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Page 1
DVL1 and DVL3 require nuclear localisation to regulate proliferation in human myoblasts.
Pruller J, Figeac N, Zammit PS. Pruller J, et al. Sci Rep. 2022 May 19;12(1):8388. doi: 10.1038/s41598-022-10536-x. Sci Rep. 2022. PMID: 35589804 Free PMC article.
DVL1 and DVL3 also contribute to regulation of proliferation in rhabdomyosarcoma. DVL1 or DVL3 must be present in the nucleus to regulate proliferation, but they operate through different protein domains: DVL3 requires the DIX and PDZ domains, while DVL1 does …
DVL1 and DVL3 also contribute to regulation of proliferation in rhabdomyosarcoma. DVL1 or DVL3 must be present in the nucleus …
Human Genetics of Ventricular Septal Defect.
Perrot A, Rickert-Sperling S. Perrot A, et al. Adv Exp Med Biol. 2024;1441:505-534. doi: 10.1007/978-3-031-44087-8_27. Adv Exp Med Biol. 2024. PMID: 38884729
Complex G-protein signaling of the adhesion GPCR, ADGRA3.
Bagger SM, Schihada H, Walser ALS, Drzazga AK, Grätz L, Palmisano T, Kuhn CK, Mavri M, Mølleskov-Jensen AS, Tall GG, Schöneberg T, Mathiasen SJ, Javitch JA, Schulte G, Spiess K, Rosenkilde MM. Bagger SM, et al. J Biol Chem. 2025 May;301(5):108441. doi: 10.1016/j.jbc.2025.108441. Epub 2025 Mar 22. J Biol Chem. 2025. PMID: 40127866 Free PMC article.
Due to the central role of ADGRA3 in planar cell polarity signaling through DVL recruitment, we investigated the G-protein signaling in the absence of DVL1-3 and found it sustained. No transcriptional activation was observed in an assay of downstream beta-catenin activity. …
Due to the central role of ADGRA3 in planar cell polarity signaling through DVL recruitment, we investigated the G-protein signaling in the …
Exploration and identification of diabetes targets in nursing: CDH1 and DVL1.
Cheng F, Li L, Zhang Y. Cheng F, et al. Medicine (Baltimore). 2024 Nov 1;103(44):e40002. doi: 10.1097/MD.0000000000040002. Medicine (Baltimore). 2024. PMID: 39495995 Free PMC article.
Core gene expression heatmap showed that core genes (CTNNB1, CDH1, DVL1) were highly expressed in diabetes samples. CTD analysis showed thatCTNNB1, CDH1, DVL1were associated with weight gain, inflammation, and necrosis. CDH1 and DVL1 are highly expressed in diabetes …
Core gene expression heatmap showed that core genes (CTNNB1, CDH1, DVL1) were highly expressed in diabetes samples. CTD analysis show …
Dishevelled-1 regulates global transcriptomic changes and associates with ETS1 transcription factor.
Martinez-Marin D, Sharma M, van Wunnik JC, Sardela de Miranda F, Boligala GP, Jull EC, Stroman GC, Babcock RL, Pruitt K. Martinez-Marin D, et al. Nat Commun. 2025 Jul 8;16(1):6288. doi: 10.1038/s41467-025-61551-1. Nat Commun. 2025. PMID: 40628704 Free PMC article.
A key unresolved question is whether nuclear DVL1 associates with a transcription factor partner. We show here that modulation of DVL1 expression globally affects the transcriptomic landscape. Additionally, analysis of DVL1 ChIP-sequencing allowed us to map g …
A key unresolved question is whether nuclear DVL1 associates with a transcription factor partner. We show here that modulation of …
Dishevelled family proteins (DVL1-3) expression in intrauterine growth restriction (IUGR) placentas.
