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Year Number of Results
2016 9
2017 11
2018 17
2019 9
2020 15
2021 13
2022 8
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2024 10
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104 results

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Page 1
The spectrum of neurodevelopmental, neuromuscular and neurodegenerative disorders due to defective autophagy.
Deneubourg C, Ramm M, Smith LJ, Baron O, Singh K, Byrne SC, Duchen MR, Gautel M, Eskelinen EL, Fanto M, Jungbluth H. Deneubourg C, et al. Autophagy. 2022 Mar;18(3):496-517. doi: 10.1080/15548627.2021.1943177. Epub 2021 Aug 19. Autophagy. 2022. PMID: 34130600 Free PMC article.
The close connection with adult-onset neurodegenerative disorders highlights the relevance of research into rare early-onset neurodevelopmental conditions for much more common, age-related human diseases.Abbreviations: AC: anterior commissure; AD: Alzheimer disease; ALR: autophag …
The close connection with adult-onset neurodegenerative disorders highlights the relevance of research into rare early-onset neurodevelopmen …
PNPO-Mediated Oxidation of DVL3 Promotes Multiple Myeloma Malignancy and Osteoclastogenesis by Activating the Wnt/beta-Catenin Pathway.
Deng Z, Sun S, Zhou N, Peng Y, Cheng L, Yu X, Yuan Y, Guo M, Xu M, Cheng Y, Zhou F, Li N, Yang Y, Gu C. Deng Z, et al. Adv Sci (Weinh). 2025 Feb;12(5):e2407681. doi: 10.1002/advs.202407681. Epub 2024 Dec 10. Adv Sci (Weinh). 2025. PMID: 39656865 Free PMC article.
Mechanistically, PNPO oxidizes disheveled 3(M282) (DVL3), leading to abnormal activation of the Wnt/beta-catenin pathway. Based on the critical sites of PNPO(R95/K117), Eltrombopag is identified as a potential therapeutic candidate for MM. ...Eltrombopag inhibited the grow …
Mechanistically, PNPO oxidizes disheveled 3(M282) (DVL3), leading to abnormal activation of the Wnt/beta-catenin pathway. Based on th …
DVL1 and DVL3 require nuclear localisation to regulate proliferation in human myoblasts.
Pruller J, Figeac N, Zammit PS. Pruller J, et al. Sci Rep. 2022 May 19;12(1):8388. doi: 10.1038/s41598-022-10536-x. Sci Rep. 2022. PMID: 35589804 Free PMC article.
DVL1 and DVL3 also contribute to regulation of proliferation in rhabdomyosarcoma. DVL1 or DVL3 must be present in the nucleus to regulate proliferation, but they operate through different protein domains: DVL3 requires the DIX and PDZ domains, while DVL1 does …
DVL1 and DVL3 also contribute to regulation of proliferation in rhabdomyosarcoma. DVL1 or DVL3 must be present in the nucleus …
Carboxy-terminal polyglutamylation regulates signaling and phase separation of the Dishevelled protein.
Kravec M, Šedo O, Nedvědová J, Micka M, Šulcová M, Zezula N, Gömöryová K, Potěšil D, Sri Ganji R, Bologna S, Červenka I, Zdráhal Z, Harnoš J, Tripsianes K, Janke C, Bařinka C, Bryja V. Kravec M, et al. EMBO J. 2024 Nov;43(22):5635-5666. doi: 10.1038/s44318-024-00254-7. Epub 2024 Sep 30. EMBO J. 2024. PMID: 39349846 Free PMC article.
TTLL11 efficiently polyglutamylates the Wnt signaling protein Dishevelled 3 (DVL3), thereby changing the interactome of DVL3. Polyglutamylation increases the capacity of DVL3 to get phosphorylated, to undergo phase separation, and to act in the noncanonical W …
TTLL11 efficiently polyglutamylates the Wnt signaling protein Dishevelled 3 (DVL3), thereby changing the interactome of DVL3. …
Dishevelled Segment Polarity Protein 3 (DVL3) Induced by Bacterial LPS Promotes the Proliferation and Migration of Prostate Cancer Cells through the TLR4 Pathway.
Zhang Y, Lin N, Liu X, Yao T. Zhang Y, et al. Arch Esp Urol. 2024 Mar;77(2):193-201. doi: 10.56434/j.arch.esp.urol.20247702.25. Arch Esp Urol. 2024. PMID: 38583012 Free article.
Bacterial lipopolysaccharides (LPSs) play a significant part in the event and development of prostate cancer. Dishevelled segment polarity protein 3 (DVL3) is a shared component of the Wnt/beta-catenin and Notch signaling pathways, which …
Bacterial lipopolysaccharides (LPSs) play a significant part in the event and development of prostate cancer. Dishevelled segment …
Dishevelled segment polarity protein 3 (DVL3): a novel and easily applicable recurrence predictor in localised prostate adenocarcinoma.
Kim PJ, Park JY, Kim HG, Cho YM, Go H. Kim PJ, et al. BJU Int. 2017 Sep;120(3):343-350. doi: 10.1111/bju.13783. Epub 2017 Feb 10. BJU Int. 2017. PMID: 28107606

