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2023 1
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Page 1
Clinical spectrum and molecular basis in 19 Chinese patients with 46, XY disorder of sexual development caused by NR5A1 mutations.
Xu Y, Liu X, Liu Y, Zhu H, Wu J, Han B, Ling S, Cao R, Yao H, Chen Y, Liu Y, Rao Y, Liu X, Zhao S, Song H, Qiao J. Xu Y, et al. Orphanet J Rare Dis. 2024 Dec 2;19(1):453. doi: 10.1186/s13023-024-03472-8. Orphanet J Rare Dis. 2024. PMID: 39623453 Free PMC article.
The IHC analysis of the testis revealed intact expression levels of SOX9 in Sertoli cells, while significant differences were observed in the expression pattern of CYP17A1 in Leydig cells among patients. The preserved maturation of adult Leydig cells in the patients may tr …
The IHC analysis of the testis revealed intact expression levels of SOX9 in Sertoli cells, while significant differences were observed in th …
Nanoparticles with curcumin and piperine modulate steroid biosynthesis in prostate cancer.
Yakubu J, Natsaridis E, du Toit T, Barata IS, Tagit O, Pandey AV. Yakubu J, et al. Sci Rep. 2025 Apr 19;15(1):13613. doi: 10.1038/s41598-025-98102-z. Sci Rep. 2025. PMID: 40253525 Free PMC article.
In assays for steroid biosynthesis, curcumin, and its nanoparticle formulations, as well as piperine and its nanoparticles, selectively inhibited 17alpha-hydroxylase and 17,20-lyase activities of cytochrome P450 17A1 (CYP17A1). Abiraterone, a CYP17A1 inhibitor, disp …
In assays for steroid biosynthesis, curcumin, and its nanoparticle formulations, as well as piperine and its nanoparticles, selectively inhi …
17α-Hydroxylase/17,20-lyase Deficiency (17-OHD): A Meta-analysis of Reported Cases.
Willemsen AL, Torpy DJ, De Sousa SMC, Falhammar H, Rushworth RL. Willemsen AL, et al. J Clin Endocrinol Metab. 2025 Mar 17;110(4):e1261-e1271. doi: 10.1210/clinem/dgae773. J Clin Endocrinol Metab. 2025. PMID: 39500362 Free PMC article.
PURPOSE: Homozygous pathogenic variants in the CYP17A1 gene result in defective activity of the steroidogenic enzymes 17alpha-hydroxylase/17,20-lyase resulting in the clinical syndrome 17-OHD characterized by hypertension, hypokalemia, and disorders of sexual development. …
PURPOSE: Homozygous pathogenic variants in the CYP17A1 gene result in defective activity of the steroidogenic enzymes 17alpha-hydroxy …
Identification and analysis of oxidative stress-related genes in endometriosis.
Xie C, Lu C, Lv N, Kong W, Liu Y. Xie C, et al. Front Immunol. 2025 Mar 7;16:1515490. doi: 10.3389/fimmu.2025.1515490. eCollection 2025. Front Immunol. 2025. PMID: 40124382 Free PMC article.
A ceRNA network was established, encompassing 28 DE-OSRGs, 32 miRNAs, and 53 lncRNAs. Four key OSRGs (CYP17A1, NR3C1, ENO2, and NGF) were selected from protein-protein interaction network analysis. ...Weighted gene co-expression network analysis identified three immune-rel …
A ceRNA network was established, encompassing 28 DE-OSRGs, 32 miRNAs, and 53 lncRNAs. Four key OSRGs (CYP17A1, NR3C1, ENO2, and NGF) …
Zika virus disrupts steroidogenesis and impairs spermatogenesis by stalling the translation of CYP17A1 mRNA.
Yang W, Li H, Wang S, Huang R, Zhang Y, Guo M, Huang L, Li S, Yang R, Zhao D, Xiong Y, Liu Y, Huang M, Hui L, Xiao W, Wu Y. Yang W, et al. Nat Commun. 2025 Jul 22;16(1):6756. doi: 10.1038/s41467-025-62044-x. Nat Commun. 2025. PMID: 40695837 Free PMC article.
Specifically, the non-structural protein NS2A of ZIKV downregulates testosterone production by directly binding to mRNA of CYP17A1, a key enzyme in testosterone synthesis, thereby inhibiting its translation. Notably, the sole membrane-traversing segment and its flanking lo …
Specifically, the non-structural protein NS2A of ZIKV downregulates testosterone production by directly binding to mRNA of CYP17A1, a …
Association between CYP17A1 rs743572 polymorphism and cancer risk: A meta-analysis.
