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Year Number of Results
2019 5
2020 14
2021 9
2022 6
2023 6
2024 2

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ZBTB1 Regulates Asparagine Synthesis and Leukemia Cell Response to L-Asparaginase.
Williams RT, Guarecuco R, Gates LA, Barrows D, Passarelli MC, Carey B, Baudrier L, Jeewajee S, La K, Prizer B, Malik S, Garcia-Bermudez J, Zhu XG, Cantor J, Molina H, Carroll T, Roeder RG, Abdel-Wahab O, Allis CD, Birsoy K. Williams RT, et al. Cell Metab. 2020 Apr 7;31(4):852-861.e6. doi: 10.1016/j.cmet.2020.03.008. Cell Metab. 2020. PMID: 32268116 Free PMC article.
ZBTB1 knockout cells are unable to synthesize asparagine due to reduced expression of asparagine synthetase (ASNS), the enzyme responsible for asparagine synthesis. Mechanistically, ZBTB1 binds to the ASNS promoter and promotes ASNS transcriptio …
ZBTB1 knockout cells are unable to synthesize asparagine due to reduced expression of asparagine synthetase (ASNS), the …
Targeting TLK2 inhibits the progression of gastric cancer by reprogramming amino acid metabolism through the mTOR/ASNS axis.
Wang M, Li J, Yang X, Yan Q, Wang H, Xu X, Lu Y, Li D, Wang Y, Sun R, Zhang S, Zhang Y, Zhang Z, Meng F, Li Y. Wang M, et al. Cancer Gene Ther. 2023 Nov;30(11):1485-1497. doi: 10.1038/s41417-023-00653-8. Epub 2023 Aug 4. Cancer Gene Ther. 2023. PMID: 37542132
Inhibiting and activating the mTORC1 pathway can upregulate and downregulate ASNS ubiquitination, respectively, and the mTORC1 pathway can reverse the regulatory effects of TLK2 on ASNS. Furthermore, TLK2 was found to regulate the mRNA expression of ASNS. TLK …
Inhibiting and activating the mTORC1 pathway can upregulate and downregulate ASNS ubiquitination, respectively, and the mTORC1 pathwa …
Multiomics analysis of adaptation to repeated DNA damage in prostate cancer cells.
Challis D, Lippis T, Wilson R, Wilkinson E, Dickinson J, Black A, Azimi I, Holloway A, Taberlay P, Brettingham-Moore K. Challis D, et al. Epigenetics. 2023 Dec;18(1):2214047. doi: 10.1080/15592294.2023.2214047. Epigenetics. 2023. PMID: 37196186 Free PMC article.
Total DNA methylation was increased while RNA-seq demonstrated these cells had dysregulated expression of genes involved in metabolism and the unfolded protein response (UPR) with Asparagine synthetase (ASNS) identified as central to this process. ...Together …
Total DNA methylation was increased while RNA-seq demonstrated these cells had dysregulated expression of genes involved in metabolism and t …
Association of aberrant ASNS imprinting with asparaginase sensitivity and chromosomal abnormality in childhood BCP-ALL.
Watanabe A, Miyake K, Nordlund J, Syvänen AC, van der Weyden L, Honda H, Yamasaki N, Nagamachi A, Inaba T, Ikawa T, Urayama KY, Kiyokawa N, Ohara A, Kimura S, Kubota Y, Takita J, Goto H, Sakaguchi K, Minegishi M, Iwamoto S, Shinohara T, Kagami K, Abe M, Akahane K, Goi K, Sugita K, Inukai T. Watanabe A, et al. Blood. 2020 Nov 12;136(20):2319-2333. doi: 10.1182/blood.2019004090. Blood. 2020. PMID: 32573712 Free PMC article.
Asparaginase therapy depletes serum asparagine. Normal hematopoietic cells can produce asparagine by asparagine synthetase (ASNS) activity, but ALL cells are unable to synthesize adequate amounts of asparagine. The ASNS gene has a typical CpG island in …
Asparaginase therapy depletes serum asparagine. Normal hematopoietic cells can produce asparagine by asparagine synthetase ( …
Association of allele-specific methylation of the ASNS gene with asparaginase sensitivity and prognosis in T-ALL.
Akahane K, Kimura S, Miyake K, Watanabe A, Kagami K, Yoshimura K, Shinohara T, Harama D, Kasai S, Goi K, Kawai T, Hata K, Kiyokawa N, Koh K, Imamura T, Horibe K, Look AT, Minegishi M, Sugita K, Takita J, Inukai T. Akahane K, et al. Blood Adv. 2022 Jan 11;6(1):212-224. doi: 10.1182/bloodadvances.2021004271. Blood Adv. 2022. PMID: 34535013 Free PMC article.
