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Year Number of Results
2020 17
2021 18
2022 9
2023 1
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42 results
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Page 1
Ribosome Collisions Trigger General Stress Responses to Regulate Cell Fate.
Wu CC, Peterson A, Zinshteyn B, Regot S, Green R. Wu CC, et al. Cell. 2020 Jul 23;182(2):404-416.e14. doi: 10.1016/j.cell.2020.06.006. Epub 2020 Jun 30. Cell. 2020. PMID: 32610081 Free PMC article.
Problems arising during translation of mRNAs lead to ribosome stalling and collisions that trigger a series of quality control events. ...Here, we uncover a function for ribosome collisions in signal transduction. Using translation elongation inhibitors and …
Problems arising during translation of mRNAs lead to ribosome stalling and collisions that trigger a series of quality control …
CC-90009, a novel cereblon E3 ligase modulator, targets acute myeloid leukemia blasts and leukemia stem cells.
Surka C, Jin L, Mbong N, Lu CC, Jang IS, Rychak E, Mendy D, Clayton T, Tindall E, Hsu C, Fontanillo C, Tran E, Contreras A, Ng SWK, Matyskiela M, Wang K, Chamberlain P, Cathers B, Carmichael J, Hansen J, Wang JCY, Minden MD, Fan J, Pierce DW, Pourdehnad M, Rolfe M, Lopez-Girona A, Dick JE, Lu G. Surka C, et al. Blood. 2021 Feb 4;137(5):661-677. doi: 10.1182/blood.2020008676. Blood. 2021. PMID: 33197925 Free PMC article.
On the other hand, GSPT1 degradation promoted the activation of the GCN1/GCN2/ATF4 pathway and subsequent apoptosis in AML cells. Collectively, CC-90009 activity is mediated by multiple layers of signaling networks and pathways within AML blasts and LSCs, whose elucidation …
On the other hand, GSPT1 degradation promoted the activation of the GCN1/GCN2/ATF4 pathway and subsequent apoptosis in AML cells. Col …
Genome-wide CRISPR screens reveal multitiered mechanisms through which mTORC1 senses mitochondrial dysfunction.
Condon KJ, Orozco JM, Adelmann CH, Spinelli JB, van der Helm PW, Roberts JM, Kunchok T, Sabatini DM. Condon KJ, et al. Proc Natl Acad Sci U S A. 2021 Jan 26;118(4):e2022120118. doi: 10.1073/pnas.2022120118. Proc Natl Acad Sci U S A. 2021. PMID: 33483422 Free PMC article.
In mammalian cells, nutrients and growth factors signal through an array of upstream proteins to regulate the mTORC1 growth control pathway. Because the full complement of these proteins has not been systematically identified, we developed a FACS-based CRISPR-Cas9 genetic …
In mammalian cells, nutrients and growth factors signal through an array of upstream proteins to regulate the mTORC1 growth control p …
GCN2 kinase activation by ATP-competitive kinase inhibitors.
Tang CP, Clark O, Ferrarone JR, Campos C, Lalani AS, Chodera JD, Intlekofer AM, Elemento O, Mellinghoff IK. Tang CP, et al. Nat Chem Biol. 2022 Feb;18(2):207-215. doi: 10.1038/s41589-021-00947-8. Epub 2021 Dec 23. Nat Chem Biol. 2022. PMID: 34949839 Free PMC article.
Loss of general control nonderepressible 2 (GCN2) kinase rendered cells resistant to neratinib, whereas depletion of the GADD34 phosphatase increased neratinib sensitivity. Loss of GCN2 conferred neratinib resistance by preventing …
Loss of general control nonderepressible 2 (GCN2) kinase rendered cells resistant to neratinib, wh …
CCCP-induced mitochondrial dysfunction - characterization and analysis of integrated stress response to cellular signaling and homeostasis.
Koncha RR, Ramachandran G, Sepuri NBV, Ramaiah KVA. Koncha RR, et al. FEBS J. 2021 Oct;288(19):5737-5754. doi: 10.1111/febs.15868. Epub 2021 Apr 27. FEBS J. 2021. PMID: 33837631 Free article.
Our findings suggest that the CCCP-induced ISR pathway is mediated by activation of HRI kinase, but not by GCN2, PERK, or PKR. Also, CCCP activates AMPK, a cellular energy sensor, and AKT, a regulator implicated in cell survival, and suppresses phosphorylation of mT …
Our findings suggest that the CCCP-induced ISR pathway is mediated by activation of HRI kinase, but not by GCN2, PERK, or PKR. …
Gene panel diagnostics reveals new pathogenic variants in pulmonary arterial hypertension.
