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Year Number of Results
2013 4
2014 4
2015 1
2016 5
2017 4
2018 1
2019 2
2020 4
2021 1
2022 7
2023 4
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32 results
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A Novel Cuproptosis-Related Prognostic Gene Signature and Validation of Differential Expression in Clear Cell Renal Cell Carcinoma.
Bian Z, Fan R, Xie L. Bian Z, et al. Genes (Basel). 2022 May 10;13(5):851. doi: 10.3390/genes13050851. Genes (Basel). 2022. PMID: 35627236 Free PMC article.
In the current study, we systematically evaluated the genetic alterations of cuproptosis-related genes in ccRCC. Our results revealed that CDKN2A, DLAT, DLD, FDX1, GLS, PDHA1 and PDHB exhibited differential expression between ccRCC and normal tissues (|log(2)(fold change)| …
In the current study, we systematically evaluated the genetic alterations of cuproptosis-related genes in ccRCC. Our results revealed that C …
The phytochemical hyperforin triggers thermogenesis in adipose tissue via a Dlat-AMPK signaling axis to curb obesity.
Chen S, Liu X, Peng C, Tan C, Sun H, Liu H, Zhang Y, Wu P, Cui C, Liu C, Yang D, Li Z, Lu J, Guan J, Ke X, Wang R, Bo X, Xu X, Han J, Liu J. Chen S, et al. Cell Metab. 2021 Mar 2;33(3):565-580.e7. doi: 10.1016/j.cmet.2021.02.007. Cell Metab. 2021. PMID: 33657393 Free article.
Using LiP-SMap (limited proteolysis-mass spectrometry) combined with a microscale thermophoresis assay and molecular docking analysis, we confirmed dihydrolipoamide S-acetyltransferase (Dlat) as a direct molecular target of HPF. Ablation of Dlat
Using LiP-SMap (limited proteolysis-mass spectrometry) combined with a microscale thermophoresis assay and molecular docking analysis, we co …
A novel signature to guide osteosarcoma prognosis and immune microenvironment: Cuproptosis-related lncRNA.
Yang M, Zheng H, Xu K, Yuan Q, Aihaiti Y, Cai Y, Xu P. Yang M, et al. Front Immunol. 2022 Jul 29;13:919231. doi: 10.3389/fimmu.2022.919231. eCollection 2022. Front Immunol. 2022. PMID: 35967366 Free PMC article.
Risk curve, survival, receiver operating characteristic (ROC) curve, and independent prognostic analyses were performed. Next, principal component analysis (PCA) and t-distributed stochastic neighbor embedding (t-SNE) analysis were performed. ...In addition, we obtained fo …
Risk curve, survival, receiver operating characteristic (ROC) curve, and independent prognostic analyses were performed. Next, principal …
Cuproptosis-related gene index: A predictor for pancreatic cancer prognosis, immunotherapy efficacy, and chemosensitivity.
Huang X, Zhou S, Tóth J, Hajdu A. Huang X, et al. Front Immunol. 2022 Aug 25;13:978865. doi: 10.3389/fimmu.2022.978865. eCollection 2022. Front Immunol. 2022. PMID: 36090999 Free PMC article.
Unsupervised consensus clustering was performed to more precisely identify different CRGI-based molecular subtypes and investigate the immunotherapy and chemotherapy efficacy. The expression of DLAT, LIPT1 and LIAS were also investigated, through real-time quantitative pol …
Unsupervised consensus clustering was performed to more precisely identify different CRGI-based molecular subtypes and investigate the immun …
PM2.5 promotes NSCLC carcinogenesis through translationally and transcriptionally activating DLAT-mediated glycolysis reprograming.
Chen Q, Wang Y, Yang L, Sun L, Wen Y, Huang Y, Gao K, Yang W, Bai F, Ling L, Zhou Z, Zhang X, Xiong J, Zhai R. Chen Q, et al. J Exp Clin Cancer Res. 2022 Jul 22;41(1):229. doi: 10.1186/s13046-022-02437-8. J Exp Clin Cancer Res. 2022. PMID: 35869499 Free PMC article.
