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2016 2
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38 results

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Page 1
EFEMP2 indicates assembly of M0 macrophage and more malignant phenotypes of glioma.
Huang L, Wang Z, Chang Y, Wang K, Kang X, Huang R, Zhang Y, Chen J, Zeng F, Wu F, Zhao Z, Li G, Huang H, Jiang T, Hu H. Huang L, et al. Aging (Albany NY). 2020 May 12;12(9):8397-8412. doi: 10.18632/aging.103147. Epub 2020 May 12. Aging (Albany NY). 2020. PMID: 32396873 Free PMC article.
EFEMP2 exhibited a remarkable preference of intercellular expression. In vitro assay showed that EFEMP2's level in medium was closely related to glioma cells' growth. Moreover, EFEMP2 expression level was remarkably correlated with immunological responses. M0 …
EFEMP2 exhibited a remarkable preference of intercellular expression. In vitro assay showed that EFEMP2's level in medium was …
Fibulin-4 is essential for maintaining arterial wall integrity in conduit but not muscular arteries.
Halabi CM, Broekelmann TJ, Lin M, Lee VS, Chu ML, Mecham RP. Halabi CM, et al. Sci Adv. 2017 May 3;3(5):e1602532. doi: 10.1126/sciadv.1602532. eCollection 2017 May. Sci Adv. 2017. PMID: 28508064 Free PMC article.
Homozygous or compound heterozygous mutations in fibulin-4 (FBLN4) lead to autosomal recessive cutis laxa type 1B (ARCL1B), a multisystem disorder characterized by significant cardiovascular abnormalities, including abnormal elastin assembly, arterial tortuos …
Homozygous or compound heterozygous mutations in fibulin-4 (FBLN4) lead to autosomal recessive cutis laxa type 1B (ARCL …
Overexpression of MFAP5 inhibits the progression of papillary thyroid cancer and aerobic glycolysis by regulating the EFEMP2/Wnt/beta-catenin pathway.
Sun Y, Dong J, Li J, Zhang Y, Han Y. Sun Y, et al. Pathol Res Pract. 2025 Apr;268:155846. doi: 10.1016/j.prp.2025.155846. Epub 2025 Feb 25. Pathol Res Pract. 2025. PMID: 40020327
MFAP5 overexpression inhibits PTC cell proliferation and aerobic glycolysis. MFAP5 overexpression activates EFEMP2 and suppresses the Wnt/beta-catenin pathway. Knockdown of EFEMP2 reverses PTC cell proliferation and aerobic glycolysis. Tumor growth can be inhibited …
MFAP5 overexpression inhibits PTC cell proliferation and aerobic glycolysis. MFAP5 overexpression activates EFEMP2 and suppresses the …
Genetic secrets of long-term glioblastoma survivors.
Jovčevska I. Jovčevska I. Bosn J Basic Med Sci. 2019 May 20;19(2):116-124. doi: 10.17305/bjbms.2018.3717. Bosn J Basic Med Sci. 2019. PMID: 30114377 Free PMC article. Review.
Moreover, a decreased expression of the CHI3L1, FBLN4, EMP3, IGFBP2, IGFBP3, LGALS3, MAOB, PDPN, SERPING1 and TIMP1 genes has been associated with prolonged survival. ...
Moreover, a decreased expression of the CHI3L1, FBLN4, EMP3, IGFBP2, IGFBP3, LGALS3, MAOB, PDPN, SERPING1 and TIMP1 genes has been as …
Discovery of pathogenic variants in EFEMP2 and RAG1 and undetectable fetal phenotype: A challenge of prenatal exome sequencing.
Favier M, Dard R, Gorincour G, Tessier A, Motte-Signoret E, Duvillier C, Racine C, Faivre L, Thauvin-Robinet C, Mau-Them FT. Favier M, et al. Prenat Diagn. 2024 Aug;44(9):1115-1118. doi: 10.1002/pd.6629. Epub 2024 Jun 25. Prenat Diagn. 2024. PMID: 38923535
RESULT: Prenatal trio exome sequencing identified two homozygous likely pathogenic variants, i.e. a missense in EFEMP2 involved in cutis laxa and a nonsense in RAG1 involved in several types of severe combined immunodeficiency. ...CONCLUSION: Both EFEMP2 and RAG1 va …
RESULT: Prenatal trio exome sequencing identified two homozygous likely pathogenic variants, i.e. a missense in EFEMP2 involved in cu …
EFEMP2 upregulates PD-L1 expression via EGFR/ERK1/2/c-Jun signaling to promote the invasion of ovarian cancer cells.
