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Page 1
Key Genetic Determinants Driving Esophageal Squamous Cell Carcinoma Initiation and Immune Evasion.
Ko KP, Huang Y, Zhang S, Zou G, Kim B, Zhang J, Jun S, Martin C, Dunbar KJ, Efe G, Rustgi AK, Nakagawa H, Park JI. Ko KP, et al. Gastroenterology. 2023 Sep;165(3):613-628.e20. doi: 10.1053/j.gastro.2023.05.030. Epub 2023 May 29. Gastroenterology. 2023. PMID: 37257519 Free PMC article.
METHODS: Using CRISPR/Cas 9-based genetic ablation, we targeted 9 genes (TP53, CDKN2A, NOTCH1, NOTCH3, KMT2D, KMT2C, FAT1, FAT4, and AJUBA) in murine esophageal organoids. Transcriptomic phenotypes of organoids and chemokine released by organoids were analyzed by single-ce …
METHODS: Using CRISPR/Cas 9-based genetic ablation, we targeted 9 genes (TP53, CDKN2A, NOTCH1, NOTCH3, KMT2D, KMT2C, FAT1, FAT4, and …
A pan-cancer analysis of FAT atypical cadherin 4 (FAT4) in human tumors.
Mao W, Zhou J, Hu J, Zhao K, Fu Z, Wang J, Mao K. Mao W, et al. Front Public Health. 2022 Aug 16;10:969070. doi: 10.3389/fpubh.2022.969070. eCollection 2022. Front Public Health. 2022. PMID: 36051999 Free PMC article.
We analyzed the expression of FAT4 in tumor and normal tissues. Meanwhile, we analyzed the expression levels of FAT4 in tissues from tumors of different stages. ...Pan-cancer analysis showed that FAT4 to be novel biomarkers for various cancers prognosis....
We analyzed the expression of FAT4 in tumor and normal tissues. Meanwhile, we analyzed the expression levels of FAT4 in tissue …
MiR-106b-5p regulates the migration and invasion of colorectal cancer cells by targeting FAT4.
Pan M, Chen Q, Lu Y, Wei F, Chen C, Tang G, Huang H. Pan M, et al. Biosci Rep. 2020 Nov 27;40(11):BSR20200098. doi: 10.1042/BSR20200098. Biosci Rep. 2020. PMID: 33063118 Free PMC article.
Overexpression of FAT4 resulted in decreased proliferation, migration, invasion and angiogenesis of CRC cells, whereas silencing of FAT4 led to the opposite results. In rescue experiment, miR-106b-5p partially reversed the function of FAT4 in CRC cells, thus …
Overexpression of FAT4 resulted in decreased proliferation, migration, invasion and angiogenesis of CRC cells, whereas silencing of …
FAT4 regulates the EMT and autophagy in colorectal cancer cells in part via the PI3K-AKT signaling axis.
Wei R, Xiao Y, Song Y, Yuan H, Luo J, Xu W. Wei R, et al. J Exp Clin Cancer Res. 2019 Mar 4;38(1):112. doi: 10.1186/s13046-019-1043-0. J Exp Clin Cancer Res. 2019. PMID: 30832706 Free PMC article.
BACKGROUND: FAT4 functions as a tumor suppressor, and previous findings have demonstrated that FAT4 can inhibit the epithelial-to-mesenchymal transition (EMT) and the proliferation of gastric cancer cells. However, few studies have investigated the role of FAT4 …
BACKGROUND: FAT4 functions as a tumor suppressor, and previous findings have demonstrated that FAT4 can inhibit the epithelial …
UBE4B promotes gastric cancer proliferation and metastasis by mediating FAT4 ubiquitination and degradation.
Wu K, Guo Z, Fu Y, Yang S, Pan Y, Yan R, Zhou X. Wu K, et al. Cell Death Dis. 2025 Jul 23;16(1):551. doi: 10.1038/s41419-025-07794-8. Cell Death Dis. 2025. PMID: 40701960 Free PMC article.
The quantitative Tandem Mass Tag (TMT) analysis revealed that FAT oncogenic homologue 4 (FAT4) is a downstream gene of UBE4B. Western blot experiments and transmission electron microscopy (TEM) results for biological samples revealed that UBE4B inhibits autophagy in GC cel …
The quantitative Tandem Mass Tag (TMT) analysis revealed that FAT oncogenic homologue 4 (FAT4) is a downstream gene of UBE4B. Western …
Mammalian cadherins DCHS1-FAT4 affect functional cerebral architecture.
