Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation

Search Page

Filters

My Custom Filters

Results by year

Table representation of search results timeline featuring number of search results per year.

Year Number of Results
2023 7
2024 8
2025 4

Publication date

Text availability

Article attribute

Article type

Additional filters

Article Language

Species

Sex

Age

Other

Search Results

17 results

Results by year

Filters applied: . Clear all
Page 1
Single-cell transcriptomic analysis deciphers heterogenous cancer stem-like cells in colorectal cancer and their organ-specific metastasis.
Li R, Liu X, Huang X, Zhang D, Chen Z, Zhang J, Bai R, Zhang S, Zhao H, Xu Z, Zeng L, Zhuang L, Wen S, Wu S, Li M, Zuo Z, Lin J, Lin D, Zheng J. Li R, et al. Gut. 2024 Feb 23;73(3):470-484. doi: 10.1136/gutjnl-2023-330243. Gut. 2024. PMID: 38050068 Free PMC article.
Population 1 (P1) cells with high delta-like ligand 4 (DLL4) and MAF bZIP transcription factor A (MAFA) expression are enriched in primary CRC and oCRC, thus may be associated with ovarian metastasis. ...Stem-like cells interacted with cancer-associated fibroblasts and end …
Population 1 (P1) cells with high delta-like ligand 4 (DLL4) and MAF bZIP transcription factor A (MAFA) expression are enriched in pr …
NCoR1 limits angiogenic capacity by altering Notch signaling.
Teichmann T, Malacarne P, Zehr S, Günther S, Pflüger-Müller B, Warwick T, Brandes RP. Teichmann T, et al. J Mol Cell Cardiol. 2024 Mar;188:65-78. doi: 10.1016/j.yjmcc.2024.02.003. Epub 2024 Feb 15. J Mol Cell Cardiol. 2024. PMID: 38359551 Free article.
NCoR1 depletion significantly upregulated angiogenesis-associated genes, especially tip cell genes, including ESM1, DLL4 and NOTCH4, as observed by RNA- and ATAC-seq. Confrontation assays comparing cells with and without NCoR1-deficiency revealed that loss of NCoR1 promote …
NCoR1 depletion significantly upregulated angiogenesis-associated genes, especially tip cell genes, including ESM1, DLL4 and NOTCH4, …
A pan-cancer analysis of TNFAIP8L1 in human tumors.
Sun J, Zhang X, Zhu B, Chen Y, Wang H. Sun J, et al. Medicine (Baltimore). 2023 Dec 8;102(49):e36291. doi: 10.1097/MD.0000000000036291. Medicine (Baltimore). 2023. PMID: 38065896 Free PMC article.
Finally, TNFAIP8L1 gene had a significant positive association with 5 genes including BCL6B, DLL4, PCDH12, COL4A1 and DLL4 in the majority of tumors. GO enrichment and KEGG pathway analyses showed that TNFAIP8L1 in thepathogenesis of cancer may be related to "purine …
Finally, TNFAIP8L1 gene had a significant positive association with 5 genes including BCL6B, DLL4, PCDH12, COL4A1 and DLL4 in …
IL-17A-producing NKp44(-) group 3 innate lymphoid cells accumulate in Familial Adenomatous Polyposis duodenal tissue.
Kaiser KM, Raabe J, ToVinh M, Hack G, Ahmad S, Müller N, Cassella J, Walravens SI, Alfaro P, Arias Garcia L, Kaczmarek DJ, Marwitz T, Goeser F, Nischalke HD, Lutz P, Sommer N, Vilz T, Toma M, Steiner S, Hommerding O, Oldenburg J, Hölzel M, Kadzik S, Maas A, Eckrich J, Zumfelde P, Shakeri F, Nesic S, Buness A, De Caro E, Becker M, Beyer MD, Ulas T, Aschenbrenner AC, Steinheuer LM, Thurley K, Kroh S, Uecker R, Hauser AE, Gohr FN, Schmidt FI, Wang D, Held K, Baranov O, Geldmacher C, Strassburg CP, Hüneburg R, Krämer B, Nattermann J. Kaiser KM, et al. Nat Commun. 2025 Apr 25;16(1):3873. doi: 10.1038/s41467-025-58907-y. Nat Commun. 2025. PMID: 40280932 Free PMC article.
We observe an increase in duodenal IL-17A(+)NKp44(-) innate lymphoid type 3 cell (ILC3) in FAP, localized near the epithelium and enriched in adenomas and carcinomas. Elevated IL1B, IL23A, and DLL4 transcript levels correlate with IL-17A(+)NKp44(-)ILC3 accumulation, and in …
We observe an increase in duodenal IL-17A(+)NKp44(-) innate lymphoid type 3 cell (ILC3) in FAP, localized near the epithelium and enriched i …
Tumor-derived Endothelial Cell: Important Etiological Factors in Endometriosis.
Dong Y, Zhang M, OuYang J, Zhou W, Yu B. Dong Y, et al. Arch Med Res. 2023 Nov;54(7):102891. doi: 10.1016/j.arcmed.2023.102891. Epub 2023 Sep 20. Arch Med Res. 2023. PMID: 37738888
