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Page 1
Exploration of ferroptosis and necroptosis-related genes and potential molecular mechanisms in psoriasis and atherosclerosis.
Fan J, Zhu T, Tian X, Liu S, Zhang SL. Fan J, et al. Front Immunol. 2024 Jul 12;15:1372303. doi: 10.3389/fimmu.2024.1372303. eCollection 2024. Front Immunol. 2024. PMID: 39072329 Free PMC article.
Two ferroptosis-related genes (NAMPT, ZFP36) and eight necroptosis-related genes (C7, CARD6, CASP1, CTSD, HMOX1, NOD2, PYCARD, TNFRSF21) showed high sensitivity and specificity in ROC curve analysis. ...CONCLUSION: The two ferroptosis-related genes (NAMPT, ZFP36) and eight …
Two ferroptosis-related genes (NAMPT, ZFP36) and eight necroptosis-related genes (C7, CARD6, CASP1, CTSD, HMOX1, NOD2, PYCARD, TNFRSF …
Bioinformatic analysis constructs an optimal prognostic index for survival-related variables (OPISV) based on whole-genome expression data in Glioblastoma.
Pan J, Yan D, Liang Y, Yang L, Hu C, Chen M. Pan J, et al. Int J Biol Macromol. 2024 Dec;282(Pt 5):137184. doi: 10.1016/j.ijbiomac.2024.137184. Epub 2024 Nov 4. Int J Biol Macromol. 2024. PMID: 39505178 Free article.
The OPISV performance is evaluated and its potential mechanisms are explored. RESULTS: Age, CTSD, PTPRN, PTPRN2, NSUN5, DNAJC30 and SOX21 emerged as the optimal variables through multivariate Cox regression iterations. ...
The OPISV performance is evaluated and its potential mechanisms are explored. RESULTS: Age, CTSD, PTPRN, PTPRN2, NSUN5, DNAJC30 and S …
A human-mouse atlas of intrarenal myeloid cells identifies conserved disease-associated macrophages in lupus nephritis.
Hoover PJ, Raparia C, Lieb DJ, Tzur Y, Kang J, Arazi A, Leavitt R, Mishra R, Shah SI, Simmons D, Li S, Peters M, Eisenhaure T, Few-Cooper TJ, Gurajala SS, Sonny A, Hodgin JB, Berthier CC, Guthridge JM, Fava A, Clancy RM, Putterman C, Izmirly PM, Belmont HM, Kalunian K, Kamen D, Wofsy D, Buyon JP, James JA, Petri M, Diamond B, Raychaudhuri S, Shen-Orr SS; Accelerating Medicines Partnership in RA/SLE network; Hacohen N, Davidson A. Hoover PJ, et al. J Exp Med. 2025 Nov 3;222(11):e20241873. doi: 10.1084/jem.20241873. Epub 2025 Sep 3. J Exp Med. 2025. PMID: 40900124
A subset of murine classical monocytes expanded in disease; these cells expressed Cd9, Spp1, Ctsd, Cd63, Apoe, and Trem2, genes associated with tissue injury in other organs that play roles in inflammation, lipid metabolism, and tissue repair. ...
A subset of murine classical monocytes expanded in disease; these cells expressed Cd9, Spp1, Ctsd, Cd63, Apoe, and Trem2, genes assoc …
Cathepsin D promotes acute myeloid leukemia progression through stabilization of the anti-apoptotic proteins.
Jiang H, Wang Y, Wang C, Yang L, Wang S, Wang F, Xue S, Zhang Z, Fu H, Dong T, Yuan J, Li Z, Li K. Jiang H, et al. Cell Death Dis. 2025 Aug 12;16(1):611. doi: 10.1038/s41419-025-07949-7. Cell Death Dis. 2025. PMID: 40796615 Free PMC article.
Cathepsin D (CTSD) is a lysosomal aspartic protease that plays vital roles in regulating the properties of solid tumors, including proliferation, apoptosis, migration, metastasis, and angiogenesis. However, the function of CTSD in haematological malign …
Cathepsin D (CTSD) is a lysosomal aspartic protease that plays vital roles in regulating the properties of solid tumors …
Swainsonine inhibits autophagic degradation and causes cytotoxicity by reducing CTSD O-GlcNAcylation.
