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Roles of Dihydrolipoamide Dehydrogenase in Health and Disease.
Yan LJ, Wang Y. Yan LJ, et al. Antioxid Redox Signal. 2023 Oct;39(10-12):794-806. doi: 10.1089/ars.2022.0181. Epub 2023 Aug 14. Antioxid Redox Signal. 2023. PMID: 37276180 Free PMC article. Review.
Significance: Dihydrolipoamide dehydrogenase (DLDH) is a flavin-dependent disulfide oxidoreductase. The active form of DLDH is a stable homodimer, and its deficiencies have been linked to numerous metabolic disorders. A better understanding of redox and nonredox fea …
Significance: Dihydrolipoamide dehydrogenase (DLDH) is a flavin-dependent disulfide oxidoreductase. The active form of DLDH is …
Dihydrolipoamide dehydrogenase (DLD) is a novel molecular target of bortezomib.
Feng Y, Luo H, Huang J, Zhang Y, Wen J, Li L, Mi Z, Gao Q, He S, Liu X, Zhai X, Wang X, Zhang L, Niu T, Zheng Y. Feng Y, et al. Cell Death Dis. 2024 Aug 13;15(8):588. doi: 10.1038/s41419-024-06982-2. Cell Death Dis. 2024. PMID: 39138149 Free PMC article.
Our data showed that bortezomib bound to DLD and inhibited DLD's enzymatic function in MM cells. DLD knocked down MM cells (DLD-KD) had decreased levels of NADH. ...Overall, our findings elucidated DLD as an alternative molecular target of borte …
Our data showed that bortezomib bound to DLD and inhibited DLD's enzymatic function in MM cells. DLD knocked down MM ce …
The moonlighting activities of dihydrolipoamide dehydrogenase: Biotechnological and biomedical applications.
Fleminger G, Dayan A. Fleminger G, et al. J Mol Recognit. 2021 Nov;34(11):e2924. doi: 10.1002/jmr.2924. Epub 2021 Jun 23. J Mol Recognit. 2021. PMID: 34164859 Review.
Dihydrolipoamide dehydrogenase (DLDH) is a homodimeric flavin-dependent enzyme that catalyzes the NAD(+) -dependent oxidation of dihydrolipoamide. ...DLDH possesses several moonlighting functions. One of these is the capacity to adhere to metal-oxides surfaces. ...
Dihydrolipoamide dehydrogenase (DLDH) is a homodimeric flavin-dependent enzyme that catalyzes the NAD(+) -dependent oxidation of dihy …
Dihydrolipoamide dehydrogenase, pyruvate oxidation, and acetylation-dependent mechanisms intersecting drug iatrogenesis.
Duarte IF, Caio J, Moedas MF, Rodrigues LA, Leandro AP, Rivera IA, Silva MFB. Duarte IF, et al. Cell Mol Life Sci. 2021 Dec;78(23):7451-7468. doi: 10.1007/s00018-021-03996-3. Epub 2021 Oct 31. Cell Mol Life Sci. 2021. PMID: 34718827 Free PMC article. Review.
This work aims to clarify the mechanisms that intersect VPA-related iatrogenic effects to PDC-associated dihydrolipoamide dehydrogenase (DLD; E3) activity. DLD is also a key enzyme of alpha-ketoglutarate dehydrogenase, branched-chain alpha-keto acid dehydrogenase, a …
This work aims to clarify the mechanisms that intersect VPA-related iatrogenic effects to PDC-associated dihydrolipoamide dehydrogenase ( …
Recurrent Liver Failure in an 11-Year-Old Boy.
Neveu J, Hoebeke C, Lebigot E, Naïmi M. Neveu J, et al. Clin Chem. 2020 Aug 1;66(8):1115-1117. doi: 10.1093/clinchem/hvaa136. Clin Chem. 2020. PMID: 32746465 No abstract available.
Pan-Cancer Analysis of the Cuproptosis-Related Gene DLD.
Lin J, Wang G, Cheng S, Hu Y, Li H, Feng W, Liu X, Xu C. Lin J, et al. Mediators Inflamm. 2023 Nov 30;2023:5533444. doi: 10.1155/2023/5533444. eCollection 2023. Mediators Inflamm. 2023. PMID: 38077227 Free PMC article.