Mechanistically, PM2.5 activated eIF4E, consequently up-regulating the expression level of DLAT in polysomes. PM2.5 also stimulated transcription factor Sp1, which further augmented transcription activity of DLAT promoter. CONCLUSIONS: This study demonstrated that P …
Mechanistically, PM2.5 activated eIF4E, consequently up-regulating the expression level of DLAT in polysomes. PM2.5 also stimulated t …
Xenobiotics and loss of tolerance in primary biliary cholangitis.
Wang J, Yang G, Dubrovsky AM, Choi J, Leung PS. Wang J, et al. World J Gastroenterol. 2016 Jan 7;22(1):338-48. doi: 10.3748/wjg.v22.i1.338. World J Gastroenterol. 2016. PMID: 26755880 Free PMC article. Review.
The serologic hallmark of PBC are the presence of high titer anti-mitochondrial autoantibodies (AMA) that recognize the lipoyl domain of the mitochondrial pyruvate dehydrogenase E2 (PDC-E2) subunit. Extensive efforts have been directed to invest …
The serologic hallmark of PBC are the presence of high titer anti-mitochondrial autoantibodies (AMA) that recognize the lipoyl domain of the …
dltA overexpression: A strain-independent keystone of daptomycin resistance in methicillin-resistant Staphylococcus aureus.
Cafiso V, Bertuccio T, Purrello S, Campanile F, Mammina C, Sartor A, Raglio A, Stefani S. Cafiso V, et al. Int J Antimicrob Agents. 2014 Jan;43(1):26-31. doi: 10.1016/j.ijantimicag.2013.10.001. Epub 2013 Oct 16. Int J Antimicrob Agents. 2014. PMID: 24183798
We analysed, by sequencing and expression studies, the role of the major molecular targets (cell-envelope charge genes, dltA, mprF, cls2; cell-wall turnover and autolysis genes, sceD, atl) involved in the emergence of DAP resistance in three series of isogenic clinical met …
We analysed, by sequencing and expression studies, the role of the major molecular targets (cell-envelope charge genes, dltA, mprF, c …
Indole signaling decreases biofilm formation and related virulence of Listeria monocytogenes.
Rattanaphan P, Mittraparp-Arthorn P, Srinoun K, Vuddhakul V, Tansila N. Rattanaphan P, et al. FEMS Microbiol Lett. 2020 Jul 1;367(14):fnaa116. doi: 10.1093/femsle/fnaa116. FEMS Microbiol Lett. 2020. PMID: 32658271
Results demonstrated that synthetic indole and indole-rich conditioned medium significantly diminished biofilm formation and related virulence of L. monocytogenes including motility, cell aggregation and exopolysaccharide production. Transcript levels of virulence-associated (pss …
Results demonstrated that synthetic indole and indole-rich conditioned medium significantly diminished biofilm formation and related virulen …
5-Dodecanolide inhibits biofilm formation and virulence of Streptococcus pyogenes by suppressing core regulons of virulence.
Valliammai A, Selvaraj A, Sangeetha M, Sethupathy S, Pandian SK. Valliammai A, et al. Life Sci. 2020 Dec 1;262:118554. doi: 10.1016/j.lfs.2020.118554. Epub 2020 Oct 6. Life Sci. 2020. PMID: 33035584
The results were further validated by the reduced survival of DD treated S. pyogenes in healthy human blood. Consequently, based on the qPCR analysis DD altered the expression of core regulons srv, ropB, mga and genes associated with biofilm formation and virulence such as …
The results were further validated by the reduced survival of DD treated S. pyogenes in healthy human blood. Consequently, based on t …
Antibodies to post-translationally modified mitochondrial peptide PDC-E2(167-184) in type 1 diabetes.
Nuti F, Gallo A, Real-Fernandez F, Crulli M, Rentier C, Piarulli F, Peroni E, Rossi G, Traldi P, Rovero P, Lapolla A, Papini AM. Nuti F, et al. Arch Biochem Biophys. 2018 Dec 1;659:66-74. doi: 10.1016/j.abb.2018.09.021. Epub 2018 Sep 25. Arch Biochem Biophys. 2018. PMID: 30266625
The PTMs were introduced at position 173 of the mitochondrial pyruvate dehydrogenase E2 complex peptide PDC-E2(167-184) and at position 7 of a structure-based designed beta-turn peptide as an irrelevant sequence to investigate the role of …
The PTMs were introduced at position 173 of the mitochondrial pyruvate dehydrogenase E2 complex peptide PDC
32 results