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2024 6
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Uncovering miRNA-mRNA Regulatory Networks Related to Olaparib Resistance and Resensitization of BRCA2(MUT) Ovarian Cancer PEO1-OR Cells with the ATR/CHK1 Pathway Inhibitors.
Biegała Ł, Kołat D, Gajek A, Płuciennik E, Marczak A, Śliwińska A, Mikula M, Rogalska A. Biegała Ł, et al. Cells. 2024 May 17;13(10):867. doi: 10.3390/cells13100867. Cells. 2024. PMID: 38786089 Free PMC article.
This study investigated microRNA (miRNA) expression in olaparib-sensitive (PEO1, PEO4) and previously established olaparib-resistant OC cell lines (PEO1-OR) using high-throughput RT-qPCR and bioinformatic analyses. ...We identified potential processes associated wit …
This study investigated microRNA (miRNA) expression in olaparib-sensitive (PEO1, PEO4) and previously established olaparib-resistant …
Mitochondrial DNA mutations attenuate Bleomycin-induced dermal fibrosis by inhibiting differentiation into myofibroblasts.
Reiter L, Niehoff N, Weiland D, Helbig D, Eming SA, Krieg T, Etich J, Brachvogel B, Wiesner RJ, Knuever J. Reiter L, et al. Matrix Biol. 2024 Sep;132:72-86. doi: 10.1016/j.matbio.2024.07.002. Epub 2024 Jul 14. Matrix Biol. 2024. PMID: 39009171 Free article.
We crossed mice carrying a dominant-negative mutant of the mitochondrial replicative helicase Twinkle (RosaSTOP system) with mice that express fibroblast-specific Cre Recombinase (Collagen1A2 Cre(ERT)) which can be activated by Tamoxifen (Twinkle(FIBRO)). ...Upon ac …
We crossed mice carrying a dominant-negative mutant of the mitochondrial replicative helicase Twinkle (RosaSTOP system) with mice tha …
TWNK gene pathogenic variant and Perrault syndrome.
Li H, Cao C, Lv Y. Li H, et al. Gene. 2025 Sep 15;965:149667. doi: 10.1016/j.gene.2025.149667. Epub 2025 Jul 14. Gene. 2025. PMID: 40669787 Review.
The disease exhibits significant clinical heterogeneity, and its pathogenesis involves pathogenic variants in multiple genes, among which pathogenic variants in the TWNK gene represent an important cause. The TWNK gene encodes the Twinkle, a mitochondrial DNA (mtDNA) helic …
The disease exhibits significant clinical heterogeneity, and its pathogenesis involves pathogenic variants in multiple genes, among which pa …
A Critical Role of Intracellular PD-L1 in Promoting Ovarian Cancer Progression.
Huang R, Nakamura B, Senguttuvan R, Li YJ, Martincuks A, Bakkar R, Song M, Ann DK, Rodriguez-Rodriguez L, Yu H. Huang R, et al. Cells. 2025 Feb 19;14(4):314. doi: 10.3390/cells14040314. Cells. 2025. PMID: 39996786 Free PMC article.
We investigated whether intracellular PD-L1 might play a critical role in ovarian cancer progression. Mutating the PD-L1 acetylation site in PEO1 and ID8(Brca1-/-) ovarian cancer cells significantly decreased PD-L1 levels and impaired colony formation, which was accompanie …
We investigated whether intracellular PD-L1 might play a critical role in ovarian cancer progression. Mutating the PD-L1 acetylation site in …
Cell-intrinsic platinum response and associated genetic and gene expression signatures in ovarian cancer.
Adams KM, Wendt JR, Wood J, Olson S, Moreno R, Jin Z, Gopalan S, Lang JD. Adams KM, et al. Cancer Gene Ther. 2025 Sep;32(9):985-996. doi: 10.1038/s41417-025-00941-5. Epub 2025 Jul 19. Cancer Gene Ther. 2025. PMID: 40683954 Free PMC article.
Further, we generated two platinum-resistant derivatives each for OVCAR3 and OVCAR4. Combined with clinically resistant PEO1/PEO4/PEO6 and PEA1/PEA2 isogenic models, we performed differential expression analysis for seven platinum-resistant isogenic pairs. ...
Further, we generated two platinum-resistant derivatives each for OVCAR3 and OVCAR4. Combined with clinically resistant PEO1/PEO4/PEO …
Autoregulation of the real-time kinetics of the human mitochondrial replicative helicase.
