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Year Number of Results
2016 3
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80 results

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Page 1
Hypoxia inducible factor-1α drives cancer resistance to cuproptosis.
Yang Z, Su W, Wei X, Pan Y, Xing M, Niu L, Feng B, Kong W, Ren X, Huang F, Zhou J, Zhao W, Qiu Y, Liao T, Chen Q, Qu S, Wang Y, Guan Q, Li D, Zen K, Chen Y, Qin C, Wang Y, Zhou X, Xiang J, Yao B. Yang Z, et al. Cancer Cell. 2025 May 12;43(5):937-954.e9. doi: 10.1016/j.ccell.2025.02.015. Epub 2025 Mar 6. Cancer Cell. 2025. PMID: 40054467
We found that HIF-1alpha activates pyruvate dehydrogenase kinase 1 and 3 (PDK1/3), resulting in decreased expression of dihydrolipoamide S-acetyltransferase (DLAT) (target of copper), and promotes the accumulation of metallothionein, which sequesters m …
We found that HIF-1alpha activates pyruvate dehydrogenase kinase 1 and 3 (PDK1/3), resulting in decreased expression of dihydrolipoamide …
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity.
Chen S, Liu X, Peng C, Tan C, Sun H, Liu H, Zhang Y, Wu P, Cui C, Liu C, Yang D, Li Z, Lu J, Guan J, Ke X, Wang R, Bo X, Xu X, Han J, Liu J. Chen S, et al. Cell Metab. 2021 Mar 2;33(3):565-580.e7. doi: 10.1016/j.cmet.2021.02.007. Cell Metab. 2021. PMID: 33657393 Free article.
Using LiP-SMap (limited proteolysis-mass spectrometry) combined with a microscale thermophoresis assay and molecular docking analysis, we confirmed dihydrolipoamide S-acetyltransferase (Dlat) as a direct molecular target of HPF. Ablation of Dlat …
Using LiP-SMap (limited proteolysis-mass spectrometry) combined with a microscale thermophoresis assay and molecular docking analysis, we co …
Isocitrate dehydrogenase 1 primes group-3 medulloblastomas for cuproptosis.
Dang D, Deogharkar A, McKolay J, Smith KS, Panwalkar P, Hoffman S, Tian W, Ji S, Azambuja AP, Natarajan SK, Lum J, Bayliss J, Manzeck K, Sweha SR, Hamanishi E, Pun M, Patel D, Rau S, Animasahun O, Achreja A, Ogrodzinski MP, Diessl J, Cotter J, Hawes D, Yang F, Doherty R, Franson AT, Hanaford AR, Eberhart CG, Raabe EH, Orr BA, Wechsler-Reya RJ, Chen B, Lyssiotis CA, Shah YM, Lunt SY, Banerjee R, Judkins AR, Prensner JR, Koschmann C, Waszak SM, Nagrath D, Simoes-Costa M, Northcott PA, Venneti S. Dang D, et al. Cancer Cell. 2025 Jun 9;43(6):1159-1174.e8. doi: 10.1016/j.ccell.2025.04.013. Epub 2025 May 15. Cancer Cell. 2025. PMID: 40378837
DLAT is induced by c-MYC and targeting DLAT lowers TCA cycle metabolism and glutathione synthesis. ...DLAT expression in group-3 MB cells correlates with increased sensitivity to cuproptosis. ...
DLAT is induced by c-MYC and targeting DLAT lowers TCA cycle metabolism and glutathione synthesis. ...DLAT expression i …
Acetate reprogrammes tumour metabolism and promotes PD-L1 expression and immune evasion by upregulating c-Myc.
Wang J, Yang Y, Shao F, Meng Y, Guo D, He J, Lu Z. Wang J, et al. Nat Metab. 2024 May;6(5):914-932. doi: 10.1038/s42255-024-01037-4. Epub 2024 May 3. Nat Metab. 2024. PMID: 38702440
Acetate-derived acetyl-CoA induces c-Myc acetylation, which is mediated by the moonlighting function of the metabolic enzyme dihydrolipoamide S-acetyltransferase. Acetylated c-Myc increases its stability and subsequent transcription of the genes encoding prog …
Acetate-derived acetyl-CoA induces c-Myc acetylation, which is mediated by the moonlighting function of the metabolic enzyme dihydrolipoa …
PM2.5 promotes NSCLC carcinogenesis through translationally and transcriptionally activating DLAT-mediated glycolysis reprograming.
Chen Q, Wang Y, Yang L, Sun L, Wen Y, Huang Y, Gao K, Yang W, Bai F, Ling L, Zhou Z, Zhang X, Xiong J, Zhai R. Chen Q, et al. J Exp Clin Cancer Res. 2022 Jul 22;41(1):229. doi: 10.1186/s13046-022-02437-8. J Exp Clin Cancer Res. 2022. PMID: 35869499 Free PMC article.