Shen X, Jin X, Fang S, Chen J. Shen X, et al. Cell Mol Biol Lett. 2023 Jul 7;28(1):53. doi: 10.1186/s11658-023-00471-8. Cell Mol Biol Lett. 2023. PMID: 37420173 Free PMC article.
BACKGROUND: Fibulin-like extracellular matrix protein 2 (EFEMP2) has been reported to be related to the progression of various cancers. We have previously reported that EFEMP2 was highly expressed in ovarian cancer and was strongly associated with poor prognosis in …
BACKGROUND: Fibulin-like extracellular matrix protein 2 (EFEMP2) has been reported to be related to the progression of various cancer …
Construction of store-operated calcium entry-related gene signature for predicting prognosis and indicates immune microenvironment infiltration in stomach adenocarcinomas.
Zhang Z, Wang C, Shi W, Wang Z, Fu W. Zhang Z, et al. Sci Rep. 2024 Sep 27;14(1):22342. doi: 10.1038/s41598-024-73324-9. Sci Rep. 2024. PMID: 39333689 Free PMC article.
Several mRNA prognostic genes, including PTPRJ, GPR146, LTBP3, FBLN1, EFEMP2, ADAMTS7 and LBH, were identified, which could be used as effective prognostic predictors for STAD patients. ...
Several mRNA prognostic genes, including PTPRJ, GPR146, LTBP3, FBLN1, EFEMP2, ADAMTS7 and LBH, were identified, which could be used a …
Fibulin-4 deposition requires EMILIN-1 in the extracellular matrix of osteoblasts.
Schiavinato A, Keene DR, Imhof T, Doliana R, Sasaki T, Sengle G. Schiavinato A, et al. Sci Rep. 2017 Jul 17;7(1):5526. doi: 10.1038/s41598-017-05835-7. Sci Rep. 2017. PMID: 28717224 Free PMC article.
We found that upon RNAi mediated depletion of EMILIN-1 in primary calvarial osteoblasts and MC3T3-E1 cells only fibulin-4 matrix deposition was lost while other fibulin family members or LTBPs remained unaffected. Immunoprecipitation and ELISA-style binding assays c …
We found that upon RNAi mediated depletion of EMILIN-1 in primary calvarial osteoblasts and MC3T3-E1 cells only fibulin-4 matr …
Downregulation of fibulin-4 inhibits autophagy and promotes the sensitivity of esophageal squamous cell carcinoma cells to apatinib by activating the Akt-mTOR signaling pathway.
Chen X, Wang J, Song L, Yu Y, Shi M, Jiang W, Liu X, He X. Chen X, et al. Thorac Cancer. 2022 Sep;13(18):2592-2605. doi: 10.1111/1759-7714.14595. Epub 2022 Aug 11. Thorac Cancer. 2022. PMID: 35950373 Free PMC article.
BACKGROUND: Fibulin-4, namely, EFEMP2, is an essential matricellular protein associated with a variety of malignancies. ...Downregulation of fibulin-4 inhibited the proliferation, invasion and migration of ESCC cells in vitro and in vivo. ...
BACKGROUND: Fibulin-4, namely, EFEMP2, is an essential matricellular protein associated with a variety of malignancies. …
Fibulin-4 reduces extracellular matrix production and suppresses chondrocyte differentiation via DKK1- mediated canonical Wnt/beta-catenin signaling.
Shangguan L, Ning G, Luo Z, Zhou Y. Shangguan L, et al. Int J Biol Macromol. 2017 Jun;99:293-299. doi: 10.1016/j.ijbiomac.2017.02.087. Epub 2017 Feb 24. Int J Biol Macromol. 2017. PMID: 28238906
Fibulin-4 is an extracellular matrix (ECM) protein implicated in connective tissue development and elastic fiber formation. However, little is known about the underlying function of Fibulin-4 in cartilage development. The aim of this study was to inves …
Fibulin-4 is an extracellular matrix (ECM) protein implicated in connective tissue development and elastic fiber formation. Ho …
38 results