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Rare Genetic Variants in LDLR, APOB, and PCSK9 Are Associated With Aortic Stenosis.
Rämö JT, Jurgens SJ, Kany S, Choi SH, Wang X, Smirnov AN, Friedman SF, Maddah M, Khurshid S, Ellinor PT, Pirruccello JP. Rämö JT, et al. Circulation. 2024 Nov 26;150(22):1767-1780. doi: 10.1161/CIRCULATIONAHA.124.070982. Epub 2024 Sep 2. Circulation. 2024. PMID: 39222019 Free PMC article.
We aimed to assess the impact on AS and peak velocity across the aortic valve conferred by lifelong alterations in LDL-C levels mediated by protein-disrupting variants in 3 clinically significant genes for LDL (low-density lipoprotein) metabolism (LDLR, APOB, and PCSK9). M …
We aimed to assess the impact on AS and peak velocity across the aortic valve conferred by lifelong alterations in LDL-C levels mediated by …
Zebrafish ApoB-Containing Lipoprotein Metabolism: A Closer Look.
Moll TOC, Farber SA. Moll TOC, et al. Arterioscler Thromb Vasc Biol. 2024 May;44(5):1053-1064. doi: 10.1161/ATVBAHA.123.318287. Epub 2024 Mar 14. Arterioscler Thromb Vasc Biol. 2024. PMID: 38482694 Free PMC article. Review.
Recent work revealed that any disturbance of lipoprotein formation leads to the accumulation of cytoplasmic lipid droplets and an opaque yolk, providing a visible phenotype to investigate disturbances of the lipoprotein pathway, already leading to discoveries in MTTP (microsomal …
Recent work revealed that any disturbance of lipoprotein formation leads to the accumulation of cytoplasmic lipid droplets and an opaque yol …
Apolipoprotein B gene expression and regulation in relation to Alzheimer's disease pathophysiology.
Aumont-Rodrigue G, Picard C, Labonté A, Poirier J. Aumont-Rodrigue G, et al. J Lipid Res. 2024 Nov;65(11):100667. doi: 10.1016/j.jlr.2024.100667. Epub 2024 Oct 10. J Lipid Res. 2024. PMID: 39395793 Free PMC article.
Apolipoprotein B (APOB), a receptor-binding protein present in cholesterol-rich lipoproteins, has been implicated in Alzheimer's disease (AD). ...Rare coding mutations in the APOB gene are associated with familial AD, suggesting a role for APOB- …
Apolipoprotein B (APOB), a receptor-binding protein present in cholesterol-rich lipoproteins, has been implicated in Al …
MicroRNA-615-3p decreases apo B expression in human liver cells.
Ansari A, Yadav PK, Valmiki S, Laine A, Rimbert A, Islam S, Osman I, Najafi-Shoushtari SH, Hussain MM. Ansari A, et al. J Lipid Res. 2024 Oct;65(10):100659. doi: 10.1016/j.jlr.2024.100659. Epub 2024 Sep 26. J Lipid Res. 2024. PMID: 39332527 Free PMC article.
Plasma lipids are mainly carried in apolipoprotein B (apoB) containing lipoproteins. High levels of these lipoproteins are associated with several metabolic diseases and lowering their plasma levels is associated with reduced incidence of atherosclerotic card …
Plasma lipids are mainly carried in apolipoprotein B (apoB) containing lipoproteins. High levels of these lipoproteins …
Hepatic Inactivation of Carnitine Palmitoyltransferase 1a Lowers ApoB-Containing Lipoproteins in Mice.
Helsley RN, Zelows MM, Noffsinger VP, Anspach GB, Dharanipragada N, Mead AE, Cobo I, Carter A, Wu Q, Shalaurova I, Saito K, Morganti JM, Gordon SM, Graf GA. Helsley RN, et al. Arterioscler Thromb Vasc Biol. 2025 Aug;45(8):1368-1388. doi: 10.1161/ATVBAHA.125.322473. Epub 2025 Jun 12. Arterioscler Thromb Vasc Biol. 2025. PMID: 40501382 Free PMC article.