Sola IM, Serman A, Karin-Kujundzic V, Paic F, Skrtic A, Slatina P, Kakarigi L, Vranic S, Serman L. Sola IM, et al. Bosn J Basic Med Sci. 2021 Aug 1;21(4):447-453. doi: 10.17305/bjbms.2020.5422. Bosn J Basic Med Sci. 2021. PMID: 33485290 Free PMC article.
Dishevelled family proteins (DVL1, DVL2, and DVL3) are cytoplasmic proteins that are involved in canonical and non-canonical Wnt signaling pathway during embryonic development. ...DVL1, DVL2, and DVL3 protein expression were semi-quantitatively analyzed using immuno …
Dishevelled family proteins (DVL1, DVL2, and DVL3) are cytoplasmic proteins that are involved in canonical and non-canonical Wnt sign …
The Wnt pathway protein Dvl1 targets somatostatin receptor 2 for lysosome-dependent degradation.
Carr HS, Zuo Y, Frost JA. Carr HS, et al. J Biol Chem. 2023 May;299(5):104645. doi: 10.1016/j.jbc.2023.104645. Epub 2023 Mar 23. J Biol Chem. 2023. PMID: 36965619 Free PMC article.
Here, we show that Sstr2 interacts with the Wnt pathway protein Dvl1 in a ligand-independent manner to target Sstr2 for lysosomal degradation. Interaction of Sstr2 with Dvl1 does not affect receptor internalization, recycling, or signaling to adenylyl cyclase but do …
Here, we show that Sstr2 interacts with the Wnt pathway protein Dvl1 in a ligand-independent manner to target Sstr2 for lysosomal deg …
Disheveled-1 Interacts with Claudin-5 and Contributes to Norrin-Induced Endothelial Barrier Restoration.
Díaz-Coránguez M, González-González L, Wang A, Liu X, Antonetti DA. Díaz-Coránguez M, et al. Cells. 2023 Oct 4;12(19):2402. doi: 10.3390/cells12192402. Cells. 2023. PMID: 37830616 Free PMC article.
These studies demonstrated that norrin restoration of barrier properties after VEGF treatment required DVL1 as an siRNA knockdown of Dvl1 but not Dvl2 or Dvl3, reduced basal barrier properties and ablated norrin-induced barrier restoration. ...DVL has previously bee …
These studies demonstrated that norrin restoration of barrier properties after VEGF treatment required DVL1 as an siRNA knockdown of …
Mechanistic studies in Drosophila and chicken give new insights into functions of DVL1 in dominant Robinow syndrome.
Gignac SJ, MacCharles KR, Fu K, Bonaparte K, Akarsu G, Barrett TW, Verheyen EM, Richman JM. Gignac SJ, et al. Dis Model Mech. 2023 Apr 1;16(4):dmm049844. doi: 10.1242/dmm.049844. Epub 2023 Apr 13. Dis Model Mech. 2023. PMID: 36916233 Free PMC article.
Cases diagnosed with Robinow syndrome do survive to adulthood with distinct skeletal phenotypes, including limb shortening and craniofacial abnormalities. Here, we focus on mutations in dishevelled 1 (DVL1), an intracellular adaptor protein that is required f …
Cases diagnosed with Robinow syndrome do survive to adulthood with distinct skeletal phenotypes, including limb shortening and craniofacial …
A novel frameshift mutation of DVL1-induced Robinow syndrome: A case report and literature review.
Hu R, Qiu Y, Li Y, Li J. Hu R, et al. Mol Genet Genomic Med. 2022 Mar;10(3):e1886. doi: 10.1002/mgg3.1886. Epub 2022 Feb 9. Mol Genet Genomic Med. 2022. PMID: 35137569 Free PMC article. Review.
METHODS: We performed DNA extraction, whole-exome sequencing analysis, and mutation analysis of DVL1 to obtain genetic data on the patient. We subsequently analyzed the patient's clinical and genetic data. ...Whole-exome sequencing of the patient's DNA revealed a heterozyg …
METHODS: We performed DNA extraction, whole-exome sequencing analysis, and mutation analysis of DVL1 to obtain genetic data on the pa …
55 results