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2015 2
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Page 1
Aurora kinase genetic polymorphisms: an association study in Down syndrome and spontaneous abortion.
de Castro CML, Pereira COB, Aprigio J, Costa Lima MA, Ribeiro MG, Amorim MR. de Castro CML, et al. Hum Cell. 2022 May;35(3):849-855. doi: 10.1007/s13577-022-00686-5. Epub 2022 Feb 26. Hum Cell. 2022. PMID: 35218477
A: OR 2.08, 95% CI 1.12-3.90, p = 0.02) and AURKC rs758099 (TT vs. CC: OR 4.34, 95% CI 1.03-18.02, p = 0.04; TT + CT vs. CC: OR 2.52, 95% CI 1.02-6.23, p = 0.04; T vs. ...Our study suggests a possible relationship between AURKA/AURKC variants and increased risk of s …
A: OR 2.08, 95% CI 1.12-3.90, p = 0.02) and AURKC rs758099 (TT vs. CC: OR 4.34, 95% CI 1.03-18.02, p = 0.04; TT + CT vs. CC: OR 2.52, …
Genetic etiological spectrum of sperm morphological abnormalities.
Arora M, Mehta P, Sethi S, Anifandis G, Samara M, Singh R. Arora M, et al. J Assist Reprod Genet. 2024 Nov;41(11):2877-2929. doi: 10.1007/s10815-024-03274-8. Epub 2024 Oct 17. J Assist Reprod Genet. 2024. PMID: 39417902 Review.
RESULTS: Mutations in the SUN5, CEP112, BRDT, DNAH6, PMFBP1, TSGA10, and SPATA20 genes result in acephalic sperm; mutations in the DPY19L2, SPATA16, PICK1, CCNB3, CHPT1, PIWIL4, and TDRD9 genes cause globozoospermia; mutations in the AURKC gene cause macrozoospermia; mutat …
RESULTS: Mutations in the SUN5, CEP112, BRDT, DNAH6, PMFBP1, TSGA10, and SPATA20 genes result in acephalic sperm; mutations in the DPY19L2, …
The oncogenic role of meiosis-specific Aurora kinase C in mitotic cells.
Bejar JF, DiSanza Z, Quartuccio SM. Bejar JF, et al. Exp Cell Res. 2021 Oct 15;407(2):112803. doi: 10.1016/j.yexcr.2021.112803. Epub 2021 Aug 27. Exp Cell Res. 2021. PMID: 34461108
Aberrant expression of meiosis-specific genes in cancer has recently emerged as a driver of some cancer formation. Aurora kinase C (AURKC) is a member of the Aurora kinase family of proteins known to regulate chromosome segregation during cell division …
Aberrant expression of meiosis-specific genes in cancer has recently emerged as a driver of some cancer formation. Aurora kinase …
Computational study of the potential impact of AURKC missense SNPs on AURKC-INCENP interaction and their correlation to macrozoospermia.
Redouane S, Charoute H, Harmak H, Malki A, Barakat A, Rouba H. Redouane S, et al. J Biomol Struct Dyn. 2023 Nov;41(19):9503-9522. doi: 10.1080/07391102.2022.2142846. Epub 2022 Nov 3. J Biomol Struct Dyn. 2023. PMID: 36326488
Aurora Kinase C (AURKC) is considered an important element in Chromosome Passenger Complex (CPC), its interaction with Inner Centromere Protein (INCENP) plays a critical role in the establishment and the recruitment of a stable CPC during spermatogenes …
Aurora Kinase C (AURKC) is considered an important element in Chromosome Passenger Complex (CPC), its interactio …
Identification and characterization of Aurora kinase B and C variants associated with maternal aneuploidy.
Nguyen AL, Marin D, Zhou A, Gentilello AS, Smoak EM, Cao Z, Fedick A, Wang Y, Taylor D, Scott RT Jr, Xing J, Treff N, Schindler K. Nguyen AL, et al. Mol Hum Reprod. 2017 Jun 1;23(6):406-416. doi: 10.1093/molehr/gax018. Mol Hum Reprod. 2017. PMID: 28369513 Free PMC article.