Mechanistic studies show that both wild-type and human apo B(100) (apoB)-transgenic mice with liver-specific deletion of Cpt1a (liver-specific knockout) display lower circulating apoB levels consistent with reduced LDL (low-density lipoprotein)-cholesterol and LDL p …
Mechanistic studies show that both wild-type and human apo B(100) (apoB)-transgenic mice with liver-specific deletion of Cpt1a (liver …
Rbm39 ameliorates metabolic dysfunction-associated steatotic liver disease by regulating Apob and Fabp4.
Zhuang C, Cui F, Chen J, He D, Sun T, Wang P. Zhuang C, et al. Biochim Biophys Acta Mol Basis Dis. 2025 Jun;1871(5):167815. doi: 10.1016/j.bbadis.2025.167815. Epub 2025 Mar 26. Biochim Biophys Acta Mol Basis Dis. 2025. PMID: 40147697
RNA sequencing data analysis indicated that Rbm39 regulated the expression of apolipoprotein B (Apob) and fatty acid-binding protein 4 (Fabp4), both of which are crucial for lipid transport. Mechanistically, Rbm39 enhanced the transcription of Apob by …
RNA sequencing data analysis indicated that Rbm39 regulated the expression of apolipoprotein B (Apob) and fatty acid-bi …
The ApoB/ApoA-I ratio supersedes conventional lipids in predicting coronary artery disease and clinical phenotypes requiring revascularization.
Jiang Y, He L, Hu D, Chen K, Li L, Fu J, Zhou B. Jiang Y, et al. Clin Exp Hypertens. 2026 Dec 31;48(1):2603463. doi: 10.1080/10641963.2025.2603463. Epub 2025 Dec 22. Clin Exp Hypertens. 2026. PMID: 41430776 Free article.
OBJECTIVE: To evaluate the apolipoprotein B (ApoB) to apolipoprotein A-I (ApoA-I) ratio as a biomarker for coronary heart disease (CHD) and its clinical phenotypes, beyond traditional lipid parameters. ...Multivariable logistic regression assessed the indepen …
OBJECTIVE: To evaluate the apolipoprotein B (ApoB) to apolipoprotein A-I (ApoA-I) ratio as a biomarker for coronary hea …
Genetic association analyses highlight apolipoprotein B as a determinant of chronic kidney disease in patients with type 2 diabetes.
Wang Z, Zhang J, Jiao F, Wu Y, Han L, Jiang G. Wang Z, et al. J Clin Lipidol. 2024 Sep-Oct;18(5):e787-e796. doi: 10.1016/j.jacl.2024.07.004. Epub 2024 Jul 17. J Clin Lipidol. 2024. PMID: 39278771
The 10-year predicted probabilities of CKD were evaluated via integrating MR and Cox models. RESULTS: Higher GRS of apolipoprotein B (ApoB) was associated with an increased CKD risk (hazard ratio (HR) [95% confidence interval (CI)]:1.07[1.02,1.13] per SD; P = …
The 10-year predicted probabilities of CKD were evaluated via integrating MR and Cox models. RESULTS: Higher GRS of apolipoprotein …
Minigene splicing reporter assay: a high-stake tool for genetic diagnosis in familial hypobetalipoproteinemia.
Henry Z, Janin A, Nony S, Marmontel O, Charrière S, Moulin P, Marrec M, Wargny M, Cariou B, Di Filippo M. Henry Z, et al. Atherosclerosis. 2025 Jun;405:119236. doi: 10.1016/j.atherosclerosis.2025.119236. Epub 2025 May 10. Atherosclerosis. 2025. PMID: 40367726
BACKGROUND & AIMS: Familial hypobetalipoproteinemia 1 (FHBL-SD2) is the most common monogenic form of primary hypocholesterolaemia, related to truncating variants in the APOB gene encoding apolipoprotein B. Due to its high level of complexity, variants of …
BACKGROUND & AIMS: Familial hypobetalipoproteinemia 1 (FHBL-SD2) is the most common monogenic form of primary hypocholesterolaemia, rela …
39 results