Beste C, Ocklenburg S, von der Hagen M, Di Donato N. Beste C, et al. Brain Struct Funct. 2016 Jun;221(5):2487-91. doi: 10.1007/s00429-015-1051-6. Epub 2015 May 1. Brain Struct Funct. 2016. PMID: 25930014
We addressed this question by examining functional cerebral asymmetries in a patient with Van Maldergem Syndrome (VMS) (MIM#601390), which is caused by mutations in DCHS1-FAT4 cadherins, using a dichotic listening task. Using neurophysiological (EEG) data, we show that whe …
We addressed this question by examining functional cerebral asymmetries in a patient with Van Maldergem Syndrome (VMS) (MIM#601390), which i …
FAT4 Fine-Tunes Kidney Development by Regulating RET Signaling.
Zhang H, Bagherie-Lachidan M, Badouel C, Enderle L, Peidis P, Bremner R, Kuure S, Jain S, McNeill H. Zhang H, et al. Dev Cell. 2019 Mar 25;48(6):780-792.e4. doi: 10.1016/j.devcel.2019.02.004. Epub 2019 Mar 7. Dev Cell. 2019. PMID: 30853441 Free PMC article.
Analysis of kidney development in Fat4(-/-) kidneys revealed abnormal ureteric budding and excessive RET signaling. Removal of one copy of the RET ligand Gdnf rescues Fat4(-/-) kidney development, supporting the proposal that loss of Fat4 hyperactivates RET s …
Analysis of kidney development in Fat4(-/-) kidneys revealed abnormal ureteric budding and excessive RET signaling. Removal of one co …
LATS2 and FAT4 as key candidate genes of hippo pathway associated with the risk and progression of breast cancer: an in-silico approach.
Sadaf, Zafar M, Massey S, Aloliqi AA, Anwar S, Ali A, Hussain MA, Bhardwaj T, Dev K. Sadaf, et al. Sci Rep. 2024 Nov 21;14(1):28857. doi: 10.1038/s41598-024-79688-2. Sci Rep. 2024. PMID: 39572650 Free PMC article.
A disease enrichment study was also done to explore the potential of the hippo pathway in various aspects. RESULTS: LATS2 and FAT4 genes of the hippo pathway have shown an interesting association with overall survival, hypermethylation, genetic alterations, and decreased e …
A disease enrichment study was also done to explore the potential of the hippo pathway in various aspects. RESULTS: LATS2 and FAT4 ge …
FAT4 silencing promotes epithelial-to-mesenchymal transition and invasion via regulation of YAP and beta-catenin activity in ovarian cancer.
Malgundkar SH, Burney I, Al Moundhri M, Al Kalbani M, Lakhtakia R, Okamoto A, Tamimi Y. Malgundkar SH, et al. BMC Cancer. 2020 May 4;20(1):374. doi: 10.1186/s12885-020-06900-7. BMC Cancer. 2020. PMID: 32366234 Free PMC article.
In the present study, we examined the role of FAT4 in proliferation and metastasis, and its mechanisms of interaction in these processes. METHODS: We have performed cell viability, colony formation, and invasion assays in ovarian cancer cells treated with siRNA to knockdow …
In the present study, we examined the role of FAT4 in proliferation and metastasis, and its mechanisms of interaction in these proces …
Dachsous1-Fat4 Signaling Controls Endothelial Cell Polarization During Lymphatic Valve Morphogenesis-Brief Report.
Pujol F, Hodgson T, Martinez-Corral I, Prats AC, Devenport D, Takeichi M, Genot E, Mäkinen T, Francis-West P, Garmy-Susini B, Tatin F. Pujol F, et al. Arterioscler Thromb Vasc Biol. 2017 Sep;37(9):1732-1735. doi: 10.1161/ATVBAHA.117.309818. Epub 2017 Jul 13. Arterioscler Thromb Vasc Biol. 2017. PMID: 28705793
OBJECTIVE: The purpose of this study was to investigate the role of Fat4 and Dachsous1 signaling in the lymphatic vasculature. APPROACH AND RESULTS: Phenotypic analysis of the lymphatic vasculature was performed in mice lacking functional Fat4 or Dachsous1. ...Final …
OBJECTIVE: The purpose of this study was to investigate the role of Fat4 and Dachsous1 signaling in the lymphatic vasculature. APPROA …
90 results