Mechanistically, PM2.5 activated eIF4E, consequently up-regulating the expression level of DLAT in polysomes. PM2.5 also stimulated transcription factor Sp1, which further augmented transcription activity of DLAT promoter. CONCLUSIONS: This study demonstrated that P …
Mechanistically, PM2.5 activated eIF4E, consequently up-regulating the expression level of DLAT in polysomes. PM2.5 also stimulated t …
DLAT activates EMT to promote HCC metastasis by regulating GLUT1-mediated aerobic glycolysis.
Yin Q, Yao Y, Ni J, Zhang Y, Wu J, Zeng H, Wu W, Zhuo W, Ying J, Li J. Yin Q, et al. Mol Med. 2025 Feb 20;31(1):71. doi: 10.1186/s10020-025-01125-5. Mol Med. 2025. PMID: 39979835 Free PMC article.
RESULTS: Our study revealed a significant upregulation of DLAT expression in HCC, which was linked to a poor prognosis. Furthermore, we discovered that DLAT facilitated tumor metastasis by driving metabolic reprogramming in HCC cells. ...Finally, we confirmed a posi …
RESULTS: Our study revealed a significant upregulation of DLAT expression in HCC, which was linked to a poor prognosis. Furthermore, …
PER2 interaction with HSP70 promotes cuproptosis in oral squamous carcinoma cells by decreasing AKT stability.
Yu W, Yin S, Tang H, Li H, Zhang Z, Yang K. Yu W, et al. Cell Death Dis. 2025 Mar 20;16(1):192. doi: 10.1038/s41419-025-07523-1. Cell Death Dis. 2025. PMID: 40113747 Free PMC article.
Mechanistically, PER2 bound to heat shock protein 70 (HSP70) through its C-terminal domain, subsequently reducing the interaction between HSP70 and AKT and leading to enhanced degradation of AKT ubiquitination, and promoting cuproptosis in OSCC cells by inhibiting the AKT pathway …
Mechanistically, PER2 bound to heat shock protein 70 (HSP70) through its C-terminal domain, subsequently reducing the interaction between HS …
A comprehensive and systematic analysis of Dihydrolipoamide S-acetyltransferase (DLAT) as a novel prognostic biomarker in pan-cancer and glioma.
Zhou H, Yu Z, Xu J, Wang Z, Tao Y, Wang J, Yang P, Yang J, Niu T. Zhou H, et al. Oncol Res. 2024 Nov 13;32(12):1903-1919. doi: 10.32604/or.2024.048138. eCollection 2024. Oncol Res. 2024. PMID: 39574473 Free PMC article.
BACKGROUND: Dihydrolipoamide S-acetyltransferase (DLAT) is a subunit of the pyruvate dehydrogenase complex (PDC), a rate-limiting enzyme complex, that can participate in either glycolysis or the tricarboxylic acid cycle (TCA). ...Single-cell analysis d …
BACKGROUND: Dihydrolipoamide S-acetyltransferase (DLAT) is a subunit of the pyruvate dehydrogenase complex (PDC) …
DLAT promotes triple-negative breast cancer progression via YAP1 activation.
Liu D, Wang X, Qian F, Ye D, Deng X, Fang L. Liu D, et al. Cancer Biol Ther. 2024 Dec 31;25(1):2421578. doi: 10.1080/15384047.2024.2421578. Epub 2024 Oct 26. Cancer Biol Ther. 2024. PMID: 39460738 Free PMC article.
New therapeutic targets are urgently needed for TNBC owing to its receptor expression characteristics, which render it insensitive to traditional targeted and endocrine therapies for BC. The role and mechanisms of dihydrolipoamide S-acetyltransferase (DLAT …
New therapeutic targets are urgently needed for TNBC owing to its receptor expression characteristics, which render it insensitive to tradit …
Identification and validation of novel genes related to immune microenvironment in polycystic ovary syndrome.
Zhao Y, Liu L, Hao J, Wang H, Cao Y, Lan Y, Ji L. Zhao Y, et al. Medicine (Baltimore). 2024 Oct 25;103(43):e40229. doi: 10.1097/MD.0000000000040229. Medicine (Baltimore). 2024. PMID: 39470566 Free PMC article.
Furthermore, the expression levels of DLAT (P = .049) and NUDT16 (P = .024) differed significantly between the PCOS patients and normal controls, as revealed by multifactorial analysis. Both DLAT and NUDT16 were negatively correlated with immune cell expression and …
Furthermore, the expression levels of DLAT (P = .049) and NUDT16 (P = .024) differed significantly between the PCOS patients and norm …
80 results