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The effect of Ureaplasma urealyticum on the level of P34H expression, the activity of hyaluronidase, and DNA fragmentation in human spermatozoa.
Ma XP, Gao XQ. Ma XP, et al. Am J Reprod Immunol. 2017 Jan;77(1). doi: 10.1111/aji.12600. Am J Reprod Immunol. 2017. PMID: 28012250
The relation among the P34H protein expression, the percentage of P34H-positive rate and HYD-positive rate, HYD-activity intensity had a significant positive correlation; Both the P34H protein expression and the percentage of P34H-positive rate were in …
The relation among the P34H protein expression, the percentage of P34H-positive rate and HYD-positive rate, HYD-activity inten …
Identification of dicarbonyl and L-xylulose reductase as a therapeutic target in human chronic kidney disease.
Perco P, Ju W, Kerschbaum J, Leierer J, Menon R, Zhu C, Kretzler M, Mayer G, Rudnicki M; Nephrotic Syndrome Study Network (NEPTUNE). Perco P, et al. JCI Insight. 2019 Jun 20;4(12):e128120. doi: 10.1172/jci.insight.128120. eCollection 2019 Jun 20. JCI Insight. 2019. PMID: 31217356 Free PMC article.
Gene expression profiles of 197 previously reported renoprotective factors were analyzed in a discovery cohort in renal biopsies of 63 CKD patients. Downregulation of dicarbonyl and L-xylulose reductase (DCXR) showed the strongest association with dise …
Gene expression profiles of 197 previously reported renoprotective factors were analyzed in a discovery cohort in renal biopsies of 63 CKD p …
Cuproptosis-related gene signatures define the immune microenvironment in diabetic nephropathy.
Luo H, Cao Y, Guo L, Li H, Yuan Y, Lu F. Luo H, et al. PLoS One. 2025 Jun 3;20(6):e0321636. doi: 10.1371/journal.pone.0321636. eCollection 2025. PLoS One. 2025. PMID: 40460381 Free PMC article.
Cluster C1 was characterized by low cuproptosis gene expression, high immune cell subtype infiltration, and high enrichment of immune-related pathways. Cluster C2 was on the contrary. Dicarbonyl/l-xylulose reductase (DCXR) and heat-responsive pr …
Cluster C1 was characterized by low cuproptosis gene expression, high immune cell subtype infiltration, and high enrichment of immune-relate …
Exploring the molecular mechanisms underlying intervertebral disc degeneration by analysing multiple datasets.
Lin L, Li D, Cai G, Zheng G, Huang D, Liu H, Lin S, Zhao F. Lin L, et al. Sci Rep. 2025 Apr 28;15(1):14748. doi: 10.1038/s41598-025-98070-4. Sci Rep. 2025. PMID: 40289127 Free PMC article.
Real-time quantitative PCR was used to confirm the expression of key genes in the tissue samples.A total of 126 differentially expressed genes were identified in the GEO database, and 4 differentially expressed hub genes (COL6A2, DCXR, GLRX, and PDGFRB) were identified thr …
Real-time quantitative PCR was used to confirm the expression of key genes in the tissue samples.A total of 126 differentially expressed gen …
A comprehensive bioinformatics analysis of pathways and biomarkers shared between type 2 diabetes mellitus and chronic obstructive pulmonary disease.
Hu T, Duan X, Gao J, Li Z, Xu D, Jing J, Li F, Ding J, Ma L, Jiang M, Wang J. Hu T, et al. Front Immunol. 2025 Jul 25;16:1536551. doi: 10.3389/fimmu.2025.1536551. eCollection 2025. Front Immunol. 2025. PMID: 40787468 Free PMC article.
Subsequent validation using human PBMC from three groups (Ctrl, COPD, and T2DM, n=15 each) confirmed PES1 (AUC 0.676 and 0.615), CANX (AUC 0.668 and 0.642), SUMF2 (AUC 0.684 and 0.679), and DCXR (0.625 and 0.606) as shared diagnostic markers. Analysis of single-cell sequen …
Subsequent validation using human PBMC from three groups (Ctrl, COPD, and T2DM, n=15 each) confirmed PES1 (AUC 0.676 and 0.615), CANX (AUC 0 …
Dimeric dihydrodiol dehydrogenase is an efficient primate 1,5-anhydro-D-fructose reductase.