RESULTS: TCGA discovery set was subgrouped into lower- and higher-risk groups for recurrence-free survival (RFS) (P < 0.001). Cyclin B1 (CCNB1), dishevelled segment polarity protein 3 (DVL3), paxillin (PXN), RAF1, transferrin, X-ray re

…

RESULTS: TCGA discovery set was subgrouped into lower- and higher-risk groups for recurrence-free survival (RFS) (P < 0.001). Cyclin B1 (

…
SMYD4 monomethylates PRMT5 and forms a positive feedback loop to promote hepatocellular carcinoma progression.
Zhou Z, Chen Z, Zhou Q, Meng S, Shi J, Mui S, Jiang H, Lin J, He G, Li W, Zhang J, Wang J, He C, Yan Y, Xiao Z. Zhou Z, et al. Cancer Sci. 2024 May;115(5):1587-1601. doi: 10.1111/cas.16139. Epub 2024 Mar 4. Cancer Sci. 2024. PMID: 38438251 Free PMC article.
SMYD4 monomethylated PRMT5 and enhanced the interaction between PRMT5 and MEP50, thereby promoting the symmetrical dimethylation of H3R2 and H4R3 on the PRMT5 target gene promoter and subsequently activating DVL3 expression and inhibiting expression of E-cadherin, RBL2, an …
SMYD4 monomethylated PRMT5 and enhanced the interaction between PRMT5 and MEP50, thereby promoting the symmetrical dimethylation of H3R2 and …
Role and mechanism of Dvl3 in the esophageal squamous cell carcinoma.
Chen XQ, Jiang J, Wang XT, Zhang CL, Ji AY, Chen XJ. Chen XQ, et al. Eur Rev Med Pharmacol Sci. 2018 Nov;22(22):7716-7725. doi: 10.26355/eurrev_201811_16393. Eur Rev Med Pharmacol Sci. 2018. PMID: 30536315 Free article.
RESULTS: Dvl3 promoted the proliferation of esophageal squamous cell carcinoma cells and cell migration of cells expressing Dvl3 siRNA was significantly lower than that of the non-transfected cells. Flow cytometry showed that silencing Dvl3 promoted apoptosis …
RESULTS: Dvl3 promoted the proliferation of esophageal squamous cell carcinoma cells and cell migration of cells expressing Dvl3 …
Expression Levels and Localizations of DVL3 and sFRP3 in Glioblastoma.
Kafka A, Tomas D, Lechpammer M, Gabud T, Pažanin L, Pećina-Šlaus N. Kafka A, et al. Dis Markers. 2017;2017:9253495. doi: 10.1155/2017/9253495. Epub 2017 Oct 19. Dis Markers. 2017. PMID: 29200599 Free PMC article.
Majority of glioblastomas had moderate expression levels for both DVL3 (52.4%) and sFRP3 (52.3%). Strong expression levels were observed in 23.1% and 36.0% of samples, respectively. ...Wilcox test indicated that the domination of the strong signal is in connection with sim …
Majority of glioblastomas had moderate expression levels for both DVL3 (52.4%) and sFRP3 (52.3%). Strong expression levels were obser …
Exosomal Dvl3 promoted the aggressive phenotypic transformation of RA-FLS via wnt pathway.
Tan W, Chen N, Qiu Y, Feng X, Li S, Zhang Y, Li H, Gao J, Zhao D. Tan W, et al. Autoimmunity. 2022 Aug;55(5):285-293. doi: 10.1080/08916934.2022.2067984. Epub 2022 May 2. Autoimmunity. 2022. PMID: 35499309 Free article.
OBJECTIVE: This study was performed to explore the function and mechanism of Dvl3 in RA-FLS by exosome intervention. METHODS: The expression pattern of Dvl3 was examined by IHC, WB, and qPCR. ...The augment of TNF-alpha, IL-1beta, IL-17, and IL-21 was observed in ex …
OBJECTIVE: This study was performed to explore the function and mechanism of Dvl3 in RA-FLS by exosome intervention. METHODS: The exp …
104 results