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Page 1
Oxidative stress gene expression, DNA methylation, and gut microbiota interaction trigger Crohn's disease: a multi-omics Mendelian randomization study.
Xu S, Li X, Zhang S, Qi C, Zhang Z, Ma R, Xiang L, Chen L, Zhu Y, Tang C, Bourgonje AR, Li M, He Y, Zeng Z, Hu S, Feng R, Chen M. Xu S, et al. BMC Med. 2023 May 11;21(1):179. doi: 10.1186/s12916-023-02878-8. BMC Med. 2023. PMID: 37170220 Free PMC article.
Putative results were validated in an independent multi-omics cohort from the First Affiliated Hospital of Sun Yat-sen University (FAH-SYS). RESULTS: A meta-analysis from six datasets identified 438 OS-related DEGs enriched in intestinal enterocytes in CD from 817 OS-relat …
Putative results were validated in an independent multi-omics cohort from the First Affiliated Hospital of Sun Yat-sen University (FAH …
Efficient expansion and CRISPR-Cas9-mediated gene correction of patient-derived hepatocytes for treatment of inherited liver diseases.
Zhang K, Wan P, Wang L, Wang Z, Tan F, Li J, Ma X, Cen J, Yuan X, Liu Y, Sun Z, Cheng X, Liu Y, Liu X, Hu J, Zhong G, Li D, Xia Q, Hui L. Zhang K, et al. Cell Stem Cell. 2024 Aug 1;31(8):1187-1202.e8. doi: 10.1016/j.stem.2024.04.022. Epub 2024 May 20. Cell Stem Cell. 2024. PMID: 38772378 Free article.
Moreover, the proliferating patient-derived hepatocytes, together with the AAV2.7m8 variant identified through screening, enabled CRISPR-Cas9-mediated targeted integration efficiently, achieving functional correction of pathogenic mutations in FAH or OTC. Importantly, thes …
Moreover, the proliferating patient-derived hepatocytes, together with the AAV2.7m8 variant identified through screening, enabled CRISPR-Cas …
Tyrosine catabolism enhances genotoxic chemotherapy by suppressing translesion DNA synthesis in epithelial ovarian cancer.
Li J, Zheng C, Mai Q, Huang X, Pan W, Lu J, Chen Z, Zhang S, Zhang C, Huang H, Chen Y, Guo H, Wu Z, Deng C, Jiang Y, Li B, Liu J, Yao S, Pan C. Li J, et al. Cell Metab. 2023 Nov 7;35(11):2044-2059.e8. doi: 10.1016/j.cmet.2023.10.002. Epub 2023 Oct 26. Cell Metab. 2023. PMID: 37890478 Free article.
Here, we report that the depletion of fumarylacetoacetate hydrolase (FAH), an enzyme that catalyzes the final step of tyrosine catabolism, reduced chemosensitivity in epithelial ovarian cancer (EOC). The expression level of FAH correlated significantly …
Here, we report that the depletion of fumarylacetoacetate hydrolase (FAH), an enzyme that catalyzes the final step of t …
Endoplasmic Reticulum Stress-Induced Upregulation of STARD1 Promotes Acetaminophen-Induced Acute Liver Failure.
Torres S, Baulies A, Insausti-Urkia N, Alarcón-Vila C, Fucho R, Solsona-Vilarrasa E, Núñez S, Robles D, Ribas V, Wakefield L, Grompe M, Lucena MI, Andrade RJ, Win S, Aung TA, Kaplowitz N, García-Ruiz C, Fernández-Checa JC. Torres S, et al. Gastroenterology. 2019 Aug;157(2):552-568. doi: 10.1053/j.gastro.2019.04.023. Epub 2019 Apr 25. Gastroenterology. 2019. PMID: 31029706 Free article.
Adult human hepatocytes were transplanted into Fah(-/-)/Rag2(-/-)/Il2rg(-/-)/NOD (FRGN) mice to create mice with humanized livers. RESULTS: Administration of VPA before administration of APAP increased the severity of liver damage in control mice. ...
Adult human hepatocytes were transplanted into Fah(-/-)/Rag2(-/-)/Il2rg(-/-)/NOD (FRGN) mice to create mice with humanized livers. RE …
Generation of an induced pluripotent stem cell line SDQLCHi026-A from a hereditary tyrosinemia type I patient carrying compound heterozygote mutations in FAH gene.
Zhang H, Liu C, Ma Y, Lin L, Lv Y, Gao M, Gai Z, Liu Y. Zhang H, et al. Stem Cell Res. 2021 May;53:102331. doi: 10.1016/j.scr.2021.102331. Epub 2021 Apr 9. Stem Cell Res. 2021. PMID: 33882394 Free article.