Wang B, Cao Z, Li Y, Zou H. Wang B, et al. PLoS One. 2025 Jun 25;20(6):e0326843. doi: 10.1371/journal.pone.0326843. eCollection 2025. PLoS One. 2025. PMID: 40561159 Free PMC article.
The role of the CYP17A1 gene's rs743572 polymorphism in cancer susceptibility has been a subject of extensive investigation, yet existing evidence remains inconclusive. In this meta-analysis, we systematically reviewed and synthesized data from 29 studies to assess the …
The role of the CYP17A1 gene's rs743572 polymorphism in cancer susceptibility has been a subject of extensive investigation, yet exis …
Human Cytochrome P450 Cancer-Related Metabolic Activities and Gene Polymorphisms: A Review.
Mokhosoev IM, Astakhov DV, Terentiev AA, Moldogazieva NT. Mokhosoev IM, et al. Cells. 2024 Nov 26;13(23):1958. doi: 10.3390/cells13231958. Cells. 2024. PMID: 39682707 Free PMC article. Review.
However, 2-hydroxy- and 4-hydroxy-estrogens and their O-methylated derivatives along with conjugated metabolites play cancer-protective roles. CYP17A1 and CYP11A1, which are involved in the biosynthesis of testosterone precursors, contribute to prostate cancer, whereas con …
However, 2-hydroxy- and 4-hydroxy-estrogens and their O-methylated derivatives along with conjugated metabolites play cancer-protective role …
A Novel A105Y Mutant of CYP17A1 Exhibits Almost Perfect Regioselectivity in the Production of 17alpha-Hydroxyprogesterone.
Du Y, Tian H, Li J, Gao J, Liu W, Lu F, Qin HM, Mao S. Du Y, et al. J Agric Food Chem. 2024 Nov 6;72(44):24609-24619. doi: 10.1021/acs.jafc.4c05982. Epub 2024 Oct 23. J Agric Food Chem. 2024. PMID: 39440611
17alpha-Hydroxyprogesterone (17alpha-OHP) is a steroid hormone with significant biological activity that can be obtained by catalyzing progesterone (PROG), the main product of sitosterol, through CYP17A1. However, increasing the catalytic specificity of HCYP17A1 for C17 hy …
17alpha-Hydroxyprogesterone (17alpha-OHP) is a steroid hormone with significant biological activity that can be obtained by catalyzing proge …
Association between CYP17A1 and HSD3B1 gene polymorphisms and testosterone levels in Nigerian prostate cancer patients.
Ekenwaneze CC, Zakari S, Amadi EC, Okesola M, Rotimi SO, Oyekan A, Fatiregun O, Iweala EEJ, Odedina F, Ogunlana OO. Ekenwaneze CC, et al. Sci Rep. 2025 Sep 29;15(1):33588. doi: 10.1038/s41598-025-18752-x. Sci Rep. 2025. PMID: 41023281 Free PMC article.
Genetic variation in androgen pathways is essential in PCa development and progression. Cytochrome P450 17A1 (CYP17A1) gene encodes a critical metabolic enzyme involved in testosterone (TT) synthesis, as it converts cholesterol into androstenedione. ...Detected genotypes w …
Genetic variation in androgen pathways is essential in PCa development and progression. Cytochrome P450 17A1 (CYP17A1) gene encodes a …
Quantitative characterization of drug metabolism and transport alterations in obesity with metabolic fatty liver disease: A physiologically based pharmacokinetic modelling approach.
Xie Y, Bai X, Shen C, Xu C, Cui C, Yang Y. Xie Y, et al. J Pharm Sci. 2025 Sep;114(9):103906. doi: 10.1016/j.xphs.2025.103906. Epub 2025 Jul 11. J Pharm Sci. 2025. PMID: 40653046
RESULTS: RNA-Seq and qPCR analyses revealed that Abcc2, Cyp2b9, Cyp2c38 and Cyp17a1 were upregulated by MAFLD in liver, whereas Slco1a1, Cyp2c29, Cyp3a11 and Cyp3a25 were downregulated. ...
RESULTS: RNA-Seq and qPCR analyses revealed that Abcc2, Cyp2b9, Cyp2c38 and Cyp17a1 were upregulated by MAFLD in liver, whereas Slco1 …
37 results