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Page 1
RIPK2 promotes colorectal cancer metastasis by protecting YAP degradation from ITCH-mediated ubiquitination.
Lu C, Liu H, Liu T, Sun S, Zheng Y, Ling T, Luo X, E Y, Xu Y, Li J, Liu L, Miao L, Liu Z, Yu C. Lu C, et al. Cell Death Dis. 2025 Apr 4;16(1):248. doi: 10.1038/s41419-025-07599-9. Cell Death Dis. 2025. PMID: 40185717 Free PMC article.
Additionally, bacterial invasion of epithelial cells was significantly suppressed in RIPK2 knockdown cells, suggesting a connection to the NOD2-RIPK2 pathway, stimulated by bacterial muramyl dipeptide (MDP). We demonstrated that MDP levels are significantly higher in CRC t …
Additionally, bacterial invasion of epithelial cells was significantly suppressed in RIPK2 knockdown cells, suggesting a connection to the …
Ubiquitin Ligases in Control: Regulating NLRP3 Inflammasome Activation.
Beesetti S. Beesetti S. Front Biosci (Landmark Ed). 2025 Mar 19;30(3):25970. doi: 10.31083/FBL25970. Front Biosci (Landmark Ed). 2025. PMID: 40152367 Free article. Review.
Furthermore, they intricately control NOD1/NOD2 signaling through K63-linked polyubiquitination of receptor-interacting protein 2 (RIP2), crucial for nuclear factor kappa-light-chain-enhancer of activated B cells (NF-kappaB) and mitogen-activated protein kinase (MAPK) acti …
Furthermore, they intricately control NOD1/NOD2 signaling through K63-linked polyubiquitination of receptor-interacting protein 2 (RI …
Alterations in mucosa branched N-glycans lead to dysbiosis and downregulation of ILC3: a key driver of intestinal inflammation.
Rodrigues CS, Gaifem J, Pereira MS, Alves MF, Silva M, Padrão N, Cavadas B, Moreira-Barbosa C, Alves I, Marcos-Pinto R, Torres J, Lavelle A, Colombel JF, Sokol H, Pinho SS. Rodrigues CS, et al. Gut Microbes. 2025 Dec;17(1):2461210. doi: 10.1080/19490976.2025.2461210. Epub 2025 Feb 7. Gut Microbes. 2025. PMID: 39918275 Free PMC article.
In addition, we demonstrated that the mucosa glycosylation remodeling through prophylactic supplementation with glycans at steady state was able to restore microbial-derived short-chain fatty acids and microbial sensing (by NOD2 expression) alongside the rescue of the expr …
In addition, we demonstrated that the mucosa glycosylation remodeling through prophylactic supplementation with glycans at steady state was …
Gene-Environment Interactions in Inflammatory Bowel Disease: A Systematic Review of Human Epidemiologic Studies.
Bai J, Bouwknegt DG, Weersma RK, Dijkstra G, van der Sloot KWJ, Festen EAM. Bai J, et al. J Crohns Colitis. 2025 Jun 4;19(6):jjaf061. doi: 10.1093/ecco-jcc/jjaf061. J Crohns Colitis. 2025. PMID: 40464295 Free PMC article.
RESULTS: Four thousand eight hundred thirty-three publications were identified and screened, resulting in 39 eligible studies, and 17 studies reported statistically significant interactions. NOD2-smoking interaction was most frequently investigated and showed variant-speci …
RESULTS: Four thousand eight hundred thirty-three publications were identified and screened, resulting in 39 eligible studies, and 17 studie …
Main genetic factors associated with inflammatory bowel diseases and their consequences on intestinal permeability: involvement in gut inflammation.
Mauduit A, Mas E, Solà-Tapias N, Ménard S, Barreau F. Mauduit A, et al. J Gastroenterol. 2025 Nov;60(11):1323-1338. doi: 10.1007/s00535-025-02289-x. Epub 2025 Aug 21. J Gastroenterol. 2025. PMID: 40841786 Free PMC article. Review.
