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2021 8
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2024 9

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Deubiquitination of CDC6 by OTUD6A promotes tumour progression and chemoresistance.
Cui J, Liu X, Shang Q, Sun S, Chen S, Dong J, Zhu Y, Liu L, Xia Y, Wang Y, Xiang L, Fan B, Zhan J, Zhou Y, Chen P, Zhao R, Liu X, Xing N, Wu D, Shi B, Zou Y. Cui J, et al. Mol Cancer. 2024 Apr 29;23(1):86. doi: 10.1186/s12943-024-01996-y. Mol Cancer. 2024. PMID: 38685067 Free PMC article.
BACKGROUND: CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle. Although several E3 ubiquitin ligases responsible for the ubiquitin-mediated proteolysis of CDC6 have been identified, the deubiquitination pathway for CDC6 has …
BACKGROUND: CDC6 is an oncogenic protein whose expression level fluctuates during the cell cycle. Although several E3 ubiquitin ligas …
Mistimed origin licensing and activation stabilize common fragile sites under tight DNA-replication checkpoint activation.
Brison O, Gnan S, Azar D, Koundrioukoff S, Melendez-Garcia R, Kim SJ, Schmidt M, El-Hilali S, Jaszczyszyn Y, Lachages AM, Thermes C, Chen CL, Debatisse M. Brison O, et al. Nat Struct Mol Biol. 2023 Apr;30(4):539-550. doi: 10.1038/s41594-023-00949-1. Epub 2023 Apr 6. Nat Struct Mol Biol. 2023. PMID: 37024657
Repli-Seq and molecular combing analyses showed a burst of replication initiations implemented in mid S-phase across a subset of late-replicating sequences, including CFSs, while the bulk genome was unaffected. CFS rescue and extra-initiations required CDC6 and CDT1 availa …
Repli-Seq and molecular combing analyses showed a burst of replication initiations implemented in mid S-phase across a subset of late-replic …
Laryngeal Squamous Cell Carcinoma: Clinical Significance and Potential Mechanism of Cell Division Cycle 45.
Li GS, Yang LJ, Chen G, Huang SN, Fang YY, Huang WJ, Lu W, He J, Liu HC, Li LY, Mo BY, Lu HP. Li GS, et al. Cancer Biother Radiopharm. 2022 May;37(4):300-312. doi: 10.1089/cbr.2020.4314. Epub 2021 Oct 21. Cancer Biother Radiopharm. 2022. PMID: 34672813
CDC45 was relevant to the progression-free interval of LSCC patients (log-rank p = 0.03). GSEAs show that CDC45 is related to the cell cycle. CDC45, CDC6, KIF2C, and AURKB were identified as hub genes of LSCC. E2F1 may be the regulatory transcription factor of CDC45. ...
CDC45 was relevant to the progression-free interval of LSCC patients (log-rank p = 0.03). GSEAs show that CDC45 is related to the cell cycle …
Role of TOP2A and CDC6 in liver cancer.
Jia W, Liu X, Zhang Z. Jia W, et al. Medicine (Baltimore). 2023 Oct 20;102(42):e35604. doi: 10.1097/MD.0000000000035604. Medicine (Baltimore). 2023. PMID: 37861550 Free PMC article.
Comparative toxicogenomics database analysis showed that 10 genes (TOP2A, CDK1, ASPM, RACGAP1, ZWINT, CDC6, AURKA, NCAPG, BUB1B, CCNB1) were related to necrosis, inflammation, HCC, liver cirrhosis, and adenoid cystic carcinoma. TOP2A and CDC6 are highly expressed in …
Comparative toxicogenomics database analysis showed that 10 genes (TOP2A, CDK1, ASPM, RACGAP1, ZWINT, CDC6, AURKA, NCAPG, BUB1B, CCNB …
Exploring the potential common denominator pathogenesis of system lupus erythematosus with COVID-19 based on comprehensive bioinformatics analysis.
Zeng H, Zhuang Y, Li X, Yin Z, Huang X, Peng H. Zeng H, et al. Front Immunol. 2023 Jun 22;14:1179664. doi: 10.3389/fimmu.2023.1179664. eCollection 2023. Front Immunol. 2023. PMID: 37426642 Free PMC article.
Finally, a single-sample gene set enrichment (ssGSEA) algorithm was used to analyze immune cell infiltration. RESULTS: A total of 6 common hub genes (CDC6, PLCG1, KIF15, LCK, CDC25C, and RASGRP1) were identified with high diagnostic validity. ...
