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Diabetes insipidus.
Christ-Crain M, Gaisl O. Christ-Crain M, et al. Presse Med. 2021 Dec;50(4):104093. doi: 10.1016/j.lpm.2021.104093. Epub 2021 Oct 27. Presse Med. 2021. PMID: 34718110 Free article. Review.
In most cases central and nephrogenic DI are acquired, but there are also congenital forms caused by genetic mutations of the AVP gene (central DI) [3] or by mutations in the gene for the AVP V2R or the AQP2 water channel (nephrogenic DI) [4]. Primary polydipsia (PP) as se …
In most cases central and nephrogenic DI are acquired, but there are also congenital forms caused by genetic mutations of the AVP gene (cent …
Micropeptide MIAC inhibits the tumor progression by interacting with AQP2 and inhibiting EREG/EGFR signaling in renal cell carcinoma.
Li M, Liu G, Jin X, Guo H, Setrerrahmane S, Xu X, Li T, Lin Y, Xu H. Li M, et al. Mol Cancer. 2022 Sep 19;21(1):181. doi: 10.1186/s12943-022-01654-1. Mol Cancer. 2022. PMID: 36117171 Free PMC article.
Further mechanistic studies have demonstrated that MIAC directly bind to AQP2 protein, inhibit EREG/EGFR expression and activate downstream pathways PI3K/AKT and MAPK to achieve anti-tumor effects. CONCLUSIONS: This study revealed for the first time the tumor suppressor po …
Further mechanistic studies have demonstrated that MIAC directly bind to AQP2 protein, inhibit EREG/EGFR expression and activate down …
The vasopressin-aquaporin-2 pathway syndromes.
Valenti G, Tamma G. Valenti G, et al. Handb Clin Neurol. 2021;181:249-259. doi: 10.1016/B978-0-12-820683-6.00018-X. Handb Clin Neurol. 2021. PMID: 34238461 Review.
In the renal collecting duct, vasopressin binds to the V2 receptor, increasing water permeability through activation of aquaporin-2 redistribution to the luminal membrane. This mechanism promotes rapid water reabsorption, important for immediate survival; however, o …
In the renal collecting duct, vasopressin binds to the V2 receptor, increasing water permeability through activation of aquaporin- …
Updates and Perspectives on Aquaporin-2 and Water Balance Disorders.
Noda Y, Sasaki S. Noda Y, et al. Int J Mol Sci. 2021 Nov 30;22(23):12950. doi: 10.3390/ijms222312950. Int J Mol Sci. 2021. PMID: 34884753 Free PMC article. Review.
One of the key factors in the maintenance of body water balance is water reabsorption in the collecting ducts of the kidney, a process that is regulated by aquaporin-2 (AQP2). AQP2 is a channel that is exclusively selective for water molecules and impe …
One of the key factors in the maintenance of body water balance is water reabsorption in the collecting ducts of the kidney, a process that …
Proteomics and AQP2 regulation.
Yang CR, Park E, Chen L, Datta A, Chou CL, Knepper MA. Yang CR, et al. J Physiol. 2024 Jul;602(13):3011-3023. doi: 10.1113/JP283899. Epub 2023 Jan 12. J Physiol. 2024. PMID: 36571566 Free PMC article. Review.
Here, we discuss these methodologies and show how they can be applied to understand the effects of the peptide hormone vasopressin to regulate the molecular water channel aquaporin-2. The emerging picture provides a detailed framework for understanding the molecular …
Here, we discuss these methodologies and show how they can be applied to understand the effects of the peptide hormone vasopressin to regula …
Genetic basis of nephrogenic diabetes insipidus.
Hureaux M, Vargas-Poussou R. Hureaux M, et al. Mol Cell Endocrinol. 2023 Jan 15;560:111825. doi: 10.1016/j.mce.2022.111825. Epub 2022 Nov 30. Mol Cell Endocrinol. 2023. PMID: 36460218 Review.
Hereditary forms are caused by molecular defects in the genes encoding either of the two main renal effectors of the arginine vasopressin pathway: the AVPR2 gene, which encodes for the type 2 vasopressin receptor, or the AQP2 gene, which encodes for the water channel aq …
Hereditary forms are caused by molecular defects in the genes encoding either of the two main renal effectors of the arginine vasopressin pa …
Mechanistic complement of autosomal dominant polycystic kidney disease: the role of aquaporins.
Lan Q, Li J, Zhang H, Zhou Z, Fang Y, Yang B. Lan Q, et al. J Mol Med (Berl). 2024 Jun;102(6):773-785. doi: 10.1007/s00109-024-02446-4. Epub 2024 Apr 26. J Mol Med (Berl). 2024. PMID: 38668786 Review.
Experimental evidence suggests that aquaporins, a class of transmembrane channel proteins, including aquaporin-1, aquaporin-2, aquaporin-3, and aquaporin-11, are involved in the mechanism of autosomal dominant polycystic kidney disease. ...
Experimental evidence suggests that aquaporins, a class of transmembrane channel proteins, including aquaporin-1, aquaporin-2, …
Genes and single nucleotide polymorphisms in the pathway of saliva and dental caries: a systematic review and meta-analysis.
Chisini LA, Varella de Carvalho R, Dos Santos Costa F, Salvi LC, Demarco FF, Britto Correa M. Chisini LA, et al. Biofouling. 2023 Jan;39(1):8-23. doi: 10.1080/08927014.2022.2162891. Epub 2023 Jan 16. Biofouling. 2023. PMID: 36644905
Forty-four SNPS, covering four genes (CA6, AQP2, AQP5, and MUC5B) were identified. Most of the SNPs were not associated with caries in meta-analysis. ...
Forty-four SNPS, covering four genes (CA6, AQP2, AQP5, and MUC5B) were identified. Most of the SNPs were not associated with caries i …
AQP2: Mutations Associated with Congenital Nephrogenic Diabetes Insipidus and Regulation by Post-Translational Modifications and Protein-Protein Interactions.
Gao C, Higgins PJ, Zhang W. Gao C, et al. Cells. 2020 Sep 26;9(10):2172. doi: 10.3390/cells9102172. Cells. 2020. PMID: 32993088 Free PMC article. Review.
The principal cell-specific water channel aquaporin-2 (AQP2) plays an essential role in water reabsorption along osmotic gradients. ...Mutations in AVPR2 result in X-linked recessive NDI, the most common form of inherited NDI. Genetic defects in AQP2 c …
The principal cell-specific water channel aquaporin-2 (AQP2) plays an essential role in water reabsorption along osmoti …
Altered Iris Aquaporin Expression and Aqueous Humor Osmolality in Glaucoma.
Huang OS, Seet LF, Ho HW, Chu SW, Narayanaswamy A, Perera SA, Husain R, Aung T, Wong TT. Huang OS, et al. Invest Ophthalmol Vis Sci. 2021 Feb 1;62(2):34. doi: 10.1167/iovs.62.2.34. Invest Ophthalmol Vis Sci. 2021. PMID: 33616622 Free PMC article.
RESULTS: Of the five AQP genes evaluated, AQP1 and AQP2 transcripts were significantly upregulated in both PACG (3.48- and 8.07-fold, respectively) and POAG (3.12- and 11.58-fold, respectively) irises relative to nonglaucoma counterparts. ...CONCLUSIONS: PACG and POAG eyes …
RESULTS: Of the five AQP genes evaluated, AQP1 and AQP2 transcripts were significantly upregulated in both PACG (3.48- and 8.07-fold, …
29 results