IBD are multifactorial diseases with a complex etiology, involving an intricate interaction between environmental and genetic factors. Since the discovery of NOD2 gene in 2001, genome-wide association studies have reported more than 200 IBD susceptibility loci. The stronge …
IBD are multifactorial diseases with a complex etiology, involving an intricate interaction between environmental and genetic factors. Since …
Resolving the field: a role for Nod2 in T cells.
Huey LM, Rosenzweig HL, Napier RJ. Huey LM, et al. J Immunol. 2025 Dec 1;214(12):3188-3198. doi: 10.1093/jimmun/vkaf204. J Immunol. 2025. PMID: 40824708 Free PMC article. Review.
NOD2 also appears to play a critical role in immune homeostasis, as NOD2 variants have been linked to multiple human inflammatory diseases, including common polymorphisms that increase the risk of Crohn's disease and rare mutations that cause Blau syndrome. The cell …
NOD2 also appears to play a critical role in immune homeostasis, as NOD2 variants have been linked to multiple human inflammat …
NOD2 and Crohn's Disease Clinical Practice: From Epidemiology to Diagnosis and Therapy, Rewired.
Kayali S, Fantasia S, Gaiani F, Cavallaro LG, de'Angelis GL, Laghi L. Kayali S, et al. Inflamm Bowel Dis. 2025 Feb 6;31(2):552-562. doi: 10.1093/ibd/izae075. Inflamm Bowel Dis. 2025. PMID: 38582044 Free PMC article. Review.
Since the late 20th century, the discovery of the first susceptibility gene (NOD2, previously referred to as CARD15) for CD has paved the way for further investigations into the correlations between clinical features and genetics, and its potential impact on clinica …
Since the late 20th century, the discovery of the first susceptibility gene (NOD2, previously referred to as CARD15) for CD ha …
Genotype-phenotype correlation in a cohort of pediatric patients with autoinflammatory diseases carrying NOD2 variants.
Natale MF, Celani C, Federici S, Passarelli C, Perrone C, Marasco E, De Benedetti F, Insalaco A. Natale MF, et al. Front Immunol. 2025 Mar 24;16:1439333. doi: 10.3389/fimmu.2025.1439333. eCollection 2025. Front Immunol. 2025. PMID: 40196132 Free PMC article.
Nucleotide binding oligomerization domain containing 2 (NOD2) gene variants are associated with Crohn's disease (CD), Blau syndrome and most recently with a polygenic autoinflammatory disease with onset in adult called NOD2-associated autoinflammatory disease (NAID) …
Nucleotide binding oligomerization domain containing 2 (NOD2) gene variants are associated with Crohn's disease (CD), Blau syndrome a …
From Cytokines to Biomarkers: Mapping the Immunopathology of Inflammatory Bowel Disease.
Baum S, Hamedi K, Loftus C, Loftus G, Zhou ER, Arce S. Baum S, et al. Cells. 2025 Oct 13;14(20):1589. doi: 10.3390/cells14201589. Cells. 2025. PMID: 41148805 Free PMC article. Review.
CD is related to loss-of-function mutations in the nucleotide oligomerization domain containing the protein 2 (NOD2) gene and Autophagy-Related 16-like 1 (ATG16L1) gene. UC risk is increased particularly in Chinese populations by the A-1661G polymorphism of the Cytotoxic T …
CD is related to loss-of-function mutations in the nucleotide oligomerization domain containing the protein 2 (NOD2) gene and Autopha …
A Systematic Review of Mendelian Pyoderma Gangrenosum: Clinical and Genetic Characteristics in 120 Published Patients.
Norouzi-Barough L, Biglari S, Sherkat R, Gudjonsson JE, Hakonarson H, Vahidnezhad H. Norouzi-Barough L, et al. Exp Dermatol. 2025 May;34(5):e70112. doi: 10.1111/exd.70112. Exp Dermatol. 2025. PMID: 40329681
PSTPIP1 was the most frequently reported PG-related gene, followed by MEFV, ITGB2, NOD2, NFKB1, RAG1, JAK2, and NCSTN. Pseudomonas aeruginosa was the most frequently identified infectious agent in PG skin lesions. ...
PSTPIP1 was the most frequently reported PG-related gene, followed by MEFV, ITGB2, NOD2, NFKB1, RAG1, JAK2, and NCSTN. Pseudomonas ae …
28 results