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Year Number of Results
2016 2
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80 results

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Page 1
DHODH-mediated ferroptosis defence is a targetable vulnerability in cancer.
Mao C, Liu X, Zhang Y, Lei G, Yan Y, Lee H, Koppula P, Wu S, Zhuang L, Fang B, Poyurovsky MV, Olszewski K, Gan B. Mao C, et al. Nature. 2021 May;593(7860):586-590. doi: 10.1038/s41586-021-03539-7. Epub 2021 May 12. Nature. 2021. PMID: 33981038 Free PMC article.
Supplementation with dihydroorotate or orotate-the substrate and product of dihydroorotate dehydrogenase (DHODH)-attenuates or potentiates ferroptosis induced by inhibition of GPX4, respectively, and these effects are particularly pronounced in cancer cells w …
Supplementation with dihydroorotate or orotate-the substrate and product of dihydroorotate dehydrogenase (DHODH)-attenu …
A targetable PRR11-DHODH axis drives ferroptosis- and temozolomide-resistance in glioblastoma.
Miao Z, Xu L, Gu W, Ren Y, Li R, Zhang S, Chen C, Wang H, Ji J, Chen J. Miao Z, et al. Redox Biol. 2024 Jul;73:103220. doi: 10.1016/j.redox.2024.103220. Epub 2024 May 30. Redox Biol. 2024. PMID: 38838551 Free PMC article.
Mechanistically, PRR11 directly binds to and stabilizes dihydroorotate dehydrogenase (DHODH), which leads to glioma ferroptosis-resistant in a DHODH-dependent manner in vivo and in vitro. Furthermore, PRR11 inhibits HERC4 and DHODH binding, by s …
Mechanistically, PRR11 directly binds to and stabilizes dihydroorotate dehydrogenase (DHODH), which leads to glioma fer …
Therapeutic targeting of SLC6A8 creatine transporter suppresses colon cancer progression and modulates human creatine levels.
Kurth I, Yamaguchi N, Andreu-Agullo C, Tian HS, Sridhar S, Takeda S, Gonsalves FC, Loo JM, Barlas A, Manova-Todorova K, Busby R, Bendell JC, Strauss J, Fakih M, McRee AJ, Hendifar AE, Rosen LS, Cercek A, Wasserman R, Szarek M, Spector SL, Raza S, Tavazoie MF, Tavazoie SF. Kurth I, et al. Sci Adv. 2021 Oct 8;7(41):eabi7511. doi: 10.1126/sciadv.abi7511. Epub 2021 Oct 6. Sci Adv. 2021. PMID: 34613776 Free PMC article.
Combining RGX-202 with 5-fluorouracil or the DHODH inhibitor leflunomide caused regressions of multiple colorectal xenograft and PDX tumors of distinct mutational backgrounds. ...
Combining RGX-202 with 5-fluorouracil or the DHODH inhibitor leflunomide caused regressions of multiple colorectal xenograft and PDX …
UBE2T-mediated Akt ubiquitination and Akt/β-catenin activation promotes hepatocellular carcinoma development by increasing pyrimidine metabolism.
Zhu Z, Cao C, Zhang D, Zhang Z, Liu L, Wu D, Sun J. Zhu Z, et al. Cell Death Dis. 2022 Feb 15;13(2):154. doi: 10.1038/s41419-022-04596-0. Cell Death Dis. 2022. PMID: 35169125 Free PMC article.
UBE2T overexpression led to the upregulation of several key enzymes catalyzing de novo pyrimidine synthesis, including CAD, DHODH, and UMPS. Moreover, the utilization of leflunomide, a clinically approved DHODH inhibitor, blocked the effect of UBE2T in promoting HCC …
UBE2T overexpression led to the upregulation of several key enzymes catalyzing de novo pyrimidine synthesis, including CAD, DHODH, an …
Mitochondrial nucleic acid binding proteins associated with diseases.
Uchiumi T, Kang D. Uchiumi T, et al. Front Biosci (Landmark Ed). 2017 Jan 1;22(1):168-179. doi: 10.2741/4479. Front Biosci (Landmark Ed). 2017. PMID: 27814609 Free article. Review.
Miller syndrome is a recessive disorder characterized by postaxial acrofacial dysostosis and caused by a mutation in DHODH. Finally, we explain that p32 and mitochondrial creatine kinase may be novel markers for the progression of prostate cancer....
