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2015 3
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60 results

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Page 1
SUMOylation-Driven mRNA Circularization Enhances Translation and Promotes Lymphatic Metastasis of Bladder Cancer.
Zhao Y, Chen J, Zheng H, Luo Y, An M, Lin Y, Pang M, Li Y, Kong Y, He W, Lin T, Chen C. Zhao Y, et al. Cancer Res. 2024 Feb 1;84(3):434-448. doi: 10.1158/0008-5472.CAN-23-2278. Cancer Res. 2024. PMID: 37991737 Free PMC article.
DHCR24 promoted lymphangiogenesis and LN metastasis of bladder cancer in vitro and in vivo. ...Collectively, these findings elucidate DHCR24-mediated translation machinery that promotes lymphatic metastasis of bladder cancer and supports the potential application of …
DHCR24 promoted lymphangiogenesis and LN metastasis of bladder cancer in vitro and in vivo. ...Collectively, these findings elucidate …
3β-hydroxysteroid-Δ24 reductase dampens anti-viral innate immune responses by targeting K27 ubiquitination of MAVS and STING.
Liu Q, Chen S, Tian R, Xue B, Li H, Guo M, Liu S, Yan M, You R, Wang L, Yang D, Wan M, Zhu H. Liu Q, et al. J Virol. 2023 Dec 21;97(12):e0151323. doi: 10.1128/jvi.01513-23. Epub 2023 Nov 30. J Virol. 2023. PMID: 38032198 Free PMC article.
MAVS and STING play key roles in immune signaling pathways activated by RNA and DNA viruses, respectively. Here, we showed that DHCR24 impaired the antiviral response by targeting MAVS and STING. Notably, DHCR24 interacts with MAVS and STING and inhibits TRIM21-trig …
MAVS and STING play key roles in immune signaling pathways activated by RNA and DNA viruses, respectively. Here, we showed that DHCR24 …
24-Dehydrocholesterol reductase promotes the growth of breast cancer stem-like cells through the Hedgehog pathway.
Qiu T, Cao J, Chen W, Wang J, Wang Y, Zhao L, Liu M, He L, Wu G, Li H, Gu H. Qiu T, et al. Cancer Sci. 2020 Oct;111(10):3653-3664. doi: 10.1111/cas.14587. Epub 2020 Aug 13. Cancer Sci. 2020. PMID: 32713162 Free PMC article.
However, it is still unclear whether the cholesterol biosynthesis pathway plays any significant role in breast carcinogenesis. 24-Dehydrocholesterol reductase (DHCR24) is a key enzyme in the cholesterol synthesis pathway. Although DHCR24 is repo …
However, it is still unclear whether the cholesterol biosynthesis pathway plays any significant role in breast carcinogenesis. 24- …
24-Dehydrocholesterol Reductase alleviates oxidative damage-induced apoptosis in alveolar epithelial cells via regulating Phosphatidylinositol-3-Kinase/Protein Kinase B activation.
Yao M, Li F, Xu L, Ma L, Zhang S. Yao M, et al. Bioengineered. 2022 Jan;13(1):155-163. doi: 10.1080/21655979.2021.2011634. Bioengineered. 2022. PMID: 34949154 Free PMC article.
In addition, the apoptosis rate in the H(2)O(2) treatment group also increased significantly. And the expression of 24-dehydrocholesterol reductase (DHCR24) was markedly reduced in the H(2)O(2) treatment group. Overexpression of DHCR24 can remar …
In addition, the apoptosis rate in the H(2)O(2) treatment group also increased significantly. And the expression of 24-dehydrochol …
Investigating causality in the association between DNA methylation and type 2 diabetes using bidirectional two-sample Mendelian randomisation.
Juvinao-Quintero DL, Sharp GC, Sanderson ECM, Relton CL, Elliott HR. Juvinao-Quintero DL, et al. Diabetologia. 2023 Jul;66(7):1247-1259. doi: 10.1007/s00125-023-05914-7. Epub 2023 May 19. Diabetologia. 2023. PMID: 37202507 Free PMC article.
RESULTS: We found strong evidence of a causal effect of DNAm at cg25536676 (DHCR24) on type 2 diabetes. An increase in transformed residuals of DNAm at this site was associated with a 43% (OR 1.43, 95% CI 1.15, 1.78, p=0.001) higher risk of type 2 diabetes. ...Thus, we hyp …
RESULTS: We found strong evidence of a causal effect of DNAm at cg25536676 (DHCR24) on type 2 diabetes. An increase in transformed re …
Phenotype-genotype correlation in aldosterone-producing adenomas characterized by intracellular cholesterol metabolism.