Wang S, Tan P, Wang H, Wang J, Zhang C, Lu H, Zhao B. Wang S, et al. Chem Biol Interact. 2023 Sep 1;382:110629. doi: 10.1016/j.cbi.2023.110629. Epub 2023 Jul 11. Chem Biol Interact. 2023. PMID: 37442287
Further analysis by Immunoprecipitation (IP) showed that SW could change the O-GlcNAcylation of Cathepsin D (CTSD), reducing the expression of mature CTSD (m-CTSD). In summary, these findings suggest that SW inhibits the O-GlcNAcylation of CT …
Further analysis by Immunoprecipitation (IP) showed that SW could change the O-GlcNAcylation of Cathepsin D (CTSD), red …
Deciphering the molecular and cellular atlas of immune cells in septic patients with different bacterial infections.
Sun P, Cui M, Jing J, Kong F, Wang S, Tang L, Leng J, Chen K. Sun P, et al. J Transl Med. 2023 Nov 2;21(1):777. doi: 10.1186/s12967-023-04631-4. J Transl Med. 2023. PMID: 37919720 Free PMC article. Review.
Several other targeted drugs were also identified in other types of sepsis, including nystatin targeting C1QA in Neisseria sepsis and dalfopristin targeting CTSD in Streptococcus viridans sepsis. CONCLUSION: Our study provides a comprehensive overview of the cellular heter …
Several other targeted drugs were also identified in other types of sepsis, including nystatin targeting C1QA in Neisseria sepsis and dalfop …
Genetic variation reveals the therapeutic potential of BRSK2 in idiopathic pulmonary fibrosis.
Chen Z, Tang M, Wang N, Liu J, Tan X, Ma H, Luo J, Xie K. Chen Z, et al. BMC Med. 2025 Jan 21;23(1):22. doi: 10.1186/s12916-025-03848-y. BMC Med. 2025. PMID: 39838395 Free PMC article.
Transcriptomic integration identified PSMB1, CTSD, and CTSH as significant downstream effectors of BRSK2, with PSMB1 showing robust shared causal variant support (PPH4 = 0.800). ...
Transcriptomic integration identified PSMB1, CTSD, and CTSH as significant downstream effectors of BRSK2, with PSMB1 showing robust s …
Cathepsin D inhibits AGEs-induced phenotypic transformation in vascular smooth muscle cells.
He X, Tian S, Bu L, Zhao X, Zheng L, Zhang P, Guo R, Ma M. He X, et al. Sci Rep. 2025 Apr 3;15(1):11502. doi: 10.1038/s41598-025-96038-y. Sci Rep. 2025. PMID: 40181129 Free PMC article.
This study investigates the role of Cathepsin D (CTSD) in diabetic vascular complications, particularly its impact on the phenotypic transformation of vascular smooth muscle cells (VSMCs) induced by advanced glycation end-products (AGEs), and explores its pot …
This study investigates the role of Cathepsin D (CTSD) in diabetic vascular complications, particularly its impact on t …
Targeted demethylation of cathepsin D via epigenome editing rescues pathology in Alzheimer's disease mouse model.
Park M, Ryu H, Heo S, Kim B, Park J, Lim KH, Han SB, Park H. Park M, et al. Theranostics. 2025 Jan 1;15(2):428-438. doi: 10.7150/thno.103455. eCollection 2025. Theranostics. 2025. PMID: 39744681 Free PMC article.
Background: Cathepsin D (Ctsd) has emerged as a promising therapeutic target for Alzheimer's disease (AD) due to its role in degrading intracellular amyloid beta (Abeta). ...Methods: This study explored Ctsd demethylation in AD mouse models using dCas9 …
Background: Cathepsin D (Ctsd) has emerged as a promising therapeutic target for Alzheimer's disease (AD) due to its ro …
Cathepsin D and G expression correlates with human fracture healing phases and specific neutrophil N1 and N2 phenotypes.
Lu F, Groven RVM, Meesters DM, Bitorina A, Poeze M, Tang S, van Griensven M, Blokhuis TJ, Shiri-Sverdlov R. Lu F, et al. Bone. 2025 Oct;199:117574. doi: 10.1016/j.bone.2025.117574. Epub 2025 Jun 26. Bone. 2025. PMID: 40581285 Free article.
CONCLUSION: This study was the first to investigate the association of CTSD and CTSG in the fracture healing cascade. It was shown that the expression of CTSD enzyme was associated with early fracture healing phases, as well as with specific neutrophil phenotypes (N …
CONCLUSION: This study was the first to investigate the association of CTSD and CTSG in the fracture healing cascade. It was shown th …
49 results