Compared to EM, the proportion of tumor-derived ECs (IGFBP3+) was significantly increased in EC (43.8 vs. 16.0%). 63 differentially expressed genes (DEGs) between tumor-derived ECs and normal ECs were enriched in "angiogenesis", such as EFNB2, DLL4, and THSD7A. Subsequentl …
Compared to EM, the proportion of tumor-derived ECs (IGFBP3+) was significantly increased in EC (43.8 vs. 16.0%). 63 differentially expresse …
The phosphodiesterase 2A controls lymphatic junctional maturation via cGMP-dependent notch signaling.
Carlantoni C, Liekfeld LMH, Hemkemeyer SA, Schreier D, Saygi C, Kurelic R, Cardarelli S, Kalucka J, Schulte C, Beerens M, Mailer RK, Schäffer TE, Naro F, Pellegrini M, Nikolaev VO, Renné T, Frye M. Carlantoni C, et al. Dev Cell. 2024 Feb 5;59(3):308-325.e11. doi: 10.1016/j.devcel.2023.12.002. Epub 2023 Dec 29. Dev Cell. 2024. PMID: 38159569 Free article.
Loss of PDE2A-mediated cGMP hydrolysis leads to the activation of p38 signaling and downregulation of NOTCH signaling. However, DLL4-induced NOTCH activation restores junctional maturation and contact inhibition in PDE2A-deficient human lymphatic endothelial cells. ...
Loss of PDE2A-mediated cGMP hydrolysis leads to the activation of p38 signaling and downregulation of NOTCH signaling. However, DLL4- …
Upregulation of Notch Signaling and Cell-Differentiation Inhibitory Transcription Factors in Stable Chronic Obstructive Pulmonary Disease Patients.
Di Stefano A, Gnemmi I, Rosani U, Maniscalco M, D'Anna SE, Brun P, Carriero V, Bertolini F, Balbi B, Ricciardolo FLM. Di Stefano A, et al. Int J Mol Sci. 2024 Mar 14;25(6):3287. doi: 10.3390/ijms25063287. Int J Mol Sci. 2024. PMID: 38542260 Free PMC article.
Transcriptomic data in lung parenchyma showed increased DLL4 and HES1 mRNA levels in those with MCOPD and CSs compared to CNSs. These data show the increased expression of the Notch pathway in the lungs of those with stable COPD. ...
Transcriptomic data in lung parenchyma showed increased DLL4 and HES1 mRNA levels in those with MCOPD and CSs compared to CNSs. These …
The N-acetylglucosaminyltransferase Radical fringe contributes to defects in JAG1-dependent turnover and signaling of NOTCH3 CADASIL mutants.
Suzuki S, Mashiko T, Tsukamoto Y, Oya M, Kotani Y, Okawara S, Matsumoto T, Mizue Y, Takeuchi H, Okajima T, Itoh M. Suzuki S, et al. J Biol Chem. 2024 Oct;300(10):107787. doi: 10.1016/j.jbc.2024.107787. Epub 2024 Sep 19. J Biol Chem. 2024. PMID: 39303912 Free PMC article.
NOTCH3 functions as a signaling receptor, activating downstream gene expression in response to ligands like JAG1 and DLL4, which regulate the development and survival of mural cells. This signal transduction process is thought to be connected with NOTCH3 endocytic degradat …
NOTCH3 functions as a signaling receptor, activating downstream gene expression in response to ligands like JAG1 and DLL4, which regu …
Identification of a prognostic model based on immune and hypoxia-related gene expressions in cervical cancer.
Wang L, Wang C, He Y, Jin M, Lin L, Jiao X, Hu X, Wang Y. Wang L, et al. J Obstet Gynaecol. 2023 Dec;43(2):2277242. doi: 10.1080/01443615.2023.2277242. Epub 2023 Nov 8. J Obstet Gynaecol. 2023. PMID: 37938121 Free article.
This study constructed a risk scoring models based on 12 characteristic gene related to hypoxia and immunity, including CX3CL1, CXCL3, GHSR, DLL4, FGFR2, PDF, KLRK1, MAP3K14, RETNLB, PRDX2, P4HA1 and PGK1, which can help predict the prognosis of PD-1 immunotherapy in CC pa …
This study constructed a risk scoring models based on 12 characteristic gene related to hypoxia and immunity, including CX3CL1, CXCL3, GHSR, …
Human endothelial cells promote a human neural stem cell type B phenotype via Notch signaling.
Gutierrez B, Liu TC, Rodriguez C, Pastor-Alonso O, Lambing H, Paredes MF, Flanagan LA. Gutierrez B, et al. Nat Commun. 2025 May 30;16(1):5031. doi: 10.1038/s41467-025-60194-6. Nat Commun. 2025. PMID: 40447618 Free PMC article.
Blocking hNSPC Notch signaling, and reducing hEC expression of the Notch ligand DLL4, abrogates the effect of hECs on type B hNSPCs. We identify S100A6 and LeX as human type B cell markers, and analysis of the postnatal human SVZ confirms co-expression of GFAP, SOX2, S100A …
Blocking hNSPC Notch signaling, and reducing hEC expression of the Notch ligand DLL4, abrogates the effect of hECs on type B hNSPCs. …
17 results