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104 results

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Page 1
POT1 recruits and regulates CST-Polalpha/primase at human telomeres.
Cai SW, Takai H, Zaug AJ, Dilgen TC, Cech TR, Walz T, de Lange T. Cai SW, et al. Cell. 2024 Jul 11;187(14):3638-3651.e18. doi: 10.1016/j.cell.2024.05.002. Epub 2024 Jun 4. Cell. 2024. PMID: 38838667 Free PMC article.
At telomeres, Polalpha/primase is bound to Ctc1/Stn1/Ten1 (CST), a single-stranded DNA-binding complex. Like mutations in telomerase, mutations affecting CST-Polalpha/primase result in pathological telomere shortening and cause a telomere biology disor …
At telomeres, Polalpha/primase is bound to Ctc1/Stn1/Ten1 (CST), a single-stranded DNA-binding complex. Like mutations in telo …
CST-Polalpha/Primase: the second telomere maintenance machine.
Cai SW, de Lange T. Cai SW, et al. Genes Dev. 2023 Jul 1;37(13-14):555-569. doi: 10.1101/gad.350479.123. Epub 2023 Jul 26. Genes Dev. 2023. PMID: 37495394 Free PMC article. Review.
Therefore, a second enzyme is needed to keep telomeres intact: DNA polymerase alpha/Primase bound to Ctc1-Stn1-Ten1 (CST). CST-Polalpha/Primase maintains telomeres through a fill-in reaction that replenishes the lost sequences at the 5' ends. CST not only ser …
Therefore, a second enzyme is needed to keep telomeres intact: DNA polymerase alpha/Primase bound to Ctc1-Stn1-Ten1 (CST). CST …
Cooperative interaction of CST and RECQ4 resolves G-quadruplexes and maintains telomere stability.
Li T, Zhang M, Li Y, Han X, Tang L, Ma T, Zhao X, Zhao R, Wang Y, Bai X, Zhang K, Geng X, Sui L, Feng X, Zhang Q, Zhao Y, Liu Y, Stewart JA, Wang F. Li T, et al. EMBO Rep. 2023 Sep 6;24(9):e55494. doi: 10.15252/embr.202255494. Epub 2023 Jul 26. EMBO Rep. 2023. PMID: 37493024 Free PMC article.
Human CST (CTC1-STN1-TEN1) is a ssDNA-binding complex that interacts with the replisome to aid in stalled fork rescue. ...Here, we identify RECQ4 as a novel CST-interacting partner and show that RECQ4 can unwind G4 structures in vitro using a FRET assay. Moreover, G4s accu …
Human CST (CTC1-STN1-TEN1) is a ssDNA-binding complex that interacts with the replisome to aid in stalled fork rescue. ...Here, we id …
The evolving genetic landscape of telomere biology disorder dyskeratosis congenita.
Tummala H, Walne AJ, Badat M, Patel M, Walne AM, Alnajar J, Chow CC, Albursan I, Frost JM, Ballard D, Killick S, Szitányi P, Kelly AM, Raghavan M, Powell C, Raymakers R, Todd T, Mantadakis E, Polychronopoulou S, Pontikos N, Liao T, Madapura P, Hossain U, Vulliamy T, Dokal I. Tummala H, et al. EMBO Mol Med. 2024 Oct;16(10):2560-2582. doi: 10.1038/s44321-024-00118-x. Epub 2024 Aug 28. EMBO Mol Med. 2024. PMID: 39198715 Free PMC article.
Dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome, caused by genetic mutations that principally affect telomere biology. Approximately 35% of cases remain uncharacterised at the genetic level. ...Functional characterisation of novel POLA1 and POT …
Dyskeratosis congenita (DC) is a rare inherited bone marrow failure syndrome, caused by genetic mutations that principally affect telomer …
CST-polymerase alpha-primase solves a second telomere end-replication problem.
Takai H, Aria V, Borges P, Yeeles JTP, de Lange T. Takai H, et al. Nature. 2024 Mar;627(8004):664-670. doi: 10.1038/s41586-024-07137-1. Epub 2024 Feb 28. Nature. 2024. PMID: 38418884 Free PMC article.
Telomerase adds G-rich telomeric repeats to the 3' ends of telomeres(1), counteracting telomere shortening caused by loss of telomeric 3' overhangs during leading-strand DNA synthesis ('the end-replication problem'(2)). ...The C-strands of leading-end telomeres …
Telomerase adds G-rich telomeric repeats to the 3' ends of telomeres(1), counteracting telomere shortening caused by loss of t …
CTC1 OB-B interaction with TPP1 terminates telomerase and prevents telomere overextension.