Plaza-G A I, Ortiz-Rodríguez M, Buchanan SP, Miguez-Amil S, Lemishko KM, Moreno-Herrero F, Fernandez-Leiro R, Ciesielski GL, Ibarra B. Plaza-G A I, et al. Nat Commun. 2025 Jul 1;16(1):5460. doi: 10.1038/s41467-025-60289-0. Nat Commun. 2025. PMID: 40592829 Free PMC article.
The human mitochondrial helicase Twinkle is essential for mitochondrial DNA (mtDNA) replication and integrity. Using biochemical and single-molecule techniques, we investigated Twinkle's real-time kinetics, including DNA loading, unwinding, and rewinding, and their …
The human mitochondrial helicase Twinkle is essential for mitochondrial DNA (mtDNA) replication and integrity. Using biochemical and …
A facile and scalable method to synthesize PEGylated PDMAEMA for gene delivery.
Dou J, Yu S, Zhang Y. Dou J, et al. Biopolymers. 2024 Jul;115(4):e23584. doi: 10.1002/bip.23584. Epub 2024 May 2. Biopolymers. 2024. PMID: 38695839
Herein, a facile, cost-effective, and scalable method was developed to synthesize PEGylated PDMAEMA polymers (PEO-PDMAEMA-PEO), where PEGylation could enable prolonged polyplexes circulation time in the blood stream. ...We believe that PEO-PDMAEMA-PEO …
Herein, a facile, cost-effective, and scalable method was developed to synthesize PEGylated PDMAEMA polymers (PEO-PDMAEMA-PEO) …
Single-molecule fluorescence reveals the DNA unwinding mechanism of mitochondrial helicase TWINKLE and its interplay with single-stranded DNA-binding proteins.
Wang HY, Lee YY, Chien PJ, Tsai WA, Sun PJ, Wang LT, Wu CC, Fan HF. Wang HY, et al. Nucleic Acids Res. 2025 Aug 27;53(16):gkaf803. doi: 10.1093/nar/gkaf803. Nucleic Acids Res. 2025. PMID: 40867054 Free PMC article.
The mitochondrial DNA helicase TWINKLE, a hexameric ring-shaped helicase, plays a crucial role in maintaining mitochondrial DNA integrity. TWINKLE translocates along one DNA strand, unwinding the duplex by excluding the complementary strand through coordinated ATP h …
The mitochondrial DNA helicase TWINKLE, a hexameric ring-shaped helicase, plays a crucial role in maintaining mitochondrial DNA integ …
Genotype-Phenotype Correlation in Progressive External Ophthalmoplegia: Insights From a Retrospective Analysis.
Wang J, Lin Y, Zhuang X, Zhao D, Li B, Zhao Y, Xu Z, Liu F, Dai T, Li W, Jiang M, Yan C, Zhao Y, Ji K. Wang J, et al. Neuropathol Appl Neurobiol. 2025 Feb;51(1):e70001. doi: 10.1111/nan.70001. Neuropathol Appl Neurobiol. 2025. PMID: 39822040
METHODS: We analysed the clinical, pathological and genetic characteristics of a large cohort of patients with PEO, based on the type of their mtDNA variations. Eighty-two PEO patients were enrolled and grouped into three categories: mtDNA single large-scale deletio …
METHODS: We analysed the clinical, pathological and genetic characteristics of a large cohort of patients with PEO, based on the type …
Proteomic Landscapes of 3D and 2D Models of High-Grade Serous Ovarian Carcinoma: Implications for Carboplatin Response.
Maillard J, Roumeliotis TI, Paranjape E, Pickard L, Ingles R Garces A, Choudhary JS, Banerji U. Maillard J, et al. J Proteome Res. 2025 Oct 3;24(10):5071-5082. doi: 10.1021/acs.jproteome.5c00391. Epub 2025 Aug 27. J Proteome Res. 2025. PMID: 40865000 Free PMC article.
Notably, membrane-associated proteins were downregulated in spheroids, particularly EGFR in PEO1. Furthermore, the 3D culture modulated the response to carboplatin, with an increased expression of drug resistance-associated proteins, including NDUF family members in all sp …
Notably, membrane-associated proteins were downregulated in spheroids, particularly EGFR in PEO1. Furthermore, the 3D culture modulat …
22 results