Here we describe the generation of induced pluripotent stem cells (iPSCs) from a patient diagnosed as hereditary tyrosinemia type I (HT1) caused by FAH gene mutation. Induced pluripotent stem cells (iPSCs) were developed using non-integrating episomal vectors containing OC …
Here we describe the generation of induced pluripotent stem cells (iPSCs) from a patient diagnosed as hereditary tyrosinemia type I (HT1) ca …
Metformin reduces hepatocarcinogenesis by inducing downregulation of Cyp26a1 and CD8+ T cells.
He W, Wang X, Chen M, Li C, Chen W, Pan L, Cui Y, Yu Z, Wu G, Yang Y, Xu M, Dong Z, Ma K, Wang J, He Z. He W, et al. Clin Transl Med. 2023 Nov;13(11):e1465. doi: 10.1002/ctm2.1465. Clin Transl Med. 2023. PMID: 37997519 Free PMC article.
RESULTS: RNA-sequencing analysis showed that chronic liver injury led to significant changes in AMPK-, glucose- and retinol metabolism-related pathways in Fah(-/-) mice. Metformin prevented the formation of non-diabetic HCC in Fah(-/-) mice with chronic liver injury …
RESULTS: RNA-sequencing analysis showed that chronic liver injury led to significant changes in AMPK-, glucose- and retinol metabolism-relat …
Protein Degradation and the Pathologic Basis of Phenylketonuria and Hereditary Tyrosinemia.
Sarodaya N, Suresh B, Kim KS, Ramakrishna S. Sarodaya N, et al. Int J Mol Sci. 2020 Jul 15;21(14):4996. doi: 10.3390/ijms21144996. Int J Mol Sci. 2020. PMID: 32679806 Free PMC article. Review.
Diseases such as phenylketonuria (PKU) and hereditary tyrosinemia-I (HT1) are caused due to mutations in PAH and FAH gene, resulting in reduced protein stability, misfolding, accelerated degradation, and deficiency in functional proteins. ...
Diseases such as phenylketonuria (PKU) and hereditary tyrosinemia-I (HT1) are caused due to mutations in PAH and FAH gene, resulting …
Adenine base editing in an adult mouse model of tyrosinaemia.
Song CQ, Jiang T, Richter M, Rhym LH, Koblan LW, Zafra MP, Schatoff EM, Doman JL, Cao Y, Dow LE, Zhu LJ, Anderson DG, Liu DR, Yin H, Xue W. Song CQ, et al. Nat Biomed Eng. 2020 Jan;4(1):125-130. doi: 10.1038/s41551-019-0357-8. Epub 2019 Feb 25. Nat Biomed Eng. 2020. PMID: 31740768 Free PMC article.
ABE treatment partially restored splicing, generated fumarylacetoacetate hydrolase (FAH)-positive hepatocytes in the liver, and rescued weight loss in mice. We also generated FAH(+) hepatocytes in the liver via lipid-nanoparticle-mediated delivery of a …
ABE treatment partially restored splicing, generated fumarylacetoacetate hydrolase (FAH)-positive hepatocytes in the li …
History of tuberculosis disease is associated with genetic regulatory variation in Peruvians.
Nieto-Caballero VE, Reijneveld JF, Ruvalcaba A, Innocenzi G, Abeydeera N, Asgari S, Lopez K, Iwany SK, Luo Y, Nathan A, Fernandez-Salinas D, Chiñas M, Huang CC, Zhang Z, León SR, Calderon RI, Lecca L, Budzik JM, Murray M, Van Rhijn I, Raychaudhuri S, Moody DB, Suliman S, Gutierrez-Arcelus M. Nieto-Caballero VE, et al. PLoS Genet. 2024 Jun 13;20(6):e1011313. doi: 10.1371/journal.pgen.1011313. eCollection 2024 Jun. PLoS Genet. 2024. PMID: 38870230 Free PMC article.
The top eQTL interaction for a protein-coding gene was with FAH, the gene encoding fumarylacetoacetate hydrolase, which mediates the last step in mammalian tyrosine catabolism. FAH expression was associated with genetic regulatory variation in cases bu …
The top eQTL interaction for a protein-coding gene was with FAH, the gene encoding fumarylacetoacetate hydrolase, which …
Modeling HBV Infection and Therapy in Immunodeficient NOD-Rag1-/-IL2RgammaC-null (NRG) Fumarylacetoacetate Hydrolase (FAH) Knockout Mice with Human Chimeric Liver.
Ahodantin J, Li F, Su L. Ahodantin J, et al. Methods Mol Biol. 2024;2837:199-206. doi: 10.1007/978-1-0716-4027-2_17. Methods Mol Biol. 2024. PMID: 39044086
Here, we describe a detailed protocol for studying hepatitis B infection in NRG-derived fumarylacetoacetate hydrolase (FAH) knockout mice repopulated with human hepatocytes (FRG-Hu HEP mice). ...
Here, we describe a detailed protocol for studying hepatitis B infection in NRG-derived fumarylacetoacetate hydrolase (FAH …
35 results