Miller syndrome is a recessive disorder characterized by postaxial acrofacial dysostosis and caused by a mutation in DHODH. Finally, …
The long non-coding RNA RSDR protects against acute kidney injury in mice by interacting with hnRNPK to regulate DHODH-mediated ferroptosis.
Li B, Lin F, Song B, Han S, Ye Z, Sun Y, Wang P, Xia Y, Yu W, Zhou X, Cheng F. Li B, et al. Nat Commun. 2025 Aug 12;16(1):7483. doi: 10.1038/s41467-025-62433-2. Nat Commun. 2025. PMID: 40796740 Free PMC article.
RSDR interacts with the RNA-binding protein hnRNPK, forming a positive feedback loop that enhances the transcription of DHODH, a key ferroptosis-suppressing gene. Mechanistically, RSDR promotes the nuclear retention of hnRNPK and facilitates epigenetic activation of DHO …
RSDR interacts with the RNA-binding protein hnRNPK, forming a positive feedback loop that enhances the transcription of DHODH, a key …
Knockdown of SLC16A3 decreases extracellular lactate concentration in hepatocellular carcinoma, alleviates hypoxia and induces ferroptosis.
Shen J, Wu Z, Zhou Y, Yang D, Wang X, Yu B, Zhao K, Ding Y. Shen J, et al. Biochem Biophys Res Commun. 2024 Nov 12;733:150709. doi: 10.1016/j.bbrc.2024.150709. Epub 2024 Sep 18. Biochem Biophys Res Commun. 2024. PMID: 39303526 Free article.
Moreover, knockdown of SLC16A3 significantly increased the level of lipid peroxidation and reactive oxygen species (ROS), while the expressions of GPX4, DHODH and SLC7A11 were inhibited. The expression of SLC16A3 affected the sensitivity of HCC cells to chemotherapy and ta …
Moreover, knockdown of SLC16A3 significantly increased the level of lipid peroxidation and reactive oxygen species (ROS), while the expressi …
A genome-wide CRISPR-Cas9 knockout screen identifies FSP1 as the warfarin-resistant vitamin K reductase.
Jin DY, Chen X, Liu Y, Williams CM, Pedersen LC, Stafford DW, Tie JK. Jin DY, et al. Nat Commun. 2023 Feb 14;14(1):828. doi: 10.1038/s41467-023-36446-8. Nat Commun. 2023. PMID: 36788244 Free PMC article.
FSP1 inhibitor that inhibited ubiquinone reduction and thus triggered cancer cell ferroptosis, displays strong inhibition of vitamin K-dependent carboxylation. Intriguingly, dihydroorotate dehydrogenase, another ubiquinone-associated ferroptosis suppressor protein p …
FSP1 inhibitor that inhibited ubiquinone reduction and thus triggered cancer cell ferroptosis, displays strong inhibition of vitamin K-depen …
Bioinformatics analysis and experimental verification of the cancer-promoting effect of DHODH in clear cell renal cell carcinoma.
Wang S, Li Y, Lin Y, Li J, Guo L, Wang H, Lin X, Liu Z, Zhang B, Liao Z, Zhang Z. Wang S, et al. Sci Rep. 2024 May 25;14(1):11985. doi: 10.1038/s41598-024-62738-0. Sci Rep. 2024. PMID: 38796629 Free PMC article.
The GSCALite and CellMiner databases were employed to explore drugs and perform molecular docking analysis with DHODH. Protein-protein interaction networks and ceRNA regulatory networks of DHODH were constructed using multiple databases. The effect of DHODH o …
The GSCALite and CellMiner databases were employed to explore drugs and perform molecular docking analysis with DHODH. Protein-protei …
Diverse evolutionary pathways challenge the use of collateral sensitivity as a strategy to suppress resistance.
Mandt REK, Luth MR, Tye MA, Mazitschek R, Ottilie S, Winzeler EA, Lafuente-Monasterio MJ, Gamo FJ, Wirth DF, Lukens AK. Mandt REK, et al. Elife. 2023 Sep 22;12:e85023. doi: 10.7554/eLife.85023. Elife. 2023. PMID: 37737220 Free PMC article.
In this study, we explore collateral sensitivity between compounds targeting the Plasmodium dihydroorotate dehydrogenase (DHODH). We profiled the cross-resistance and collateral sensitivity phenotypes of several DHODH mutant lines to a diverse panel of …
In this study, we explore collateral sensitivity between compounds targeting the Plasmodium dihydroorotate dehydrogenase (D …
80 results