STUDY QUESTION: Are single nucleotide variants (SNVs) in Aurora kinases B and C (AURKB, AURKC) associated with risk of aneuploid conception? SUMMARY ANSWER: Two SNVs were found in patients with extreme aneuploid concepti rates with respect to their age; one variant, AUR …
STUDY QUESTION: Are single nucleotide variants (SNVs) in Aurora kinases B and C (AURKB, AURKC) associated with risk of aneuploid conc …
Aurora Kinase B Inhibition: A Potential Therapeutic Strategy for Cancer.
Borah NA, Reddy MM. Borah NA, et al. Molecules. 2021 Apr 1;26(7):1981. doi: 10.3390/molecules26071981. Molecules. 2021. PMID: 33915740 Free PMC article. Review.
Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the aurora kinase family along with aurora kinase A (AURKA) and aurora kinase C (AURKC). AURKB is a member of the chromosomal passenger protein complex and plays a rol …
Aurora kinase B (AURKB) is a mitotic serine/threonine protein kinase that belongs to the aurora kinase family along with aurora kinase A (AU …
Characterization of macrozoospermia-associated AURKC mutations in a mammalian meiotic system.
Fellmeth JE, Ghanaim EM, Schindler K. Fellmeth JE, et al. Hum Mol Genet. 2016 Jul 1;25(13):2698-2711. doi: 10.1093/hmg/ddw128. Epub 2016 Apr 22. Hum Mol Genet. 2016. PMID: 27106102
Aneuploidy is the leading genetic abnormality that leads to miscarriage, and it is caused by a failure of accurate chromosome segregation during gametogenesis or early embryonic divisions. Aurora kinase C (AURKC) is essential for formation of euploid s …
Aneuploidy is the leading genetic abnormality that leads to miscarriage, and it is caused by a failure of accurate chromosome segregation du …
Male infertility and its genetic causes.
Miyamoto T, Minase G, Okabe K, Ueda H, Sengoku K. Miyamoto T, et al. J Obstet Gynaecol Res. 2015 Oct;41(10):1501-5. doi: 10.1111/jog.12765. Epub 2015 Jul 14. J Obstet Gynaecol Res. 2015. PMID: 26178295 Review.
We discuss here the contribution to male factor infertility of a number of genes identified in the azoospermia factor (AZF) region on the Y chromosome, as well as the autosomally located genes: SYKP3, KLHL10, AURKC and SPATA16. CONCLUSIONS: Non-obstructive azoospermia is t …
We discuss here the contribution to male factor infertility of a number of genes identified in the azoospermia factor (AZF) region on the Y …
From azoospermia to macrozoospermia, a phenotypic continuum due to mutations in the ZMYND15 gene.
Kherraf ZE, Cazin C, Lestrade F, Muronova J, Coutton C, Arnoult C, Thierry-Mieg N, Ray PF. Kherraf ZE, et al. Asian J Androl. 2022 May-Jun;24(3):243-247. doi: 10.4103/aja202194. Asian J Androl. 2022. PMID: 35017390 Free PMC article.
A precise genetic diagnosis is obtained for a minority of patients and only for the most severe defects like azoospermia or macrozoospermia which is very often due to defects in the aurora kinase C (AURKC gene. Here, we studied a subject with a severe …
A precise genetic diagnosis is obtained for a minority of patients and only for the most severe defects like azoospermia or macrozoospermia …
Genetic variations in AURORA cell cycle kinases are associated with glioblastoma multiforme.
Mesic A, Rogar M, Hudler P, Bilalovic N, Eminovic I, Komel R. Mesic A, et al. Sci Rep. 2021 Aug 31;11(1):17444. doi: 10.1038/s41598-021-96935-y. Sci Rep. 2021. PMID: 34465813 Free PMC article.
We examined the association between single nucleotide polymorphisms (SNPs) in Aurora kinase A (AURKA), Aurora kinase B (AURKB), Aurora kinase C (AURKC) and Polo-like kinase 1 (PLK1) mitotic checkpoint genes and GBM risk by qPCR genotyping. ...Our resul …
We examined the association between single nucleotide polymorphisms (SNPs) in Aurora kinase A (AURKA), Aurora kinase B (AURKB), Aurora …
37 results