on genotype-phenotype correlat …
Recently, next-generation sequencing (NGS) techniques have shown tremendous potential in the diagnosis of HS. HS commonly originates from va …
Genotype-degree of hemolysis correlation in hereditary spherocytosis.
Shi Y, Li Y, Yang X, Li X, Peng G, Zhao X, Liu X, Zhao Y, Hu J, Hu X, Zhang B, Zhou K, Yang Y, Xiong Y, Li J, Fan H, Yang W, Ye L, Jing L, Zhang L, Zhang F. Shi Y, et al. BMC Genomics. 2023 Jun 6;24(1):304. doi: 10.1186/s12864-023-09364-8. BMC Genomics. 2023. PMID: 37280519 Free PMC article.
The median RBC lifespan of patients with ANK1, SPTB and SLC4A1 mutations was 13 (8-23), 13 (8-48) and 14 (12-39) days, respectively, with no statistically significant difference (P = 0.618). ...In contrast, 46.7% of patients with severe hemolysis had ANK1 or SPTA1 m …
The median RBC lifespan of patients with ANK1, SPTB and SLC4A1 mutations was 13 (8-23), 13 (8-48) and 14 (12-39) days, respectively, …
Renin-angiotensin system and inflammation update.
Cantero-Navarro E, Fernández-Fernández B, Ramos AM, Rayego-Mateos S, Rodrigues-Diez RR, Sánchez-Niño MD, Sanz AB, Ruiz-Ortega M, Ortiz A. Cantero-Navarro E, et al. Mol Cell Endocrinol. 2021 Jun 1;529:111254. doi: 10.1016/j.mce.2021.111254. Epub 2021 Mar 30. Mol Cell Endocrinol. 2021. PMID: 33798633 Review.
We additionally discuss an often overlooked effect of the RAS on inflammation which is the downregulation of anti-inflammatory factors such as klotho, peroxisome proliferator-activated receptor gamma co-activator 1alpha (PGC-1alpha), transient receptor potential ankyrin …
We additionally discuss an often overlooked effect of the RAS on inflammation which is the downregulation of anti-inflammatory factors such …
TRPA1 activation and Hsp90 inhibition synergistically downregulate macrophage activation and inflammatory responses in vitro.
Radhakrishnan A, Mukherjee T, Mahish C, Kumar PS, Goswami C, Chattopadhyay S. Radhakrishnan A, et al. BMC Immunol. 2023 Jun 30;24(1):16. doi: 10.1186/s12865-023-00549-0. BMC Immunol. 2023. PMID: 37391696 Free PMC article.
BACKGROUND: Transient receptor potential ankyrin 1 (TRPA1) channels are known to be actively involved in various pathophysiological conditions, including neuronal inflammation, neuropathic pain, and various immunological responses. ...
BACKGROUND: Transient receptor potential ankyrin 1 (TRPA1) channels are known to be actively involved in various pathophysiolo …
Clinical and genetic diagnosis for 26 paitents with hereditary spherocytosis.
Bai L, Zheng L, Li B, Huang H, Shi X, Yi Y. Bai L, et al. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023 Apr 28;48(4):565-574. doi: 10.11817/j.issn.1672-7347.2023.220390. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2023. PMID: 37385619 Free PMC article. Chinese, English.
There were no significant differences in peripheral blood cell parameters and hemolysis indicators between the SPTB mutant group and the ANK1 mutant group (all P>0.05). The rate of splenectomy in ANK1 mutation group was higher than that in SPTB mutation group, an …
There were no significant differences in peripheral blood cell parameters and hemolysis indicators between the SPTB mutant group and the …
Sex differences of the shared genetic landscapes between type 2 diabetes and peripheral artery disease in East Asians and Europeans.
Lu Z, Zhang H, Yang Y, Zhao H. Lu Z, et al. Hum Genet. 2023 Jul;142(7):965-980. doi: 10.1007/s00439-023-02573-x. Epub 2023 Jun 21. Hum Genet. 2023. PMID: 37341850
East Asian females exhibit higher causal effects of T2D on PAD than males. The gene-level analysis found KCNJ11 and ANK1 genes associated with the cross-trait of T2D and PAD in both sexes. ...
East Asian females exhibit higher causal effects of T2D on PAD than males. The gene-level analysis found KCNJ11 and ANK1 genes associ …
Transient Receptor Potential Channel Ankyrin 1: A Unique Regulator of Vascular Function.
Alvarado MG, Thakore P, Earley S. Alvarado MG, et al. Cells. 2021 May 11;10(5):1167. doi: 10.3390/cells10051167. Cells. 2021. PMID: 34064835 Free PMC article. Review.
TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a Ca(2+)-permeable, non-selective cation channel. ...
TRPA1 (transient receptor potential ankyrin 1), the lone member of the mammalian ankyrin TRP subfamily, is a Ca(2+)-permeable, …
Targeting novel human transient receptor potential ankyrin 1 splice variation with splice-switching antisense oligonucleotides.
Huang H, Tay SH, Ng W, Ng SY, Soong TW. Huang H, et al. Pain. 2021 Jul 1;162(7):2097-2109. doi: 10.1097/j.pain.0000000000002216. Pain. 2021. PMID: 33938719 Free PMC article.
Activation of transient receptor potential ankyrin 1 (TRPA1) channels by both environmental irritants and endogenous inflammatory mediators leads to excitation of the nerve endings, resulting in acute sensation of pain, itch, or chronic neurogenic inflammation. ...
Activation of transient receptor potential ankyrin 1 (TRPA1) channels by both environmental irritants and endogenous inflammat …
49 results