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Year Number of Results
2015 42
2016 115
2017 128
2018 136
2019 96
2020 10
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US Emergency Department Visits for Outpatient Adverse Drug Events, 2013-2014.
Shehab N, Lovegrove MC, Geller AI, Rose KO, Weidle NJ, Budnitz DS. Shehab N, et al. JAMA. 2016 Nov 22;316(20):2115-2125. doi: 10.1001/jama.2016.16201. JAMA. 2016. PMID: 27893129 Free PMC article.
Anticoagulants, antibiotics, and diabetes agents were implicated in an estimated 46.9% (95% CI, 44.2%-49.7%) of ED visits for adverse drug events, which included clinically significant adverse events, such as hemorrhage (anticoagulants), moderate to severe al …
Anticoagulants, antibiotics, and diabetes agents were implicated in an estimated 46.9% (95% CI, 44.2%-49.7%) of ED visits for adve
Effectiveness of pharmacist-led medication reconciliation programmes on clinical outcomes at hospital transitions: a systematic review and meta-analysis.
Mekonnen AB, McLachlan AJ, Brien JA. Mekonnen AB, et al. BMJ Open. 2016 Feb 23;6(2):e010003. doi: 10.1136/bmjopen-2015-010003. BMJ Open. 2016. PMID: 26908524 Free PMC article. Review.
Meta-analysis was carried out using a random effects model, and subgroup analysis was conducted to determine the sources of heterogeneity. ...The pooled relative risks showed a more substantial reduction of 67%, 28% and 19% in adverse drug event-related hospital
Meta-analysis was carried out using a random effects model, and subgroup analysis was conducted to determine the sources of heterogen …
Early or Delayed Cardioversion in Recent-Onset Atrial Fibrillation.
Pluymaekers NAHA, Dudink EAMP, Luermans JGLM, Meeder JG, Lenderink T, Widdershoven J, Bucx JJJ, Rienstra M, Kamp O, Van Opstal JM, Alings M, Oomen A, Kirchhof CJ, Van Dijk VF, Ramanna H, Liem A, Dekker LR, Essers BAB, Tijssen JGP, Van Gelder IC, Crijns HJGM; RACE 7 ACWAS Investigators. Pluymaekers NAHA, et al. N Engl J Med. 2019 Apr 18;380(16):1499-1508. doi: 10.1056/NEJMoa1900353. Epub 2019 Mar 18. N Engl J Med. 2019. PMID: 30883054 Clinical Trial.
METHODS: In a multicenter, randomized, open-label, noninferiority trial, we randomly assigned patients with hemodynamically stable, recent-onset (<36 hours), symptomatic atrial fibrillation in the emergency department to be treated with a wait-and-see approach (delayed- …
METHODS: In a multicenter, randomized, open-label, noninferiority trial, we randomly assigned patients with hemodynamically stable, recent-o …
Levetiracetam versus phenytoin for second-line treatment of paediatric convulsive status epilepticus (EcLiPSE): a multicentre, open-label, randomised trial.
Lyttle MD, Rainford NEA, Gamble C, Messahel S, Humphreys A, Hickey H, Woolfall K, Roper L, Noblet J, Lee ED, Potter S, Tate P, Iyer A, Evans V, Appleton RE; Paediatric Emergency Research in the United Kingdom & Ireland (PERUKI) collaborative. Lyttle MD, et al. Lancet. 2019 May 25;393(10186):2125-2134. doi: 10.1016/S0140-6736(19)30724-X. Epub 2019 Apr 17. Lancet. 2019. PMID: 31005385 Free PMC article. Clinical Trial.
METHODS: This open-label, randomised clinical trial was undertaken at 30 UK emergency departments at secondary and tertiary care centres. ...Convulsive status epilepticus was terminated in 106 (70%) children in the levetiracetam group and in 86 (64%) in the …
METHODS: This open-label, randomised clinical trial was undertaken at 30 UK emergency departments at secondary and tertiary ca …
Levetiracetam versus phenytoin for second-line treatment of convulsive status epilepticus in children (ConSEPT): an open-label, multicentre, randomised controlled trial.
Dalziel SR, Borland ML, Furyk J, Bonisch M, Neutze J, Donath S, Francis KL, Sharpe C, Harvey AS, Davidson A, Craig S, Phillips N, George S, Rao A, Cheng N, Zhang M, Kochar A, Brabyn C, Oakley E, Babl FE; PREDICT research network. Dalziel SR, et al. Lancet. 2019 May 25;393(10186):2135-2145. doi: 10.1016/S0140-6736(19)30722-6. Epub 2019 Apr 17. Lancet. 2019. PMID: 31005386 Clinical Trial.