RESULTS: The mRNA and protein expression of DLD differs in most cancers. Survival analysis showed that DLD was associated with prognosis with KIRC, KIRP, KICH, and UCS. DLD had a strong diagnostic value in KIRC, GBM, PAAD, and LGG (AUC > 0.9). DLD p …
RESULTS: The mRNA and protein expression of DLD differs in most cancers. Survival analysis showed that DLD was associated with …
Maple syrup urine disease in Brazilian patients: variants and clinical phenotype heterogeneity.
Margutti AVB, Silva WA Jr, Garcia DF, de Molfetta GA, Marques AA, Amorim T, Prazeres VMG, Boy da Silva RT, Miura IK, Seda Neto J, Santos ES, Santos MLSF, Lourenço CM, Tonon T, Sperb-Ludwig F, de Souza CFM, Schwartz IVD, Camelo JS Jr. Margutti AVB, et al. Orphanet J Rare Dis. 2020 Nov 1;15(1):309. doi: 10.1186/s13023-020-01590-7. Orphanet J Rare Dis. 2020. PMID: 33131499 Free PMC article.
BACKGROUND: Maple syrup urine disease (MSUD) is an autosomal recessive inherited metabolic disease caused by deficient activity of the branched-chain alpha-keto acid dehydrogenase (BCKD) enzymatic complex. BCKD is a mitochondrial complex encoded by BCK …
BACKGROUND: Maple syrup urine disease (MSUD) is an autosomal recessive inherited metabolic disease caused by def …
Maple syrup urine disease diagnosis in Brazilian patients by massive parallel sequencing.
Tresbach RH, Sperb-Ludwig F, Ligabue-Braun R, Bitencourt FH, Tonon T, Souza CFM, Poswar FO, Leite MEQ, Amorim T, Porta G, Seda Neto J, Miura IK, Steiner CE, Martins AM, Pessoa ALS, Ribeiro EM, Schwartz IVD. Tresbach RH, et al. Mol Genet Metab. 2024 Sep-Oct;143(1-2):108569. doi: 10.1016/j.ymgme.2024.108569. Epub 2024 Aug 29. Mol Genet Metab. 2024. PMID: 39270351
Biallelic pathogenic variants cause maple syrup urine disease (MSUD) in one of the branched-chain alpha-keto acid dehydrogenase (BCKDH) complex genes (BCKDHA, BCKDHB, DBT, DLD, and PPM1K) leading to the accumulation of leucine, isoleucine, and v …
Biallelic pathogenic variants cause maple syrup urine disease (MSUD) in one of the branched-chain alpha-keto aci …
Molecular basis of various forms of maple syrup urine disease in Chilean patients.
Campanholi DRR, Margutti AVB, Silva WA Jr, Garcia DF, Molfetta GA, Marques AA, Schwartz IVD, Cornejo V, Hamilton V, Castro G, Sperb-Ludwig F, Borges ES, Camelo JS Jr. Campanholi DRR, et al. Mol Genet Genomic Med. 2021 May;9(5):e1616. doi: 10.1002/mgg3.1616. Epub 2021 May 6. Mol Genet Genomic Med. 2021. PMID: 33955723 Free PMC article.
BACKGROUND: Maple syrup urine disease (MSUD) is an autosomal recessive inherited metabolic disorder caused by the deficient activity of the branched-chain alpha-keto acid dehydrogenase (BCKD) enzymatic complex. BCKD is a mitochondrial complex encoded b …
BACKGROUND: Maple syrup urine disease (MSUD) is an autosomal recessive inherited metabolic disorder caused by th …
Identification of Dihydrolipoamide Dehydrogenase as Potential Target of Vemurafenib-Resistant Melanoma Cells.
Tabolacci C, Giordano D, Rossi S, Cordella M, D'Arcangelo D, Moschella F, D'Atri S, Biffoni M, Facchiano A, Facchiano F. Tabolacci C, et al. Molecules. 2022 Nov 12;27(22):7800. doi: 10.3390/molecules27227800. Molecules. 2022. PMID: 36431901 Free PMC article.
DLD expression was observed to be increased in resistant cells by Western blot analysis. Protein modeling analyses of DLD's catalytic site coupled to in vitro assays with CPI-613, a specific DLD inhibitor, highlighted the role of DLD enzymatic function
DLD expression was observed to be increased in resistant cells by Western blot analysis. Protein modeling analyses of DLD's ca
20 results