Harashima S, Yamazaki Y, Motomura N, Ono Y, Omata K, Tezuka Y, Morimoto R, Nakamura Y, Satoh F, Suzuki H, Kwon GE, Choi MH, Sasano H. Harashima S, et al. J Steroid Biochem Mol Biol. 2022 Jul;221:106116. doi: 10.1016/j.jsbmb.2022.106116. Epub 2022 May 6. J Steroid Biochem Mol Biol. 2022. PMID: 35533918
Results demonstrated that both SR-B1 and DHCR24 were significantly lower in the ZG than in fasciculata or reticularis of NAs but LDL-R was not significantly different among them in immunohistochemical analysis. ...LDL-R, ACAT1/2, HSL, DHCR24 were all significantly l …
Results demonstrated that both SR-B1 and DHCR24 were significantly lower in the ZG than in fasciculata or reticularis of NAs but LDL- …
Identification and characterization of prescription drugs that change levels of 7-dehydrocholesterol and desmosterol.
Wages PA, Kim HH, Korade Z, Porter NA. Wages PA, et al. J Lipid Res. 2018 Oct;59(10):1916-1926. doi: 10.1194/jlr.M086991. Epub 2018 Aug 7. J Lipid Res. 2018. PMID: 30087204 Free PMC article.
Evidence is provided that three tyrosine kinase inhibitors, imatinib, ponatinib, and masitinib, elevate Des levels as well as other substrates of 24-dehydrocholesterol reductase, the enzyme responsible for converting Des to Chol. Additionally, the mechanism o …
Evidence is provided that three tyrosine kinase inhibitors, imatinib, ponatinib, and masitinib, elevate Des levels as well as other substrat …
Endothelial cells control vascular smooth muscle cell cholesterol levels by regulating 24-dehydrocholesterol reductase expression.
Kohlhaas J, Jäger MA, Lust L, De La Torre C, Hecker M, Korff T. Kohlhaas J, et al. Exp Cell Res. 2021 Feb 15;399(2):112446. doi: 10.1016/j.yexcr.2020.112446. Epub 2021 Jan 7. Exp Cell Res. 2021. PMID: 33422461
Microarray-based analyses indicated that interaction with ECs for 48 h down-regulates expression of genes in VSMCs controlling rate-limiting steps of the cholesterol biosynthesis such as HMGCR, HMGCS1, DHCR24 and DHCR7. Protein analyses revealed a decrease in the abundance …
Microarray-based analyses indicated that interaction with ECs for 48 h down-regulates expression of genes in VSMCs controlling rate-limiting …
MicroRNA-124 regulates cardiomyocyte apoptosis and myocardial infarction through targeting Dhcr24.
Han F, Chen Q, Su J, Zheng A, Chen K, Sun S, Wu H, Jiang L, Xu X, Yang M, Yang F, Zhu J, Zhang L. Han F, et al. J Mol Cell Cardiol. 2019 Jul;132:178-188. doi: 10.1016/j.yjmcc.2019.05.007. Epub 2019 May 15. J Mol Cell Cardiol. 2019. PMID: 31100313
The miR-124-Dhcr24 axis was responsible for cardiomyocyte apoptosis regulation. Furthermore, myocardial infarction induced miR-124 activation and Dhcr24 reduction in vivo. ...The miR-124-Dhcr24 axis could be a potential biomarker as well as the therapeutic ta …
The miR-124-Dhcr24 axis was responsible for cardiomyocyte apoptosis regulation. Furthermore, myocardial infarction induced miR-124 ac …
Oncogenic role of the SOX9-DHCR24-cholesterol biosynthesis axis in IGH-BCL2+ diffuse large B-cell lymphomas.
Shen Y, Zhou J, Nie K, Cheng S, Chen Z, Wang W, Wei W, Jiang D, Peng Z, Ren Y, Zhang Y, Fan Q, Richards KL, Qi Y, Cheng J, Tam W, Ma J. Shen Y, et al. Blood. 2022 Jan 6;139(1):73-86. doi: 10.1182/blood.2021012327. Blood. 2022. PMID: 34624089 Free PMC article.
Whole-transcriptome analysis and chromatin immunoprecipitation-sequencing assays identified DHCR24, a terminal enzyme in cholesterol biosynthesis, as a direct target of SOX9, which promotes cholesterol synthesis by increasing DHCR24 expression. ...In summary, our st …
Whole-transcriptome analysis and chromatin immunoprecipitation-sequencing assays identified DHCR24, a terminal enzyme in cholesterol …
60 results