FINDINGS: Between March 19, 2015, and Nov 29, 2017, 639 children presented to participating emergency departments with convulsive status epilepticus; 127 were missed, and 278 did not meet eligibility criteria. The parents of one child declined to give …
FINDINGS: Between March 19, 2015, and Nov 29, 2017, 639 children presented to participating emergency departments with …
Non-traumatic rhabdomyolysis: Background, laboratory features, and acute clinical management.
Cervellin G, Comelli I, Benatti M, Sanchis-Gomar F, Bassi A, Lippi G. Cervellin G, et al. Clin Biochem. 2017 Aug;50(12):656-662. doi: 10.1016/j.clinbiochem.2017.02.016. Epub 2017 Feb 21. Clin Biochem. 2017. PMID: 28235546 Review.
The essential clinical management in the emergency department is based on a targeted intervention to manage the underlying cause, combined with infusion of fluids and eventually sodium bicarbonate. We will present and discuss in this article the pathophysiological and clin …
The essential clinical management in the emergency department is based on a targeted intervention to manage the underlying cause, com …
Trimethoprim-Sulfamethoxazole versus Placebo for Uncomplicated Skin Abscess.
Talan DA, Mower WR, Krishnadasan A, Abrahamian FM, Lovecchio F, Karras DJ, Steele MT, Rothman RE, Hoagland R, Moran GJ. Talan DA, et al. N Engl J Med. 2016 Mar 3;374(9):823-32. doi: 10.1056/NEJMoa1507476. N Engl J Med. 2016. PMID: 26962903 Free PMC article. Clinical Trial.
BACKGROUND: U.S. emergency department visits for cutaneous abscess have increased with the emergence of methicillin-resistant Staphylococcus aureus (MRSA). ...METHODS: We conducted a randomized trial at five U.S. emergency departments to …
BACKGROUND: U.S. emergency department visits for cutaneous abscess have increased with the emergence of methicillin-res …
A multicentre randomised controlled trial of levetiracetam versus phenytoin for convulsive status epilepticus in children (protocol): Convulsive Status Epilepticus Paediatric Trial (ConSEPT) - a PREDICT study.
Dalziel SR, Furyk J, Bonisch M, Oakley E, Borland M, Neutze J, Donath S, Sharpe C, Harvey S, Davidson A, Craig S, Phillips N, George S, Rao A, Cheng N, Zhang M, Sinn K, Kochar A, Brabyn C, Babl FE; PREDICT research network. Dalziel SR, et al. BMC Pediatr. 2017 Jun 22;17(1):152. doi: 10.1186/s12887-017-0887-8. BMC Pediatr. 2017. PMID: 28641582 Free PMC article. Clinical Trial.
The current standard of care, phenytoin, is only 60% effective, and associated with considerable adverse effects. A newer anti-convulsant, levetiracetam, can be given faster, is potentially more efficacious, with a more tolerable side effect profile. The prim …
The current standard of care, phenytoin, is only 60% effective, and associated with considerable adverse effects. A new …
Incidence of adverse events in paediatric procedural sedation in the emergency department: a systematic review and meta-analysis.
Bellolio MF, Puls HA, Anderson JL, Gilani WI, Murad MH, Barrionuevo P, Erwin PJ, Wang Z, Hess EP. Bellolio MF, et al. BMJ Open. 2016 Jun 15;6(6):e011384. doi: 10.1136/bmjopen-2016-011384. BMJ Open. 2016. PMID: 27311910 Free PMC article. Review.
OBJECTIVE AND DESIGN: We conducted a systematic review and meta-analysis to evaluate the incidence of adverse events in the emergency department (ED) during procedural sedation in the paediatric population. ...PARTICIPANTS: Children. INTERVENTIONS: Procedural …
OBJECTIVE AND DESIGN: We conducted a systematic review and meta-analysis to evaluate the incidence of adverse events in the emerge
Prevalence and Preventability of Drug-Related Hospital Readmissions: A Systematic Review.
El Morabet N, Uitvlugt EB, van den Bemt BJF, van den Bemt PMLA, Janssen MJA, Karapinar-Çarkit F. El Morabet N, et al. J Am Geriatr Soc. 2018 Mar;66(3):602-608. doi: 10.1111/jgs.15244. Epub 2018 Feb 22. J Am Geriatr Soc. 2018. PMID: 29468640
Nine measured readmissions due to drug-related problems, seven due to adverse drug reactions, two due to adverse drug events, and one due to drug-drug interactions. Rates of readmissions due to drugs varied from 3% to 64% (median 21%, interquartile range (IQR …
Nine measured readmissions due to drug-related problems, seven due to adverse drug reactions, two due to adverse drug events, …
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