Eichstaedt CA, Saßmannshausen Z, Shaukat M, Cao D, Xanthouli P, Gall H, Sommer N, Ghofrani HA, Seyfarth HJ, Lerche M, Halank M, Kleymann J, Benjamin N, Harutyunova S, Egenlauf B, Milger K, Rosenkranz S, Ewert R, Klose H, Hoeper MM, Olsson KM, Lankeit M, Lange TJ, Hinderhofer K, Grünig E. Eichstaedt CA, et al. Respir Res. 2022 Mar 27;23(1):74. doi: 10.1186/s12931-022-01987-x. Respir Res. 2022. PMID: 35346192 Free PMC article.
For the first year the panel contained thirteen PAH genes: ACVRL1, BMPR1B, BMPR2, CAV1, EIF2AK4, ENG, GDF2, KCNA5, KCNK3, KLF2, SMAD4, SMAD9 and TBX4. These were extended by the three genes ATP13A3, AQP1 and SOX17 from March 2018 onwards following the genes' discovery. ...
For the first year the panel contained thirteen PAH genes: ACVRL1, BMPR1B, BMPR2, CAV1, EIF2AK4, ENG, GDF2, KCNA5, KCNK3, KLF2, SMAD4 …
GCN2: roles in tumour development and progression.
Gold LT, Masson GR. Gold LT, et al. Biochem Soc Trans. 2022 Apr 29;50(2):737-745. doi: 10.1042/BST20211252. Biochem Soc Trans. 2022. PMID: 35311890 Free PMC article. Review.
GCN2 (general control nonderepessible 2) is an eIF2alpha kinase responsible for entirely rewiring the metabolism of cells when they are put under amino acid starvation stress. ...This review aims to comprehensively summarise the biochemic …
GCN2 (general control nonderepessible 2) is an eIF2alpha kinase responsible for entirely rewiring …
Proteasomal degradation of WT proinsulin in pancreatic beta cells.
Xu X, Arunagiri A, Haataja L, Alam M, Ji S, Qi L, Tsai B, Liu M, Arvan P. Xu X, et al. J Biol Chem. 2022 Oct;298(10):102406. doi: 10.1016/j.jbc.2022.102406. Epub 2022 Aug 19. J Biol Chem. 2022. PMID: 35988641 Free PMC article.
However, we found that within 60 min after proteasomal inhibition, intracellular proinsulin levels begin to fall in conjunction with increased phosphorylation of eukaryotic initiation factor 2 alpha, which can be inhibited by blocking the gen …
However, we found that within 60 min after proteasomal inhibition, intracellular proinsulin levels begin to fall in conjunction with increas …
The Genetic Epidemiology of Pediatric Pulmonary Arterial Hypertension.
Haarman MG, Kerstjens-Frederikse WS, Vissia-Kazemier TR, Breeman KTN, Timens W, Vos YJ, Roofthooft MTR, Hillege HL, Berger RMF. Haarman MG, et al. J Pediatr. 2020 Oct;225:65-73.e5. doi: 10.1016/j.jpeds.2020.05.051. Epub 2020 Jun 2. J Pediatr. 2020. PMID: 32502478
Targeted next-generation sequencing was performed on PAH-associated genes (BMPR2, ACVRL1, EIF2AK4, CAV1, ENG, KCNK3, SMAD9, and TBX4). Also, children were tested for specific genetic disorders in case of clinical suspicion. ...RESULTS: Nineteen children (27%) had a PAH-ass …
Targeted next-generation sequencing was performed on PAH-associated genes (BMPR2, ACVRL1, EIF2AK4, CAV1, ENG, KCNK3, SMAD9, and TBX4) …
The role of host eIF2α in viral infection.
Liu Y, Wang M, Cheng A, Yang Q, Wu Y, Jia R, Liu M, Zhu D, Chen S, Zhang S, Zhao XX, Huang J, Mao S, Ou X, Gao Q, Wang Y, Xu Z, Chen Z, Zhu L, Luo Q, Liu Y, Yu Y, Zhang L, Tian B, Pan L, Rehman MU, Chen X. Liu Y, et al. Virol J. 2020 Jul 23;17(1):112. doi: 10.1186/s12985-020-01362-6. Virol J. 2020. PMID: 32703221 Free PMC article. Review.
BACKGROUND: eIF2alpha is a regulatory node that controls protein synthesis initiation by its phosphorylation or dephosphorylation. General control nonderepressible-2 (GCN2), protein kinase R-like endoplasmic reticulum kin …
BACKGROUND: eIF2alpha is a regulatory node that controls protein synthesis initiation by its phosphorylation or dephosphorylat …
42 results