Wang H, Ma T, Zhang X, Chen W, Lan Y, Kuang G, Hsu SJ, He Z, Chen Y, Stewart J, Bhattacharjee A, Luo Z, Price C, Feng X. Wang H, et al. Nucleic Acids Res. 2023 Jun 9;51(10):4914-4928. doi: 10.1093/nar/gkad237. Nucleic Acids Res. 2023. PMID: 37021555 Free PMC article.
CST (CTC1-STN1-TEN1) is a telomere associated complex that binds ssDNA and is required for multiple steps in telomere replication, including termination of G-strand extension by telomerase and synthesis of the complementary C-strand. ...However, it caused pro …
CST (CTC1-STN1-TEN1) is a telomere associated complex that binds ssDNA and is required for multiple steps in telomere r …
STN1 Shields CTC1 From TRIM32-Mediated Ubiquitination to Prevent Cellular Aging.
Lan Y, Liang X, Kuang G, Ma T, Zhang F, Huang Z, Wang H, Luo Z, Feng X. Lan Y, et al. Aging Cell. 2025 Nov;24(11):e70214. doi: 10.1111/acel.70214. Epub 2025 Sep 9. Aging Cell. 2025. PMID: 40923710 Free PMC article.
The CST (CTC1-STN1-TEN1) complex, a single-stranded DNA (ssDNA) binding complex, is essential for telomere maintenance and genome stability. ...In this study, we demonstrate that the direct STN1-CTC1 interaction stabilizes CTC1 by preventing its degrad …
The CST (CTC1-STN1-TEN1) complex, a single-stranded DNA (ssDNA) binding complex, is essential for telomere maintenance and gen …
Loss of Ten1 in mice induces telomere shortening and models human dyskeratosis congenita.
Sanz-Moreno A, Becker L, Xie K, da Silva-Buttkus P, Dragano NRV, Aguilar-Pimentel A, Amarie OV, Calzada-Wack J, Kraiger M, Leuchtenberger S, Seisenberger C, Marschall S, Rathkolb B, Scifo E, Liu T, Thanabalasingam A, Sanchez-Vazquez R, Martinez P, Blasco MA, Savage SA, Fuchs H, Ehninger D, Gailus-Durner V, de Angelis MH. Sanz-Moreno A, et al. Sci Adv. 2025 Apr 11;11(15):eadp8093. doi: 10.1126/sciadv.adp8093. Epub 2025 Apr 11. Sci Adv. 2025. PMID: 40215293 Free PMC article.
Telomere length regulation is essential for genome stability as short telomeres can trigger cellular senescence and apoptosis constituting an integral aspect of biological aging. Telomere biology disorders (TBDs) such as dyskeratosis congenita (DC) are rare, …
Telomere length regulation is essential for genome stability as short telomeres can trigger cellular senescence and apoptosis …
Molecular mechanisms of telomere biology disorders.
Grill S, Nandakumar J. Grill S, et al. J Biol Chem. 2021 Jan-Jun;296:100064. doi: 10.1074/jbc.REV120.014017. Epub 2020 Nov 22. J Biol Chem. 2021. PMID: 33482595 Free PMC article. Review.
In contrast, disease-associated mutations in either CTC1 or RTEL1 are more broadly associated with telomere replication defects. Yet even with the recent surge in studies decoding the mechanisms underlying these diseases, a significant proportion of dyskeratosis con …
In contrast, disease-associated mutations in either CTC1 or RTEL1 are more broadly associated with telomere replication defect …
Models for human telomere C-strand fill-in by CST-Polalpha-primase.
He Q, Lim CJ. He Q, et al. Trends Biochem Sci. 2023 Oct;48(10):860-872. doi: 10.1016/j.tibs.2023.07.008. Epub 2023 Aug 15. Trends Biochem Sci. 2023. PMID: 37586999 Free PMC article. Review.
Telomere maintenance is essential for the genome integrity of eukaryotes, and this function is underpinned by the two-step telomeric DNA synthesis process: telomere G-overhang extension by telomerase and complementary strand fill-in by DNA polymerase alpha-primase ( …
Telomere maintenance is essential for the genome integrity of eukaryotes, and this function is underpinned by the two-step telomeric …
104 results