Asparaginase depletes serum asparagine by deamination into aspartic acid. Normal hematopoietic cells can survive due to asparagine synthetase (ASNS) activity, whereas leukemia cells are supposed to undergo apoptosis due to silencing of the ASNS gene. . …
Asparaginase depletes serum asparagine by deamination into aspartic acid. Normal hematopoietic cells can survive due to asparagine
Utility of ASNS gene methylation evaluated with the HPLC method as a pharmacogenomic biomarker to predict asparaginase sensitivity in BCP-ALL.
Watanabe A, Miyake K, Yamada Y, Sunamura EI, Yotani T, Kagami K, Kasai S, Tamai M, Harama D, Akahane K, Goi K, Sakaguchi K, Goto H, Kitahara S, Inukai T. Watanabe A, et al. Epigenetics. 2023 Dec;18(1):2268814. doi: 10.1080/15592294.2023.2268814. Epub 2023 Oct 15. Epigenetics. 2023. PMID: 37839090 Free PMC article.
Asparaginase depletes serum asparagine by deaminating asparagine into aspartic acid, and ALL cells are thought to be sensitive to asparaginase due to reduced asparagine synthetase (ASNS) activity. We have recently shown that allele-specific methylation of the …
Asparaginase depletes serum asparagine by deaminating asparagine into aspartic acid, and ALL cells are thought to be sensitive to asparagina …
A novel compound heterozygous missense mutation in ASNS broadens the spectrum of asparagine synthetase deficiency.
Wang C, He G, Ge Y, Li R, Li Z, Lin Y. Wang C, et al. Mol Genet Genomic Med. 2020 Jun;8(6):e1235. doi: 10.1002/mgg3.1235. Epub 2020 Apr 7. Mol Genet Genomic Med. 2020. PMID: 32255274 Free PMC article. Review.
BACKGROUND: Asparagine synthetase deficiency (ASNSD) is a rare pediatric congenital disorder that clinically manifests into severe progressive microcephaly, global developmental delay, spastic quadriplegia, and refractory seizures. ASNSD is caused by inheritable aut …
BACKGROUND: Asparagine synthetase deficiency (ASNSD) is a rare pediatric congenital disorder that clinically manifests into se …
NUCKS1, a LINC00629-upregulated gene, facilitated osteosarcoma progression and metastasis by elevating asparagine synthesis.
Zheng S, Ji R, He H, Li N, Han C, Han J, Li X, Zhang L, Wang Y, Zhao W. Zheng S, et al. Cell Death Dis. 2023 Aug 1;14(8):489. doi: 10.1038/s41419-023-06010-9. Cell Death Dis. 2023. PMID: 37528150 Free PMC article.
Mechanistically, NUCKS1 facilitated asparagine (Asn) synthesis by transcriptionally upregulating asparagine synthetase (ASNS) expression and elevating the levels of Asn in osteosarcoma cells, leading to increased cell growth and metastasis. Inhibition of A
Mechanistically, NUCKS1 facilitated asparagine (Asn) synthesis by transcriptionally upregulating asparagine synthetase (ASN
In vitro functional analysis of four variants of human asparagine synthetase.
Matsumoto H, Kawashima N, Yamamoto T, Nakama M, Otsuka H, Ago Y, Sasai H, Kubota K, Ozeki M, Kawamoto N, Esaka Y, Ohnishi H. Matsumoto H, et al. J Inherit Metab Dis. 2021 Sep;44(5):1226-1234. doi: 10.1002/jimd.12408. Epub 2021 Jun 9. J Inherit Metab Dis. 2021. PMID: 34080208
The loss-of-function variants of the human asparagine synthetase (ASNS) gene cause asparagine synthetase deficiency (ASNSD). ...The four ASNS variants displayed significantly low enzymatic activity. The ASNS deficient HEK293 cells …
The loss-of-function variants of the human asparagine synthetase (ASNS) gene cause asparagine synthetase
An intractable epilepsy phenotype of ASNS novel mutation in two patients with asparagine synthetase deficiency.
Liu L, Wang J, Li H, Dong Y, Li Y, Xia L, Yang B, Wang H, Xu Y, Cheng G, Du K, Zhang X, Zhu C, Cui S, Ren C. Liu L, et al. Clin Chim Acta. 2022 Jun 1;531:331-336. doi: 10.1016/j.cca.2022.04.989. Epub 2022 Apr 22. Clin Chim Acta. 2022. PMID: 35469797
BACKGROUND AND OBJECTIVE: Asparagine synthetase deficiency (ASNSD) is a rare neurometabolic disease caused by variations of the ASNS gene. ...This study has expanded the disease phenotype spectrum of ASNSD and broadened the variation profile of the ASNS
BACKGROUND AND OBJECTIVE: Asparagine synthetase deficiency (ASNSD) is a rare neurometabolic disease caused by variations of th …
39 results