Finally, a single-sample gene set enrichment (ssGSEA) algorithm was used to analyze immune cell infiltration. RESULTS: A total of 6 common h …
CDC6, a key replication licensing factor, is overexpressed and confers poor prognosis in diffuse large B-cell lymphoma.
Shen M, Zhang Y, Tang L, Fu Q, Zhang J, Xu Y, Zeng H, Li Y. Shen M, et al. BMC Cancer. 2023 Oct 13;23(1):978. doi: 10.1186/s12885-023-11186-6. BMC Cancer. 2023. PMID: 37833632 Free PMC article.
BACKGROUND: Cell division cycle 6 (CDC6) is a key licensing factor in the assembly of pre-replicative complexes at origins of replication. ...METHODS: Initial bioinformatic analysis was performed to screen the potential role of CDC6 in DL …
BACKGROUND: Cell division cycle 6 (CDC6) is a key licensing factor in the assembly of pre-replicative com …
Persistent DNA damage underlies tubular cell polyploidization and progression to chronic kidney disease in kidneys deficient in the DNA repair protein FAN1.
Airik M, Phua YL, Huynh AB, McCourt BT, Rush BM, Tan RJ, Vockley J, Murray SL, Dorman A, Conlon PJ, Airik R. Airik M, et al. Kidney Int. 2022 Nov;102(5):1042-1056. doi: 10.1016/j.kint.2022.07.003. Epub 2022 Aug 2. Kidney Int. 2022. PMID: 35931300 Free PMC article.
In vitro and in vivo studies showed that polyploidization was caused by the overexpression of DNA replication factors CDT1 and CDC6 in FAN1 deficient cells. Mechanistically, inhibiting DNA replication with Roscovitine reduced tubular injury, blocked the development of KIN …
In vitro and in vivo studies showed that polyploidization was caused by the overexpression of DNA replication factors CDT1 and CDC6 i …
RRM2 and CDC6 are novel effectors of XBP1-mediated endocrine resistance and predictive markers of tamoxifen sensitivity.
Barua D, Sultana A, Islam MN, Cox F, Gupta A, Gupta S. Barua D, et al. BMC Cancer. 2023 Mar 30;23(1):288. doi: 10.1186/s12885-023-10745-1. BMC Cancer. 2023. PMID: 36997866 Free PMC article.
Expression of RRM2, CDC6, and TOP2A was increased upon estrogen stimulation and in cells harbouring point-mutants (Y537S, D538G) of ESR1 in steroid free conditions. Ectopic expression of RRM2 and CDC6 increased cell growth and reversed the hypersensitivity of XBP1 K …
Expression of RRM2, CDC6, and TOP2A was increased upon estrogen stimulation and in cells harbouring point-mutants (Y537S, D538G) of E …
The Effect of High CDC6 Levels on Predicting Poor Prognosis in Colorectal Cancer.
Yang C, Xie N, Luo Z, Ruan X, Zhang Y, Wang W, Huang Y. Yang C, et al. Chemotherapy. 2022;67(1):47-56. doi: 10.1159/000519913. Epub 2022 Jan 14. Chemotherapy. 2022. PMID: 35034031
INTRODUCTION: We investigated the function of cell division cycle 6 (CDC6) on the prognosis in colorectal carcinoma (CRC). ...CONCLUSION: CDC6 is highly expressed in CRC, and downregulation of CDC6 can slow the growth of CRC cells …
INTRODUCTION: We investigated the function of cell division cycle 6 (CDC6) on the prognosis in colorectal …
LCAT1 is an oncogenic LncRNA by stabilizing the IGF2BP2-CDC6 axis.
Yang J, Qian X, Qiu Q, Xu L, Pan M, Li J, Ren J, Lu B, Qiu T, Chen E, Ying K, Zhang H, Lu Y, Liu P. Yang J, et al. Cell Death Dis. 2022 Oct 18;13(10):877. doi: 10.1038/s41419-022-05316-4. Cell Death Dis. 2022. PMID: 36257938 Free PMC article.
Mechanistically, the LCAT1/IGF2BP2 complex increased the levels of CDC6, a key cell cycle regulator, by stabilizing its mRNA in an m(6)A-dependent manner. Like IGF2BP2, CDC6 is also overexpressed in lung cancer tissues with poor patient survival, and CDC6 kno …
Mechanistically, the LCAT1/IGF2BP2 complex increased the levels of CDC6, a key cell cycle regulator, by stabilizing its mRNA in an m( …
38 results