Hara A, Nishinaka T, Abe N, El-Kabbani O, Matsunaga T, Endo S. Hara A, et al. Biochem Biophys Res Commun. 2020 Jun 4;526(3):728-732. doi: 10.1016/j.bbrc.2020.03.176. Epub 2020 Apr 3. Biochem Biophys Res Commun. 2020. PMID: 32253031
AF was reduced by monkey dimeric dihydrodiol dehydrogenase (DHDH), human aldehyde reductase (AKR1A1) and human dicarbonyl/L-xylulose reductase (DCXR). DHDH showed the lowest K(M) (21 muM) for AF, and its k(cat)/K(M) value (1208 s(-1)mM(-1)) was …
AF was reduced by monkey dimeric dihydrodiol dehydrogenase (DHDH), human aldehyde reductase (AKR1A1) and human dicarbonyl/L- …
Human carbonyl reductase 1 participating in intestinal first-pass drug metabolism is inhibited by fatty acids and acyl-CoAs.
Hara A, Endo S, Matsunaga T, El-Kabbani O, Miura T, Nishinaka T, Terada T. Hara A, et al. Biochem Pharmacol. 2017 Aug 15;138:185-192. doi: 10.1016/j.bcp.2017.04.023. Epub 2017 Apr 24. Biochem Pharmacol. 2017. PMID: 28450226
Unsaturated fatty acids (oleic, elaidic, gamma-linolenic and docosahexaenoic acids) and acyl-CoAs (palmitoyl-, stearoyl- and oleoyl-CoAs) were more potent inhibitors (IC(50) 1.0-2.5M), and showed high inhibitory selectivity to CBR1 over its isozyme CBR3 and other SDR superfamily …
Unsaturated fatty acids (oleic, elaidic, gamma-linolenic and docosahexaenoic acids) and acyl-CoAs (palmitoyl-, stearoyl- and oleoyl-CoAs) we …
Quantitative analysis of mRNA expression levels of aldo-keto reductase and short-chain dehydrogenase/reductase isoforms in human livers.
Amai K, Fukami T, Ichida H, Watanabe A, Nakano M, Watanabe K, Nakajima M. Amai K, et al. Drug Metab Pharmacokinet. 2020 Dec;35(6):539-547. doi: 10.1016/j.dmpk.2020.08.004. Epub 2020 Aug 26. Drug Metab Pharmacokinet. 2020. PMID: 33036882
In humans, 12 AKR isoforms (AKR1A1, AKR1B1, AKR1B10, AKR1B15, AKR1C1, AKR1C2, AKR1C3, AKR1C4, AKR1D1, AKR1E2, AKR7A2, and AKR7A3) and 6 SDR isoforms (CBR1, CBR3, CBR4, HSD11B1, DHRS4, and DCXR) have been found to catalyze the reduction in xenobiotics, but their hepatic exp …
In humans, 12 AKR isoforms (AKR1A1, AKR1B1, AKR1B10, AKR1B15, AKR1C1, AKR1C2, AKR1C3, AKR1C4, AKR1D1, AKR1E2, AKR7A2, and AKR7A3) and 6 SDR …
Delving into the Heterogeneity of Different Breast Cancer Subtypes and the Prognostic Models Utilizing scRNA-Seq and Bulk RNA-Seq.
Xu J, Qin S, Yi Y, Gao H, Liu X, Ma F, Guan M. Xu J, et al. Int J Mol Sci. 2022 Sep 1;23(17):9936. doi: 10.3390/ijms23179936. Int J Mol Sci. 2022. PMID: 36077333 Free PMC article.
We establish a prognostic model containing 10 genes (risk genes: ATP6AP1, RNF139, BASP1, ESR1 and TSKU; protective genes: RPL31, PAK1, STARD10, TFPI2 and SIAH2) for luminal BC, seven genes (risk genes: ACTR6 and C2orf76; protective genes: DIO2, DCXR, NDUFA8, SULT1A2 and AQ …
We establish a prognostic model containing 10 genes (risk genes: ATP6AP1, RNF139, BASP1, ESR1 and TSKU; protective genes: RPL31, PAK1, STARD …